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Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis

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World Journal of Hepatology 2024年第5期16卷 822-831页

作者： Irina Efremova Roman Maslennikov Elena Poluektova Oleg Medvedev Anna Kudryavtseva George Krasnov Maria Fedorova Filipp Romanikhin Maria Zharkova Oxana Zolnikova Gyunay bagieva vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Department of Scientific Scientific Community for the Promotion of the Clinical Study of the Human MicrobiomeMoscow 119435Russia Department of Pharmacology Lomonosov Moscow State UniversityMoscow 119192Russia Department of Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

bACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a *** To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious *** This study included 48 patients with Child–Pugh cirrhosis classes b and C and 15 healthy *** fecal microbiome was assessed using 16S rRNA gene *** levels of presepsin were measured.A total of 22 patients received a probiotic(Saccharomyces boulardii)for 3 *** Presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;P=0.048].Patients with elevated presepsin levels accounted for 56.3%of all included *** had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–Pugh *** with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely bacilli and Proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and Stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier *** presepsin level directly correlated with the relative abundance of bacilli,Proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and *** 3 months of taking the probiotic,the severity of cirrhosis on the Child–Pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);P=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);P=0.123].A high level of presepsin

关键词： Dysbiosis Gut Intestinal permeability Leaky gut Gut-liver axis Liver Microbiota

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Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev vladimir A.Chernyshev Aleksandr S.Aleksandrovsky Alexander S.Krylov Svetlana N.Krylova Nikolai P.Shestakov Dmitriy A.Velikanov Alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and Educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the baLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the baLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of EuRECuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

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TELS: A Novel Computational Framework for Identifying Motif Signatures of Transcribed Enhancers

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Genomics, Proteomics & bioinformatics 2018年第5期16卷 332-341页

作者： Dimitrios Kleftogiannis Haitham Ashoor vladimir b.bajic Centre for Evolution and Cancer Division of Molecular PathologyThe Institute of Cancer Research(ICR)London SM2 5NGUnited Kingdom The Jackson Laboratory for Genomic Medicine FarmingtonCT 06032USA Computational bioscience Research Center(CbRC) ComputerElectrical and Mathematical Sciences and Engineering

In mammalian cells, transcribed enhancers(TrEns) play important roles in the initiation of gene expression and maintenance of gene expression levels in a spatiotemporal manner. One of the most challenging questions is how the genomic characteristics of enhancers relate to enhancer activities. To date, only a limited number of enhancer sequence characteristics have been investigated, leaving space for exploring the enhancers’ DNA code in a more systematic way. To address this problem, we developed a novel computational framework, Transcribed Enhancer Landscape Search(TELS), aimed at identifying predictive cell type/tissue-specific motif signatures of *** a case study, we used TELS to compile a comprehensive catalog of motif signatures for all known TrEns identified by the FANTOM5 consortium across 112 human primary cells and *** results confirm that combinations of different short motifs characterize in an optimized manner cell type/tissue-specific TrEns. Our study is the first to report combinations of motifs that maximize classification performance of TrEns exclusively transcribed in one cell type/tissue from TrEns exclusively transcribed in different cell types/tissues. Moreover, we also report 31 motif signatures predictive of enhancers’ broad activity. TELS codes and material are publicly available at http://***/TELS.

关键词： Sequence analysis Machine learning Transcription regulation Transcribed enhancer Motif identification

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The Value and Significance of Metagenomics of Marine Environments

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Genomics, Proteomics & bioinformatics 2015年第5期13卷 271-274页

作者： Fangqing Zhao vladimir b.bajic Computational Genomics Lab Beijing Institutes of Life ScienceChinese Academy of Sciences Computational bioscience Research Center (CbRC) ComputerElectrical and Mathematical Sciences and Engineering Division (CEMSE)King Abdullah University of Science and Technology (KAUST)

Microbes have played a fundamental role in the natural his- tory of our planet, and have done so for billions of years. They have adapted to Earth＇s many environments from the mild to the very extreme. Studying their diversity and their way of life is critical for understanding their full impact on the global ecology. Although the field of metagenomics is still young, it has unravelled a wider microbial diversity that had otherwise been completely overlooked by the traditional methods of microbiology. There are three major metagenomic themes：（a） marker metagenomics that surveys microbial community structure by targeting the highly-conserved 16S rRNA gene, （b） functional metagenomics that takes the total environmental DNA, from which it infers the metabolic potential of the microbial community, and （c） identification of novel enzymes.

关键词： The Value and Significance of Metagenomics of Marine Environments

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica b 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of Vrcb with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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Integer Codes Correcting Single Errors and Random Asymmetric Errors within a byte

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Journal of Systems Science & Complexity 2020年第6期33卷 2103-2113页

作者： RADONJIC Aleksandar VUJICIC vladimir Institute of Technical Sciences of the Serbian Academy of Sciences and Arts BelgradeSerbia

In optical networks without optical amplifiers(ONWOAs) photons may fade or fail to be detected, but new photons cannot be generated. Hence, under normal conditions, only 1 → 0 errors can occur. However, in some situations, the photodetector may generate a false 0 → 1 error. This mostly occurs in cases when the dark current is higher than specified. With this in mind, in this paper,the authors present a class of codes suitable for use in ONWOAs using self-synchronous *** presented codes can correct single errors and random asymmetric(1 → 0) errors within a b-bit byte. Unlike classical codes, these codes use integer and lookup table operations. As a result, their interleaved version, implemented on a dual-core 3.0 GHz processor, achieves the theoretical throughput above the operating rate of 10 G networks.

关键词： Asymmetric errors decoding throughput integer codes optical networks single errors

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Study of cobalt ferrite nanosuspensions for low-frequency ferromagnetic hyperthermia

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Particuology 2008年第5期6卷 322-333页

作者： bronislav E.Kashevsky vladimir E.Agabekov Sergei b.Kashevsky Katsiaryna A.Kekalo Elena Yu.Manina Igor V.Prokhorov vladimir S.Ulashchik A.V.Luikov Heat and Mass Transfer Institute Belarus Academy of Sciences P.Brovka Str.15Minsk 220072Belarus Institute of Chemistry of New Materials Belarus Academy of SciencesSkoriny Str.36Minsk 220141Belarus Institute of Physiology Belarus Academy of SciencesAkademicheskaiy Str.28Minsk 220072Belarus

High-coercive cobalt ferrite nanoparticles were synthesized and studied for magnetic hyperthermia by direct injection of their suspension into a tumor and application of a strong audio-frequency magnetic field for heating. Physical （dynamic magnetic hysteresis and heat generation in both liquid and solid dispersions）, biological （toxicity and penetration of particles in therapeutic quantities into mouse tumor tissue） as well as other properties of the particles were studied. A model was developed to describe the magnetodynamics in suspensions of magnetic nanoclusters with an account for both brownian and regular rotations, to provide understanding of observed phenomena. The experimental and theoretical techniques developed have formed a basis for controllable synthesis of the magnetic nanoparticles for low-frequency heat generation in medical and other applications.

关键词： Cobalt ferrite nanoparticles Magnetic suspensions Dynamic magnetic hysteresis Medical hyperthermia

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Finite-element analysis of scattering parameters of surface acoustic wave bandpass filter formed on barium titanate thin film

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International Journal of Smart and Nano Materials 2018年第2期9卷 88-98,I0002页

作者： Pavel E.Timoshenko Valery V.Kalinchuk vladimir b.Shirokov Department of Nanotechnology Southern Federal UniversityRostov-on-DonRussia Southern Scientific Center RAS Rostov-on-DonRussia

The frequency dependence of scattering parameters of interdigital surface acoustic wave transducers placed on ferroelectric barium titanate(baTiO_(3))epitaxial film in c-phase coated over magnesium oxide has been studied using the finite-element method(FEM)approach along with the perfectly matched layer(PML)*** interdigital transducer which has a comb-like structure with aluminum electrodes excites the mechanical *** distance between the fingers allows tuning the frequency properties of the wave *** magnesium oxide is taken as the *** two-dimensional model of two-port surface acoustic wave filter is created to calculate scattering parameters and to show how to design the fixture in COMSOL_(TM).Some practical computational challenges of finite element modeling of SAW devices in COMSOL_(TM)are *** effect of lattice misfit strain on acoustic properties of heterostructures of baTiO_(3)epitaxial film in c-phase at room temperature is discussed in present article for two lowfrequency surface acoustic resonances.

关键词： SAW filters ferroelectrics thin films finite element method(FEM) COMSOL

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Carbon monoxide production using a steel mill gas in a combined chemical looping process

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Journal of Energy Chemistry 2022年第5期31卷 811-825页

作者： Varun Singh Lukas C.buelens Hilde Poelman Mark Saeys Guy b.Marin vladimir V.Galvita Laboratory for Chemical Technology Technologiepark 125B-9052 GhentBelgium

Up to 9% of the global CO_(2) emissions come from the iron and steel industry. Here, a combined chemical looping process to produce CO, a building block for the chemical industry, from the CO_(2) -rich blast furnace gas of a steel mill is proposed. This cyclic process can make use of abundant Fe_(3)O_(4) and CaO as solid oxygen and CO_(2) carriers at atmospheric pressure. A proof of concept was obtained in a laboratory-scale fixed bed reactor with synthetic blast furnace gas and Fe_(3)O_(4) /CaO = 0.6 kg/kg. CO production from the proposed process was investigated at both isothermal conditions(1023 K) and upon imposing a temperature program from 1023 to 1148 K. The experimental results were compared using performance indicators such as CO yield, CO space time yield, carbon recovery of the process, fuel utilisation, and solids’ *** temperature-programmed CO production resulted in a CO yield of 0.056 ± 0.002 mol per mol of synthetic blast furnace gas at an average CO space time yield of 7.6 mmol kgFe^(-1) s^(-1) over 10 cycles, carbon recovery of 48% ± 1%, fuel utilisation of 23% ± 2%, and an average calcium oxide and iron oxide utilisation of 22% ± 1% and 11% ± 1%. These experimental performance indicators for the temperature-programmed CO production were consistently better than those of the isothermal implementation mode by 20% to 35%. Over 10 consecutive process cycles, no significant losses in CO yield were observed in either implementation mode. Process simulation was carried out for 1 million metric tonnes per year of equivalent CO_(2) emissions from the blast furnace gas of a steel mill to analyse the exergy losses in both modes of operation. Comparison of the exergy efficiency of the temperature-programmed process to the isothermal process showed that the former is more efficient because of the higher CO concentration achievable,despite 20% higher exergy losses caused by heat transfer required to change temperature.

关键词： Steel industry CO_(2)capture Calcium oxide CO_(2)sorbent Reverse water gas shift Circular economy Process intensification

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Improved theory of generalized meteo-ballistic weighting factor functions and their use

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Defence Technology（防务技术） 2016年第3期12卷 242-254页

作者： vladimir CECH Jiri JEVICKY Department of Weapons and Ammunition University of Defence Oprox Inc. Department of Mathematics and Physics University of Defence

It follows from the analysis of artillery fire errors that approximately two-thirds of the inaccuracy of indirect artillery fire is caused by inaccuracies in the determination of the meteo parameters included in fire error budget *** calculated under non-standard conditions are considered to be *** tools utilized for the analysis of perturbed trajectories are weighting factor functions(WFFs)which are a special kind of sensitivity *** are used for calculation of meteo ballistic elements b(ballistic wind w b,densityρb,virtual temperatureτb,pressure p b)as *** have found that the existing theory of WFF calculation has several significant *** aim of the article is to present a new,improved theory of generalized WFFs that eliminates the deficiencies *** this theory will improve methods for designing firing tables,fire control systems algorithms,and meteo message generation algorithms.

关键词： Exterior ballistic Non-standard projectile trajectory Perturbation Meteoconditions Sensitivity function (Generalized) weighting (factor) function(curve) (Generalized) effect function Norm effect

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