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Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery

Nano Research 2018年第10期11卷 5584-5595页

作者： Jonathan Wang Christopher Poon Deborah Chin Sarah Milkowski vivian lu Kenneth R. Hallows Eun Ji Chung Department of Biomedical Engineering University of Southern California Los Angeles CA 90089 USA Division of Nephrology and Hypertension Department of Medicine Keck School of Medicine University of Southern California Los Angeles CA 90033 USA USC/UKRO Kidney Research Center Keck School of Medicine University of Southern California Los Angeles CA 90033 USA Norris Comprehensive Cancer Center University of Southern California Los Angeles CA 90033 USA Department of Stem Cell Biology and Regenerative Medicine University of Southern California Los Angeles CA 90033 USA Mork Family Department of Chemical Engineering and Materials Science University of Southern California Los Angeles CA 90089 USA

One in three Americans is at risk for developing chronic kidney disease （CKD） and end-stage renal disease （ESRD）, leading to the need for dialysis or a kidney transplant. Small-molecule drugs have been proposed as therapies to manage kidney diseases, but high dosages are often required to achieve therapeutic efficacy, generating off-target side effects, some of which are lethal. To address these limitations, we developed a novel kidney-targeting multimodal micelle （KM） system for drug delivery applications. SpecificaU~ we incorporated the kidney-targeting peptide （Lysine-Lysine-Glutamic acid-Glutamic acid-Glutamic acid）3-Lysine）（（KKEEE）3K） into micelles. This peptide binds to megalin, a multi-ligand cell surface receptor present on renal tubule cells. When incubated with human kidney proximal tubule cells, KMs were found to be biocompatible in vitro. In vivo, KMs showed higher accumulation in the kidneys as compared to a non-targeted （NT） control upon intravenous injection in wild-type C57BL/6J mice. Histological evaluation showed no signs of tissue damage, while blood urea nitrogen （BUN） and creatinine levels were within normal ranges, validating the preservation of kidney health upon micelle administration. To our knowledge, this is the first utilization of （KKEEE）BK in a nanoparticle formulation, and our study offers strong evidence that this novel nanoparticle platform can be used as a candidate drug delivery carrier to direct therapeutics to diseased tissue in CKD.

关键词： micelle kidney disease renal targeting biodistribution nanoparticle

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写一封信给未来的自己

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中文自修 2010年第2期 30-31页

作者： vivian-lu 小唯张画海凌陈婳怡陈佳源上海市复兴初级中学上海市进华中学上海市光明中学上海市崇明县大公中学

我是不是未来的你,你是不是曾经的我?曾经的我一直在奋斗,为了未来的你。千篇一律地重复同一种步调,过几乎同一种生活,经历了不大不小的离别,学会了不冷不暖的哭泣。

关键词：你的微笑一封信中文自修

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沿路错过的风景

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中文自修 2010年第3期 31-31页

作者： vivian-lu

当明白失去后才更加留恋拥有的一切,当与唾手可得的失之交臂才会更加奋发向上。我们可以在窗边虚度年华,也可以在灯下勤学不止。两种都有错过,后者错过了美丽而前者失去了人生。

关键词：中文自修

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Quantitative structure-activity relationships of antimicrobial fatty acids and derivatives against Staphylococcus aureus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第2期13卷 83-93页

作者： Hui ZHANG lu ZHANG Li-juan PENG Xiao-wu DONG Di WU vivian Chi-Hua WU Feng-qin FENG Department of Food Science and Nutrition Zhejiang UniversityHangzhou 310058China ZJU-ENS Joint Laboratory of Medicinal Chemistry College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Food Science and Human Nutrition University of MaineOrono 04469USA

Fatty acids and derivatives(FADs)are resources for natural *** order to screen for additional potent antimicrobial agents,the antimicrobial activities of FADs against Staphylococcus aureus were examined using a microplate *** of fatty acids were the most potent class of fatty acids,among which monotridecanoin possessed the most potent antimicrobial *** conventional quantitative structure-activity relationship(QSAR)and comparative molecular field analysis(CoMFA)were performed to establish two statistically reliable models(conventional QSAR:R2=0.942,Q 2 LOO=0.910;CoMFA:R 2=0.979,Q 2=0.588,respectively).Improved forecasting can be achieved by the combination of these two models that provide a good insight into the structureactivity relationships of the FADs and that may be useful to design new FADs as antimicrobial agents.

关键词： Fatty acid derivatives Quantitative structure-activity relationship Comparative molecular field analysis Antimicrobial activity

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Extremely thin but very robust:Surprising cryptogam trait combinations at the end of the leaf economics spectrum

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Plant Diversity 2024年第5期46卷 621-629页

作者： Tana Wuyun lu Zhang Tiina Tosens Bin Liu Kristiina Mark JoséÁngel Morales-Sanchez Jesamine Jöneva Rikisahedew vivian Kuusk Ülo Niinemets Institute of Agricultural and Environmental Sciences Estonian University of Life SciencesKreutzwaldi 1Tartu 51014Estonia College of Landscape and Architecture Zhejiang A&F University666 Wusu StreetHangzhou 311300China Estonian Academy of Sciences Kohtu 6Tallinn 10130Estonia

Leaf economics spectrum(LES)describes the fundamental trade-offs between leaf structural,chemical,and physiological ***,structurally robust thick leaves with high leaf dry mass per unit area(LMA)exhibit lower photosynthetic capacity per dry mass(Amass).Paradoxically,“soft and thinleaved”mosses and spikemosses have very low Amass,but due to minute-size foliage elements,their LMA and its components,leaf thickness(LT)and density(LD),have not been systematically ***,we characterized LES and associated traits in cryptogams in unprecedented details,covering five evolutionarily different *** found that mosses and spikemosses had the lowest LMA and LT values ever measured for terrestrial *** a broad range of species from different lineages,Amass and LD were negatively *** contrast,Amass was only related to LMA when LMA was greater than 14 g cm^(-2).In fact,low Amass reflected high LD and cell wall thickness in the studied *** conclude that evolutionarily old plant lineages attained poorly differentiated,ultrathin mesophyll by increasing *** plant lineages,LD,not LMA,is the trait that represents the trade-off between leaf robustness and physiology in the LES.

关键词： Investment strategy Leaf density Leaf structural traits LMA estimation bias Non-seed plants Trait trade-offs

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From Design to Assembly of luminescent Platinumand Gold-based Molecular Functional Materials

From Design to Assembly of Luminescent Platinumand Gold-base...

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2008年两岸三地高分子液晶态与超分子有序结构学术研讨会暨第十次全国高分子液晶态与超分子有序结构学术论文报告会

作者： Yam vivian Wing-Wah Centre for Carbon-Rich Molecular and Nano-Scale Metal-Based Materials Research and Department of Chemistry The University of Hong Kong State Key Laboratory of Supramolecular Structure and Materials Jilin University

Recent works in our laboratory have shown that novel luminescent metal-based molecular materials could be assembled through the use of various metal-ligand building *** this presentation,various design and synthetic strategies together with the successful isolation of new classes of complexes of platinum and gold will be described.A number of these complexes have been structurally characterized and shown to display rich lu-

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Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013

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Chinese Birds 2015年第3期6卷 153-168页

作者： Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong vivian Wing Kan Fu Yongxiang Han Gang lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng Forestry Bureau of Dandong Tianjin Birdwatching Society Xiamen Birdwatching Society Shenzhen Birdwatching Society Management Office of Guangdong Neilingding–Futian National Nature Reserve Shanghai Huaxia Wildlife Travel Limited The Hong Kong Bird Watching Society Xugou Primary School Kadoorie Conservation China Kadoorie Farm & Botanic Garden Corporation Spoon-billed Sandpipers in China State Key Laboratory of Biocontrol and College of Ecology and Evolution Xiamen Costal Wetlands and Birds Research Center Department of Life Science Cangzhou Normal University 14 bis rue des Temples45240 La FertéSaint AubinFrance Fujian Birdwatching Society Management Office of Yellow River Delta National Nature Reserve Guangxi Mangrove Research Center Tianjin Natural History Museum Shanghai Wildbird Society Panjin Birdwatching Society Panjin Maternal and Child Care Service Centre Haifeng Nature Reserve

Background:China's coastal wetlands belong to some of the most threatened ecosystems *** loss and degradation of these wetlands seriously threaten waterbirds that depend on ***:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal *** were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December ***:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one *** number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % ***-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,***:The results highlight the international importance of China's coastal wetlands for *** study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management.

关键词： 1 % criterion Citizen science Coastal wetlands Ramsar site Waterbirds

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Atypical Hemolytic Uremic Syndrome in a Post-COVID-19 Child: Its Differential Diagnosis with COVID-19, Multisystemic Inflammatory Syndrome and Outcome

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Open Journal of Pediatrics 2022年第4期12卷 657-664页

作者： Fernanda Aparecida De Oliveira Peixoto Célia Regina Malveste Ito André luís Elias Moreira Paulo Alex N. Silva Mônica Oliveira Santos Isabela Jubé Wastowski Liana De Medeiros Machado Braga vivian Da Cunha Rabelo Lilian Carla Carneiro Melissa Ameloti Gomes Avelino Department of Pediatrics Neonatal ICU of Clinical Hospital of Federal University of Goiás/Ebserh Goiania Brazil Microorganism Biotechnology Laboratory of Institute of Tropical Pathology and Public Health Federal University of Goiás Goiania Brazil Molecular Immunology Laboratory of Goiás State University Anápolis Brazil Pediatrics ICU of State Emergency Hospital Governor Otávio Lage of Siqueira Goiania Brazil Surgical Department of Pediatrics Medical School Federal University of Goiás Goiania Brazil

Pediatric Multisystemic Inflammatory Syndrome (MIS-C) is one of the most severe manifestations of SARS-CoV-2 in pediatrics [1]. This is a report of MIS-C with clinical presentation in infants with atypical Hemolytic U... 详细信息

关键词： MISC COVID-19 aHUS Children Critical Care

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Novel diamond shuttle to deliver flexible neural probe with reduced tissue compression

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Microsystems & Nanoengineering 2020年第1期6卷 903-915页

作者： Kyounghwan Na Zachariah J.Sperry Jiaao lu Mihaly Voroslakos Saman S.Parizi Tim M.Bruns Euisik Yoon John P.Seymour Electrical Engineering&Computer Science Department University of MichiganAnn ArborMI 48105USA Biomedical Engineering Department University of MichiganAnn ArborMI 48105USA Biointerfaces Institute University of MichiganAnn ArborMI 48105USA The Neuroscience Institute New York UniversityNew YorkNY 10016USA Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Korea Graduate Program of Nano Biomedical Engineering(Nano BME) Yonsei-IBS InstituteYonsei UniversitySeoul 03722Korea vivian L Smith Department of Neurosurgery University of Texas Health Science CenterHoustonTX 77030USA Department of Electrical and Computer Engineering Rice UniversityHoustonTX 77005USA

The ability to deliver flexible biosensors through the toughest membranes of the central and peripheral nervous system is an important challenge in neuroscience and neural *** devices implanted through dura mater and thick epineurium would ideally create minimal compression and acute damage as they reach the neurons of *** demonstrate that a three-dimensional diamond shuttle can be easily made with a vertical support to deliver ultra-compliant polymer microelectrodes(4.5-µm thick)through dura mater and thick *** diamond shuttle has 54%less cross-sectional area than an equivalently stiff silicon shuttle,which we simulated will result in a 37%reduction in blood vessel *** also discovered that higher frequency oscillation of the shuttle(200Hz)significantly reduced tissue compression regardless of the insertion speed,while slow speeds also independently reduced tissue *** and recording performance are demonstrated in rat and feline models,but the large design space of these tools are suitable for research in a variety of animal models and nervous system targets.

关键词： sectional neural thick

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REP-PCR及ERIC-PCR法对分离自海产品副溶血性弧菌分型分析

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食品科学 2013年第10期34卷 263-267页

作者：马月姣孙晓红赵勇卢瑛吴启华潘迎捷上海海洋大学食品学院上海水产品加工及贮藏工程技术研究中心上海201306 缅因大学食品科学与人类营养系美国欧洛诺04469

目的:采用细菌基因外重复回文序列扩增(REP-PCR)和肠道细菌基因间重复序列扩增(ERIC-PCR)两种方法对副溶血性弧菌2株标准株,13株实验室保存菌株和73株分离菌株共88株进行分子分型。方法:通过REP和ERIC-PCR指纹图谱扩增,利用NTsys-pc软... 详细信息

目的:采用细菌基因外重复回文序列扩增(REP-PCR)和肠道细菌基因间重复序列扩增(ERIC-PCR)两种方法对副溶血性弧菌2株标准株,13株实验室保存菌株和73株分离菌株共88株进行分子分型。方法:通过REP和ERIC-PCR指纹图谱扩增,利用NTsys-pc软件采用Dice系数对指纹图谱进行聚类结果分析。结果:所有供试菌株可通过此两种方法进行分型得到清晰的指纹图谱,并反映出副溶血性弧菌具有丰富的遗传多样性,REP-PCR扩增出5～9条分布在609～4200bp之间的条带,可将副溶血性弧菌分为5个群12类型,分辨指数达0.93,其中tdh+株在相似系数0.86时可聚类在第Ⅰ群;ERIC-PCR扩增出5～11条分布在400～7593bp之间的条带,将副溶血性弧菌分为7个群11个类型,分辨指数为0.94,其中tdh+株在相似系数0.76时可聚类在第Ⅰ群。结论:两种方法均显现出很好的分型能力,能够很好地将环境分离tdh+菌株和标准菌株聚类在一起,其中REP-PCR较ERIC-PCR重复性更好。

关键词：副溶血性弧菌 tdh 肠内细菌基因组间重复序列分析细菌基因外重复回文序列扩增分型

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