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哈尔滨工程大学学报（英文版） 2024年第2期23卷 316-326页

作者： f.Mannacio f.Di Marzo M.Gaiotti C.M.Rizzo M.Venturini Italian Navy Naval Support and Experimentation CentreCSSN Viale S.Bartolomeo40019126 La Spezia(Italy) University of Genova Polytechnic SchoolDITEN Via Montallegro116145 Genova(Italy).

Despite the non-contact underwater explosion phenomena(UNDEX)have been studied for decades and several numerical methods have been proposed in literature,its effects on military structures,especially composite ones,are even nowadays matter of *** early design phases,it is not always possible to verify the shock resistance of hull structures modelling the whole phenomenon,in which fluid,gas and solid properties must be properly set in a fully coupled fluid-structure interaction(fSI)numerical *** ones are extremely complex to set,computationally demanding and certainly not suitable for everyday design *** this paper,a simplified finite element(fE)model,easy to use in an early design phase,is ***,the structure and the fluid are *** this approximation,the fluid behaviour is simplified,using special finite elements,available in a commercial software *** choice reduces the computational time and numerical efforts avoiding the problem of combining computational fluid dynamics(CfD)and fE domains and equations in a fully coupled fluid-structure interaction model.A typical parallel body block of a minesweeper is modelled,using two-dimensional multi-layered shell elements to properly account for the composite materials *** the fluid instead,three dimensional volumetric elements,directly coupled to the structural elements,are *** addition,the same calculation is performed,modelling separately fluid in the CfD environment and structures in the finite element ***,realizing a fully coupled fluid-structure interaction *** results obtained by applying both numerical models are compared with the structural response measured on board of a composite ship during a full-scale shock *** simplified proposed procedure provides results in satisfactory agreement with experiments,allowing the validation of the *** are discussed and differences with the real phenomenon and fully coupled CfD+

关键词： Underwater explosions Shock resistance Composites fluid-structure interaction Experimental analysis Numerical simulation Vulnerability Preliminary design

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Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine

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Signal Transduction and Targeted Therapy 2024年第1期9卷 47-50页

作者： Mengyu Guo Mingjing Cao Jiufeng Sun Ziwei Chen Xin Wang Lianpan Dai George f.Gao Yuliang Zhao Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina Guangdong Provincial Institute of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhouChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyBeijingChina

Dear editor,Vaccines are the most efficient and effective means to prevent infectious diseases,but improving the long-term protective efficacy is still a major challenge in contemporary vaccine development.1 The waning immunity varies depending on the diversification of the pathogen and the number of booster doses.1 Strategies to overcome this warrant is using adjuvants that amplify the immune response,and drive the production of memory B and T cells or long-lived plasma cells that recognize the pathogen for durable protection.2–4 Although existing adjuvants have achieved promising results,research on generating durable protective immunity is lacking in promoting vaccine development and staying ahead of global pandemics such as coronavirus disease 2019(COVID-19).The precisely designed nanoadjuvants can enhance lymph node targeting and increase antigenpresenting cell(APCs)uptake,achieving the co-delivery of adjuvants and antigens and activating innate and adaptive immune responses.5 Previously,we reported a manganese nanoadjuvant(MnARK)and receptor-binding domain(RBD)monomer antigen formulated nanovaccine.6 MnARK transported antigens to lymph nodes,activated the STING pathway,elicited strong neutralizing abilities and increased immune memory T cell percentage against the infection of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).6 Regarding the long-term protection potential of MnARK for subunit vaccine development,we further explored the durable immune regulation abilities of MnARK to a SARS-CoV-2 RBD dimer antigen,which has been used in an approved COVID-19 subunit vaccine Zf2001 with aluminum adjuvant(alum).7,8 TEM result revealed that RBD dimer could interact with BSA on MnARK surface and epitope can be well preserved(Supplementary fig.1a).The size and zeta potential of MnARK-RBD dimer nanovaccine was~58 nm and-14 mV,respectively(Supplementary fig.1b,c).

关键词： manganese immunity protective

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Stubborn Hypoxia in Neonates with D-Transposition of the Great Arteries after Arterial Switch Operation: Central Sleep Apnea as the Cause and Potential Indicator of Brain Immaturity

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Congenital Heart Disease 2024年第2期19卷 185-195页

作者： Camden L.Hebson Kyle Bliton Amr Y.Hammouda Kaitlyn Barr W.Hampton Gray Mohini Gunnett Waldemar f.Carlo Department of Pediatrics Division of Pediatric CardiologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics Division of Pediatric PulmonologyUniversity of Alabama BirminghamBirmingham35233USA Department of Pediatrics University of Alabama BirminghamBirmingham35233USA Department of Surgery Division of Cardiothoracic SurgeryUniversity of Alabama BirminghamBirmingham35233USA

D-transposition of the great arteries(d-TGA)is surgically repaired with the arterial switch operation(ASO)with excellent results,however short and long-term morbidities still develop including neurocognitive *** significant central sleep apnea is uncommon in non-premature infants,but when present indicates immature autonomic control of respiration likely due to a neurologic *** report the unanticipatedfinding of central sleep apnea in four-term neonates with d-TGA after uncomplicated ASO,with the short-term complication of delayed hospital discharge and long-term concerns regarding this early marker of brain immaturity and its hindrance to normal *** this report,we will review each patient’s clinical course and then examine the literature on pediatric central sleep apnea,neurodevelopmental outcomes after ASO,and the important overlap of these entities in the care of patients going forward.

关键词： Transposition congenital heart disease sleep apnea polysomnography

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Phase composition,conductivity,and sensor properties of cerium-doped indium oxide

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Nano Materials Science 2024年第2期6卷 193-200页

作者： M.I.Ikim G.N.Gerasimov V.f.Gromov O.J.Ilegbusi L.I.Trakhtenberg N.N.Semenov federal Research Center for Chemical Physics of RAS MoscowRussia University of Central florida OrlandoFLUSA Moscow Institute of Physics and Technology(State University) DolgoprudnyMoscow RegionRussia Lomonosov Moscow State University MoscowRussia

The hydrothermal synthesis of In_(2)O_(3)and CeO_(2)–In_(2)O_(3)is investigated as well as the properties of sensor layers based on these *** the synthesis of In_(2)O_(3),intermediate products In(OH)_(3)and InOOH are formed,which are the precursors of stable cubic(c-In_(2)O_(3))and metastable rhombohedral(rh-In_(2)O_(3))phases,respectively.A transition from c-In_(2)O_(3)to rh-In_(2)O_(3)is observed with the addition of CeO_(2).The introduction of cerium into rh-In_(2)O_(3)results in a decrease in the sensor response to hydrogen,while it increases in composites based on c-In_(2)O_(3).The data on the sensor activity of the composites correlate with XPS results in which CeO_(2)causes a decrease in the concentrations of chemisorbed oxygen and oxygen vacancies in rh-In_(2)O_(3).The reverse situation is observed in composites based on c-In_(2)O_(3).Compared to In_(2)O_(3)and CeO_(2)–In_(2)O_(3)obtained by other methods,the synthesized composites demonstrate maximum response to H_(2)at low temperatures by 70–100℃,and have short response time(0.2–0.5 s),short recovery time(6–7 s),and long-term stability.A model is proposed for the dependence of sensitivity on the direction of electron transfer between In_(2)O_(3)and CeO_(2).

关键词： Cerium oxide Indium oxide Nanocomposite Hydrothermal method Cubic phase Rhombohedral phase Sensor response Conductivity Hydrogen Response/recovery time

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fast efficient photon deceleration in plasmas by using two laser pulses at different frequencies

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Matter and Radiation at Extremes 2024年第3期9卷 11-18页

作者： Y.X.Wang X.L.Zhu S.M.Weng P.Li X.f.Li H.Ai H.R.Pan Z.M.Sheng Key Laboratory for Laser Plasmas(moe) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of IfSA Shanghai Jiao Tong UniversityShanghai 200240China Research Center of Laser fusion of China Academy of Engineering Physics MianyangSichuan 621900China State key Laboratory of High field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

The generation of ultrashort high-power light sources in the mid-infrared(mid-IR)to terahertz(THz)range is of interest for applications in a number of fields,from fundamental research to biology and *** conventional laser technology,photon deceleration in plasma wakes provides an alternative approach to the generation of ultrashort mid-IR or THz ***,we present a photon deceleration scheme for the efficient generation of ultrashort mid-IR or THz pulses by using an intense driver laser pulse with a relatively short wavelength and a signal laser pulse with a relatively long *** signal pulse trails the driver pulse with an appropriate time delay such that it sits at the front of the second wake bubble that is driven by the driver *** to its relatively long wavelength,the signal pulse will be subjected to a large gradient of the refractive index in the plasma wake ***,the photon deceleration in the plasma wake becomes faster and more efficient for signal pulses with longer *** greatly enhances the capacity and efficiency of photon deceleration in the generation of ultrashort high-power light sources in the long-wavelength IR and THz spectral ranges.

关键词： laser ultrashort photon

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Quantum-mechanical effects in photoluminescence from thin crystalline gold films

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Light(Science & Applications) 2024年第4期13卷 783-794页

作者： Alan R.Bowman Alvaro Rodríguez Echarri fatemeh Kiani fadil Iyikanat Ted V.Tsoulos Joel D.Cox Ravishankar Sundararaman f.Javier García de Abajo Giulia Tagliabue Laboratory of Nanoscience for Energy Technologies(LNET) STIÉcole Polytechnique Fédérale de Lausanne(EPFL)LausanneSwitzerland ICfO–Institut de Ciencies fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)Spain. MBI–Max-Born-Institut BerlinGermany. POLIMA–Center for Polariton-driven Light–Matter Interactions University of Southern DenmarkOdense MDenmark. Danish Institute for Advanced Study University of Southern DenmarkOdense MDenmark. Department of Materials Science&Engineering Rensselaer Polytechnic InstituteTroyNYUSA. Department of Physics Applied Physicsand AstronomyRensselaer Polytechnic InstituteTroyNYUSA. ICREA–Institucio Catalana de Recerca i Estudis Avancats BarcelonaSpain

Luminescence constitutes a unique source of insight into hot carrier processes in metals,including those in plasmonic nanostructures used for sensing and energy ***,being weak in nature,metal luminescence remains poorly understood,its microscopic origin strongly debated,and its potential for unraveling nanoscale carrier dynamics largely ***,we reveal quantum-mechanical effects in the luminescence emanating from thin monocrystalline gold ***,we present experimental evidence,supported by first-principles simulations,to demonstrate its photoluminescence origin(i.e.,radiative emission from electron/hole recombination)when exciting in the interband *** model allows us to identify changes to the measured gold luminescence due to quantum-mechanical effects as the gold film thickness is ***,such effects are observable in the luminescence signal from flakes up to 40 nm in thickness,associated with the out-of-plane discreteness of the electronic band structure near the fermi *** qualitatively reproduce the observations with first-principles modeling,thus establishing a unified description of luminescence in gold monocrystalline flakes and enabling its widespread application as a probe of carrier dynamics and light-matter interactions in this *** study paves the way for future explorations of hot carriers and charge-transfer dynamics in a multitude of material systems.

关键词： luminescence quantum crystalline

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Gram-negative bacterial diversity and evidence of international clones of multidrug-resistant strains in zoo animals

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Integrative Zoology 2024年第3期19卷 417-423页

作者： João Pedro Rueda fURLAN Micaela Santana RAMOS fábio Parra SELLERA Irys Hany Lima GONZALEZ Patrícia Locosque RAMOS Eliana Guedes STEHLING Department of Clinical Analyses Toxicology and Food ScienceSchool of Pharmaceutical Sciences of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil Department of Internal Medicine School of Veterinary Medicine and Animal ScienceUniversity of São PauloSão PauloBrazil School of Veterinary Medicine Metropolitan University of SantosSantosBrazil Coordination of Wild fauna Secretary of EnvironmentInfrastructure and LogisticsSão PauloBrazil

Antimicrobial resistance(AMR)is a growing phenomenon that poses a major public health challenge worldwide(Dhingra et al.2020;Antimicrobial Resistance Collaborators 2022).The selective pressure exerted in clinical settings has contributed to the longlasting successful dissemination of multidrug-resistant(MDR)Gram-negative bacteria in these environments(Chia et al.2020).

关键词： multidrug clinical

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Acute pancreatitis in the critical care setting:A review of assessment and intervention strategies

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Journal of Acute Disease 2024年第3期13卷 93-99页

作者： Ashraf H.Zaki Mohammad f.Katranji ICU Department Fakeeh University HospitalDubaiUAE Pulmonology Department Al Zahra HospitalDubaiUAE

The incidence of acute pancreatitis(AP),a condition characterized by inflammation in the pancreas,has been increasing globally and is associated with several *** review elaborated on the etiology,clinical presentation,severity assessment,and treatment modalities of AP,mainly in the critical care *** with severe AP,as indicated by organ failure(>48 hours from onset),warrant treatment in the intensive care unit *** most common etiologies,biliary disease and alcohol consumption,and the advanced diagnostic tools used for the identification of the cause are *** severity assessment tools are utilized for grading the severity of the disease,predicting patient outcomes,determining the associated risk,and guiding treatment *** treatment interventions comprise various approaches,such as anti-infective therapy enteral nutrition,analgesics for pain,or minimally invasive surgical procedures,thereby demonstrating an evolving landscape of AP ***,various complications such as necrosis,organ failure,and hemorrhage,necessitate disease monitoring and differential diagnosis and are crucial for optimal management of *** treatment modalities and advancements in multidisciplinary care emphasize the potential for reducing the burden of AP in critical care settings.

关键词： Acute pancreatitis Critical care Intensive care unit Necrotizing pancreatitis Organ failure

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San Antonio witnesses Chinese urological achievements:The World Chinese Urological Society achievement and Rising Star Awards at the 16th annual meeting

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UroPrecision 2024年第2期2卷 65-72页

作者： Guiting Lin Run Wang Tom f.Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Department of Urology Uniersity of Texas MD Anderson Cancer CenterHoustonTexasUSA Division of Urology Department of SurgeryUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

San Antonio,May 3,2024—The 16th Annual meeting of the World Chinese Urological Society(WCUS)was successfully held in San Antonio,drawing together experts and scholars from around the globe in the field of Chinese *** conference served as a platform for academic exchange,as well as an occasion for medical professionals of Chinese descent to learn from,inspire,and motivate one *** events are crucial for advancing research and clinical practice in Chinese urology worldwide,and the success of this conference signals a bright and progressive future for the field.

关键词： World exchange witness

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Buechel Pappas Resurfacing Shoulder Replacement: Evolution and over 40 Years of Clinical Experience

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Open Journal of Orthopedics 2024年第5期14卷 218-228页

作者： frederick f. Buechel Michael J. Pappas Rutgers NJ Medical School Newark NJ USA South Mountain Orthopaedic Associates South Orange NJ USA New Jersey Institute of Technology Newark NJ USA

Background: Early exploration of the semi constrained “floating-Socket” total shoulder replacement (TSR) in 1974 led to a proliferation of various unconstrained designs that allowed resection or retention of the humeral head, depending upon the pathological process involved. Degenerative glenohumeral arthritis with mild to moderate involvement of subchondral bone allowed for a resurfacing option, while severe humeral head involvement required a partial or full humeral head replacement attached to an intramedullary stem for fixation. All components evolved from cemented to cementless application by 1982. The purpose of this paper is to describe the progression of Buechel-Pappas (B-P) shoulder replacement development from the early 1970’s in both cemented and cement less applications. Methods: Clinical evaluations of “floating-Socket” TSR, followed by B-P stem-type, resurfacing types, bipolar-type and revision components, all of which comprise the B-P Shoulder Replacement System, were performed over a 49-year period. Results: “floating-Socket” implants improved the results of simple, constrained ball-in-socket designs, but generally failed by glenoid component loosening in both chimpanzee and human applications. Unconstrained resurfacing-type components, both anatomical humeral head and full proximal humeral components, were quite successful, with minimal failures observed in long-term studies. Bipolar salvage implants, used for severe proximal deficiencies, revisions and massive rotator cuff arthropathy, were also very successful;providing overhead range of motion in many patients. Conclusions: Resurfacing hemiarthroplasty, in patients with intact or repairable rotator cuff mechanisms, gave the most satisfactory results and were the least technically complicated to perform, requiring minimal instrumentation. Resurfacing of full proximal humeral deficiencies, using femoral resurfacing components, gave similar clinical results to more complex semi-constrained devices,

关键词： Total Shoulder Replacement Resurfacing Shoulder Replacement

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