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Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma

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World Journal of Gastroenterology 2005年第44期11卷 6920-6925页

作者： Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus vito de pascale Mario Plebani Davide Francesco D'Amico Clinica Chirurgica Ⅰ Dipartimento di Medicina di Laboratono Dipartimento Assistenziale di Chirurgia Generale ed Emergenze Chirurgiche Dipartimento di Medicina di Laboratorio Clinica Chirurgica I

AIM： To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma （HCC） eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria. METHODS： Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were：（1） histological assessment of tumor grade by means of percutaneous biopsies; （2） determination of AFP mRNA status in the blood; （3） patient＇s eligibility for radical therapies. RESULTS： At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery （resection or liver transplantation） was performed in 29 patients, while 21 had percutaneous ablation procedures. After a median follow-up of 28 too, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables （AFP mRNA, HCC grade and gross vascular invasion） resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile （AFP mRNA negative and well-differentiated tumor without gross vascular invasion） as independent survival variables. CONCLUSION： The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies.

关键词： Hepatocellular carcinoma Prognosis Treatment policy Biomarker Tumor biology

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Rigidity of non-renormalizable Newton maps

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Science China Mathematics 2024年第4期67卷 855-872页

作者： pascale Roesch Yongcheng Yin Jinsong Zeng Institut de Mathématiques de Toulouse Universite Paul SabatierToulouse 31062France School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China College of Mathematics and Statistics Shenzhen UniversityShenzhen 518061China

Non-renormalizable Newton maps are *** precisely,we prove that their Julia sets carry no invariant line fields and that a topological conjugacy between them is equivalent to a quasiconformal conjugacy.

关键词： Newton map non-renormalizable rigidity invariant line field

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SAGeLogE: A decision Support System for Students’ Accommodation Management

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Journal of Computer and Communications 2024年第3期12卷 107-145页

作者： Rôlin Gabriel Rasoanaivo pascale Zaraté Institut de Recherche en Informatique de Toulouse (IRIT) ADRIA Toulouse France Université Toulouse Capitole Toulouse France Faculté des sciences et technologies Université de Toamasina Toamasina Madagascar

SAGeLogE is the acronym of “Système d’Aide à la Gestion de Logements étudiants” which means student accommodation management support system. It’s a multi-criteria decision support system designed to manage accommodation allocation for university students. Within SAGeLogE we developed the “Minimum of Ranks” (MIRA) aggregation method. MIRA method involves the application of multi-criteria decision-making methods (MCDM) to initially obtain different ranking. Thus, we chose the Weighted Sum Method (WSM), Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) and Combined Compromise Solution (CoCoSo) methods to be implemented in SAGeLogE. To prioritize the weights of criteria, the Anality Hierarchy Process (AHP) method was used. The interest of using the MIRA method was to obtain a compromised ranking coming from these three multi-criteria decision-making methods (WSM, TOPSIS, CoCoSo). So, we know that the accommodation to be allocated to students is always lower than the number of accommodation requests received by the organization. Thus, SAGeLogE proposed a technique that makes it easier to select students ranked by the multi-criteria decision-making and MIRA methods according to a method of calculation of quota of available accommodations within university residences. Finally, university accommodation managers had a wide choice of student ranking according to the methods implemented in SAGeLogE. The SAGeLogE experiment was carried out on the site of Toamasina University in Madagascar for an academic year with 2026 student accommodation applications received. The experimentation showed the ability of SAGeLogE to achieve the result.

关键词： MIRA Method MCDM Accommodation Quota SAGeLogE

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Stem cell transplantation in cerebrovascular accidents:A global bibliometric analysis(2000-2023)

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World Journal of Stem Cells 2024年第9期16卷 832-841页

作者： Jad El Masri Ahmad Afyouni Maya Ghazi Karim Hamideh Israe Moubayed Abdo Jurjus Hanine Haidar Ruzanna Petrosyan pascale Salameh Hassan Hosseini École Doctorale Sciences de la Vie et de la Santé UniversitéParis-Est CréteilCréteil 94010France INSERM U955-E01 Institut Mondor de Recherche BiomédicaleUniversitéParis-Est CréteilCréteil 94000France Faculty of Medical Sciences Lebanese UniversityBeirut 1533Lebanon department of Anatomy Cell Biology and Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 1107Lebanon department of Neurology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon department of Pathology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon Faculty of Pharmacy Lebanese UniversityBeirut 1102Lebanon Faculty of Medicine Lebanese American UniversityBeirut 1102Lebanon department of Primary Care and Population Health University of Nicosia Medical SchoolNicosia 2408Cyprus Institut National de SantéPublique d'Épidémiologie Clinique et de Toxicologie-Liban Beirut 1103Lebanon department of Neurology Henri Mondor HospitalAP-HPCréteil 94000France

BACKGROUND Cerebrovascular accident(CVA)is a major global contributor to death and *** part of its medical management,researchers have recognized the importance of promising neuroprotective strategies,where stem cell transplantation(SCT)is thought to confer advantages via trophic and neuroprotective *** To evaluate the current state of research on SCT in patients with CVA,assess key trends and highlight literature *** PubMed was screened for SCT in CVA-related articles in October 2023,for each country during the period between 2000 and *** the World Bank data,total population and gross domestic product were collected for ***_1.6.19 was used to create the VOS figure using the results of the same *** and tables were obtained using Microsoft Office *** A total of 6923 studies were identified on SCT in CVA,making 0.03%of all published studies ***,68%were conducted in high-income countries,with a significant focus on mesenchymal stem *** journal“Stroke”featured the largest share of these articles,with mesenchymal SCT having the highest rate of inclusion,followed by hematopoietic *** time,there has been a noticeable shift from in vitro studies,which assess stem cell proliferation and neurogenesis,to in vivo studies aimed at evaluating efficacy and ***,the number of reviews increased along this *** This bibliometric analysis provides a comprehensive guide for physicians and researchers in the field through an objective overview of research activity,and highlights both current trends and *** a potential therapeutic role in CVA,more research is needed in the future to focus on different aspects of SCT,aiming to reach a better treatment strategy and improve life quality in patients.

关键词： Bibliometric analysis PubMed Stem cell transplantation Cerebrovascular accidents Stroke

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Iron and Heart Failure: Current Concepts and Emerging Pharmacological Paradigms

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World Journal of Cardiovascular Diseases 2024年第4期14卷 195-216页

作者： Maria Rosaria de pascale Maria Beatrice Rondinelli Flora Ascione Vincenzo Maffei Chiara Di Lorenzo Sarah Scagliarini Raffaella Faraonio Antonio Faiella Immunohematology and Transfusion Medicine Unit Cardarelli Hospital Naples Italy Immunohematology and Transfusion Medicine Unit San Camillo-Forlanini Hospital Rome Italy Health Management Office Cardarelli Hospital Naples Italy Anesthesiology Unit Cardarelli Hospital Naples Italy department of Medical and Translational Sciences University of Naples Federico II Naples Italy Oncology Unit Cardarelli Hospital Naples Italy department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples Italy

Background: Emerging evidence has recognized that anemia and iron deficiency are recurrent comorbidities in chronic heart failure (HF) and several trials have established that iron administration improves myocardial asset and clinical scenario in HF. Purpose: Recent acquisitions suggest that iron deficiency represents a concrete bias in the pathogenetic mechanism of chronic HF, so we have investigated the putative role of the hepcidin/ferroportin axis in the cardiovascular setting to advocate novel pharmacological and clinical approaches. Methods: Here, after an excursus on iron metabolism, we first reviewed the ongoing studies on novel iron targeted compounds. Then, we summarize large clinical interventional studies conducted on patient suffering from iron deficiency and HF which have tested the effects of drugging iron regard QoL, hospitalizations and cardiovascular death. Results: Novel compounds such as hepcidin agonist (PTG 300), synthetic human hepcidin (LJPC-401) and anti FPN (Vamifeport) are ongoing in iron overloaded patients, while the hepcidin blocker (PRS-080) is under investigation in anemic patients. Noteworthy, novel insights could arise from the results of a Phase IV interventional study regarding the modification of hepcidin pathway in a large cohort of HF patients (n = 1992) by sodium glucose cotransporter 2 inhibitors. To date, several studies highlight the beneficial effect of iron administration in cardiovascular setting and latest evidences consider hepcidin level as a novel biomarker of cardiac injury and atherosclerosis. Conclusions: We advocate that data from ongoing studies will suggest novel iron targeted therapies for diagnosis, prognosis and therapy transferable in selected heart failed patients.

关键词： Heart Failure Iron Anemia Iron deficiency Hepcidin

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Management of a Huge Ovarian Cyst in Pregnancy at the Douala General Hospital, Cameroon: A Case Report and Review of the Literature

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Advances in Reproductive Sciences 2024年第3期12卷 165-178页

作者： Fidelia Mbi Kobenge Felix-Adolphe Elong Emenguele pascale Mpono Thomas Obinchemti Egbe department of Obstetrics and Gynecology Douala General Hospital Douala Cameroon Faculty of Health Sciences University of Bamenda Bamenda Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Faculty of Medicine and Biomedical Sciences University of Yaound 1 Yaound Cameroon department of Obstetrics and Gynecology CHRACERH Yaound Cameroon

Background: Ovarian cysts in pregnancy are common and are usually small benign functional cysts (corpus luteum and theca-lutein cysts) that usually resolve spontaneously between 14 and 16 weeks of gestation. However, large ovarian cysts are rare in pregnancy, with an incidence of 0.2% - 2%, and most of them are benign. The first-line diagnostic modality is ultrasonography. Complications of ovarian cysts in pregnancy include miscarriage, ovarian torsion, cyst rupture, etc. Laparotomy is the treatment modality commonly used in our setting, and histopathologic diagnosis is important for the prognosis of the treatment. Case Presentation: MC is a 32-year-old G3P2002 married housewife of the Bakweri tribe who was referred to our department because of progressive abdominal discomfort and shortness of breath for 1 month’s duration. Her medical history is consistent with two normal vaginal deliveries at term and the use of implants (for contraception) until one month prior to the index pregnancy. Her booking visit was at 16 weeks gestation at a primary (missionary) healthcare facility, and she underwent ultrasonography and was diagnosed with a singleton viable intrauterine pregnancy and a simple septate cystic mass measuring 17 cm situated on top of the uterus, appearing to originate from the left ovary. She was referred to seek the expertise of an obstetrician-gynecologist, but she came to our department at 35 weeks gestation and underwent cesarean birth at 37 weeks gestation. In the pathological review, serous cystadenoma was diagnosed, and there were no positive findings in peritoneal cytology. Conclusion: The ultrasonographic diagnosis of the huge ovarian cyst in the index case was after 16 weeks gestation because of her late booking visit at 16 weeks gestation. The index case deferred referral to the obstetrician because of a lack of finances, came to our department at 35 weeks gestation because of abdominal pain that may have resulted from a torsion of the ovarian cyst

关键词： Ovarian Cyst Ultrasonography Magnetic Resonance Imaging Histopathology Pregnancy Cesarean Section

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Adverse events related to physical restraint use in intensive care units: A review of the literature

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Journal of Intensive Medicine 2024年第3期4卷 318-325页

作者： Sebastian Berger pascale Grzonka Simon A.Amacher Sabina Hunziker Anja I.Frei Raoul Sutter Clinic for Intensive Care Department of Acute MedicineUniversity Hospital BaselBaselSwitzerland Medical Communication and Psychosomatic Medicine University Hospital BaselBaselSwitzerland Medical faculty University of BaselBaselSwitzerland department of Clinical Research University of BaselBaselSwitzerland

Physical restraints are widely used and accepted as protective measures during treatment in intensive care unit (ICU). This review of the literature summarizes the adverse events and outcomes associated with physical restraint use, and the risk factors associated with their use during treatment in the ICU. The PubMed, Scopus, and Google Scholar databases were screened using predefined search terms to identify studies pertaining to adverse events and/or outcomes associated with physical restraint use, and the factors associated with their use in adult patients admitted to the ICU. A total of 24 articles (including 6126 patients) that were published between 2006 and 2022 were identified. The described adverse events associated with physical restraint use included skin injuries, subsequent delirium, neurofunctional impairment, and a higher rate of post-traumatic stress disorder. Subsequent delirium was the most frequent adverse event to be reported. No alternative measures to physical restraints were discussed, and only one study reported a standardized protocol for their use. Although physical restraint use has been reported to be associated with adverse events (including neurofunctional impairment) in the literature, the available evidence is limited. Although causality cannot be confirmed, a definite association appears to exist. Our findings suggest that it is essential to improve awareness regarding their adverse impact and optimize approaches for their detection, management, and prevention using protocols or checklists.

关键词： Physical restraint Intensive care unit delirium Complication Adverse event

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The Support Systems and Coping Strategies of Infertile Women Attending the Out-Patient Consultation Unit of CHRACERH Yaoundé, Cameroon: A Cross-Sectional Study

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Open Journal of Obstetrics and Gynecology 2024年第6期14卷 869-887页

作者： Emenguele pascale Mpono Fidelia Mbi Kobenge Gabrielle Laure Mengne Etienne Belinga Jean Marie Kasia Thomas Obinchemti Egbe department of Obstetrics and Gynecology CHRACERH Yaound Yaound Cameroon department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciences University of Yaound 1 Yaound Cameroon department of Obstetrics and Gynecology Faculty of Health Sciences University of Bamenda Bamenda Cameroon department of Obstetrics and Gynecology Douala General Hospital Douala Cameroon department of Obstetrics and Gynecology Faculty of Health Sciences University of Buea Buea Cameroon

Background: Infertility is a complex disorder with significant psycho-social and economic consequences. It globally affects 10% - 15% of couples. In Cameroon, little is known about what women do to overcome the psychosocial aspects of the disease. Objectives: This study aimed to identify the support systems and coping strategies of infertile women attending the outpatient consultation unit of the Gynaecological Endoscopic Surgery and Reproductive Teaching Hospital (CHRACERH), Yaoundé, Cameroon. Methods: A hospital-based cross-sectional study was conducted from the 14th of March to the 6th of April 2023 at CHRACERH Yaoundé. A total of 190 participants were recruited using a convenience sampling method. Data regarding socio-demographic characteristics, support systems and coping strategies were collected using a pretested questionnaire. descriptive and analytic statistics were conducted using SPSS version 25. Results: The mean age of participants was 39.52 ± 7.64 years. The majority 78.9% of participants were workers (public, private sector, or traders) and were Christians 95.8%. The most common source of psychological support was from family 76.8 and husbands 72.63%. Most of the participants 89.5% resorted to prayer and getting busy 48.4% as a coping strategy. There was no statistically significant relationship between coping strategies and psychological disorders p > 0.05. Conclusion: The main support system of participants was family, husband, and friends. Prayer, getting busy and adoption were the most common coping strategies. There is a need for the Ministry of Public Health and other stakeholders to put in place other support systems and coping strategies (FELICIA) used elsewhere and provide adequate health education and infection control to prevent infertility in Cameroon.

关键词： Infertility Coping Strategies Support Systems Mental Health Women

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Association between the Different Phenotypes of Polycystic Ovary Syndrome and the Outcome in in Vitro Fertilization at Human Reproductive Center Paul et Chantal Biya-Yaoundé

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 18-28页

作者： Ngono Akam Vanina Ngah Minala Belinga Etienne Belinga Etienne Mpono pascale Nyada Serges Onana Y. Kasia Cho Joselyne Kasia Florence Adjessa Abega Kasia Jean Marie Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital Yaoundé Cameroon department of Gynecology and Obstetrics Faculty of Medicine and Biomedical Sciences University of Yaoundé 1 Yaoundé Cameroon

Background: In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) represents the final step in the management of Polycystic Ovarian Syndrome (PCOS). Our objective was to study the association between PCOS phenotypes and IVF/ICSI results in women admitted to Gynaecological Endoscopic Surgery and Human Reproductive Teaching Hospital (CHRACERH). Material and Method: We carried out a cohort study with historical-prospective data collection over a period of seven years (January 2016 to March 2023) at Chracerh. PCOS patients were subdivided into 4 subgroups A, B, C and D. Results: We recruited 128 patients including 64 PCOS patients divided into four phenotypes and 64 non-PCOS patients constituting the control group. Phenotype D without hyperandrogenism had used the lowest dose of gonadotropins, i.e. 1939.7 ± 454.3 IU, and had produced a greater quantity of estradiol on the day ovulation was triggered (6529.8 ± 4324.8 ng/ml). The average number of punctured follicles and mature oocytes were higher in the phenotype D group. Ovarian hyperstimulation syndrome (OHSS) occurred mainly in phenotype D (3/35), with an estimated prevalence of 2.3%. The fertilization rate seemed lower in the hyperandrogenic phenotypes A, B, C compared to the group without hyperandrogenism without significant difference (p = 0.461). The biological pregnancy rate and live birth rate were comparable between the different groups. Conclusion: Phenotype D used less dose of gonadotropins. Biological pregnancy and live birth rates were comparable between the different phenotypes.

关键词： Phenotype Polycystic Ovarian Syndrome IVF/ICSI Prognosis CHRACERH

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Assessment of Linear and Non-Linear Two-Equation Turbulence Models for Aerothermal Turbomachinery Flows

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Journal of Thermal Science 2006年第1期15卷 14-26页

作者： pascale KULISA Cedric DANO Laboratoire de Mecanique des Fluides et d'Acoustique UMR5509 Ecole Centrale de Lyon 69134 ECULLY Cedex France

Three linear two-equation turbulence models k- ε, k- ω and k- 1 and a non-linear k- 1 model are used for aerodynamic and thermal turbine flow prediction. The pressure profile in the wake and the heat transfer coefficient on the blade are compared with experimental data. Good agreement is obtained with the linear k-1 model. No significant modifications are observed with the non-linear model. The balance of transport equation terms in the blade wake is also presented. Linear and non-linear k - 1 models are evaluated to predict the threedimensional vortices characterising the turbine flows. The simulations show that the passage vortex is the main origin of the losses.

关键词： turbulence model numerical simulation turbomachinery.

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