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Detection and evaluation of different morphological forms of Mycoplasma hominis in human semen

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Asian Journal of Andrology 2024年第1期26卷 71-76页

作者： Elizaveta Bragina Tatyana Sorokina Avtandil Chogovadze Yulia shevchenko Vyacheslav Chernykh Olga Barkhatova Irina Rakovskaya Research Centre for Medical genetics Moscow 115522Russia A.N.Belozersky Institute of Physico-Chemical Biology Lomonosov Moscow State University Moscow 119992Russia Reprolab Limited Liability Company Moscow 119333Russia N.I.Pirogov Russian National Research Medical University Moscow 117997Russia Federal government Budgetary Institution"National Research Center for Epidemiology and Microbiology Named after Honorary Academician N.F.gamaleya of the Ministry of Health of the Russian Federation" Moscow 123098Russia

Recently discovered microcolonial forms of Mycoplasma hominis(***)and their impact on human spermatogenesis are *** spermatozoa of 125 fertile men(sperm donors;from Reprobank[Reproductive Tissue Bank,Moscow,Russial)and of 93 patients with fertility problems(from the Federal State Budgetary Institution"Research Centre for Medical genetics[RCMg]",Moscow,Russia)were *** colonies of *** and microcolonies were detected by molecular biological methods,culture of bacteria,and transmission electron *** unique structure of microcolonial cells,in which the cytoplasmic cylinder is surrounded by concentric electron-dense and electron-light layers with a periodicity of 12-14 nm,and the ability of microcolonial cells to attach to spermatozoa are *** patients with lower sperm quality,microcolonies of *** were detected 2.5 times more frequently than classical *** detection of microcolonies in the ejaculate and the frequent isolation of microcolonies from sperm samples of patients with fertility problems suggest that microcolonial cells may be one cause of infertility.

关键词： ejaculate fertility Mycoplasma hominis spermatogenesis transmission electron microscopy

The Relationship between Marx and Marxism: the Relevance of the Issue: in the XXIst Century

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学术界 2019年第1期 190-196页

作者： Vladimir shevchenko Institute of Philosophy Russian Acadamy of Science

The paper looks at the issue of the relationship between Marx and Marxism. Three approaches to the issue,which are widespread in contemporary Marxist literature and among marxologists are discussed. The first approach: the true Marx is the philosophy of Marx minus political theory. The second approach: the true Marx is the philosophy of Marx plus political theory of social-democratic parties. The third approach: the true Marx is the philosophy of Marx plus political theory,developed most fully by Lenin in the preparation of the R ussian revolution. The third approach,from our point of view,corresponds most to the essence of genuine Marxism,at least as applied to the twentieth century. The paper examines in detail the principal novelty of Lenin speaking of the need to translate Marx's materialistic theory of history to the political level as a theoretical issue. The author also notes the contribution of the Chinese leaders into further development of the political theory of Marxism closely connected with the issues of strategy and tactics of building socialism with Chinese characteristics. In conclusion,the paper states that world history nowbecomes increasingly complex and mixed. Therefore,the question of whether Marxist philosophers in this situation will be able to find ways of realization the 11th thesis of Marx "On Feuerbach"remains open.

关键词： Marx true Marxism three approaches Lenin Chinese development

Evaluation of airlift pump performance for vertical conveying of coal particles

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International Journal of Coal Science & Technology 2023年第3期10卷 155-166页

作者： Parviz Enany Oleksandr shevchenko Carsten Drebenshtedt Faculty of Mining and Special Civil Engineering Technische Universitat BergakademieGustav-Zeuner StraBe 1A09599 FreibergGermany UTF gmbH ErzstraBe 1509618 Brand-ErbisdorfGermany

One of the crucial aspects of reducing air consumption when conveying particles with an airlift pump is to know the factors that affect the process of particle motion at an initial velocity of *** determine the influence of submer-gence ratio and physical properties of particles(such as size,shape,and mass)on the onset of vertical particle motion,the airlift pump was taken as the research object,and spherical glass together with irregular shaped coal were used as experimental test *** results show that unlike the water-solid environment,the start of particle motion in the water-air mixture does not always occur at a certain value of superficial water velocity and this value also increases with increasing submergence *** the parameters considered,the role of submergence ratio is much more effective than the dimensions and the shape of the particle,because by increasing submergence from 0.3 to 0.8,it is possible to reduce air consumption by up to 8 *** on this study the corresponding theoretical model derived by Fujimoto et *** optimized,wherein the overall agreement between the modified theory and present experimental data is particularly *** to Fujimoto,the minimum superficial water velocity for lifting solids in the air-water mixture is not always smaller than water ambient which indicates on optimum submergence ratio higher than ***,a new criterion was introduced to describe the moment of onset of the particle motion as a function of the superficial fluid velocity ratio for each submergence value.

关键词： Air-water-solid flow Slurry- Coal Submergence ratio Taylor bubble Superficial velocity

Forecasting of Survival Rate in Patients with the Early Stage of Non Small Cell Lung Cancer

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Journal of Cancer Therapy 2013年第10期4卷 1472-1477页

作者： Oleksey P. Kolesnik Anatoliy I. shevchenko Yuriy E. Lyakh vitaliy g. gurianov Department of Medical Biophysics Medical Informatics and Biostatistics M. Gorky Donetsk National Medical University Donetsk Ukraine Department of Oncology Zaporizhzhya State Medical University Zaporizhzhya Ukraine

Lung cancer is the most common cause of death from oncological diseases all over the world. Primary treatment of patients with the early stage of non-small cell lung cancer is a surgery. However, after surgery 30% - 85% of patients undergo disease progression. In order to improve the results of treatment of patients with non-small cell lung cancer it is necessary to separate a group of patients with dismal prognosis for whom adjuvant chemotherapy will permit improving the survival rate. The aim of our research was to create a forecasting model with a view to detect the patients with the early stage of non-small cell lung cancer and dismal prognosis. Our research covered 254 patients with the early stage of non-small cell lung cancer who underwent a cure from June 2008 till December 2012 in the department of thoracic surgery of Zaporizhzhia Regional Clinical Oncologic Dispensary. In order to identify the factors connected with the risks of low survival rate of patients with the early stage of non-small cell lung cancer after curative treatment (surgical treatment, adjuvant chemotherapy), a method of design of neural network models of classification was used. 39 factors were taken for input characteristics. During investigation two forecasting models were built. As follows from the analysis of first forecasting model with the increase of the patient’s BMI, the risk of low patient survival rate statistically and significantly (p = 0.03) decreases, OR = 0.89 (95% CI 0.80 - 0.99) for each kg/m2 index value. The risk of low patient survival rate also decreases (p = 0.02) if he has a squamous cell carcinoma, OR = 0.36 (95% CI 0.15 - 0.88) compared with other histological forms of tumor. The connection between the risk of low patient survival rate and the volume of surgical intervention was discovered (p = 0.01), OR = 3.19 (95% CI 1.29 - 7.86) for patients who underwent a pulmonectomy compared with patients who underwent an upper bilobectomy. As follows from the analysis of

关键词： Forecasting Model Survival Rate Non-Small Cell Lung Cancer

Usage of Cox-Regression Model for Forecasting of Survival Rate in Patients with the Early Stage of Non-Small Cell Lung Cancer

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Advances in Lung Cancer 2014年第1期3卷 26-33页

作者： Oleksey P. Kolesnik Anatoliy I. shevchenko Yuriy E. Lyakh vitaliy g. gurianov Pavel A. Alyoshechkin Department of Medical Biophysics Medical Informatics and Biostatistics M. Gorky Donetsk National Medical University Donetsk Ukraine Department of Oncology Zaporizhzhya State Medical University Zaporizhzhya Ukraine

In the past decades a lot of investigations were focused on searching for more accurate markers of lung cancer progression. Researchers indicate that molecular markers may be useful in forecasting of treatment outcome and overall survival rate in patients with non-small cell lung cancer. The aim of our research was to create a forecasting model in order to identify patients with stage I-II of non-small cell lung cancer and dismal prognosis. Our research covered 254 patients with the early stage of non-small cell lung cancer who underwent a cure from June 2008 till December2012 inthe Department of Thoracic Surgery of Zaporizhzhia Regional Clinical Oncologic Dispensary. Surgery was performed for all patients. Adjuvant chemotherapy was performed for 101 patients. In order to carry out multivariate Cox-regression analysis, STATISTICA 6.0 (StatSoft Inc.) program was used. The most significant from 39 variables were selected (tumor size, histological form of tumor, volume of surgical intervention, volume of conducted lymph node dissection, Ki-67 expression, EgFR expression, E-cadherin expression). We propose the computer system which can forecast survival rate in patients with the early stage of non-small cell lung cancer.

关键词： Forecasting Model Survival Rate Non-Small Cell Lung Cancer

Comparative Case Study on Hostile Takeovers in China and Russia

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Comparative Case Study on Hostile Takeovers in China and Rus...

作者： shevchenko Kristina 华东师范大学

学位级别：硕士

本文对中国和俄罗斯的恶意并购活动进行了不同的观察。我依据制度背景,简要的立法描述和中西经验以及西方并购模式的比较来构建我的论文。我对两个国家最近发生的两起恶意并购企图进行了案例研究,并在最后一章中对恶意并购模式进行了比... 详细信息

本文对中国和俄罗斯的恶意并购活动进行了不同的观察。我依据制度背景,简要的立法描述和中西经验以及西方并购模式的比较来构建我的论文。我对两个国家最近发生的两起恶意并购企图进行了案例研究,并在最后一章中对恶意并购模式进行了比较。得出的结论是,两国并购模式的主要差异可以分为经济和法律两个方面。根据进行的比较,两国恶意并购的企业氛围正在发生变化。国家参与控制恶意并购的过程在中国模式中比俄罗斯更加明确。关于投资者的吸引力,企业家的资本和商业环境安全水平,中国模式更为有利。由于研究局限性导致数据不可用,并且关于该主题的学术研究的数量微不足道,为了更好地理解问题,必须进行进一步的研究并不断监测立法的变化。

关键词：兼并和收购恶意并购中国俄罗斯对照

Pre-clinical evaluation of soybean-based wound dressings and dermal substitute formulations in pig healing and non-healing in vivo models

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Burns & Trauma 2014年第4期2卷 187-195页

作者： Rostislav V.shevchenko Matteo Santin Pharmidex Pharmaceutical Services Ltd London Brighton Centre for Regenerative Medicine University of BrightonBrightonUnited Kingdom

In the last decade,a new class of natural biomaterials derived from de-fatted soybean fl our processed by either thermoset or extraction procedures has been *** biomaterials uniquely combine adaptability to various clinical applications to proven tissue regeneration *** the present work,the biomaterials were formulated either as hydrogel or as paste formulation and their potential as wound dressing material or as dermal substitute was assessed by two in vivo models in pig skin:The healing full-thickness punch biopsy model and the non-healing full-thickness polytetrafl uoroethylene(PTFE)chamber *** results clearly show that collagen deposition is induced by the presence of these biomaterials.A unique pattern of early infl ammatory response,eliciting neutrophils and controlling macrophage infi ltration,is followed by tissue cell colonization of the wound bed with a signifi cant deposition of collagen fi *** study also highlighted the importance in the use of optimal formulations and appropriate handling upon *** large size,non-healing wounds,wound dermis was best obtained with the paste formulation as hydrogels appeared to be too loose to ensure lasting scaff olding *** the contrary,packing of the granules during the application of paste reduced biomaterial degradation rate and prevent the penetration of newly vascularized tissue,thus impeding grafting of split-thickness autologous skin grafts on the dermal substitute base.

关键词： Dermal substitutes in vivo models wound dressings soyabean-based biomaterials

The Training of Future Teachers in Ukraine and China

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Frontiers of Education in China 2018年第2期13卷 288-314页

作者： Liubov HUNKO Nataliia PAZIURA Katerina shevchenko Institute of Education Studies and Adult Education National Academy of Pedagogical Sciences of UkraineKyiv 02000Ukraine Department of Aviation English National Aviation University03058 KyivUkraine

This paper explores distinctive features of Bachelor of Education(***.)training at several well known Ukrainian and Chinese *** analysis was performed taking into consideration important criteria in the educational process of the degree programs(legislative,social,organizational,technological).The Chinese experience is of particular interest to Ukrainian educators because of China’s ancient history and educational *** changes took place in the education systems of both countries in the period of transition to a market-based economy in the 1990s and to knowledge-based *** contribution of the educational system to fast economic development of China has brought the county to second place among the largest economies in the *** authors found similarities in the documentation on the organization of educational processes at the universities,the shared purpose of the training,the use of traditional forms of education,and the emphasis on the practical part of the *** the same time,different features were found in the content of theoretical training,the organization of practical training,the approaches to innovation,the social benefits provided to teachers,the prestige of the teaching profession,principles of moral education,as well as financial and technical *** authors considered a number of progressive ideas in China’s ***,the implementation of which,at national and institutional levels in Ukraine,might contribute considerably to the modernization of pedagogical education.

关键词： Bachelor of Education(B.Ed.) university teacher pedagogical education comparative analysis

TNF-α gene polymorphisms: association with age-related macular degeneration in Russian population

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 25-29页

作者： Valeriy Chernykh Alla shevchenko Vladimir Konenkov Viktor Prokofiev Alena Eremina Alexander Trunov Novosibirsk Branch S.Fyodorov Eye microsurgery Federal State Scientific Institute of Clinical and Experimental Lymрhology

AIM: To study polymorphisms in promotor regions of tumor necrosis factor(TNF)-α TNF-863 A/C(rs1800630), TNF-308 A/g(rs1800629), and TNF-238 A/g(rs361525) in patients with age-related macular degeneration(AMD) and associations of complex TNF-α genotypes with AMD. METHODS: One hundred and two patients(82 women, 20 men; mean age 64.2±1.2 y) with AMD and 100 healthy age-and sex-matched controls(82 women, 18 men; 60±1.4 y) were included in the study. All subjects were Caucasian, all subjects and their parents were inhabitants of Russia. genomic DNA was obtained from EDTA-preserved blood using the standard phenol-chloroform method. Polymorphisms were detected by polymerase chain reaction followed by the restriction fragment length polymorphism method. The following TNF-α genotypes were studied: TNF-α-238 AA, gA, gg, TNF-α-308 AA, gA, gg, TNF-α-863 AA, CA, CC. RESULTS: Differences in TNF-α-863 and TNF-α-238 genotypes frequencies in patients with AMD and healthy controls were not found. The distribution of TNF-α-308 AA and TNF-α-308 gA genotypes was significantly different between the studied group and the controls [odds ratios(OR) =0.22, P=0.0287 and OR=2.91, P=0.0063, respectively]. TNF-863 CC/TNF-308 gA and TNF-308 gA/TNF-238 gg genotypes were associated with the increased risk of AMD(OR=2.48, P=0.0332 and OR=2.51, P=0.0187, respectively). Five genotypes combinations appeared to be protective. CONCLUSION: In the present study, single nucleotide polymorphisms and complex polymorphisms of one of the key inflammatory cytokines TNF-α, and a number of significant associations of these polymorphisms with AMD in Russian population have been shown. Complexanalysis of genotypes could be important in AMD risk factors detection and studying pathogenesis.

关键词： tumor necrosis factor-a genetic polymorphisms age-related macular degeneration