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Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica(L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors

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Chinese Journal of Natural Medicines 2015年第4期13卷 274-282页

作者： Vijeta Bobade Subhash L.Bodhankar Urmila Aswar vishwaraman mohan Prasad Thakurdesai Department of Pharmacology Poona College of Pharmacy Bharati Vidyapeeth Deemed University Department of Pharmacology Sinhgad Institute of Pharmacy Indus Biotech Private Limited 1 Rahul residency Kondhwa Pune-411026 India

The present study aimed at evaluation of prophylactic efficacy and possible mechanisms of asiaticoside(AS) based standardized extract of Centella asiatica(L.) Urban leaves(INDCA) in animal models of migraine. The effects of oral and intranasal(i.n.) pretreatment of INDCA(acute and 7-days subacute) were evaluated against nitroglycerine(NTG, 10 mg·kg-1, i.p.) and bradykinin(BK, 10 μg, intra-arterial) induced hyperalgesia in rats. Tail flick latencies(from 0 to 240 min) post-NTG treatment and the number of vocalizations post-BK treatment were recorded as a measure of hyperalgesia. Separate groups of rats for negative(Normal) and positive(sumatriptan, 42 mg·kg-1, s.c.) controls were included. The interaction of INDCA with selective 5-HT1 A, 5-HT1 B, and 5-HT1 D receptor antagonists(NAN-190, Isamoltane hemifumarate, and BRL-15572 respectively) against NTG-induced hyperalgesia was also evaluated. Acute and sub-acute pre-treatment of INDCA [10 and 30 mg·kg-1(oral) and 100 μg/rat(i.n.) showed significant anti-nociception activity, and reversal of the NTG-induced hyperalgesia and brain 5-HT concentration decline. Oral pre-treatment with INDCA(30 mg·kg-1, 7 d) showed significant reduction in the number of vocalization. The anti-nociceptive effects of INDCA were blocked by 5-HT1 A and 5-HT1 B but not 5-HT1 D receptor antagonists. In conclusion, INDCA demonstrated promising anti-nociceptive effects in animal models of migraine, probably through 5-HT1A/1B medicated action.

关键词： Centella asiatica(L.) Urban Experimental migraine Anti-nociception Serotonin,5HT1A and 5HT1B receptors

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Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats

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Food Science and Human Wellness 2013年第2期2卷 59-67页

作者： Sachin Vetal Subhash L.Bodhankar vishwaraman mohan Prasad A.Thakurdesai Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed UniversityErandwanePune 411038India Indus Biotech Private Limited 1Rahul ResidencyOff Salunke Vihar RoadKondhwaPune 411048India

Type-A procyanidine polyphenols(TAPP)are reported to have immunomodulatory and anti-inflammatory potential in *** objective of present work is to evaluate potential of TAPP extracted from Cinnamon(Cinnamomum zeylanicum)bark in animal models of inflammation and rheumatoid arthritis in ***-induced rat paw edema(CPE)and adjuvant induced established arthritis(AIA),in rats were used as the experimental models for inflammation and arthritis *** activity was evaluated in Randall–Selitto assay in AIA *** showed significant anti-inflammatory effect at dose of 4,8 and 25 mg/kg,*** not at 2 mg/kg,*** in CPE *** dose of 8 mg/kg,*** selected for the evaluation of anti-arthritic activity in AIA ***(8 mg/kg,p.o.,daily from day-12 to day-21)treatment in established arthritic rats showed significant reversal of changes induced in AIA with respect to body weight drop(cachexia),ankle diameter,arthritic score,serum C-reactive protein(CRP)***,TAPP was found to be non-ulcerogenic as compared to AIA control ***,TAPP did not show analgesic effect on AIA-induced pain as seen in Randall–Selitto *** conclusion,TAPP showed disease-modifying potential in animal models of inflammation and arthritis in rats.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Type-A procyanidine polyphenols Cinnamon bark Anti-inflammatory Rheumatoid arthritis

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男性在抗阻训练过程中摄取葫芦巴糖苷补剂的益处:一项随机对照预实验研究(英文)

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Journal of Sport and Health Science 2016年第2期5卷 176-182页

作者： Sachin Wankhede vishwaraman mohan Prasad Thakurdesai Department of Microbiology Smt.Kashibai Navale Medical College Department of Scientific Affairs Indus Biotech Private Limited

目的:运用预测、随机、双盲、安慰剂对照实验设计,测试服用葫芦巴种子糖苷补剂对进行8周抗阻训练健康男性的肌肉代谢、雄激素指标、体脂含量等相关生理参数的作用及安全性。方法:将60名健康男性随机分为2组,按照1:1比例剂量分别服用葫... 详细信息

目的:运用预测、随机、双盲、安慰剂对照实验设计,测试服用葫芦巴种子糖苷补剂对进行8周抗阻训练健康男性的肌肉代谢、雄激素指标、体脂含量等相关生理参数的作用及安全性。方法:将60名健康男性随机分为2组,按照1:1比例剂量分别服用葫芦巴种子胶囊(每粒300 mg,每日2次)和安慰剂。所有受试者参加一项受监督抗阻训练,训练为期8周,每周4次,在训练前后记录相关数据。监测结果包括血清睾酮水平、肌肉力量、正确完成次数、合成代谢活性的生化指标(血清肌酐、血尿素氮)及体脂百分比。标准安全性测验方法包括不良事件监测、生命特征,以及血液、生化和尿检验。结果:与安慰剂对照组相比,葫芦巴种子补剂对受试者新陈代谢和雄激素活性均有显著作用。葫芦巴种子补剂能明显改善体脂含量,但不会降低肌肉力量和正确完成次数,其安全性和耐受性均良好。结论:葫芦巴种子补剂能对从事抗阻训练的男性产生有益作用,且无任何临床副作用。

关键词：耐力训练胡芦巴男性对照实验随机合成代谢肌肉力量苷

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Corrigendum to “Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study” [J Sport Health Sci 5(2016) 176à182]

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Journal of Sport and Health Science 2018年第2期7卷 251-251页

作者： Sachin Wankhede vishwaraman mohan Prasad Thakurdesai Department of Microbiology Smt. Kashibai Navale Medical College

The authors regret the error in the unit of"free testosterone"in Table 2(Page 179)and Section 3.2(Page 180)as"ng/dL"instead of the correct unit"pg/mL".Taged PThe authors would like to apologise for any inconvenience c... 详细信息

关键词： A randomized controlled pilot study Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training Corrigendum to J Sport Health Sci 5

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