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丙酮酸脱氢酶复合体激活NLRP3炎症小体并增加单核细胞向内皮细胞的黏附

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丙酮酸脱氢酶复合体激活NLRP3炎症小体并增加单核细胞向内皮细胞...

作者： vishnu Basappa 大连医科大学

学位级别：硕士

目的:丙酮酸脱氢酶复合体(PDC)是位于线粒体的催化丙酮酸脱羧成乙酰辅酶A的复杂酶系。PDC介导一系列病理生理过程包括乳酸性酸中毒、高血压、肿瘤细胞突变等。目前尚不清楚PDC是否介导动脉粥样硬化的病理生理过程。动脉粥样硬化被认为... 详细信息

目的:丙酮酸脱氢酶复合体(PDC)是位于线粒体的催化丙酮酸脱羧成乙酰辅酶A的复杂酶系。PDC介导一系列病理生理过程包括乳酸性酸中毒、高血压、肿瘤细胞突变等。目前尚不清楚PDC是否介导动脉粥样硬化的病理生理过程。动脉粥样硬化被认为是一种慢性炎症过程,其中NLRP3炎症小体起着重要的作用。本课题,我们探讨PDC对NLRP3炎症小体的活化及其随后在动脉粥样硬化的发生发展中所起的潜在作用。方法:实验分为四组:对照组、氧化低密度脂蛋白(OX-LDL)组、二氯乙酸钠(DCA)组和雷诺嗪组。细胞模型采用人单核细胞/巨噬细胞系THP 1细胞。用DCA(1 mM)或雷诺嗪(5μM)分别直接或间接地激活PDC。免疫印迹(Western blot)分析用来确定NLRP3和其下游蛋白半胱氨酸蛋白酶-1、白细胞介素(IL)-1β,和IL-18的蛋白表达水平。酶联免疫吸附试验(ELISA)用于确定释放到培养上清液中的IL-1β和IL-18。用共培养人脐静脉内皮细胞(HUVEC)和THP-1单核细胞的方法测定单核细胞向内皮细胞的黏附功能。结果:DCA,类似于Ox-LDL,增加了 NLRP3和其下游蛋白半胱氨酸蛋白酶-1、IL-1 β和IL-18蛋白表达量。IL-1 β和IL-18释放到上清液的量也随着DCA的处理而增加,表明在THP-1细胞,PDC可激活NLRP3炎症小体的活化。DCA所介导的PDC和NLRP3的活化可致单核细胞向内皮细胞的粘附功能增加,提示PDC的活化在动脉粥样硬化病理生理过程的起始阶段起着潜在的重要作用。然而,雷诺嗪作为间接的PDC激活剂,无论是免疫印迹还是酶联免疫吸附试验,均未发现NLRP3小体各组分的蛋白表达或其下游的细胞因子的释放的增加,单核细胞向内皮细胞粘附亦未见明显变化。结论:在THP-1细胞,DCA直接激活PDC可诱导NLRP3炎症小体的活化及单核细胞向内皮细胞的粘附功能增加。

关键词：丙酮酸脱氢酶复合体 NLRP3炎症小体动脉粥样硬化细胞粘附 IL-1β IL-18 THP-1 细胞

High-performance carbon fiber/gold/copper composite wires for lightweight electrical cables

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Journal of Materials Science & Technology 2020年第7期42卷 46-53页

作者： Thang Q.Tran Jeremy Kong Yoong Lee Amutha Chinnappan Nguyen Huu Loc Long T.Tran Dongxiao Ji W.A.D.M.Jayathilaka vishnu Vijay Kumar Seeram Ramakrishna Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1EA-07-05Singapore 117575Singapore Faculty of Mechanical Engineering Ho Chi Minh City University of TechnologyVNUHCM268 Ly Thuong KietDistrict 10Ho Chi Minh City 740400Viet Nam

In this study,we synthesized high-performance Carbon Fiber/Gold/Copper(CF/Au/Cu)composite wires by using a 2-step deposition method via sputtering and *** Au was sputtered on PANbased CFs as a pre-treatment,the wettability and surface reactivity of the CFs were improved,resulting in a homogeneous deposition of Cu on their *** different Cu electrodeposition time,the resulting CF/Au/Cu composite wires could possess a high strength of up to 3.27 GPa(~10 times stronger than copper wires)while their electrical conductivity could be as high as 4.4×10^5 S/cm(~75%of that for copper).More importantly,since the composite wires were lightweight(up to 70%lower than Cu mass density),they are a promising candidate to substitute conventional heavy metal wires in the future electrical applications.

关键词： Carbon fiber Copper composite wires Strength Electrical properties

Expedited extraction of xylan from corncob by power ultrasound

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International Journal of Agricultural and Biological Engineering 2009年第4期2卷 76-83页

作者： Wade Yang vishnu K.Ajapur Kathiravan Krishnamurthy Hao Feng Ruijin Yang Taha M.Rababah Department of Food Science and Human Nutrition University of FloridaGainesvilleFL 32611USA Department of Food and Animal Sciences Alabama A&M UniversityNormalAL 35762USA Illinois Institute of Technology Summit-ArgoIL 60501USA Department of Food Science and Human Nutrition University of Illinois at Urbana-ChampaignUrbanaIL 61801USA School of Food Science and Technology Southern Yangtze UniversityWuxi 214036China Department of Food Science and Human Nutrition Jordan University of Science and TechnologyIrbid22110Jordan

Some lignocellulosic biomass like corncob contains a large amount of xylan,a valuable material for applications in food,chemical and pharmaceutical *** extraction of xylan is a time consuming process,requiring 12 to 24 hours to *** this study,the efficacy of power ultrasound for reducing the extraction time and increasing the xylan yield was *** acoustic energy densities(0.18 W/mL and 0.45 W/mL)of the power ultrasound were applied to corncob for 10,20,30,and 60 *** treated samples were steamed at 110,118 and 121℃for 30 *** 0.45 W/mL acoustic energy density and 121℃steaming temperature,ultrasonic treatment was able to extract 39%of xylan in 43 *** contrast,the conventional treatment was able to extract only 34%of xylan in 24 *** ultrasound assisted extraction reduced the processing time by 97%in addition to yield increase by 14.7%.Power ultrasound can be a potential technology for enhanced xylan extraction from corncob to result in significant processing time savings.

关键词： Power ultrasound sonication lignocellulusic biomass xylan extraction corncob steaming

A Universal Object Oriented Expert System Frame Work for Fault Diagnosis

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International Journal of Intelligence Science 2012年第3期2卷 63-70页

作者： Dattatraya vishnu Kodavade Shaila Dinakar Apte Computer Science & Engineering D. K. T. E. Society’s Textile & Engineering Institute Ichalkaranji INDIA Electronics Engineering Department of Electronics Engineering Rajarshi Shahu College of Engineering Pune INDIA

The paper presents a universal fault diagnostic expert system frame work. The frame work is characterized by two basic features. The first includes a fault diagnostic strategy which utilizes the fault classification and checks knowledge about unit under test. The degree of accuracy to which faults are located is improved by using fault classification knowledge. The second characteristic is object oriented inference mechanism using message passing. Object orientation in inference mechanism improved inference efficiency. The developed framework demonstrates its effectiveness and superiority compared to earlier approaches using case studies.

关键词： Knowledge Inference Object Microcontroller Heuristics Inheritance

MHD flow of Boungiorno model nanofluid over a vertical plate with internal heat generation/absorption

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Propulsion and Power Research 2016年第3期5卷 211-222页

作者： B.Ganga S.Mohamed Yusuff Ansari N.vishnu Ganesh A.K.Abdul Hakeem Department of Mathematics Providence College for WomenCoonoor 643104India Department of Mathematics Jamal Mohamed CollegeTrichy 620020India Department of Mathematics Sri Ramakrishna Mission Vidyalaya College of Arts&ScienceCoimbatore 641020India

A mathematical analysis has been carried out to investigate the effect of internal heat generation/absorption on steady two-dimensional radiative magnetohydrodynamics(MHD)boundary-layer flow of a viscous,incompressible nanofluid over a vertical plate.A system of governing nonlinear PDEs is converted into a set of nonlinear ODEs by suitable similarity transformations and then solved analytically using HAM and numerically by the fourth order Runge–Kutta integration scheme with shooting *** effects of different controlling parameters on the dimensionless velocity,temperature and nanoparticle volume fraction profiles are discussed *** reduced Nusslet number and the local Sherwood number are *** is found that the nanosolid volume fraction profile decreases in the presence of heat generation and increases in the case of heat absorption and a reverse trend is observed in velocity *** excellent agreement is observed between present analytical and numerical ***,comparisons have been made with bench mark solutions for a special case and obtained a very good agreement.

关键词： Heat generation/absorption Homotopy analysis method Magnetohydrodynamics(MHD) Nanofluid Vertical plate

Native and transplant kidney histopathological manifestations in association with COVID-19 infection: A systematic review

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World Journal of Transplantation 2021年第11期11卷 480-502页

作者： vishnu Jeyalan Joshua Storrar Henry H L Wu Arvind Ponnusamy Smeeta Sinha Philip A Kalra Rajkumar Chinnadurai Department of Renal Medicine Royal Preston HospitalPreston PR29HTUnited Kingdom Department of Renal Medicine Salford Care OrganisationNorthern Care Alliance NHS Foundation TrustSalford M68HDUnited Kingdom Faculty of Biology Medicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can result in clinically significant multi-system disease including involvement in the *** underlying histopathological processes were unknown at the start of the *** case reports and series have been published describing the underlying renal histopathology from kidney biopsies,we have started to gain an insight into the renal manifestations of this novel *** To provide an overview of the current literature on the renal histopathological features and mechanistic insights described in association with coronavirus disease 2019(COVID-19)*** A systematic review was performed by conducting a literature search in the following websites-‘PubMed’,‘Web of Science’,‘Embase’and‘Medline-ProQuest’with the following search terms-“COVID-19 AND kidney biopsy”,“COVID-19 AND renal biopsy”,“SARS-CoV-2 AND kidney biopsy”and“SARS-CoV-2 AND renal biopsy”.We have included published data up until February 15,2021,which includes kidney biopsies(native,transplant and postmortem)from patients with *** on clinical presentation,histopathological features,management and outcome was extracted from the reported *** The total number of biopsies reported on here is 288,of which 189 are postmortem,84 native and 15 *** results are varied and show underlying pathologies ranging from collapsing glomerulopathy and acute tubular injury(ATI)to anti-nuclear cytoplasmic antibody associated vasculitis and pigment *** was variation in the specific treatment used for the various renal conditions,which included steroids,hydroxychloroquine,eculizumab,convalescent plasma,rituximab,anakinra,cyclophosphamide and renal replacement therapy,amongst *** pathological process which occurs in the kidney following COVID-19 infection and leads to the described biopsy findings has been hypothesized in some conditions but not others(for example,sepsis related hypoperf

关键词： COVID-19 Histopathology Kidney biopsy Transplant SARS-CoV-2

被动超声冲洗对弯曲根管的碎屑清理能力和根管形态的影响

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上海口腔医学 2022年第1期31卷 6-11页

作者： PRIYA vishnu 邵皎皎封菲张旗同济大学口腔医学院牙体牙髓病学教研室上海牙组织再生与修复工程技术研究中心上海200072 上海市口腔医院牙体牙髓病科上海200001

目的:评价被动超声冲洗在弯曲根管内碎屑清理能力和根管偏移量。方法:选取下颌磨牙近中弯曲根管36个,弯曲度在25°以上,以机用XP-endo Shaper根管锉预备根管。根据弯曲长度(curved length,CL)和冲洗方式分为A1组(CL>3 mm,注射器冲洗)、B... 详细信息

目的:评价被动超声冲洗在弯曲根管内碎屑清理能力和根管偏移量。方法:选取下颌磨牙近中弯曲根管36个,弯曲度在25°以上,以机用XP-endo Shaper根管锉预备根管。根据弯曲长度(curved length,CL)和冲洗方式分为A1组(CL>3 mm,注射器冲洗)、B1组(CL>3 mm,超声K锉冲洗)、C1组(CL>3 mm,irrisafe超声锉冲洗)、A2组(CL3 mm的根管根尖区,PUI+irrisafe组的根管体积增量显著高于PUI+K锉和注射器冲洗(P0.05)。在CL<3 mm的根管中,PUI+irrisafe组和PUI+K锉组的根管体积增量均显著高于注射器冲洗(P<0.05),但根管偏移量与注射器冲洗无显著差异(P<0.05)。结论:在弯曲长度较大的根管中,被动超声冲洗结合预弯锉可获得更好的清理效果;而在弯曲长度较小的根管中,被动超声冲洗结合K锉和预弯锉均安全有效。

关键词：被动超声冲洗弯曲根管根管偏移

An Existence Theorem of Solutions for the System of Generalized Vector Quasi-Variational-Like Inequalities

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American Journal of Operations Research 2013年第3期3卷 329-336页

作者： Shamshad Husain Sanjeev Gupta vishnu Narayan Mishra Department of Applied Mathematics & Humanities Sardar Vallabhbhai National Institute of Technology Surat India Department of Applied Mathematics Faculty of Engineering & Technology Aligarh Muslim University Aligarh India

In this paper, we introduce and study the system of generalized vector quasi-variational-like inequalities in Hausdorff topological vector spaces, which include the system of vector quasi-variational-like inequalities, the system of vector variational-like inequalities, the system of vector quasi-variational inequalities, and several other systems as special cases. Moreover, a number of C-diagonal quasiconvexity properties are proposed for set-valued maps, which are natural generalizations of the g-diagonal quasiconvexity for real functions. Together with an application of continuous selection and fixed-point theorems, these conditions enable us to prove unified existence results of solutions for the system of generalized vector quasi-variational-like inequalities. The results of this paper can be seen as extensions and generalizations of several known results in the literature.

关键词： The System of Generalized Vector Quasi-Variational-Like Inequalities Fixed Point Theorem Open Lower Section Upper Semicontinuous C-Diagonal Quasiconvexity

Study on the Status of Metabolic Syndrome Components and Dyslipidemia among Initially Diagnosed Breast Cancer Patients and Breast Cancer Patients Pre and Post Chemotherapy

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Study on the Status of Metabolic Syndrome Components and Dys...

作者： vishnu Prasad Adhikari 重庆医科大学

学位级别：硕士

BACKGROUND AND PURPOSE The prevalence of risk factors contributing to metabolic syndrome（Met S）is increasing,and numerous components of Met S are associated with increased primary breast cancer（BC）***,less is known about the relationship of metabolic syndrome to BC *** this paper,we will study the status of blood lipid among breast cancer patients and normal cohorts and also the breast cancer patients before and after undergoing *** the incidence of metabolic syndrome and its components among normal populace and breast cancer group were comparatively *** *** clinical data of 1054 cases of initially diagnosed breast cancer patients and 2484 cases of normal women（as controls）with the reports of their blood lipid levels were collected from the Electronic Medical Records in the Breast Cancer Center of Chongqing and Medical Examination Center of the First Affiliated Hospital of Chongqing Medical University,from July 2015 to October *** data were comparatively analysed and stratified according to their *** the status of lipidemia among 446 breast cancer patients were comparatively analyzed before and after undergoing *** obtained age,sex,pathological diagnosis,menstrual status,and the status of various lipid components in those subejects from our medical record *** clinical data of 605 initially diagnosed breast cancer patients and 3212 general population with the reports of their metabolic components were collected for comparitive analysis from Chongqing Breast Cancer Center of Chongqing and Medical Centre of the First Affiliated Hospital of Chongqing Medical *** this study we calculated the stauts of BMI and metabolic components and stratified them according to their age between breast cancer group and normal population *** the end,the metabolic components were also stratified according to the number of components present in those *** *** total incidence of dyslipidemi

关键词：乳腺癌化疗前后代谢综合征血脂异常胆固醇血症甘油三酯血症