Native and transplant kidney histopathological manifestations in association with COVID-19 infection: A systematic review

作     者：Vishnu Jeyalan Joshua Storrar Henry H L Wu Arvind Ponnusamy Smeeta Sinha Philip A Kalra Rajkumar Chinnadurai 

作者机构：Department of Renal MedicineRoyal Preston HospitalPreston PR29HTUnited Kingdom Department of Renal MedicineSalford Care OrganisationNorthern Care Alliance NHS Foundation TrustSalford M68HDUnited Kingdom Faculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom 

出 版 物：《World Journal of Transplantation》 (世界移植杂志)

年 卷 期：2021年第11卷第11期

页      面：480-502页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：COVID-19 Histopathology Kidney biopsy Transplant SARS-CoV-2 

摘      要：BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can result in clinically significant multi-system disease including involvement in the *** underlying histopathological processes were unknown at the start of the *** case reports and series have been published describing the underlying renal histopathology from kidney biopsies,we have started to gain an insight into the renal manifestations of this novel *** To provide an overview of the current literature on the renal histopathological features and mechanistic insights described in association with coronavirus disease 2019(COVID-19)*** A systematic review was performed by conducting a literature search in the following websites-‘PubMed’,‘Web of Science’,‘Embase’and‘Medline-ProQuest’with the following search terms-“COVID-19 AND kidney biopsy,“COVID-19 AND renal biopsy,“SARS-CoV-2 AND kidney biopsyand“SARS-CoV-2 AND renal biopsy.We have included published data up until February 15,2021,which includes kidney biopsies(native,transplant and postmortem)from patients with *** on clinical presentation,histopathological features,management and outcome was extracted from the reported *** The total number of biopsies reported on here is 288,of which 189 are postmortem,84 native and 15 *** results are varied and show underlying pathologies ranging from collapsing glomerulopathy and acute tubular injury(ATI)to anti-nuclear cytoplasmic antibody associated vasculitis and pigment *** was variation in the specific treatment used for the various renal conditions,which included steroids,hydroxychloroquine,eculizumab,convalescent plasma,rituximab,anakinra,cyclophosphamide and renal replacement therapy,amongst *** pathological process which occurs in the kidney following COVID-19 infection and leads to the described biopsy findings has been hypothesized in some conditions but not others(for example,sepsis related hypoperf