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Apple(Malus domestica Borkh.)seed:A review on health promoting bioactivities and its application as functional food ingredient

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Food Bioscience 2022年第6期50卷 2051-2066页

作者： Manoj kumar Mrunal D.Barbhai Tuba Esatbeyoglu Baohong Zhang Vijay Sheri Sangram Dhumal Nadeem Rais Radha Eman Mohammad Said Al Masry Deepak Chandran Ravi Pandiselvam Marisennayya Senapathy Abhijit Dey Sheetal vishal Deshmukh Mohamed El Sayed Negm Marthandan Vishvanathan Sangeetha Kizhakkumkara Sathyaseelan Sabareeshwari Viswanathan Pran Mohankumar José M.Lorenzo Chemical and Biochemical Processing Division ICAR—Central Institute for Research on Cotton TechnologyMumbai400019India Department of Food Development and Food Quality Institute of Food Science and Human NutritionGottfried Wilhelm Leibniz University HannoverAm Kleinen Felde 3030167HannoverGermany Department of Biology East Carolina UniversityGreenville27858USA Division of Horticulture RCSM College of AgricultureKolhapur416004India Department of Pharmacy Bhagwant UniversityAjmerRajasthan305004India School of Biological and Environmental Sciences Shoolini University of Biotechnology and Management SciencesSolan173229India Faculty of Libral Arts and Ancient Indian Wisdom Shoolini UniversitySolan173229India Department of Veterinary Sciences and Animal Husbandry Amrita School of Agricultural SciencesAmrita Vishwa Vidyapeetham UniversityCoimbatore642109India Division of Physiology Biochemistry and Post-Harvest TechnologyICAR-Central Plantation Crops Research Institute (CPCRI)KasaragodKerala671124India Department of Rural Development and Agricultural Extension College of AgricultureWolaita Sodo UniversityWolaita SodoSNNPREthiopia Department of Life Sciences Presidency University86/1 College StreetKolkata700073India Bharati Vidyapeeth (Deemed to be University) Yashwantrao Mohite Institute of ManagementKaradIndia Cotton Research Institute Agriculture Research CenterGiza3725004Egypt Department of Seed Science and Technology Amrita School of Agricultural SciencesAmrita Vishwa Vidyapeetham UniversityCoimbatore642109India Department of Plantation Crops and Spices Kerala Agricultural UniversityVellanikkaraThrissur680656KeralaIndia Department of Soil Science and Agricultural Chemistry Amrita School of Agricultural SciencesAmrita Vishwa Vidyapeetham UniversityCoimbatore642109India School of Agricultural Sciences Karunya Institute of Technology and SciencesCoimbatore - 641114India Centro Tecnológico de la Carne de Galicia Parque Tecnológico de GaliciaAvd.Galicia n° 4Sa

Recent trends in food industry focus on utilization of fruit processing waste and by-products as novel ingredients due to their nutritional *** seed is one such novel ingredient that can find application as functional ingredient in food,nutraceutical and pharmaceutical *** existing studies suggest that apple seed is a rich source of amino acids,fatty acids and polyphenolic *** review discusses the nutritional and phytochemical profile as well as biological activities exhibited by the apple *** also highlights the current application of apple seed in food,pharmaceutical and nutraceutical industries along with the safety aspects considering the presence of *** apple seed meal,extracts or seed oil as novel ingredient can find various industrial applications given their dense nutritional *** their functionality,rigorous and extensive research is required to promote its usage at industrial level for harnessing the benefits of apple seeds.

关键词： Apple seed Biological activities Industrial applications Phytochemicals

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Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes

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Cellular & Molecular Immunology 2019年第12期16卷 946-946页

作者： Ankita Singh vishal Singh Rajiv L.Tiwari Tulika Chandra Ashutosh kumar Madhu Dikshit Manoj K.Barthwal Pharmacology Division CSIR-Central Drug Research InstituteB.S.10/1Sector 10Sitapur RoadJankipuram ExtensionLucknow 226031 Uttar PradeshIndia Department of Transfusion Medicine and Blood Bank King George’s Medical UniversityLucknowUttar PradeshIndia Department of Pathology King George’s Medical UniversityLucknowUttar PradeshIndia

In this article,published online on 31 August 2015,there was an unintended error during image processing of Fig.2b leading to pasting of total ERK andβ-Actin blots not intended for this *** blots have now been replaced with the total ERK andβ-Actin panels that were generated for this *** corrected Fig.2b is shown ***,the conclusion made from the experiment remains unaltered,and this correction has no bearing on the final outcome of the *** inconvenience caused by this error is deeply regretted.

关键词： correction intended conclusion

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Multi-omic Microbiome Profiles in the Female Reproductive Tract in Early Pregnancy

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Infectious Microbes & Diseases 2019年第2期1卷 49-60页

作者： Sophonie Jean Bernice Huang Hardik I.Parikh David J.Edwards J.Paul Brooks Naren Gajenthra kumar Nihar U.Sheth vishal Koparde Ekaterina Smirnova Snehalata Huzurbazar Philippe H.Girerd Dayanjan S.Wijesinghe Jerome F.StraussIII Myrna G.Serrano Jennifer M.Fettweis Kimberly K.Jefferson Gregory A.Buck Department of Microbiology and Immunology Virginia Commonwealth UniversityRichmondVA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVA Department of Statistical Sciences and Operations Research Virginia Commonwealth UniversityRichmondVA Supply Chain Management and Analytics School of BusinessVirginia Commonwealth UniversityRichmondVA Life Sciences Virginia Commonwealth UniversityRichmondVA DNAnexus Inc. Mountain ViewCA Frederick National Laboratory for Cancer Research FrederickMD Department of Biostatistics Virginia Commonwealth UniversityRichmondVA Department of Statistics University of WyomingLaramieWY Obstetrics and Gynecology Virginia Commonwealth UniversityRichmondVA Pharmacotherapy and Outcomes Science Virginia Commonwealth UniversityRichmondVA Department of Computer Science Virginia Commonwealth UniversityRichmondVA.

The vaginal microbiome likely influences host signaling compounds within the reproductive tract,including pro-inflammatory signals,which may play an important role during *** lactobacilli are associated with positive pregnancy outcome,whereas bacterial vaginosis,a dysbiosis of the vaginal microbiome,is associated with an increased risk of adverse pregnancy outcomes including preterm *** the host response could be predicted based on the taxonomic composition of the vaginal microbiome,particularly early in pregnancy,then those predictions could potentially be used to personalize intervention methods to reduce preterm birth and other adverse *** this proof of principle study,we apply multivariate strategies to analyze 16S rRNA-based taxonomic surveys in conjunction with targeted immuno-proteomic and lipidomic data from vaginal samples from 58 women enrolled in the Multi-Omic Microbiome Study-Pregnancy Initiative during early *** between the vaginal microbiome and the vaginal lipidome have not been previously *** from this study reveal significant multiple pairwise associations between microbial taxa,specific eicosanoids and sphingomyelins,and *** the biologic significance of these associations is not yet known,these results support the utility of such multi-omic approaches as a means to predict the impact of the microbiome on the host.

关键词： vaginal microbiome preterm birth multi-omics metagenomics cytokine profiles lipidomics

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Spatial-Temporal Analysis of LU/LC Classification in Nirmal Mandal, Adilabad, Telangana State, India, by Using Remote Sensing and GIS

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International Journal of Geosciences 2017年第11期8卷 1315-1331页

作者： Dr T. Madhu D. Naresh kumar D. Niteesh Reddy P. V. E. Ravi Teja L. Narayana V. vishal B. Subash A. Maniratnam Y. Vasavi V. Shakeena Sri Venkateswara University Tirupati India St. Martin’s Engineering College Civil Engineering Department Secunderabad India

In this project, we studied land use and land cover classification of Nirmal Mandal, Adilabad district, Telenagna state by using Geographical Information system and Remote sensing techniques. LISS-IV satellite image resolution 5 m × 5 m provides quality information for identification of Land use/Land cover characteristics. The image accuracy shows 45.70% of Agricultural land, 9.10% Built-up land, Forest area is 7.90%, Barren land have 7.60% and Uncultivated land occupied 29.70%. National land use and land cover mapping report based on 5 divisions classified in the study area. The area land use and land cover classification provide reliable data to understand land, water, soil, forests, urban sprawl. This socio economic survey significantly shows the changes that so far have taken place. This will help the people/farmers for the future land use and land cover change detection. Regular monitoring of agriculture, forest and greening efforts for plantation at suitable area, schemes and limitations. Free ware browsing of land cover gives sufficient development to plenty resource.

关键词： Nirmal Mandal GIS LU/LC Classification

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Rationale and protocol for estimating the economic value of a multicomponent quality improvement strategy for diabetes care in South Asia

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Global Health Research and Policy 2019年第1期4卷 333-342页

作者： Kavita Singh Mohammed KAli Raji Devarajan Roopa Shivashankar Dimple Kondal Vamadevan S.Ajay VUsha Menon Premlata KVarthakavi Vijay Viswanathan Mala Dharmalingam Ganapati Bantwal Rakesh kumar Sahay Muhammad Qamar Masood Rajesh Khadgawat Ankush Desai Dorairaj Prabhakaran K.M.Venkat Narayan Victoria LPhillips Nikhil Tandon On behalf of the CARRS Trial Group Public Health Foundation of India Center of Excellence-Center for CArdio-metabolic Risk Reduction in South Asia4th FloorPlot No.47Sector 44Institutional AreaGurgaonHaryana 122002India Rollins School of Public Health Emory University1518 Clifton RoadRm CNR 7041AtlantaGA 30322USA Department of Endocrinology&Diabetes Amrita Institute of Medical SciencesAmrita Vishwa VidyapeethamPonekkara P.O.KochiKerala 682041India Department of Endocrinology TNM College&BYL Nair Charity HospitalDr.A.L.Nair RoadMumbai CentralMumbaiMaharashtra 400008India MV Hospital for Diabetes&Diabetes Research Centre No 4West Madha Church StreetRoyapuramChennaiTamil Nadu 600013India Bangalore Endocrinology&Diabetes Research Centre #355th CrossMalleswaram CircleBangaloreKarnataka 560003India Department of Endocrinology St.John’s Medical College&HospitalSarjapur RoadKoramangalaBangaloreKarnataka 560034India Department of Endocrinology Osmania General Hospital2nd FloorGolden Jubilee BlockAfzalgunjHyderabadTelangana 500012India Department of Medicine Section of Endocrinology and DiabetesAga Khan UniversityStadium RoadKarachi 74800Pakistan Department of Endocrinology&Metabolism All India Institute of Medical SciencesBiotechnology Block3rd FloorAnsari NagarNew Delhi 110029India Endocrine Unit Department of MedicineGoa Medical CollegeBambolimGoa 403202India Public Health Foundation of India 4th FloorPlot No.47Sector 44Institutional AreaGurgaonHaryana 122002India Rollins School of Public Health Emory University1518 Clifton RoadRm CNR 7049AtlantaGA 30322USA Rollins School of Public Health Emory University1518 Clifton RoadAtlantaGA 30322USA Department of Endocrinology&Metabolism All India Institute of Medical SciencesBiotechnology Block3rd FloorRm#312Ansari NagarNew Delhi 110029India Centre for Chronic Disease Control C 1/52Second FloorSafdarjung Development AreaNew Delhi110016India London School of Hygiene and Tropical Medicine Keppel StBloomsburyLondon WC1E 7HTUK. 不详

Background:Economic dimensions of implementing quality improvement for diabetes care are understudied *** describe the economic evaluation protocol within a randomised controlled trial that tested a multicomponent quality improvement(QI)strategy for individuals with poorly-controlled type 2 diabetes in South ***/design:This economic evaluation of the Centre for Cardiometabolic Risk Reduction in South Asia(CARRS)randomised trial involved 1146 people with poorly-controlled type 2 diabetes receiving care at 10 diverse diabetes clinics across India and *** economic evaluation comprises both a within-trial cost-effectiveness analysis(mean 2.5 years follow up)and a microsimulation model-based cost-utility analysis(life-time horizon).Effectiveness measures include multiple risk factor control(achieving HbA1c<7%and blood pressure<130/80 mmHg and/or LDL-cholesterol<100 mg/dl),and patient reported outcomes including quality adjusted life years(QALYs)measured by EQ-5D-3 L,hospitalizations,and diabetes related complications at the trial *** measures include direct medical and non-medical costs relevant to outpatient care(consultation fee,medicines,laboratory tests,supplies,food,and escort/accompanying person costs,transport)and inpatient care(hospitalization,transport,and accompanying person costs)of the intervention compared to usual diabetes ***,healthcare system,and societal perspectives will be applied for *** cost and health effects will be discounted at 3%per year for within trial cost-effectiveness analysis over 2.5 years and decision modelling analysis over a lifetime *** will be reported as the incremental cost-effectiveness ratios(ICER)to achieve multiple risk factor control,avoid diabetes-related complications,or QALYs gained against varying levels of willingness to pay threshold *** analyses will be performed to assess uncertainties around ICER estimates by varying costs(95%CIs)across publ

关键词： Economic evaluation Diabetes care Multicomponent strategy Quality improvement South Asia

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