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Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin

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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani vishal Jain Veenu joshi Ravindra Kumar Pandey Shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

Sedimentological evidence of climate-tectonic interaction in the upper Satluj catchment of NW Himalaya

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Journal of Mountain Science 2024年第6期21卷 1978-1991页

作者： joshi Moulishree JALAL Poonam Department of Geology Kumaun UniversityNainitalUttarakhand 263001India

Quaternary valley fill deposits in the Upper Satluj Valley of NW Himalaya act as archives of changing climate-tectonic dynamics in a *** landforms help in decoding the relationship between climate and *** region is traversed by several active faults and thrusts such as the Kaurik-Chango Fault(KCF)and Sangla Detachment(SD),thereby making upper Satluj Valley tectonically *** parameters such as width of valley floor(Vfw),Normalized Steepness Index(KSn)and geomorphological evidences such as the presence of huge strath terraces,narrowing of the river valley and palaeolake deposits point towards the tectonically active nature of the *** arid,high elevation region is also climatically sensitive as it falls in a transient climatic zone which receives rainfall only during abnormal monsoon *** rainfall causes outburst floods,a common phenomenon in the area due to the blocking of headwater in the upper reaches of the Satluj *** a result,the Quaternary sequence is modified from time to *** transition from hypo concentrated deposits to channel deposits and ponding events are prominent in the depositional sequence,resulting from a response to *** studied Quaternary sediments reveal that the Trans-Himalayan region of the upper Satluj valley is affected by tectonic-climate variability,making it vulnerable to geohazards.

关键词： Himachal Pradesh Quaternary Lithofacies association Tectonics Climate

Temperature field characteristics of CF/PEEK thermoplastic composites formed by automated fiber placement using hot gas torch with slit structure nozzle

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Chinese Journal of Aeronautics 2024年第6期37卷 392-409页

作者： Ziang JIN Shouzheng SUN Sunil Chandrakant joshi Zhenyu HAN Hongya FU State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150001China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

In-situ consolidation forming of high-performance thermoplastic composites by Automated Fiber Placement(AFP)is of significant interest in *** the laying process,the heating temperature has a great influence on the quality of the formed components.A threedimensional heat transfer finite element model of Carbon Fiber(CF)/Polyether Ether Ketone(PEEK)heated by Slit Structure Nozzle Hot Gas Torch(SSNHGT)assisted AFP is *** influence of gas flow rate,heat transfer distance,and laying speed on heating temperature is *** results show that the overall temperature increases and then decreases as the gas flow rate *** the increase in heat transfer distance and laying speed,the overall temperature ***,the gas flow rate has the greatest influence on the temperature of CF/PEEK being heated,followed by the laying speed and finally the heat transfer ***,the model can also be extended to other fiber-reinforced polymer composites formed by hot gas torch assisted AFP,which can guide the optimization of process parameters for subsequent heating temperature control.

关键词： Fiber reinforced plastics Thermoplastics Heating temperature Automated fiber placement CF/PEEK

Prediction of left ventricle ejection fraction from HRV in diabetics and cardiac diseased subjects:A mathematical model approach

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Medicine in Novel Technology and Devices 2024年第3期23卷 98-103页

作者： Ulka Shirole Manjusha joshi A.C.Patil College of Engineering Navi MumbaiIndia Amity University MumbaiIndia

Heart Rate variability(HRV)is the variation between beat-to-beat intervals in a consecutive *** provides enormous information about cardiac *** and echocardiography(2D echo)are the two major techniques used by medical practitioners to diagnose cardiac *** 2D echo provides more accurate results as compared to electrocardiography but costs ten times *** research provides low-cost solution for cardiac health diagnosis to the level of 2D echo derived from the *** and the 2D echo data of the same cohort are collected from 15 diabetics and 15 cardiac-diseased *** this research,we found a correlation between significant HRV parameters and 2D Echo *** correlation is obtained between LF/HF(low-frequency power to high-frequency power ratio),the HRV parameter,and LVEF(left ventricle ejection fraction),the 2D echo *** derived various mathematical models,to predict the LVEF,from LF/HF for both cardiac diseased and diabetics *** combined best-fit model is obtained using nonlinear regression with the goodness of fit,R^(2)=94.54%.

关键词： Left ventricle ejection fraction Heart rate variability Autonomous nervous system Cardiac health Diabetes

Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika M.joshi Theresa Currier Thomas Nafisa M.Jadavji College of Osteopathic Medicine Midwestern UniversityGlendaleCAUSA Department of Biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary Medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin B12 vitamin B2 vitamin B3

Technological advancements in millet dehulling and polishing process: An insight into pretreatment methods, machineries and impact on nutritional quality

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Grain & Oil Science and Technology 2024年第3期7卷 186-195页

作者： Shagolshem Mukta Singh Jayasree joshi T P.Srinivasa Rao Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India

Millets are widely recognized for their nutritional significance;however, the methods employed for their processing are currently lacking. This article primarily focuses on the advanced technologies and progressions in millet dehulling and polishing. These technologies operate based on the fundamental principles of compression-shearing, abrasion-friction, and centrifugal-impact forces. Processing of millets can be challenging because of the physical characteristics and tight attachment of hull and bran to the endosperm. However, several dehullers have been designed to solve this problem for different kinds of millets. In addition, the nutritional and anti-nutritional characteristics undergo alterations due to both dehulling and polishing processes. These alterations are thoroughly examined and discussed in this article. Specifically, anti-nutrients such as tannins and phytate are predominantly found in the outer pericarp of the grain and experience a reduction after undergoing dehulling and polishing. The nutritional properties are also subjected to a reduction;however, this reduction can be mitigated by subjecting the grains to certain pretreatments before dehulling and polishing. These treatments serve to enhance dehulling efficiency and nutrient digestibility while simultaneously reducing the presence of anti-nutrients. Novel thermal and non-thermal methodologies such as microwave, hydrothermal, high-pressure processing, and ohmic heating can be employed for processing millets, thereby diminishing the loss of nutrients. Additional research can be carried out to investigate their impact on the dehulling and polishing of millets.

关键词： Millets Dehulling Polishing Pretreatment Novel thermal and non-thermal techniques

Hydrothermal treatment of pearl millet grains:Effects on nutritional composition,antinutrients and flour properties

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Grain & Oil Science and Technology 2024年第2期7卷 87-95页

作者： P.Prashanth T.Jayasree joshi Shagolshem Mukta Singh P.Srinivasa Rao Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpurWest Bengal 721302India

Pearl millet(Pennisetum glaucum)is one of the major millets with high nutritional *** crop exhibits exceptional resilience to drought and high ***,the processing of pearl millet poses a significant challenge due to its high lipid content,enzyme activity,and presence of ***,it becomes imperative to enhance the quality and prolong the shelf life of pearl millet flour by employing suitable *** treatment in the food industry has long been seen as promising due to its potential to reduce microbial load,inactivate enzymes,and improve nutrient *** study aims to investigate the effects of hydrothermal treatment on the quality characteristics of pearl *** independent variables of the study were soaking temperature(35,45,55℃),soaking time(2,3,4 h),and steaming time(5,10,15 min).Treatment conditions had a statistically significant effect on nutrient *** antinutrients like tannins and phytates were reduced by 0.99% to 5.94% and 0.36% to 6.00%,respectively,after the *** activity decreased significantly up to 10% with the treatment *** findings of this study could potentially encourage the use of pearl millet flour in the production of various food items and promote the application of hydrothermal treatment in the field of food processing.

关键词： Pearl millet Hydrothermal treatment Nutritional properties Antinutrients

Overcoming the Challenges Encountered in the Performance Appraisal of Faculty Members

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Journal of Forensic Science and Medicine 2024年第2期10卷 152-154页

作者： Saurabh RamBihariLal Shrivastava Ulfa Zora Yulia Putri Ayunigdyah Abhishek joshi Deputy Director(Research and Development) Datta Meghe Institute of Higher Education and Research NagpurOff CampusDepartment of Community MedicineDatta Meghe Medical CollegeOff-campus Centre of Datta Meghe Institute of Higher Education and ResearchHingna RoadWanadongriNagpurMaharashtraIndia Department of Medical Education Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia Department of Research and Education Dr.Yap Eye HospitalYogyakartaIndonesia Department of Community Medicine Jawaharlal Nehru Medical CollegeDatta Meghe Institute of Higher Education and ResearchSawangiWardhaMaharashtraIndia

Performance appraisal of teaching faculty who are involved in the act of delivery of medical education to prepare future doctors plays a pivotal role in measuring their competency level to train students,assessing the effectiveness in discharging their other roles,and acts as a motivating factor to continuously improvise and augment their knowledge and ***,the ground reality is that in most settings,this task is not acknowledged as an action for motivating a faculty member,but rather just an act of *** the identification of these challenges,we must look for remedial measures to overcome them to streamline and enhance the effectiveness of the performance appraisal *** conclusion,the performance appraisal of teaching faculty is an essential and indispensable ***,the success of performance appraisal,in terms of promoting professional development and organizational success,will depend a lot on the effective redressal of the existing challenges.

关键词： Faculty medical education performance appraisal

Gonad indices,morphology and muscle fatty acid compositions of male and female golden mahseer(Tor putitora)sampled from lake Bhimtal(Himalaya)at different seasons of the year

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Aquaculture and Fisheries 2024年第4期9卷 603-616页

作者： Annu Sharma Debajit Sarma Rini joshi Partha Das MdShahbaz Akhtar Veena Pande Prakash Sharma ICAR-Directorate of Coldwater Fisheries Research Bhimtal263136India Department of Biotechnology Kumaun UniversityBhimtal CampusBhimtal263136India

Adult male and female golden mahseer(n=10-12)were collected during summer,monsoon,pre-winter and winter for evaluating gonadal seasonality,condition factor(CF),viscera-hepatosomatic index(VHSI),hepatocyte density(HD)and muscle fatty acid(FA)*** summer and monsoon,all males,but only 67%and 71%of females,were spawning capable in respective *** pre-winter,males were mostly in regressing,but females were in regenerating *** winter,50%of males and 14%of females were in the early spawning capable *** and HD,in males only,were respectively highest and lowest in winter,indicating their nutrient recovery starting in pre-winter and completing in *** muscle FA profile of females only was linked to gonadal status,where C20:1,C22:1,C18:3n-6,C18:3n-3,C20:4n-3,C22:6n-3,total n-3 and n-6 FAs were depleted in peak spawning ***,it was found that their spawning peak falls in summer and monsoon,but few early and late spawners were detected in winter and pre-winter,*** and females exhibited a different reproduction-linked nutrient allocation pattern;hepatic nutrient dynamic was prominent in males,but muscle FA dynamic was pronounced in *** dynamic was similar in both sexes.

关键词： Golden mahseer Seasonal gonadal cycle Nutritional status Muscle fatty acid