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Antidiabetic,hypolipidemic and histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 347-352页

作者： Sunil kumar vipin kumar Om Prakash Institute of Pharmaceutical Sciences Kurukshetra UniversityHaryanaIndia

Objective:To investigate antidiabetic,hypolipidemic histopathological analysis of Dillenia indica(***) methanolic leaves(DIME) extract in alloxan induced diabetic rat by administering oral doses(250 and 500 mg/kg body weight).Methods:Blood glucose levels were measured using blood glucose test strips with elegance glucometer on weekly intervals till the end of study(i.e.3 weeks).Other parameters *** profile,renal profile and total lipid levels were determined in normal and alloxan induced diabetic rats after oral administration of the extract for 21 *** changes in diabetic rat organs(pancreas,liver and kidney) were also observed after extract treatment Results:Daily oral administration DIME(250 and 500 mg/kg body weight) and glibenclamide(10 mg/kg) showed beneficial effects on blood glucose level (P<0.001) as well as improving kidney,liver functions and hyperlipidaemia due to diabetes. The extract treatment also showed to enhanced serum insulin level and body weight of diabetic rats as compared to diabetic control ***,the extract has a favorable effect on the histopathological changes of the pancreas,liver and kidney in alloxan induced diabetes. Conclusions:*** possess antidiabetic property as well improve body weight,liver profile, renal profile and total lipid *** has also favorable effect to inhibit the histopathological changes of the pancreas and kidney in alloxan induced diabetes.

关键词： Antidiabetic Dillenia indica Hypolipidemic Rat Serum cholesterol

A cautionary note on decadal sea level pressure predictions from GCMs

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Advances in Climate Change Research 2018年第1期9卷 43-56页

作者： Stefan LIESS Peter K.SNYDER Arjun kumar vipin kumar Department of Earth Sciences University of MinnesotaMinneapolis MN 55455USA Department of Soil Waterand ClimateUniversity of MinnesotaSt.Paul MN 55108USA Computer Science&Engineering University of MinnesotaMinneapolis MN 55455USA

A comparison of sea level pressure(SLP)trends in a subset of seven Coupled Model Intercomparison Project(CMIP)phase 5 general circulation models(GCM),namely decadal simulations with CCSM4,CanCM4,MPI-ESM-LR,FGOALS-g2,MIROC4h,MIROC5,and MRICGCM3,to their CMIP3 counterparts reveals an unrealistically strong forecast skill in CMIP3 models for trend predictions for 2001e2011 when using the 1979e2000 period to train the ***-winter SLP trends over five high-,mid-,and low-latitude zones were calculated over the 1979e2000 initialization period for each ensemble member and then ranked based on their performance relative to HadSLP2 *** same method is used to rank the ensemble members during the 2001e2011 *** CMIP3,17 out of 38 ensemble members retain their rank in the 2001e2011 hindcast period and 3 retain the neighboring ***,numbers are much lower in more recent CMIP5 decadal predictions over the similar 2001e2010 period when using the 1981e2000 period as initialization with the same number of *** periods were used for CMIP3 and CMIP5 because although the 1979e2000 initialization is widely used for CMIP3,CMIP5 decadal predictions are only available for 30-year *** conclusion to consider the forecast skill in CMIP3 predictions during 2001e2011 as unrealistic is corroborated by comparisons to earlier periods from the 1960s to the 1980s in both CMIP3 and CMIP5 ***,although the 2001e2011 CMIP3 predictions show statistically significant forecast skill,this skill should be treated as a spurious result that is unlikely to be reproduced by newer more accurate GCMs.

关键词： sea level pressure CMIP3 Coupled Model Intercomparison Project

Evaluation of potential landslide damming: Case study of Urni landslide,Kinnaur, Satluj valley, India

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Geoscience Frontiers 2019年第2期10卷 753-767页

作者： vipin kumar Vikram Gupta Imlirenla Jamir Shovan Lal Chattoraj Wadia Institute of Himalayan Geology Indian Institute of Remote Sensing

This work aims to understand the process of potential landslide damming using slope failure mechanism,dam dimension and dam stability evaluation. The Urni landslide, situated on the right bank of the Satluj River, Himachal Pradesh(India) is taken as the case study. The Urni landslide has evolved into a complex landslide in the last two decade(2000-2016) and has dammed the Satluj River partially since year 2013,damaging ～200 m stretch of the National Highway(NH-05). The crown of the landslide exists at an altitude of ～2180-2190 m above msl, close to the Urni village that has a human population of about *** high resolution imagery shows ～50 m long landslide scarp and ～100 m long transverse cracks in the detached mass that implies potential for further slope failure movement. Further analysis shows that the landslide has attained an areal increase of 103,900 ± 1142 m^2 during year 2004-2016. About 86% of this areal increase occurred since year 2013. Abrupt increase in the annual mean rainfall is also observed since the year 2013. The extreme rainfall in the June, 2013; 11 June(～100 mm) and 16 June(～115 mm),are considered to be responsible for the slope failure in the Urni landslide that has partially dammed the river. The finite element modelling(FEM) based slope stability analysis revealed the shear strain in the order of 0.0-0.16 with 0.0-0.6 m total displacement in the detachment zone. Further, kinematic analysis indicated planar and wedge failure condition in the jointed rockmass. The debris flow runout simulation of the detached mass in the landslide showed a velocity of ～25 m/s with a flow height of ～15 m while it(debris flow) reaches the valley floor. Finally, it is also estimated that further slope failure may detach as much as 0.80 ±0.32 million m^3 mass that will completely dam the river to a height of 76±30 m above the river bed.

关键词： Urni landslide Slope stability Rainfall Landslide damming Satluj valley

Self-powered pressure sensor for ultra-wide range pressure detection

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Nano Research 2017年第10期10卷 3557-3570页

作者： Kaushik Parida Venkateswarlu Bhavanasi vipin kumar Ramaraju Bendi Pooi See Lee School of Materials Science and Engineering Nanyang Technological University Nanyang Avenue 639798 Singapore

The next generation of sensors should be self-powered, maintenance-free, precise, and have wide-ranging sensing abilities. Despite extensive research and development in the field of pressure sensors, the sensitivity of most pressure sensors declines significantly at higher pressures, such that they are not able to detect a wide range of pressures with a uniformly high sensitivity. In this work, we demonstrate a single-electrode triboelectric pressure sensor, which can detect a wide range of pressures from 0.05 to 600 kPa with a high degree of sensitivity across the entire range by utilizing the synergistic effects of the piezoelectric polarization and triboelectric surface charges of self-polarized polyvinyldifluoride-trifluoroethylene （P（VDF-TrFE）） sponge. Taking into account both this wide pressure range and the sensitivity, this device exhibits the best performance relative to that of previously reported self-powered pressure sensors. This achievement facilitates wide-range pressure detection for a broad spectrum of applications, ranging from simple human touch, sensor networks, smart robotics, and sports applications, thus paving the way forward for the realization of next-generation sensing devices. Moreover, this work addresses the critical issue of saturation pressure in triboelectric nanogenerators and provides insights into the role of the surface charge on a piezoelectric polymer when used in a triboelectric nanogenerator.

关键词： self-powered triboelectric piezoelectric nanogenerator pressure sensor

Evaluation of potential surface instability using finite element method in Kharsali Village,Yamuna Valley,Northwest Himalaya

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Journal of Mountain Science 2017年第8期14卷 1666-1676页

作者： Imlirenla JAMIR Vikram GUPTA vipin kumar Glenn T.THONG Wadia Institute of Himalayan Geology Department of Geology Nagaland UniversityKohima Campus

Kharsali village, located in the Northwest Himalaya near the confluence of the Yamuna River and Unta Gad, is situated on a thick(>150 m) paleolandslide deposit. The village is continuously being eroded at its base by the two rivers. Cracks are noted in most houses while the ancient Shani Temple lying to the south of the village has tilted ~5° towards the northeast. Three slope sections(S-1, S-2, S-3) were modelled and analysed to determine the displacement and shear strain patterns of the slopes. Based on surface failure conditions, potential slope instability of the Kharsali village was evaluated from 2D Finite Element Method(FEM) using Shear Strain Reduction(SSR) analysis in the Phase2 software. Results indicate a critical Stress Reduction Factor(SRF) of 1.5 for the southern edge of the village(S-1) housing the Shani Temple. The development of failure surfaces at its lower portion signifies the propagating, progressive nature of the slope. The S-2 slope section is most vulnerable to slope failure, with a critical SRF of 1.08. This has been inferred by the formation of failure surfaces with displacements of 0.05-0.08 m. The S-3 section in the northern part of the Kharsali shows highest critical SRF of 2.76. The un-metalled road section in the north of the village near S-3 hasdeveloped a failure surface with displacement of 0.003-0.004 m, and a zone of subsidence. The S-3 section is relatively stable, whereas the S-2 section is the most vulnerable portion of the village.

关键词： Finite element method Kharsali Yamuna valley Landslide Slope stability NorthwestHimalaya

Ethnomedicinal, phytochemical and pharmacological updates on Hygrophila auriculata (Schum.) Hiene： an overview

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Journal of Integrative Medicine 2018年第5期16卷 299-311页

作者： Neeraj K. Sethiya Nasir M. Ahmed Raeesh M. Shekh Vivek kumar Pawan kumar Singh vipin kumar National Innovation Foundation-India Amrapur Crambharti Mahudi Road Candhinagar 382 650 Gujarat India

This article explores the most recent evidence-based information on ethnomedicinal, phytochemical and pharmacological understanding of Hygrophila auriculata for the treatment of various diseases and health conditions. Various ethnomedicinal writings suggest the use of the plant or its parts for the treatment of jaundice, oedema, gastrointestinal ailments, diarrhoea, dysentery, urinogenital disorder, gall stones, urinary calculi, kidney stone, leucorrhoea, rheumatism, tuberculosis, anaemia, body pain, constipation, skin disease, and as an aphrodisiac. The plant has been reported to contain flavonoids （apigenin, luteolin, ellagic acid, gallic acid and quercetin）, alkaloids （asteracanthine and asteracanthicine）, triterpenes （lupeol, lupenone, hentricontane and betulin）, sterols （stigmasterol and asterol）, minerals, amino acids, fatty acids, aliphatic esters and essential oils. Extracts and bioactive compounds from the plant have been found to possess antimicrobial, anthelmintic, antitermite, nephroprotective, hepatoprotective, central nervous system protective, antitumour, antidiabetic, anticataract, antioxidant, haematopoietic, diuretic, antinociceptive, anti-inflammatory, antipyretic, antimotility, aphrodisiac, neuroprotection, anti- endotoxin and anti-urolithiatic activities. For this paper, we reviewed patents, clinical studies, analytical studies and marketed formulations from the earliest found examples from 1887 to the end of 2017.

关键词： Ethnomedicine Hygrophila auriculata Pharmacology Phytochemical

Property-performance relationship of core-shell structured black TiO_(2) photocatalyst for environmental remediation

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Frontiers of Environmental Science & Engineering 2023年第9期17卷 177-195页

作者： Sajjad Haider Rab Nawaz Muzammil Anjum Tahir Haneef vipin kumar Oad Salah Uddinkhan Rawaiz Khan Muhammad Aqif Chemical Engineering Department College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia Department of Environmental Sciences Institute of Soil and Environmental SciencesPir Mehr Ali Shah Arid Agriculture University ShamsabadRawalpindi 46300Pakistan Centre of Innovative Nanostructures and Nanodevices(COINN) Institute of Autonomous SystemUniversiti Teknologi PETRONASBandar Seri Iskandar 32610Malaysia Civil and Environmental Engineering Department The University of Alabama in HuntsvilleHuntsvilleAL 35899USA Faculty of Civil and Environmental Engineering Gdansk University of TechnologyGdansk 80-233Poland College of Engineering King Saud UniversityRiyadh 11421Saudi Arabia Restorative Dental Sciences Department College of DentistryKing Saud UniversityRiyadh 11545Saudi Arabia Faculty of Materials and Chemical Engineering Department of Chemical EngineeringGhulam Ishaq Khan InstituteKhyber Pakhtunkhwa Topi 23460Pakistan

Understanding the relationship between the properties and performance of black titanium dioxide with core-shell structure(CSBT)for environmental remediation is crucial for improving its prospects in practical *** this study,CSBT was synthesized using a glycerol-assisted sol-gel *** effect of different water-to-glycerol ratios(W:G=1:0,9:1,2:1,and 1:1)on the semiconducting and physicochemical properties of CSBT was *** effectiveness of CSBT in removing phenolic compounds(PHCs)from real agro-industrial wastewater was *** CSBT synthesized with a W:G ratio of 9:1 has optimized properties for enhanced removal of *** has a distinct coreshell structure and an appropriate amount of Ti3+cations(11.18%),which play a crucial role in enhancing the performance of *** exposed to visible light,the CSBT performed better:48.30%of PHCs were removed after 180 min,compared to only 21.95%for TiO_(2) without core-shell *** CSBT consumed only 45.5235 kWh/m^(3) of electrical energy per order of magnitude and cost$2.4127 per unit volume of treated agro-industrial *** the conditions tested,the CSBT demonstrated exceptional stability and *** CSBT showed promising results in the treatment of phenols-containing agro-industrial wastewater.

关键词： Black TiO_(2) Core-shell structure Property-performance relationship Agro-industrial effluent Environmental remediation

Association of metabolic NCD risk factors with oral, breast and cervical precancers and cancers in India

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Family Medicine and Community Health 2019年第4期7卷 37-45页

作者： Ashwini Kedar Roopa Hariprasad vipin kumar Kavitha Dhanasekaran Ravi Mehrotra Department of Clinical Oncology National Institute of Cancer Prevention and ResearchNoidaIndia

Objective To find an association between metabolic non-communicable disease(NCD)risk factors(high blood pressure(BP),high random blood sugar(RBS)and overweight/obesity)and oral,breast,cervical cancers/precancerous or potentially malignant *** This is an observational study using convenience *** participants were screened through opportunistic or population-based *** The study was conducted at a health promotion clinic(HPC)located in Northern India under the Indian Council of Medical *** is a screening clinic where screening is done for hypertension(HT),diabetes mellitus(DM),obesity,and oral,breast and cervical *** study was conducted between December 2016 and January *** The number of participants screened was 8352(6712 women and 1640 men).All consenting men and women above 18 years were *** participants were screened for oral cancer,DM,HT and *** women were also screened for breast and cervical *** screening was done for non-pregnant women 21 years and above with history of sexual *** Oral potentially malignant disease(OPMD)was the most prevalent,followed by breast cancer,oral cancer,cervical cancer and cervical *** RBS had a strong association with oral cancer(OR=2.29,95%CI 1.09 to 4.82,p=0.03)and breast cancer(OR=1.95,95%CI 1.01 to 3.76,p=0.05).High BP had a strong association with breast cancer(OR=2.50,95%CI 1.43 to 4.35,p<0.0001).An inverse association was noted between oral cancer and overweight/obesity(OR=0.20,95%CI 0.08 to 0.48,p<0.0001).Current tobacco use was strongly associated with oral cancer(OR=6.51,95%CI 3.63 to 11.67,p<0.0001)and OPMD(OR=9.82,95%CI 8.13 to 11.86,p<0.0001).No association was elicited between the metabolic NCD risk factors and cervical cancer/*** The study reaffirms that NCD metabolic risk factors determine oral and breast *** NCD risk factors,current tobacco use was a strong determinant

关键词： cervical breast cancers

NKT cell subsets as key participants in liver physiology and pathology

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Cellular & Molecular Immunology 2016年第3期13卷 337-346页

作者： Keya Bandyopadhyay Idania Marrero vipin kumar Department of Medicine University of California San Diego La Jolla CA 92037 USA

Natural killer T （NKT） cells are innate-like lymphocytes that generally recognize lipid antigens and are enriched in microvascular compartments of the liver. NKT cells can be activated by self- or microbial-lipid antigens and by signaling through toll-like receptors. Following activation, NKT cells rapidly secrete pro-inflammatory or anti- inflammatory cytokines and chemokines, and thereby determine the milieu for subsequent immunity or tolerance. It is becoming clear that two different subsets of NKT cells-type I and type II--have different modes of antigen recognition and have opposing roles in inflammatory liver diseases. Here we focus mainly on the roles of both NKT cell subsets in the maintenance of immune tolerance and inflammatory diseases in liver. Furthermore, how the differential activation of type I and type II NKT cells influences other innate cells and adaptive immune cells to result in important consequences for tissue integrity is discussed. It is crucial that better reagents, including CDld tetramers, be used in clinical studies to define the roles of NKT cells in liver diseases in patients.

关键词： CDld lipids liver disease NKT cells