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Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 92-94,I0008页

作者： Shilpa Barthwal Bennet Angel Annette Angel vinod joshi BM Shareef Nuzhat M Peer Poorna Khaneja Ambreen S Khan Bhawna Sharma Neha Singh Ramesh joshi Komal Tomar Kiran Yadav Satendra P Singh Advance Centre for Virology&Immunology Sharda UniversityGreater NoidaU.P.201310India Sharda School of Agricultural Sciences Sharda UniversityGreater NoidaU.P.201310India Department of Microbiology School of Medical Sciences&ResearchSharda HospitalGreater NoidaU.P.201310India

Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern *** and Omicron *** we are using vaccines which are either mRNA of spike protein of Wuhan strain or its whole virion vaccine,these vaccines will trigger antibodies to be able to bind with the epitopes of spike protein of Wuhan *** appears a need to study whether vaccine generated circulating neutralizing antibodies in vaccinated people are able to neutralize the receptor binding domain of spike protein of currently circulating Delta and Omicron strains as *** need to address this contention in two phases:first to undertake docking studies of vaccine generated antibodies with Wuhan,Delta and Omicron strains and second to conduct the wet lab studies and observe antigen-antibody bindings employing Immunofluorescence and Cryo-Electron Microscopic *** present paper reports results of docking studies using bioinformatic softwares to provide the baseline information for wet lab studies.

关键词： vaccine antibodies neutral

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Effect of Carbonitriding on Endurance Life of Ball Bearing Produced from SAE 52100 Bearing Steels

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Journal of Surface Engineered Materials and Advanced Technology 2013年第3期3卷 172-177页

作者： Karthikeyan Rajan vinod joshi Arindam Ghosh Research & Development National Engineering Industries Ltd. Jaipur India.

The present paper reports the unusual enhancement of endurance life of ball bearings subjected to carbonitriding treatment. The microstructure was characterized by scanning electron microscopy and correlated with hardness and X-ray diffraction analysis. Endurance tests at 90% reliability revealed that the carbonitrided bearings exhibit nearly ten times more life than the non-carbonitrided bearings. This is attributed to synergic combination of retained austenitic, fine martensitic microstructure and ultrafine carbide precipitates obtained by carbonitriding treatment.

关键词： Carbonitriding Retained Austenite Martensite Endurance Test Bearing Steel

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