Neutralizing possibilities of whole virion and mRNA vaccine triggered antibodies of Wuhan strain of SARS-CoV-2 with receptor binding domains of spike proteins of Delta and Omicron strains
作者机构：Advance Centre for Virology&ImmunologySharda UniversityGreater NoidaU.P.201310India Sharda School of Agricultural SciencesSharda UniversityGreater NoidaU.P.201310India Department of MicrobiologySchool of Medical Sciences&ResearchSharda HospitalGreater NoidaU.P.201310India
出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)
年 卷 期：2023年第16卷第2期
页 面：92-94,I0008页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：funded by Indian Council of Medical Research Grant Number 2021-6369
主 题：vaccine antibodies neutral
摘 要：Mutations in the receptor binding domain(RBD)of SARS-CoV-2 spike protein have given birth to the new variants of concern *** and Omicron *** we are using vaccines which are either mRNA of spike protein of Wuhan strain or its whole virion vaccine,these vaccines will trigger antibodies to be able to bind with the epitopes of spike protein of Wuhan *** appears a need to study whether vaccine generated circulating neutralizing antibodies in vaccinated people are able to neutralize the receptor binding domain of spike protein of currently circulating Delta and Omicron strains as *** need to address this contention in two phases:first to undertake docking studies of vaccine generated antibodies with Wuhan,Delta and Omicron strains and second to conduct the wet lab studies and observe antigen-antibody bindings employing Immunofluorescence and Cryo-Electron Microscopic *** present paper reports results of docking studies using bioinformatic softwares to provide the baseline information for wet lab studies.
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