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Stem cell treatments for oropharyngeal dysphagia:Rationale,benefits,and challenges

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World Journal of Stem Cells 2020年第9期12卷 1001-1012页

作者： Eric K tran Kevin O Juarez Jennifer L long David Geffen School of Medicine University of California-Los AngelesLos AngelesCA 90095United States Department of Otolaryngology Yale School of MedicineNew HavenCT 06511United States Department of Head and Neck Surgery David Geffen School of MedicineUniversity of California-Los AngelesLos AngelesCA 90095United States Greater Los Angeles VA Healthcare System Los AngelesCA 90073United States

Dysphagia,defined as difficulty swallowing,is a common symptom negatively impacting millions of adults *** prevalence ranges from 14 to 33 percent in those over age 65 to over 70 percent in a nursing home *** elderly,those with neurodegenerative diseases,head and neck cancer patients,and those with autoimmune conditions such as Sjögren's syndrome are disproportionately *** dysphagia refers specifically to difficulty in initiating a swallow due to dysfunction at or above the upper esophageal sphincter,and represents a large proportion of dysphagia *** treatments are limited and are often *** cell therapy is a new and novel advancement that may fill a much-needed role in our treatment ***,we review the current literature regarding stem cell treatments for oropharyngeal *** discussed include tissue regeneration advancements as a whole and translation of these principles into research surrounding tongue dysfunction,xerostomia,cricopharyngeal dysfunction,and finally an overview of the challenges and future directions for *** this field of study remains in its early stages,initial promising results show potential for the use of stem cell-based therapies to treat oropharyngeal dysphagia and warrant further research.

关键词： Dysphagia Xerostomia Hemiglossectomy Stem cells Myoblasts Mesenchymal stem cells

Adaptive Relaying Protocol for Decode and Forward Full-Duplex System over Rician Fading Channel: System Performance Analysis

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china Communications 2019年第3期16卷 92-102页

作者： Tan N.Nguyen Minh tran Thanh-long Nguyen Miroslav Voznak Wireless Communications Research Group Faculty of Electrical and Electronics Engineering Ton Duc Thang University Optoelectronics Research Group Faculty of Electrical and Electronics Engineering Ton Duc Thang University Center for Information Technology Ho Chi Minh City University of Food Industry Faculty of Electrical Engineering and Computer Science VSB-Technical University of Ostrava

In this paper, the system performance of a decode-and-forward(DF) full-duplex(FD) adaptive relaying network over the Rician fading environment is proposed, analyzed and demonstrated. In the first stage, the system is presented with the energy harvesting and information transmission processes. After that, the analytical expressions of the achievable throughput, the outage probability, and symbol error ratio(SER) were proposed, analyzed and demonstrated. Finally, the analytical results are also demonstrated by Monte-Carlo simulation in comparison with the closed-form expressions in the influence of the key system parameters. The results show that the analytical and simulated results match for all possible parameter values.

关键词： relaying network throughput outage probability SER wireless energy harvesting(EH)

Production of 5-Hydroxymethylfurfural and Furfural from Lignocellulosic Biomass in Water-Tetrahydrofuran Media with Sodium Bisulfate

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chinese Journal of Chemical Physics 2015年第5期28卷 -页

作者： Ning Shi Qi-ying Liu Tie-jun Wang Qi Zhang long-long Ma chi-liu Cai CAS Key Laboratory of Renewable Energy4 Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 ChinaSchool of Chemical Engineering Guizhou Institute of Technology Guiyang 550003 China CAS Key Laboratory of Renewable Energy4 Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou 510640 China

5-Hydroxymethylfurfural (HMF) and furfural (FF), two bio-based platform chemicals, were produced from various raw lignocellulosic materials (corncob, corn stover, wheat straw, rice straw and sugarcane bagasse) in a water-tetrahydrofuran media by using NaHSO4 as catalyst. The influences of reaction temperature (160–200 °C), reaction time (30–120 min), solvent volume ratio, feedstock concentration (2.4wt%–11.1wt%) and catalyst dosage were studied. The highest HMF and FF yields obtained from corncob were 47mol% and 56mol% under condition of 190 °C, 90 min, 10/1 of THF/H2O. Besides, the lignin in the raw biomass was also depolymerized into organosolv lignin.

关键词： 5-Hydroxymethylfurfural Furfural Lignocellulosic biomass Hydrolysis Dehydration Tetrahydrofuran Sodium bisulfate

Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen Jiang Fei long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

How knowledge of hepatitis B disease and vaccine influences vaccination practices among parents in Ho chi Minh City, Vietnam

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Asian Pacific Journal of Tropical Medicine 2021年第3期14卷 122-127页

作者： Giao Huynh Le An Pham Thien Thuan tran Ngoc Nga Cao Thi Ngoc Han Nguyen Quang vinh Bui Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Center for Training of Family Medicine University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Department of Infectious Diseases University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Infection Control Department University Medical Center at Ho Chi Minh CityVietnam Department of Pediatrics University of Medicine and Pharmacy at Ho Chi Minh CityVietnam

Objective:To assess the influences of the knowledge of parents about hepatitis B virus(HBV)infection and the benefit of HBV vaccination on the practice of HBV vaccination among ***:A prospective cross-sectional study recruited parents whose children,aged 12-24 months,received HBV vaccination at Commune Health Centers(CHCs)in Ho chi Minh City from Feb.2016 to *** were interviewed using a questionnaire that included 11-item binary knowledge questions and checked their children’s vaccination ***:A total of 768 parents had a mean age of(30.8±5.1)*** mean knowledge score of the 11-item questions was(7.0±2.4).The knowledge score was positively associated with full and timely HBV *** addition,children who received complete and timely HBV vaccination were significantly more likely to live in rural areas(Adjusted OR 4.02,95%CI 2.79-5.79,Pchildren whose parents received vaccination information from health care providers,and had knowledge about HBV risk,had a higher rate of full and timely HBV vaccination(Adjusted OR 1.60,95%CI 1.13-2.29,and Adjusted OR 1.47,95%CI 1.01-2.13,P all<0.05).Conclusions:Parents possessed a great deal of incorrect knowledge about *** health education from health care providers should target parents living in specific locations and focus on the benefits of HBV vaccine.

关键词： Knowledge Hepatitis Health Belief Model Vaccination Questionnaire

transfer Learning for Disease Diagnosis from Myocardial Perfusion SPECT Imaging

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Computers, Materials & Continua 2022年第12期73卷 5925-5941页

作者： Phung Nhu Hai Nguyen chi Thanh Nguyen Thanh Trung tran Trung Kien Institute of Information Technology AMSTHanoi11307Vietnam Department of Medical Equipment 108 Military Central HospitalHanoi11610Vietnam

Coronary artery disease(CAD)is one of the most common pathological conditions and the major global cause of *** perfusion imaging(MPI)using single-photon emission computed tomography(SPECT)is a non-invasive method and plays an essential role in diagnosing ***,there is currently a shortage of doctors who can diagnose using SPECT-MPI in developing countries,especially *** on deploying machine learning and deep learning in supporting CAD diagnosis has been noticed for a long ***,these methods require a large dataset and are therefore time-consuming and *** study aims to develop a cost-effective and high-performance CAD classification model to support doctors in these *** this paper,we propose a transfer learning framework for a multi-stage training process with different learning *** process consists of two training stages:a warming up stage in which all layers of a pre-trained model(on ImageNet dataset)are frozen;and a finetuning stage in which a small amount of the top layers are unfrozen and then retrained with a lower learning *** dataset for this study consists of the polar maps from 218 *** popular CNN-based pre-trained models have been investigated,and ResNet152V2-based model has obtained the highest performances with an accuracy of 95.5%,area under the receiver operating characteristic curve(AUC)score 0.932,sensitivity 94.4%,precision 96.4%,and F1-score 95.2%.These performances are competitive or even better than all state-of-the-art approaches in terms of classification accuracy and *** also apply the class activation mapping technique to help explain the model’s predictions and increase the model’s reliability,proving capable of assisting the SPECT image readers in the CAD diagnosis.

关键词： Coronary artery disease deep learning transfer learning SPECTMPI polar maps

Attribute Reduction on Decision Tables Based on Hausdorff Topology

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Computers, Materials & Continua 2024年第11期81卷 3097-3124页

作者： Nguyen long Giang tran Thanh Dai Le Hoang Son tran Thi Ngan Nguyen Nhu Son Cu Nguyen Giap Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10000Vietnam Faculty of Information Technology University of Economics-Technology for IndustriesHanoi10000Vietnam VNU Information Technology Institute Vietnam National UniversityHanoi10000Vietnam International School Vietnam National UniversityHanoi10000Vietnam Center of Science and Technology Research and Development Thuongmai UniversityHanoi10000Vietnam

Attribute reduction through the combined approach of Rough Sets(RS)and algebraic topology is an open research topic with significant potential for *** research works have introduced a strong relationship between RS and topology spaces for the attribute reduction ***,the mentioned recent methods followed a strategy to construct a new measure for attribute ***,the strategy for searching for the reduct is still to select each attribute and gradually add it to the ***,those methods tended to be inefficient for high-dimensional *** overcome these challenges,we use the separability property of Hausdorff topology to quickly identify distinguishable attributes,this approach significantly reduces the time for the attribute filtering stage of the *** addition,we propose the concept of Hausdorff topological homomorphism to construct candidate reducts,this method significantly reduces the number of candidate reducts for the wrapper stage of the *** are the two main stages that have the most effect on reducing computing time for the attribute reduction of the proposed algorithm,which we call the Cluster Filter Wrapper algorithm based on Hausdorff *** validation on the UCI Machine Learning Repository Data shows that the proposed method achieves efficiency in both the execution time and the size of the reduct.

关键词： Hausdorff topology rough sets topology from rough sets attribute reduction

Vacuum Ultraviolet Excited Photoluminescence Properties of Y_2O_2S:Eu^(3+),Bi^(3+) Phosphor

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Chemical Research in chinese Universities 2008年第6期24卷 679-682页

作者： WANG Zhi-long WANG Yu-hua ZHANG Jia-chi Department of Materials Science Lanzhou University Lanzhou 730000 P. R. China

As an Hg-free lamp using phosphor, the Bi^3＋ and EH^3＋ co-doped Y2O2S phosphors were prepared and their luminescence properties under vacuum ultraviolet（VUV） excitation were investigated. The VUV photoluminescent intensity of Y2O2S：Eu^3＋ was weak, however, considerably stronger red emission at 626 nm with good color purity was observed in Y2O2S：Eu^3＋,Bi^3＋ systems. Investigation on the photoluminescence reveals that the strong VUV luminescence of Y2O2S：Eu^3＋,Bi^3＋ at 147 nm is mainly because the Bi^3＋ acts as a medium and effectively performs the energy transfer process： Y^3＋-O^2-→Bi^3＋→Eu^3＋, while the intense emission band at 172 nm is attributed to the absorption of the characteristic ^1So-^1P1 transition of Bi^3＋ and the direct energy transfer from Bi^3＋ to Eu^3＋. The Y2O2S：Eu^3＋,Bi^3＋ shows excellent VUV optical properties compared with the commercial （Y,Gd）BO3：Eu^3＋. Thus, the Y2O2S：Eu^3＋,Bi^3＋ can be a potential red VUV-excited candidate applied in Hg-free lamps for backlight of liquid crystal display.

关键词： Y2O2S:Eu^3+,Bi^3+ Vacuum ultraviolet(VUV) Phosphor