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Journal of Magnesium and Alloys 2023年第2期11卷 462-479页

作者： Jiheon Jun vineet v.joshi Alasdair Crawford vilayanur viswanathan Donovan N.Leonard Jian Chen Piyush Updadhyay Yong Chae Lim Zhili Feng Oak Ridge National Laboratory Oak RidgeTNUSA Pacific Northwest National Laboratory RichlandWashingtonUSA

Galvanic corrosion of AZ31B joined with bare or Zn-coated DP590 steel by ultrasonic spot welding or linear friction stir welding was quantitatively studied by pre-defining anode and cathode in the lap joint samples. Corrosion volume and depth from Mg anode surfaces exposed to 0.1 M sodium chloride solution was analyzed as functions of cathode surface type and welding method. Characterization of as-welded joints was performed to identify any microstructural feature of the bonding zone that could impact galvanic corrosion behavior.COMSOL modeling with modified user subroutine was conducted to simulate the progression of Mg corrosion in the same joint and electrode configurations used for the corrosion experiments. The experimental results indicated that Zn-coated cathode surface can reduce Mg galvanic corrosion significantly as galvanic polarization and cathodic current on Zn-coated surface remained relatively low for Mg in the weld joints.COMSOL modeling described the growth of Mg galvanic corrosion in a reasonable manner but showed limitation by underestimating the corrosion volume as it did not capture self-corrosion.

关键词： Mg alloy Zn coating Ultrasonic spot welding Friction stir welding Galvanic corrosion

A six months old neglected anterior shoulder dislocation managed by closed reduction and Latarjet procedure

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Chinese Journal of Traumatology 2016年第5期19卷 295-297页

作者： Deepak Chaudhary Deepak joshi vineet Jain Mukul Mohindra Nitin Mehta Sports Injury Center Safdarjung Hospital and VMM College New Delhi India

忽视的肩膀脱臼是一个更稀罕的实体，仅仅很少案例在文学被报导。肩膀的前面的脱臼很少在诱拐和外部旋转作为与手足在场的病人被错过，对整形外科的外科医生很熟悉的态度。当时，偶尔，如此的案例被错过他们与近似肱骨的骨折在场或当他... 详细信息

忽视的肩膀脱臼是一个更稀罕的实体，仅仅很少案例在文学被报导。肩膀的前面的脱臼很少在诱拐和外部旋转作为与手足在场的病人被错过，对整形外科的外科医生很熟悉的态度。当时，偶尔，如此的案例被错过他们与近似肱骨的骨折在场或当他们从通常在农村区域练习的全然的专业人员接受治疗时。由于很少的报告，有文学的少量，没有标准治疗协议为肩膀的忽视的前面的脱臼存在，尽管最如此的长期的案例被开的减小管理。这份案例报告与重要的山 Sachs 损害描述六个月旧的忽视的前面的脱臼，它被关上的减小和 Latarjet 过程管理。

关键词：肩膀脱臼肱骨的破裂 Latarjet 过程

A stochastic SIR model for analysis of testosterone suppression of CRH-stimulated cortisol in men

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第3期13卷 223-229页

作者： A.Manickam Pushpendra Kumar K.Dasunaidu v.Govindaraj Dheeraj Kumar joshi School of Advanced Sciences 8 Languages Department of Mathematics vIT Bhopal University Kottri Kalan(village)466114 Sehore(District) Madhya PradeshIndia Department of Mathematics National Institute of Technology Puducherry Karaikal 609609 India Department of Basic Sciences 8 Humanities GMR Institute of Technology Rajam 532127 Srikakulam(Dt)Andhra PradeshIndia DIT University Dehradun 248009 UttarakhandIndiamanickammaths2011@***.kxumarsaraswatpk@*****dasunaidu.k@gmrit.edu.in ttgovindaraj.maths@*** t+maths.dj44010@***

A stochastic SIR influenza vertical transmission model is examined in this paper where vaccination and an incidence rate that is not linear are considered.To determine whether testosterone regulates lower sintering HPA axis function in males,we used a stochastic SIR epidemic procedure with divergent influences on ACTH and cortisol.The suppressive effects on cortisol can be attributed to a peripheral(adrenal)locus.Following that,we came to the conclusion that experimental solutions have been discovered and the requisite statistical findings have been examined.Finally,we deduce that the given mathematical model and the results are relevant to medical research.In the future,this research can be further extended to simulate more results in the medical field.

关键词： ACTH cortisol CRH estradiol HPA SIR model testosterone

Outcome of repair of chronic tear of the pectoralis major using corkscrew suture anchors by box suture sliding technique

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World Journal of Orthopedics 2016年第10期7卷 670-677页

作者： Deepak joshi Jitesh Kumar Jain Deepak Chaudhary Utkarsh Singh vineet Jain Ajay Lal Sports Injury Centre Safdarjung Hospital Sports Injury Centre Safdarjung Hospital and Vardhman Mahavir Medical College

AIM To assess the functional and clinical results of repair of chronic tears of pectoralis major using corkscrew and sliding suture technique. METHODS In this retrospective study, we reviewed the results of pectoralis major repair in 11 chronic cases(> 6 wk) done between September 2011 and December 2014 at our institute. In all cases repair was done by same surgeon using corkscrew suture anchors and box suture sliding technique. At 6 mo, after surgery magnetic resonance imaging was done to see the integrity of the repair. Functional evaluation was done using Penn and ASES scores. Pre and postoperative Isokinetic strength was measured.RESULTS Average follow-up was 48.27 ± 21.0 mo. The Wilcoxon signed rank test was used to evaluate the outcome scores. The average ASES score increased from an average of 54.63 ± 13.0 preoperatively to 95.09 ± 2.60 after surgery at their last follow-up. The average Penn score also increased from 5.72 ± 0.78, 2.81 ± 1.32 and 45.81 ± 1.72 to 9.36 ± 0.80, 8.27 ± 0.90 and 59 ± 1.34 for pain, satisfaction and function respectively. Follow up magnetic resonance imaging(MRI)(at 6 mo) showed continuity and the bulk of pectoralis major muscle in all cases. Average isokinetic strength deficiency in horizontal adduction at 60° was 13.63% ± 6.93% and at 120° was 10.18% ± 4.93% and in flexion at 60° was 10.72% ± 5.08% and at 120° was 6.63% + 3.74%. Results showed that both ASES and Penn score improved significantly(2 tailed P value = 0.0036).CONCLUSION We could conclude from this series that pectoralis major repair even in chronic cases using 5.5 mm corkscrew anchors give excellent functional and cosmetic results. In chronic cases the repairable length of the tendon is not available and sliding suture technique allows for fixation of worn out tendomuscular junction to bone without letting cutting through the muscle.

关键词： Pectoralis major tear Corkscrew suture anchors Chronic tears Bench press Tendon repair

Intelligent Deep Learning Based Cybersecurity Phishing Email Detection and Classification

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Computers, Materials & Continua 2023年第3期74卷 5901-5914页

作者： R.Brindha S.Nandagopal H.Azath v.Sathana Gyanendra Prasad joshi Sung Won Kim Department of Computing Technologies SRM Institute of Science and TechnologyKattankulathur603203India Department of Computing Science and Engineering Nandha College of TechnologyErode638052India School of Computing Science and Engineering VIT Bhopal UniversityBhopal466114India Department of Computer Science and Engineering K.Ramakrishnan College of EngineeringTiruchirappalli621112India Department of Computer Science and Engineering Sejong UniversitySeoul05006Korea Department of Information and Communication Engineering Yeungnam UniversityGyeongsan-si38541Gyeongbuk-doKorea

Phishing is a type of cybercrime in which cyber-attackers pose themselves as authorized persons or entities and hack the victims’sensitive data.E-mails,instant messages and phone calls are some of the common modes used in cyberattacks.Though the security models are continuously upgraded to prevent cyberattacks,hackers find innovative ways to target the victims.In this background,there is a drastic increase observed in the number of phishing emails sent to potential targets.This scenario necessitates the importance of designing an effective classification model.Though numerous conventional models are available in the literature for proficient classification of phishing emails,the Machine Learning(ML)techniques and the Deep Learning(DL)models have been employed in the literature.The current study presents an Intelligent Cuckoo Search(CS)Optimization Algorithm with a Deep Learning-based Phishing Email Detection and Classification(ICSOA-DLPEC)model.The aim of the proposed ICSOA-DLPEC model is to effectually distinguish the emails as either legitimate or phishing ones.At the initial stage,the pre-processing is performed through three stages such as email cleaning,tokenization and stop-word elimination.Then,the N-gram approach is;moreover,the CS algorithm is applied to extract the useful feature vectors.Moreover,the CS algorithm is employed with the Gated Recurrent Unit(GRU)model to detect and classify phishing emails.Furthermore,the CS algorithm is used to fine-tune the parameters involved in the GRU model.The performance of the proposed ICSOA-DLPEC model was experimentally validated using a benchmark dataset,and the results were assessed under several dimensions.Extensive comparative studies were conducted,and the results confirmed the superior performance of the proposed ICSOA-DLPEC model over other existing approaches.The proposed model achieved a maximum accuracy of 99.72%.

关键词： Phishing email data classification natural language processing deep learning cybersecurity

Identification,synthesis and characterization of an unknown process related impurity in eslicarbazepine acetate active pharmaceutical ingredient by LC/ESI-IT/MS,~1H,^(13)C and ~1H-~1H COSY NMR

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Journal of Pharmaceutical Analysis 2014年第5期4卷 339-344页

作者： Saji Thomas Saroj Kumar Paul Subhash Chandra joshi vineet Kumar Ashutosh Agarwal Dharam vir Analytical Research Department Jubilant Life Sciences Ltd.R&D CentreC-26Sector-59NoidaUttar Pradesh 201301India Chemical Research Department Jubilant Life Sciences Ltd.R&D CentreC-26Sector-59NoidaUttar Pradesh 201301India

A new impurity was detected during high performance liquid chromatographic （HPLC） analysis of eslicarbazepine acetate active pharmaceutical ingredient. The structure of unknown impurity was postulated based on liquid chromatography mass spectrometry using electrospray ionization and ion trap analyzer （LC/ESI-IT/MS） analysis. Proposed structure of impurity was unambiguously confirmed by synthesis followed by characterization using 1H, 13C nuclear magnetic resonance spectrometry （NMR）, 1H-1H correlation spectro-scopy （COSY） and infrared spectroscopy （IR）. Based on the spectroscopic and spectrometric data, unknown impurity was characterized as 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl propionate.

关键词： Eslicarbazepine acetate Characterization LC/ES I-IT/MS NMR Impurity

Design of QoS Aware Routing Protocol for IoT Assisted Clustered WSN

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Computers, Materials & Continua 2022年第5期71卷 3785-3801页

作者： Ashit Kumar Dutta S.Srinivasan Bobbili Prasada Rao B.Hemalatha Irina v.Pustokhina Denis A.Pustokhin Gyanendra Prasad joshi Department of Computer Science and Information Systems College of Applied SciencesAlmaarefa UniversityRiyadh13713Kingdom of Saudi Arabia Saveetha School of Engineering Saveetha Institute of Medical and Technical SciencesSaveetha NagarThandalamChennai602105India Department of Electrical and Electronics Engineering Vignan’s Institute of Information TechnologyVisakhapatnam530049India Department of Electronics and Communication Engineering Thirumalai Engineering CollegeKancheepuram631551India Department of Entrepreneurship and Logistics Plekhanov Russian University of Economics117997MoscowRussia Department of Logistics State University of Management109542MoscowRussia Department of Computer Science and Engineering Sejong UniversitySeoul05006Korea

In current days,the domain of Internet of Things(IoT)and Wireless Sensor Networks(WSN)are combined for enhancing the sensor related data transmission in the forthcoming networking applications.Clustering and routing techniques are treated as the effective methods highly used to attain reduced energy consumption and lengthen the lifetime of the WSN assisted IoT networks.In this view,this paper presents an Ensemble of Metaheuristic Optimization based QoS aware Clustering with Multihop Routing(EMOQoSCMR)Protocol for IoT assisted WSN.The proposed EMO-QoSCMR protocol aims to achieve QoS parameters such as energy,throughput,delay,and lifetime.The proposed model involves two stage processes namely clustering and routing.Firstly,the EMO-QoSCMR protocol involves crossentropy rain optimization algorithm based clustering(CEROAC)technique to select an optimal set of cluster heads(CHs)and construct clusters.Besides,oppositional chaos game optimization based routing(OCGOR)technique is employed for the optimal set of routes in the IoT assisted WSN.The proposed model derives a fitness function based on the parameters involved in the IoT nodes such as residual energy,distance to sink node,etc.The proposed EMOQoSCMR technique has resulted to an enhanced NAN of 64 nodes whereas the LEACH,PSO-ECHS,E-OEERP,and iCSHS methods have resulted in a lesser NAN of 2,10,42,and 51 rounds.The performance of the presented protocol has been evaluated interms of energy efficiency and network lifetime.

关键词： Internet of things wireless sensor networks clustering routing metaheuristics cluster head selection QoS parameters

Improved Fracture Toughness of Cryorolled and Room Temperature Rolled 6082 Al Alloys

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Acta Metallurgica Sinica(English Letters) 2014年第2期27卷 359-367页

作者： vineet Kumar I.v.Singh B.K.Mishra R.Jayaganthan Department of Mechanical and Industrial Engineering Indian Institute of Technology Department of Metallurgical and Materials Engineering Indian Institute of Technology

In the present work, 6082 Al alloy has been rolled to 40% and 70% thickness reductions at the cryogenic and room temperatures for the improvement in mechanical and fracture toughness properties. All cryorolled samples are subjected to aging at different temperatures, i.e., 140, 160, and 190 ℃ to improve the strength, ductility, and fracture toughness. The microstructures of the cryorolled （CR） and room temperature rolled （RTR） alloy after 40% and 70% thickness reductions are characterized by FE-SEM to reveal the modes of failure. The results show that the starting bulk Al alloy specimen is fractured in total ductile manner, consisting of well-developed dimples over the entire surface. The mechanical properties and fracture toughness of the 70% CR alloy are found better than 70% RTR alloy due to higher dislocations density and formation of sub-grain structures in the CR alloy.

关键词： 6082 Al alloy Rolling Mechanical properties Fracture toughness J-Integral Material characterization

Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition

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Cancer Biology & Medicine 2018年第2期15卷 137-156页

作者： Aniket v.Mali Asavari A.joshi Mahabaleshwar v.Hegde Shivajirao S.Kadam Center for Innovation in Nutrition Health and Disease (CINHD) Interactive Research School for Health Affairs (IRSHA)Bharati Vidyapeeth Deemed to be University (BVDU) Pharmaceutical Sciences Poona College of PharmacyBharati Vidyapeeth Deemed to be University (BVDU)

Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against metastasis.The transforming growth factor-β(TGF-β)is known to promote the invasive and migratory potential of breast cancer cells through induction of epithelial–mesenchymal transition(EMT)via the ERK/NF-κB/Snail signaling pathway,leading to breast cancer metastasis.Targeting this pathway to revert the EMT would be an attractive,novel therapeutic strategy to halt breast cancer metastasis.Methods:Effects of enterolactone(EL)on the cell cycle and apoptosis were investigated using flow cytometry and a cleaved caspase-3 enzyme-linked immunosorbent assay(ELISA),respectively.Effects of TGF-βinduction and EL treatment on the functional malignancy of MDA-MB-231 breast cancer cells were investigated using migration and chemo-invasion assays.The effects of EL on EMT markers and the ERK/NF-κB/Snail signaling pathway after TGF-βinduction were studied using confocal microscopy,quantitative reverse transcription polymerase chain reaction(q RT-PCR),Western blot,and flow cytometry.Results:Herein,we report that EL exhibits a significant antimetastatic effect on MDA-MB-231 cells by almost reverting the TGF-β-induced EMT in vitro.EL downregulates the mesenchymal markers N-cadherin and vimentin,and upregulates the epithelial markers E-cadherin and occludin.It represses actin stress fiber formation via inhibition of mitogen-activated protein kinase p-38(MAPK-p38)and cluster of differentiation 44(CD44).EL also suppresses ERK-1/2,NF-κB,and Snail at the m RNA and protein levels.Conclusions:Briefly,EL was found to inhibit TGF-β-induced EMT by blocking the ERK/NF-κB/Snail signaling pathway,which is a promising target for breast cancer metastasis therapy.

关键词：三元组小径房间否定回复上皮癌乳

Attenuation of Carbon Tetrachloride-Induced Hepatotoxicity by Cow Urine Distillate in Rats

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Biomedical and Environmental Sciences 2009年第4期22卷 345-347页

作者： M P GURURAJA A B joshi HIMANSHU joshi D SATHYANARAYANA E v S SUBRAHMANYAM K S CHANDRASHEKHAR Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences Paneer

Objective To study the carbon tetrachloride-induced hepatoprotective activity in cow urine. Methods Effect of cow urine distillate on liver function was studied in vivo in rats intoxicated with carbon tetrachloride （CC14）. Hepatotoxicity was induced by a 1 ： 1 （v/v） mixture of CCl4 in olive oil （5 mL/kg i.p）. Protective effect of cow urine distillate （in three dose levels） and standard drug Silymarin （100 mg/kg, p.o） on liver function were studied in intoxicated rats. Parameters in the study included liver function tests and histological observations. Results The cow urine distillate decreased the levels of SGOT, SGPT, ALP, GGT, and total bilirubin in a dose-dependent manner （P〈0.05） as sylimarin. Conclusion The observed protective effects of cow urine distillate on liver function might be due to the presence of antioxidants in cow urine.

关键词： Hepatotoxicity Cow urine distillate CCl4 Silymarin