检索结果-南通市图书馆

From chronic liver disorders to hepatocellular carcinoma: Molecular and genetic pathways

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2010年第6期2卷 259-264页

作者： Enzo Ierardi Rosa Rosania Mariangela Zotti Floriana Giorgio Simonetta Prencipe Nicola della Valle vincenzo de francesco Carmine Panella Section of Gastroenterology Department of Medical Sciences University of Foggia

Hepatocarcinogenesis is a process attributed to progressive genomic changes that alter the hepatocellular phenotype producing cellular intermediates that evolve into hepatocellular carcinoma (HCC). During the preneoplastic phase, the liver is often the site of chronic hepatitis and/or cirrhosis, and these conditions induce liver regeneration with accelerated hepatocyte cycling in an organ that is otherwise proliferatively at rest. Hepatocyte regeneration is accelerated by upregulation of mitogenic pathways involving molecular and genetic mechanisms. Hepatic growth factors, inhibitors and triggers may also play a role. This process leads to the production of monoclonal populations of aberrant and dysplastic hepatocytes that have telomerase reexpression, microsatellite instability, and occasionally structural aberrations in genes and chromosomes. development of dysplastic hepatocytes in foci and nodules and the emergence of HCC are associated with the accumulation of irreversible structural alterations in genes and chromosomes even if the genomic basis of the malignant phenotype is largely heterogeneous. Therefore, a malignant hepatocyte phenotype may be produced by changes in genes acting through different regulatory pathways, thus producing several molecular variants of HCC. On these bases, a key point for future research will be to determine whether the deletions are specific, due to particular loci in the minimally deleted regions of affected chromosome arms, or whether they are nonspecific with loss of large portions of chromosomes or entire chromosome arms leading to passive deletion of loci. The final aim is the possibility of identifying a step where carcinogenetic processes could be terminated.

关键词： Hepatocarcinoma Chronic liver disorders Genetic pathways Molecular pathways Hepatic growth factors Augmenter liver regeneration

Furazolidone therapy for Helicobacter pylori:Is it effective and safe?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第15期15卷 1914-1915页

作者： vincenzo de francesco Enzo Ierardi Cesare Hassan Angelo Zullo Gastroenterology Unit "Riuniti"Hospital Gastroenterology and Digestive Endoscopy Nuovo Regina Margherita Hospital

Some aspects related with the use of furazolidone as a rescue therapy for Helicobacter pylori （H pylorl） infection should be remarked, especially regarding its potential oncologic risk. The inclusion of furazolidone... 详细信息

关键词： Helicobacter pylori Therapy Furazolidone Rescue therapy

Is concomitant quadruple therapy for Helicobacter pylori eradication really needed for Japanese patients?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2012年第6期3卷 103-104页

作者： vincenzo de francesco Angelo Zullo Cesare Hassan Gastroenterology Unit Department of Medical Sciences University of Foggia Ospedali Riuniti 71100Foggia Italy Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital 00183 RomeItaly

The study found that the 7 d of concomitant therapy (lansoprazole, amoxicillin, clarithromycin and metronidazole) achieved significantly higher eradication rates compared to 7 d of triple therapy (lansoprazole, amoxicillin, clarithromycin), the intention to treat (ITT) cure rates being 94.9% and 68.3%, respectively. According to our opinion, this study is clinically relevant for Japanese physicians for at least 2 reasons: (1) the standard triple therapy (clarithromycin plus amoxicillin) achieved disappointing cure rates in Japan-in agreement with what was observed in several countries; and (2) the concomitant quadruple therapy is an effective therapeutic alternative.

关键词： Helicobacter pylori Triple therapy Japanese patients

Helicobacter pylori therapy:Present and future

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2012年第4期3卷 68-73页

作者： vincenzo de francesco Enzo Ierardi Cesare Hassan Angelo Zullo Gastroenterology Unit Department of Medical SciencesUniversity of FoggiaOspedali Riuniti71100 FoggiaItaly Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital00153 RomeItaly

Helicobacter pylori(***) plays a crucial role in the pathogenesis of chronic active gastritis,peptic ulcer and gastric mucosa-associated lymphoid tissue-lymphoma,and is also involved in carcinogenesis of the *** treatment still remains a challenge for physicians,since no current first-line therapy is able to cure the infection in all treated *** factors may help in the eradication of therapy *** reviewed both bacterial and host factors involved in therapeutic management of the *** *** addition,we evaluated data on the most successful therapy regimens-sequential and concomitant therapies-currently available for *** eradication.

关键词： Helicobacter pylori Antibiotic resistance Virulence factors Therapy Eradication

Mechanisms of Helicobacter pylori antibiotic resistance:An updated appraisal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2011年第3期2卷 35-41页

作者： vincenzo de francesco Angelo Zullo Cesare Hassan Floriana Giorgio Rosa Rosania Enzo Ierardi Section of Gastroenterology Department of Medical SciencesUniversity of Foggia Gastroenterology and Digestive Endoscopy 'Nuovo Regina Margherita' Hospital

Helicobacter pylori(H. pylori) antibiotic resistance is the main factor affecting the efficacy of the current eradicating therapies. The aim of this editorial is to report on the recent information about the mechanisms accounting for the resistance to the different antibiotics currently utilized in H. pylori eradicating treatments. Different mechanisms of resistance to clarithromycin,metronidazole,quinolones,amoxicillin and tetracycline are accurately detailed(point mutations,redox intracellular potential,pump efflux systems,membrane permeability) on the basis of the most recent data available from the literature. The next hope for the future is that by improving the knowledge of resistance mechanisms,the elaboration of rational and efficacious associations for the treatment of the infection will be possible. Another auspicious progress might be the possibility of a cheap,feasible and reliable laboratory test to predict the outcome of a therapeutic scheme.

关键词： Helicobacter pylori Clarithromycin Metronidazole Levofloxacin Amoxicillin Tetracycline Resistance Antibiotic Point mutation

Metabolic syndrome and gastro-esophageal reflux:A link towards a growing interest in developed countries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2010年第3期1卷 91-96页

作者： Enzo Ierardi Rosa Rosania Mariangela Zotti Simonetta Principe Giulio Laonigro Floriana Giorgio vincenzo de francesco Carmine Panella Gastroenterology Section Department of Medical SciencesUniversity of Foggia

The aim of this Editorial is to describe the growing possibility of a link between gastro-esophageal reflux disease (GERD) and metabolic syndrome on the light of recent epidemiological and pathophysiological evidence. The state of the art of GERD is described,based on recent definitions,pathophysiological evidence,epidemiology in developed countries,clinical subtypes together with a diagnostic approach specifically focussed on the appropriateness of endoscopy. Metabolic syndrome is accurately defined and the pivotal role of insulin resistance is emphasized. The strong relationship between GERD and metabolic syndrome has been pathophysiologically analyzed,taking into account the role of obesity,mechanical factors and metabolic changes. Data collected by our group regarding eating habits and GERD are briefly summarized at the end of a pathophysiological analysis. The literature on the subject strongly supports the possibility that lifestyle and eating habits may be involved in both GERD and metabolic syndrome in developed countries.

关键词： Gastroesophageal reflux disease Metabolic syndrome Obesity Insulin resistance

Primary clarithromycin resistance to Helicobacter pylori : Is this the main reason for triple therapy failure?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2013年第3期4卷 43-46页

作者： Floriana Giorgio Mariabeatrice Principi vincenzo de francesco Angelo Zullo Giuseppe Losurdo Alfredo Di Leo Enzo Ierardi Division of Gastroenterology Department of Medical and Surgical Sciences University of Foggia 71100 Foggia Italy Division of Gastroenterology Department of Emergency and Organ Transplantation University of Bari 70124 Bari Italy department of Gastroenterology and Digestive Endoscopy 'Nuovo Regina Margherita' Hospital 00153 Rome Italy

Conventional triple therapies for Helicobacter pylori (H. pylori ) eradication have recently shown a disappointing reduction in effectiveness in many countries. The main reason for failure was found to be bacterial resistance to one of the most commonly used antibiotics, clarithromycin. An additional problem for conventional triple therapy is the high rate of resistance to metronidazole found in Europe, America and Asia. In Italy, in the last 15 years a 2-fold increase in resistance has occurred. A recent study of the whole of Italy included about 20 patients from each region at the first endoscopic diagnosis of H. pylori infection. The most surprising result was the patchy distribution of resistance, which was almost absent in two regions (one northern and one southern), although the highest prevalence was found in some regions of the South. In the paediatricpopulation we found a 25% prevalence of resistance in a sample of H. pylori positive children observed between 2002 and 2007, mirroring data obtained in southern European countries. Clarithromycin resistance assessment is currently based on phenotypic detection performed after culture the agar dilution method or E-test, and genotypic methods based on polymerase chain reaction (PCR). In a recent comparative study we found a 71.2% agreement between the two methods. Culture-free techniques are highly accurate in finding even minimal traces of genotypically resistant strains. Moreover, PCR-based tools are accurate in detecting a heteroresistant status, defined as the co-existence of some strains that are susceptible and some resistant to the same antibiotic in an individual patient. Three point mutations, namely A2143G , A2142G and A2142C , are responsible for 90% of cases of primary clarithromycin resistance in H. pylori strains isolated in Western countries, although we previously demonstrated that the presence of the A2143G mutation, but not A2142G or A2142C , significantly lowered the H. pylori eradication rate

关键词： Helicobacter pylori Clarithromycin Genotypic resistance Phenotypic resistance Therapy failure cost Resistance epidemiology

How can the holder trust the verifier?A CP-ABPRE-based solution to control the access to claims in a Self-Sovereign-Identity scenario

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blockchain(Research and Applications) 2024年第3期5卷 22-41页

作者： francesco Buccafurri vincenzo de Angelis Roberto Nardone University of Reggio Calabria 89124 Reggio CalabriaItaly University of Calabria 87036 Arcavacata di Rende(CS)Italy University of Naples“Parthenope” 80143 NaplesItaly

The interest in Self-Sovereign Identity(SSI)in research,industry,and governments is rapidly *** is a paradigm where users hold their identity and credentials issued by authorized *** is revolutionizing the concept of digital identity and enabling the definition of a trust framework wherein a service provider(verifier)validates the claims presented by a user(holder)for accessing ***,current SSI solutions primarily focus on the presentation and verification of claims,overlooking a dual aspect:ensuring that the verifier is authorized to access the holder’s *** this gap,this paper introduces an innovative SSI-based solution that integrates decentralized wallets with Ciphertext-Policy Attribute-Based Proxy Re-Encryption(CP-ABPRE).This combination effectively addresses the challenge of verifier *** solution,implemented on the Ethereum platform,enhances accountability by notarizing key operations through a smart *** paper also offers a prototype demonstrating the practicality of the proposed ***,it provides an extensive evaluation of the solution’s performance,emphasizing its feasibility and efficiency in real-world applications.

关键词： Blockchain IPFS Self Sovereign Identity Smart contract Access control

Seismic protection of frame structures via semi-active control:modeling and implementation issues

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2009年第4期8卷 627-645页

作者： vincenzo Gattulli Marco Lepidi francesco Potenza Dipartimento di Ingegneria delle Strutture delle Acque e del TerrenoUniversità dell'Aquila

Theoretical and practical issues concerning the multi-faceted task of mitigating the latero-torsional seismic response of a prototypal frame structure with asymmetric mass distribution are approached, Chevron braces with embedded magnetorheological dampers acting on the interstory drift are used to ensure additional energy dissipation. The semi-active control strategy employed to govern the modification of the damper characteristics via feedback is based on the selection of optimal forces according to a H2/LQG criterion, with respect to which the actual forces are regulated by a clipped-optimal logic. A dynamic observer is used to estimate the state through a non-collocated placement of the acceleration sensors. Several aspects to be addressed throughout the complex process including the design, modelization, and implementation phases of semi-active protection systems are discussed. Finally, experimental results obtained to mitigate the motion induced by ground excitation in a large-scale laboratory prototype, simulating the seismic response of a two-story building, are summarized.

关键词： seismic protection: flame structures semi-active control magnetorheological damper