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Understanding neutralising antibodies against SARS-CoV-2 and theirimplications in clinical practice

Military Medical Research 2022年第2期9卷 215-230页

作者： Natalie Yan-Lin Pang Alexander Shao-Rong Pang vincent T.Chow De-Yun Wang Yong Loo Lin School of Medicine National University of SingaporeSingapore 119228Singapore Department of Microbiology and Immunology National University of SingaporeScience Drive 2Singapore 117545Singapore Infectious Diseases Translational Research Program Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore Department of Otolaryngology Yong Loo Lin School of MedicineNational University of Singapore1E Kent Ridge RoadSingapore 119228Singapore

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a newly identified member of the coronavirus family that has caused the coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2has disrupted the lives and livelihoods of millions worldwide. As of 23 August 2021, a total of 211,373,303 COVID-19cases have been confirmed globally with a death toll of 4,424,341. A strong understanding of the infection pathway of SARS-CoV-2, and how our immune system responds to the virus is highly pertinent for guiding the development and improvement of effective treatments. In this review, we discuss the current understanding of neutralising antibodies(NAbs) and their implications in clinical practice. The aspects include the pathophysiology of the immune response,particularly humoral adaptive immunity and the roles of NAbs from B cells in infection clearance. We summarise the onset and persistence of IgA, IgM and IgG antibodies, and we explore their roles in neutralising SARS-CoV-2, their persistence in convalescent individuals, and in reinfection. Furthermore, we also review the applications of neutralising antibodies in the clinical setting—from predictors of disease severity to serological testing to vaccinations, and finally in therapeutics such as convalescent plasma infusion.

关键词： Severe acute respiratory syndrome coronavirus Coronavirus disease 2019 Neutralising antibodies Persistence Spike glycoprotein Receptor-binding domain B cells T cells Convalescent plasma

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Poorly cohesive cells gastric carcinoma including signet-ring cell cancer:Updated review of definition,classification and therapeutic management

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1406-1428页

作者： vincent Drubay Frederiek Nuytens Florence Renaud Antoine Adenis Clarisse Eveno Guillaume Piessen Department of Digestive and Oncological Surgery University LilleClaude Huriez University HospitalLille 59000France Department of Digestive Surgery Cambrai Hospital Center and Sainte MarieGroup of Hospitals of The Catholic Institute of LilleCambrai 59400France Department of Digestive and Hepatobiliary/Pancreatic Surgery AZ Groeninge HospitalKortrijk 8500Belgium Department of Pathology University Lille HospitalLille 59000France Clarisse Eveno Guillaume PiessenCNRSInsermUMR9020-U1277-CANTHER-CancerUniversity LilleCHU LilleLille 59000France FREGAT Network Claude Huriez University HospitalLille 59000France Department of Medical Oncology Montpellier Cancer InstituteMonpellier 34000France IRCM InsermUniversity of MonpellierMonpellier 34000France

While the incidence of gastric cancer(GC)in general has decreased worldwide in recent decades,the incidence of diffuse cancer historically comprising poorly cohesive cells-GC(PCC-GC)and including signet ring cell cancer is *** concerning PCC-GC is scarce and unclear,mostly due to a large variety of historically used definitions and *** to other histological subtypes of GC,PCC-GC is nevertheless characterized by a distinct set of epidemiological,histological and clinical features which require a specific diagnostic and therapeutic *** aim of this review was to provide an update on the definition,classification and therapeutic strategies of *** focus on the updated histological definition of PCC-GC,along with its implications on future treatment strategies and study ***,specific considerations in the diagnostic management are ***,the impact of some recent developments in the therapeutic management of GC in general such as the recently validated taxane-based regimens(5-Fluorouracil,leucovorin,oxaliplatin and docetaxel),the use of hyperthermic intraperitoneal chemotherapy as well as pressurized intraperitoneal aerosol chemotherapy and targeted therapy have been reviewed in depth for their relative importance for PCC-GC in particular.

关键词： Poorly cohesive cells gastric carcinoma Review Definition Classification Therapeutic management

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Characterization of the Omni-Processor Sewage Sludge Ash for Reuse as Construction Material

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Fluid Dynamics & Materials Processing 2022年第6期18卷 1581-1593页

作者： Prince Momar Gueye Siham Kamali-Bernard Dame Keinde Fabrice Bernard vincent Sambou LE3PI of E S P-UCAD DakarSenegal LGCGM of INSA of Rennes RennesFrance

Omni Processors(OP)are machines which use sludge as a fuel to generate electricity and clean water,but create ash at the same *** the present study,fly ash and bottom ash are investigated as materials for potential reuse in the construction ***,the granular size,density and Blaine finesse are ***,the chemical composition and microstructure are obtained by means of X-ray fluorescence and Scanning Electron Microscopy-Energy Dispersive Spectroscopy(SEM-EDS),***,ashes reactivity is determined by two chemical methods(modified Chapelle test,bound water content R3)and a mechanical method(pozzolanic activity index).The characterization results indicate two material types:fly ash similar to cement and bottom ash similar to fine ***’s why the mortars mechanical strength with fly ash 0%-30%is better than that with bottom ash at the same *** ash slightly decreases the mechanical strength of mortars while bottom ash induces a much more significant decrease.

关键词： Characterization Omni-processor fly Ash bottom ash

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Accelerating peripheral nerve regeneration using electrical stimulation of selected power spectral densities

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Neural Regeneration Research 2022年第4期17卷 781-782页

作者： Wei-Ming Yu Madelyn A.McCullen vincent C.-F.Chen Department of Biology Loyola University of ChicagoChicagoILUSA Engineering Program Loyola University of ChicagoChicagoILUSA

Peripheral nerve injuries are common consequences of extremity trauma or chronic compression with a prevalence of 43.8 per1 million people(on average)reported in the U nited States annually,accompanied by a yearly inc... 详细信息

关键词： stimulation injuries annually

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Exploring self-organization and self-adaption for smart manufacturing complex networks

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Frontiers of Engineering Management 2023年第2期10卷 206-222页

作者： Zhengang GUO Yingfeng ZHANG Sichao LIU Xi vincent WANG Lihui WANG Key Laboratory of Industrial Engineering and Intelligent Manufacturing of Ministry of Industry and Information Technology School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Department of Electrical and Electronic Engineering Imperial College LondonLondon SW72AZUK Department of Production Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden

Trends toward the globalization of the manufacturing industry and the increasing demands for small-batch,short-cycle,and highly customized products result in complexities and fluctuations in both external and internal manufacturing environments,which poses great challenges to manufacturing ***,recent advances in the Industrial Internet of Things(IIoT)and the widespread use of embedded processors and sensors in factories enable collecting real-time manufacturing status data and building cyber–physical systems for smart,flexible,and resilient manufacturing *** this context,this paper investigates the mechanisms and methodology of self-organization and self-adaption to tackle exceptions and disturbances in discrete manufacturing ***,a general model of smart manufacturing complex networks is constructed using scale-free networks to interconnect heterogeneous manufacturing resources represented by network vertices at multiple ***,the capabilities of physical manufacturing resources are encapsulated into virtual manufacturing services using cloud technology,which can be added to or removed from the networks in a plug-and-play ***,information,and financial assets are passed through interactive links across the ***,analytical target cascading is used to formulate the processes of self-organizing optimal configuration and self-adaptive collaborative control for multilevel key manufacturing resources while particle swarm optimization is used to solve local problems on network ***,an industrial case based on a Chinese engine factory demonstrates the feasibility and efficiency of the proposed model and method in handling typical *** simulation results show that the proposed mechanism and method outperform the event-triggered rescheduling method,reducing manufacturing cost,manufacturing time,waiting time,and energy consumption,with reasonable computational time.T

关键词： cyber–physical systems Industrial Internet of Things smart manufacturing complex networks self-organization and self-adaption analytical target cascading collaborative optimization

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Tourism Developments Increase Tsunami Disaster Risk in Pangandaran, West Java, Indonesia

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International Journal of Disaster Risk Science 2021年第5期12卷 764-769页

作者： vincent Nijman Department of Social Sciences Oxford Brookes UniversityOxford OX30BP.United Kingdom

On 17 July 2006,the tourist resort of Pangandaran on Java’s south coast was hit by a tsunami,resulting in 413 fatalities and severe damage to *** tsunami resulted in major rebuilds with a focus on mass *** of the impact of a future tsunami focussed on building development and suggest limited change since *** article presents a case study on the development of(largely domestic)tourism in Pangandaran and how this has increased the tsunami disaster *** numbers were stable at about 900,000 visitors a year prior to the tsunami,down to slightly over 250,000 visitors a year in its aftermath,and from 2007 onwards numbers are doubling every three years to about 4 million visitors in *** increase has been most pronounced during *** to 2006,Pangandaran was characterized by wooden structures and one-and two-story buildings of clay-brick masonry;by 2019,14 three to sixstory hotels have been erected along the *** many more visitors,most of whom are unfamiliar with tsunami risks,and shelter facilities for less than a quarter of visitors during peak times,future impacts and the potential cost to life are considerably higher now than in 2006,especially if a tsunami were to hit over a *** tourists upon arrival and throughout their stay should be better informed about the risks of tsunamis,and of the location of tsunami shelters and evacuation routes.

关键词： Disaster resilience Effective warning Indonesia Risk mitigation Tourism Tsunami

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Strain and stress analysis on Zn multicrystal film by XRD method

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中国有色金属学会会刊：英文版 2006年第B2期16卷 735-738页

作者： vincent JI LIM UMR CNRS8006ENSAM 151Boulevard de I'Hopital75013 ParisFrance

A new method was denonstrated to determine stress in a single crystal for multicrystal material and this new method could be specially applied for any symmetric crystalline systems. The strain tensor e was determined by the change of the metric tensor G before the initial state and after the deformed state in the crystal reference system. Then stress tensor at grain scale was calculated by the HOOK's law. The stress evaluations were carried out in coarse grains of a thin galvanized coating on a steel substrate during tensile loading. This makes it possible to link the microstructure evolution to the elastic heterogeneity at grain scale or between the grains.

关键词：锌多晶膜单晶应力应变分析 XRD法锌镀层

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钛的晶体结构和结构转变研究进展

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稀有金属材料与工程 2022年第12期51卷 4398-4409页

作者：李磊郭荻子应扬洪权 vincent JI 西北有色金属研究院陕西西安710016 巴黎萨克雷大学法国奥赛91405

钛具有高强度,低密度,耐腐蚀等特性,并在多个领域得到应用。多年来,钛的同素异构体的晶体结构和结构转变受到了学者的广泛关注。除了密排六方结构的平衡相(α-Ti),面心立方结构的高温相(β-Ti)和六方结构的高压相(ω-Ti)外,学者通过各... 详细信息

钛具有高强度,低密度,耐腐蚀等特性,并在多个领域得到应用。多年来,钛的同素异构体的晶体结构和结构转变受到了学者的广泛关注。除了密排六方结构的平衡相(α-Ti),面心立方结构的高温相(β-Ti)和六方结构的高压相(ω-Ti)外,学者通过各种方法尝试在极端条件下制备钛的其他亚稳相结构。在过去的几十年中,人们在超高压条件下发现了γ-Ti和δ-Ti,并通过高压扭转实验、激光冲击实验和超薄薄膜实验等方法制备了在室温条件下可以稳定存在的ω-Ti和fcc-Ti。综述了钛的同素异构体(不包括合金)的晶体结构和结构转变类型,并介绍了不同结构钛的稳定性以及结构转变机理。

关键词：晶体结构结构转变高压面心立方钛

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Physics-based,data-driven approach for predicting natural ventilation of residential high-rise buildings

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Building Simulation 2022年第1期15卷 129-148页

作者： vincent J.L.Gan Boyu Wang C.M.Chan A.U.Weerasuriya Jack C.P.Cheng Department of Building School of Design and EnvironmentNational University of SingaporeSingapore117566 Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong Kong999077China

Natural ventilation is particularly important for residential high-rise buildings as it maintains indoor human comfort without incurring the energy demands that air-conditioning *** improve a building’s natural ventilation,it is essential to develop models to understand the relationship between wind flow characteristics and the building's *** more effort is still needed for developing such reliable,accurate,and computationally economical models instead of currently the most popular physics-based models such as computational fluid dynamics(CFD)*** paper,therefore,presents a novel model developed based on physics-based modelling and a data-driven approach to evaluate natural ventilation in residential high-rise *** model first uses CFD to simulate wind pressures on the exterior surfaces of a high-rise *** the surface pressures have been obtained,multizone modelling is used to predict the air change per hour(ACH)for different flats in various ***-driven prediction models are then developed using data from the simulation and deep neural networks that are based on mean absolute error,mean absolute percentage error,and a fusion algorithm *** data-driven models are used to predict the ACH of 25 *** results from multizone modelling and data-driven modelling are *** results imply a high accuracy of the data-driven prediction in comparison with physics-based *** fusion algorithm-based neural network performs best,achieving 96%accuracy,which is the highest of all models *** study contributes a more efficient and robust method for predicting wind-induced natural *** findings describe the relationship between building design(e.g.,plan layout),distribution of surface pressure,and the resulting ACH,which serve to improve the practical design of sustainable buildings.

关键词： computational fluid dynamics data-driven prediction machine learning multizone model natural ventilation residential building

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Non-invasive tests of non-alcoholic fatty liver disease

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Chinese Medical Journal 2022年第5期135卷 532-546页

作者： Guanlin Li Xinrong Zhang Huapeng Lin Lilian Yan Liang Grace Lai-Hung Wong vincent Wai-Sun Wong Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Medical Data Analytics Centre The Chinese University of Hong KongHong KongChina

For the detection of steatosis,quantitative ultrasound imaging techniques have achieved great progress in past *** resonance imaging proton density fat fraction is currently the most accurate test to detect hepatic *** blood biomarkers correlate with non-alcoholic steatohepatitis,but the accuracy is *** liver fibrosis,liver stiffness measurement by transient elastography(TE)has high accuracy and is widely used across the *** resonance elastography is marginally better than TE but is limited by its cost and *** blood biomarkers of fibrosis have been used in clinical trials and hold promise for selecting patients for treatment and monitoring treatment *** article reviews new developments in the non-invasive assessment of non-alcoholic fatty liver disease(NAFLD).Accumulating evidence suggests that various non-invasive tests can be used to diagnose NAFLD,assess its severity,and predict the *** studies are needed to determine the role of the tests as monitoring *** cannot overemphasize the importance of context in selecting appropriate tests.

关键词： Fatty liver Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Cirrhosis Transient elastography FibroScan Magnetic resonance imaging

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