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Journal of Materials Science & Technology 2024年第2期169卷 235-242页

作者： h.X.Lu h.Liu Z.Z.Fu Y.Y.chen h.Q.Dai Z.hu W.L.Zhang R.Q.Guo Institute for Electric Light Sources School of Information Science and TechnologyFudan UniversityShanghai 200433China Institute of Future Lighting Academy for Engineering and TechnologyFudan UniversityShanghai 200433China Yiwu Research Institute of Fudan University YiwuZhejiang 322000China Zhongshan-Fudan Joint Innovation center Zhongshan 528437China

In this study,a two-step method was used to synthesize highly luminescent AgGaS/ZnS/ZnS quantum dots(QDs).In the first step,an inner ZnS shell was formed via a one-pot method,which resulted in a smaller lattice mismatch between the AgGaS core and the outer ZnS shell,thereby facilitating the formation of a thick outer *** the two-step shelling process,the synthesized AgGaS/ZnS/ZnS QDs showed an excellent photoluminescence quantum yield(PLQY)of 96.4%with a peak wavelength of 508 nm,repre-senting the highest PLQY reported thus far for AgGaS ***,the effect of halogen ions in Zn precursors on the shelling process was *** was proposed that the capacity of halogen ions to coordinate with the QDs influenced the balance between Zn cation diffusion and ZnS shelling ***,the ZnS shelling reaction was dominant when Zncl_(2)was employed,while Zn cation diffusion was the dominant process under the I^(−)-rich *** work provides insights into the interfacial restructuring during the ZnS shelling and offers a clear map for the tailored synthesis of core/shell QDs.

关键词： AgGaS Quantum dots Photoluminescence core/shell Alloyed core/shell interface

Adhesion G protein-coupled receptor latrophilin 1(ADGRL1):a novel regulator of glucose and energy homeostasis

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3143-3144页

作者： Kavaljit h.chhabra Department of Pharmacology and Nutritional Sciences Barnstable Brown Diabetes and Obesity Research CenterUniversity of KentuckyLexingtonKYUSA

Recently,I read with interest the research article entitled'Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPhN1)increases the risk of obesity published in Signal Transduction and Targeted *** report confirms and extends our findings that ADGRL1(aka latrophilin 1)regulates energy balance and glucose homeostasis.?Using affinity chromatography coupled with proteomics and electrophysiology,we showed that ADGRL1 is likely a glucose receptor in the *** findings demonstrated that lack of ADGRL1 in the hypothalamus or whole-body causes obesity and features of type 2 diabetes in *** is refreshing to see Dietzsch et al.i reached the same conclusion.

关键词： homeostasis obesity hypothalamus

The Role of the Size Effect on the Drying of Refractory castables—how Its Under-standing could Narrow the Gap between Laboratory Studies and Industrial Reality

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china's Refractories 2024年第2期33卷 35-40页

作者： M.h.MOREIRA h.PENG S.Dal PONT V.c.PANDOLFELLI Materials Engineering Department Federal University of São Carlos(UFSCar)São Carlos 13565-905Brazil Materials Innovation Elkem Silicon Products DevelopmentKristiansand 4621Norway cNRS Grenoble INP3SRUniversitéGrenoble AlpesGrenoble 38000France

Refractories have unique capabilities such as sustaining their shape and properties at extreme conditions such as the combination of high temperatures and thermal shock,contact with molten metals and slags and in some circumstances resistance to erosion from abrasive *** the large processing output of the heavy industries such as the cement and steel ones which both require high temperature processes,the refractories structures span various meters and weight of several *** the water removal stage of hydraulic bonded castables in industrial sites takes hours(10-60 h)due to the risk of explosive spalling,efforts to mitigate it are commonly *** has provided theoretical understanding of the general aspects of drying and important tools,such as the thermogravimetry analysis(TGA),for the design of refractory compositions with higher explosive spalling ***,the optimization of this process is still far from the industrial reality especially because the actual linings that require the drying are orders of magnitude larger than the samples considered in the laboratory ***,this study proposed the analysis of the sample volume effect on the water removal dynamics through TGA of high alumina castables with calcium aluminate ***φ5 cm×5 cm cylindrical samples were assessed in a laboratory scale equipment whereas macro TGA were carried out considering 20 cm×20 cm×20 cm and 30 cm×30 cm×30 cm cubic ***,the effect of polymeric fibers was also *** was found out that the different thermal gradients within the macro TGA samples resulted in an inflection on the sample’s heating rate and that the mass loss was affected by the volume considered,especially for the composition without *** findings highlight the requirement of carefully taking into consideration the different dimensional sizes and thermal gradients in the samples when analyzing and interpreting the laboratory studies,and

关键词： drying refractory castables size effect thermogravimetry analysis

An Improved Binary Quantum-based Avian Navigation Optimizer Algorithm to Select Effective Feature Subset from Medical Data:A cOVID-19 case Study

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Journal of Bionic Engineering 2024年第1期21卷 426-446页

作者： Ali Fatahi Mohammad h.Nadimi-Shahraki hoda Zamani Faculty of computer Engineering Najafabad BranchIslamic Azad UniversityNajafabad ***Iran Big Data Research center Najafabad BranchIslamic Azad UniversityNajafabad ***Iran

Feature Subset Selection(FSS)is an NP-hard problem to remove redundant and irrelevant features particularly from medical data,and it can be effectively addressed by metaheuristic ***,existing binary versions of metaheuristic algorithms have issues with convergence and lack an effective binarization method,resulting in suboptimal solutions that hinder diagnosis and prediction *** paper aims to propose an Improved Binary Quantum-based Avian Navigation Optimizer Algorithm(IBQANA)for FSS in medical data preprocessing to address the suboptimal solutions arising from binary versions of metaheuristic *** proposed IBQANA’s contributions include the hybrid Binary Operator(hBO)and the Distance-based Binary Search Strategy(DBSS).hBO is designed to convert continuous values into binary solutions,even for values outside the[0,1]range,ensuring accurate binary *** the other hand,DBSS is a two-phase search strategy that enhances the performance of inferior search agents and accelerates *** combining exploration and exploitation phases based on an adaptive probability function,DBSS effectively avoids local *** effectiveness of applying hBO is compared with five transfer function families and thresholding on 12 medical datasets,with feature numbers ranging from 8 to 10,***'s effectiveness is evaluated regarding the accuracy,fitness,and selected features and compared with seven binary metaheuristic ***,IBQANA is utilized to detect *** results reveal that the proposed IBQANA outperforms all comparative algorithms on cOVID-19 and 11 other medical *** proposed method presents a promising solution to the FSS problem in medical data preprocessing.

关键词： Feature subset selection Optimization Binary metaheuristic algorithms Bioinspired Machine learning Medical datasets

基于任务型教学法在越南初级汉语口语线上教学中的行动研究

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基于任务型教学法在越南初级汉语口语线上教学中的行动研究

作者： hOANG ThI chung（黄氏钟）华东师范大学

学位级别：硕士

任务型教学法是20世纪80年代以来在对外汉语教学中逐渐形成和应用的一种新的教学方法。此后这种教学方法逐渐发展并在对外汉语教学领域得到广泛应用。由于该教学方法具有许多优点,最突出的优点是促进学生学习的创造力和主动性,提高学生... 详细信息

任务型教学法是20世纪80年代以来在对外汉语教学中逐渐形成和应用的一种新的教学方法。此后这种教学方法逐渐发展并在对外汉语教学领域得到广泛应用。由于该教学方法具有许多优点,最突出的优点是促进学生学习的创造力和主动性,提高学生的语言能力。因此,近年来世界上有很多语言学家对该教学方法从不同角度进行研究。对越南的汉语教学界来说,任务型教学法因为诸多客观条件的限制,并未在汉语教育领域中得到广泛应用,尤其是线上教学形式。本论文在前人语言专家成果的理论基础上,继续对基于任务型教学法应用在越南初级汉语口语线上课堂进行深入研究。本论文分为6章:其中第一章、第二章主要论述基于任务型教学法的理论基础,设计原则以及相关文献综述。第三章的内容是从第二章的理论基础进行教学设计,本论文的研究对象是信锦越南厂责任有限公司的越南人员,使用的教材是速通汉语教程。第四章根据第三章的教学设计进行两轮实施教学,收集学生的反馈。第五章根据教师和学生对初级汉语口语线上课堂设计任务的反馈,进行对任务型初级汉语口语教学的反思。最后,第六章针对任务型教学法在越南汉语初级口语线上课堂的设计任务和编写任务型教学法的口语教材提出建议。本研究的研究方法是行动研究,通过两轮行动研究,实施教学,提出问题,从自己实施教学中的观察和经验提出建议。本研究的教学设计结果包括:速通汉语教程第一册第八课《你的生日是几月几号?》,第十课《你家有几口人?》;第二册第一课《你在听什么?》,第二课《你平时几点起床?》基于任务型教学法设计的教案。通过这篇论文,基于任务型教学法在越南初级汉语口语线上课堂教案设计和两轮实施教学创建一个在信锦越南厂责任有限公司应用的汉语教学模式,任务的设计会考虑到学习者的学习特点。希望未来能够推广在越南河南工业区所有的中国台湾公司应用。

关键词：任务型教学法初级汉语口语越南学生线上教学

The Rising Burden of hepatocellular carcinoma: Is the Gender Gap Narrowing?

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Journal of clinical and Translational hepatology 2024年第9期12卷 763-764页

作者： James K.h.ho Prem h.Thurairajah Daniel Q.huang Kristie h.Fan Division of Gastroenterology and hepatology National University HospitalNational University Health SystemSingaporeSingapore

Dear Editors,The landscape of hepatocellular carcinoma(hcc)is continuously *** global trends indicate a significant shift in the epidemiology of hcc from viral-related to non-viral-related ***-associated fatty liver disease has emerged as the fastest-growing contributor to hcc in recent years,due to the increased prevalence of obesity and metabolic risk factors.

关键词： carcinoma epidemiology obesity

Influence of confined concrete Models on the Seismic Response of Rc Frames

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Structural Durability & health Monitoring 2024年第3期18卷 197-222页

作者： hüseyin Bilgin Bredli Plaku Department of civil Engineering EPOKA UniversityTirana1039Albania

In this study, the influence of confined concrete models on the response of reinforced concrete structures is investigatedat member and global system levels. The commonly encountered concrete models such as Modified Kent-Park, Saatçioğlu-Razvi, and Mander are considered. Two moment-resisting frames designed according to thepre-modern code are taken into consideration to reflect the example of an Rc moment-resisting frame in thecurrent building stock. The building is in an earthquake-prone zone located on Z3 Soil Type. The inelasticresponse of the building frame is modelled by considering the plastic hinges formed on each beam and columnelement for different concrete classes and stirrups spacings. The models are subjected to non-linear static *** differences between confined concrete models are comparatively investigated at both reinforced concretemember and system levels. Based on the results of the comparative analysis, it is revealed that the column behaviouris mostly influenced by the choice of model, due to axial loads and confinement effects, while the beams areless affected, and also it is observed that the differences exhibited in the moment-curvature response of columncross-sections do not significantly affect the overall behaviour of the global system. This highlights the critical roleof model selection relative to the concrete strength and stirrup spacing of the member.

关键词： Non-linear static analysis moment-curvature relationships plastic hinges concrete confinement models seismic action

Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3009-3026页

作者： Saini Setua Shabia Shabir Poornima Shaji Ana Martinez Bulnes Anupam Dhasmana Swathi holla Nivesh K.Mittal Nirakar Sahoo Tripti Saini Francesco Giorgianni Mohammad Sikander Andrew E.Massey Bilal B.hafeez Manish K.Tripathi vincent P.Diego Meena Jaggi Junming Yue Nadeem Zafar Murali M.Yallapu Stephen W.Behrman Sheema Khan Subhash c.chauhan Department of Pharmaceutical Sciences College of Pharmacyand College of MedicineUniversity of Tennessee Health Science Center(UTHSC)MemphisTN 36163USA Department of computer Science Islamic University of Science and TechnologyAwantiporaJ&K 192122India Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX 78504USA South Texas center of Excellence in cancer Research School of Medicinethe University of Texas Rio Grande ValleyMcAllenTX 78504USA himalayan School of Biosciences and cancer Research Institute Himalayan Institute of Medical SciencesSwami Rama Himalayan UniversityDehradun 248016India Plough center for Sterile Drug Delivery Solutions UTHSCMemphisTN 38104USA Department of Biology College of SciencesUTRGVMcAllenTX 78539USA National Institute of Biomedical Imaging and Bioengineering(NIBIB) National Institutes of HealthBethesdaMD 20892USA South Texas Diabetes and Obesity Institute UTRGVMcAllenTX 78504USA Dept.of Laboratory Medicine&Pathology University of WashingtonSeattleWA 98195USA Department of Surgery Baptist Memorial Medical EducationBaptist Memorial HospitalMemphisTN 38120USA Baptist health Sciences University MemphisTN 38104USA

The application of extracellular vesicles,particularly exosomes(EXs),is rapidly expanding in the field of medicine,owing to their remarkable properties as natural carriers of biological *** study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues(NAF-EXs)for personalized medicine,which can be derived at the time of diagnosis by endoscopic ***,we show that exosomes(EXs)derived from NAFs demonstrate differential bio-physical characteristics,efficient cellular internalization,drug loading efficiency,pancreatic tumor targeting and delivery of ***-derived EXs(NAF-EXs)were used for loading ormeloxifene(ORM),a potent anti-cancer and desmoplasia inhibitor as a model *** found that ORM maintains normal fibroblast cell phenotype and renders them incompatible to be triggered for a cAF-like phenotype,which may be due to regulation of ca^(2+) influx in fibroblast ***-EXs-ORM effectively blocked oncogenic signaling pathways involved in desmoplasia and epithelial mesenchymal transition(EMT)and repressed tumor growth in xenograft mouse *** conclusion,our data suggests preferential tropism of NAF-EXs for PDAc tumors,thus imply feasibility of developing a novel personalized medicine for PDAc patients using autologous NAF-EXs for improved therapeutic outcome of anti-cancer ***,it provides the opportunity of utilizing this biological scaffold for effective therapeutics in combination with standard therapeutic regimen.

关键词： Pancreatic cancer Tumor adjacent normal tissue fibroblasts(NAF) Desmoplasia Extracellular vesicles Exosomes Tumor targeting Ormeloxifene Personalized medicine

Impact of Paenibacillus elgii supernatant on screening bacterial strains with potential for biotechnological applications

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Engineering Microbiology 2024年第3期4卷 1-15页

作者： I.c.cunha-Ferreira c.S.Vizzotto T.D.Frederico J.Peixoto L.S carvalho M.R.Tótola R.h.Krüger Laboratory of Enzymology Department of Cellular BiologyUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratory of Environmental Sanitation Department of Civil and Environmental EngineeringUniversity of Brasília(UNB)Brasília70910-900Brazil Laboratório de Biotecnologia e Biodiversidade para o Meio Ambiente Universidade Federal de Viçosa(UFV)Viçosa36570-900Brazil

The biotechnological industry faces a crucial demand for novel bioactive compounds,particularly antimicrobial agents,to address the rising challenge of bacterial resistance to current available *** strate-gies for cultivating naturally occurring microorganisms often limit the discovery of novel antimicrobial *** study presents a protocol for targeted selection of bacterial strains using the supernatant of Paenibacillus el-gii,which produces abundant signal molecules and antimicrobial *** samples were inoculated in these enriched culture media to selectively cultivate bacteria resistant to the supernatant,indicating their potential to produce similar *** bacterial strains isolated through this method were assessed for their antibac-terial *** addition,the functional annotation of the genome of one of these strains revealed several gene clusters of biotechnological *** study highlights the effectiveness of using this approach for selective cultivation of microorganisms with potential for biotechnological applications.

关键词： Prospecting Supernatant Antibacterial activity

RARRES2's impact on lipid metabolism in triplenegative breast cancer:a pathway to brain metastasis

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Military Medical Research 2024年第2期11卷 311-312页

作者： Quazi T.h.Shubhra Institute of chemistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BcBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BcBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(Pc)and triacylglycerols(TAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling *** commentary aims to elaborate on the key findings and their relevance to the field.

关键词： Retinoic acid receptor responder 2(RARRES2) Lipid metabolism cancer PTEN-mTOR-SREBP1 signaling Metabolic reprogramming Brain metastasis