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Cancer: Principles And Practice Of Oncology Single Volume (Book With CD-ROM) Phila. :

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Motion visualization and estimation for flapping wing systems

2001年

作者： vincent T. DeVita Jr. md Samuel Hellman Steven A

ISBN: (纸本)9780781722292

Acclaimed by the worldwide medical community as the standard-setting oncology reference, Cancer: Principles and Practice of Oncology is now in its Sixth Edition. This thoroughly revised and updated classic reflects the latest breakthroughs in every aspect of oncology, from molecular biology, to multimodality treatment, to new data on cancer prevention by drugs and *** edition places increased emphasis on the role of molecular biology in cancer diagnosis and treatment. In light of the growing clinical importance of biological therapy, a new section on Pharmacology of Cancer Biotherapeutics has been added. Chapters describe new radiotherapy techniques such as intensity-modulated radiation therapy and innovative surgical techniques such as radiofrequency ablation of tumors, isolation-perfusion for visceral cancers, and image-guided surgery. Rehabilitation is integrated into each of this edition's chapters on organ-specific cancers. Also included are new chapters on information systems in oncology, particularly on accessing information from the World Wide *** edition now includes a CD-ROM bound into the book. The CD-ROM has advanced search capabilities and gives you full text, high-quality video and color slides not found in the book, direct links to PubMed, and links to our new oncology portal, ***. The CD-ROM is also available separately

关键词： volume book single oncology principles practice cancerBiochemistry Biological Sciences Science & Math

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畅想之星图书光盘版（南通市图书馆镜像）

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Acta Mechanica Sinica 2017年第2期33卷 327-340页

作者： Tzu-Sheng Shane Hsu Timothy Fitzgerald vincent Phuc Nguyen Trisha Patel Balakumar Balachandran Department of Mechanical Engineering University of Maryland College Park MD 20742 USA

Studies of fluid-structure interactions associated with flexible structures such as flapping wings require the capture and quantification of large motions of bodies that may be opaque. As a case study, motion capture of a free flying Manduca sexta, also known as hawkmoth, is considered by using three synchronized high-speed cameras. A solid finite element (FE) representation is used as a reference body and successive snapshots in time of the displacement fields are reconstructed via an optimization procedure. One of the original aspects of this work is the formulation of an objective function and the use of shadow matching and strain-energy regularization. With this objective function, the authors penalize the projection differences between silhouettes of the captured images and the FE representation of the deformed body. The process and procedures undertaken to go from high-speed videography to motion estimation are discussed, and snapshots of representative results are presented. Finally, the captured free-flight motion is also characterized and quantified.

关键词： Insect flight Deformable body High-speed videography Motion estimation

Sleep disturbances and predictors of nondeployability among active-duty army soldiers: an odds ratio analysis of medical healthcare data from fiscal year 2018

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Military Medical Research 2020年第3期7卷 335-342页

作者： Jaime K.Devine Jacob Collen Jake J.Choynowski vincent Capaldi Institutes for Behavior Resources Operational Fatigue and Performance2104 Maryland AveBaltimoreMD 21218USA Pulmonary Critical Care and Sleep Medicine Walter Reed National Military Medical CenterBethesdaMD 20889USA Behavioral Biology Branch Center for Military Psychiatry and NeuroscienceWalter Reed Army Institute of ResearchSilver SpringMD 20910USA

Background:The impact of sleep disorders on active-duty soldiers’medical readiness is not currently *** data generated at military treatment facilities can be accessed to create research reports and thus can be used to estimate the prevalence of sleep disturbances and the role of sleep on overall health in service *** current study aimed to quantify sleep-related health issues and their impact on health and nondeployability through the analysis of *** healthcare records from fiscal year 2018(FY2018).Methods:Medical diagnosis information and deployability profiles(e-Profiles)were queried for all active-duty *** patients with a concurrent sleep disorder diagnosis receiving medical care within *** was predicted from medical reasons for having an e-Profile(categorized as sleep,behavioral health,musculoskeletal,cardiometabolic,injury,or accident)using binomial logistic *** e-Profiles were investigated as a moderator between other e-Profile categories and ***:Out of 582,031 soldiers,48.4%(n=281,738)had a sleep-related diagnosis in their healthcare records,9.7%(n=56,247)of soldiers had e-Profiles,and 1.9%(n=10,885)had a sleep *** with sleep e-Profiles were more likely to have had a motor vehicle accident(p OR(prevalence odds ratio)=4.7,95%CI 2.63–8.39,P≤0.001)or work/duty-related injury(p OR=1.6,95%CI 1.32–1.94,P≤0.001).The likelihood of nondeployability was greater in soldiers with a sleep e-Profile and a musculoskeletal e-Profile(p OR=4.25,95%CI 3.75–4.81,P≤0.001)or work/dutyrelated injury(p OR=2.62,95%CI 1.63–4.21,P≤0.001).Conclusion:Nearly half of soldiers had a sleep disorder or sleep-related medical diagnosis in 2018,but their sleep problems are largely not profiled as limitations to medical *** issues and physical injury predict nondeployability,and nondeployability is more likely to occur in soldiers who have sleep e-Profiles in addition t

关键词： Medical readiness Behavioral sleep medicine Deployability Healthcare records Military Big data Data mining

小于胎龄儿的血清低胰岛素样生长因子I和C肽水平

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中华内分泌代谢杂志 2000年第1期16卷 38-42页

作者：肖昕冯泽康张宁周晓光暨南大学医学院附属第一医院儿科广州510632 广州市第六人民医院儿科广东省妇幼保健院新生儿科

目的　动态观察轻度和重度小于胎龄儿 (SGA)血清胰岛素样生长因子 I(IGF I)和C肽 (CP)水平 ,并与适于胎龄儿 (AGA)的水平进行比较 ,以探讨SGA的可能发病机制。方法　用放射免疫分析法测定了SGA和AGA出生时脐血、生后 3～ 7天和 2 2～ 2 ... 详细信息

目的　动态观察轻度和重度小于胎龄儿 (SGA)血清胰岛素样生长因子 I(IGF I)和C肽 (CP)水平 ,并与适于胎龄儿 (AGA)的水平进行比较 ,以探讨SGA的可能发病机制。方法　用放射免疫分析法测定了SGA和AGA出生时脐血、生后 3～ 7天和 2 2～ 2 8天外周血IGF I和CP浓度。结果　 (1)AGA出生时、出生后 3～ 7天和 2 2～ 2 8天的IGF I水平无明显差异 ,分别为 (10 .7± 4.5 )、(10 .8± 3.5 )和 (11.1± 3.4)nmol/L ;出生时和出生后 3～ 7天的CP水平相似〔(0 .43± 0 .13)和 (0 .41± 0 .12 )nmol/L〕 ,于出生后 2 2～ 2 8天下降〔(0 .32± 0 .11)nmol/L〕。 (2 )重度和轻度SGA出生时的IGF I〔(6 .1± 1.8)和 (8.9± 2 .8)nmol/L〕和CP〔(0 .2 6± 0 .0 9)和 (0 .33± 0 .11)nmol/L〕水平均低于AGA出生时水平 ;重度SGA出生后 3～ 7天和 2 2～ 2 8天的IGF I〔(6 .8± 2 .4)和 (6 .6± 1.9)nmol/L〕和CP〔(0 .2 7± 0 .10 )和 (0 .2 5± 0 .12 )nmol/L〕水平仍相当于其出生时水平 ;轻度SGA出生后IGF I和CP水平则明显上升 ,于 1周内达到AGA水平〔(11.4± 3.4)和 (0 .41± 0 .11)nmol/L〕 ,3～ 4周超过AGA水平〔(14.0± 3.5 )和 (0 .40± 0 .14)nmol/L〕。 (3)AGA出生时、出生后 3～ 7天和 2 2～ 2 8天的IGF

关键词： C肽低体重儿 IGF-Ⅰ

Practice parameters for the use of actigraphy in the military operational context: the Walter Reed Army Institute of Research Operational Research Kit-Actigraphy(WORK-A)

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Military Medical Research 2021年第1期8卷 103-115页

作者： Jaime K.Devine Jake Choynowski Tina Burke Kajsa Carlsson vincent F.Capaldi Ashlee B.McKeon Walter J.Sowden Operational Fatigue and Performance Institutes for Behavior ResourcesBaltimoreMD 21218USA Behavioral Biology Branch Walter Reed Army Institute of Research503 Robert Grant AveSilver SpringMD 20910USA Tripler Army Medical Center HonoluluHI 96859USA

Background: The Walter Reed Army Institute of Research(WRAIR) Operational Research Kit-Actigraphy(WORK-A) is a set of unique practice parameters and actigraphy-derived measures for the analysis of operational military sleep patterns. The WORK-A draws on best practices from the literature and comprises 15 additional descriptive variables. Here, we demonstrate the WORK-A with a sample of United States Army Reserve Officers’ Training Corps(ROTC) cadets(n=286) during a month-long capstone pre-commissioning training ***: The sleep of ROTC cadets(n=286) was measured by Philips Actiwatch devices during the 31-day training exercise. The preliminary effectiveness of the WORK-A was tested by comparing differences in sleep measures collected by Actiwatches as calculated by Philips Actiware software against WORK-A-determined sleep measures and self-report sleep collected from a subset of ROTC cadets(n=140).Results: Actiware sleep summary statistics were significantly different from WORK-A measures and self-report sleep(P≤0.001). Bedtimes and waketimes as determined by WORK-A major sleep intervals showed the best agreement with self-report bedtime(22:21±1:30 vs. 22:13±0:40, P=0.21) and waketime(04:30±2:17 vs. 04:31±0:47, P=0.68). Though still significantly different, the discrepancy was smaller between the WORK-A measure of time in bed(TIB) for major sleep intervals(352±29) min and self-report nightly sleep duration [(337±57) min, P=0.006] than that between the WORK-A major TIB and Actiware TIB [(177±42) min, P≤0.001].Conclusions: Default actigraphy methods are not the most accurate methods for characterizing soldier sleep, but reliable methods for characterizing operational sleep patterns is a necessary first step in developing strategies to improve soldier readiness. The WORK-A addresses this knowledge gap by providing practice parameters and a robust variety of measures with which to profile sleep behavior in service members.

关键词： Actigraphy Sleep-wake patterns Military sleep assessment Operational environment Scoring methodology

健康志愿者心脏指数的无创性评估：胸阻抗心动图与多普勒超声心动图的对比研究

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麻醉与镇痛 2011年第2期7卷 17-24页

作者： Jean-Luc Fellahi, md, PhD vincent Caille, md Cyril Charron, md Pierre-Herve Deschamps-Berger, md Antoine Vieillard-Baron, md, PhD 黄建廷(译) 喻田(校) Department of Anesthesiology Centre Hospitalier Prive Saint-Martin Caen France The Intensive Care Unit Centre Hospitalier Universitaire Ambroise Pard Assistance Publique-Hopitaux de Paris Boulogne France The Department of Cardiology Polydinique Deauville France 不详

背景胸阻抗心动图（ICG），一直被认为是一种无创性、连续性、可独立操作且经济有效的方法，用于监测心输出量。本研究比较了在静息状态下改变健康志愿者血流动力学参数时，胸阻抗心动图（Niccomo装置）与经胸超声多普勒心动图对心脏指... 详细信息

背景胸阻抗心动图（ICG），一直被认为是一种无创性、连续性、可独立操作且经济有效的方法，用于监测心输出量。本研究比较了在静息状态下改变健康志愿者血流动力学参数时，胸阻抗心动图（Niccomo装置）与经胸超声多普勒心动图对心脏指数（CI）的测量情况。方法本研究共纳入了25例健康志愿者（7例男性，18例女性；平均年龄36±6岁；体表面积1．75±0．17m^2），分别在3种实验条件进行测定：基础水平、呼气末正压通气（＋10cm H2O）、下半身加压（用医疗抗休克裤对腹部施加30cm H2O的压力）。结果在所有测量中，胸阻抗心动图的信号质量〉89％。胸阻抗心动图与多普勒心动图测定的心脏指数（CITTE和CIICG）间存在着较弱但有统计学意义的相关性（r=0．36；P=0．002）。2种技术测得的心脏指数的一致性数值为0．94L·min^-1·m^-2（95％可信区间0．77—1．11）；一致性可变范围为-0．47—2．35L·min^-1·m^-2，误差百分率为53％。施加呼气末正压＋10cm H2O（r=0．21；P=0．31）或医疗抗休克裤（r=0．22；P=0．30）后，CITTE和CIICG的变化率之间的相关性没有统计学意义。结论采用胸阻抗心动图与多普勒心动图测量健康志愿者静息状态下的CI，两者测量所得CI的绝对值相关性较差，缺乏一致性。在血流动力学变化时，使用Niccomo装置测量心脏指数的变化也缺乏可靠性.

关键词：阻抗心动图健康志愿者心脏指数无创性评估多普勒超声心动图超声多普勒心动图呼气末正压通气胸

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甲状腺肿瘤CD15抗原表达及临床意义

中华内分泌代谢杂志 2000年第1期16卷 31-33页

作者：谷化平尚培中纪小龙苏红李春光中国人民解放军第251医院病理科张家口市075000 中国人民解放军第251医院普外科张家口市075000 中国人民解放军总医院病理科

目的　研究甲状腺癌组织中CD15抗原的表达情况及其临床意义。方法　应用微波 LSAB免疫组织化学法 ,检测 5 0例甲状腺癌、45例甲状腺腺瘤、2 0例癌旁甲状腺组织和 10例正常甲状腺组织中CD15抗原的表达。结果　在甲状腺癌中CD15表达阳性... 详细信息

目的　研究甲状腺癌组织中CD15抗原的表达情况及其临床意义。方法　应用微波 LSAB免疫组织化学法 ,检测 5 0例甲状腺癌、45例甲状腺腺瘤、2 0例癌旁甲状腺组织和 10例正常甲状腺组织中CD15抗原的表达。结果　在甲状腺癌中CD15表达阳性率为 6 8.0 % ,显著高于甲状腺腺瘤 (42 .0 % )和癌旁甲状腺组织 (35 .0 % ) (P <0 .0 5 ) ,10例正常甲状腺组织中 2例呈CD15弱阳性反应。CD15表达与甲状腺癌组织类型无关 ,在淋巴结转移病例和病理分期Ⅲ～Ⅳ期病例 ,CD15表达阳性率显著高于相应的无淋巴结转移病例和病理分期Ⅰ～Ⅱ期病例 (P <0 .0 5 )。CD15阳性的甲状腺癌复发及死亡率显著高于CD15阴性者 (P <0 .0 5 )。结论　CD15表达对甲状腺癌及恶性程度的判断、生物学行为预测和预后评估是一种很有意义的指标。

关键词：甲状腺肿瘤 CD15抗原基因表达

脑电双频指数在监测重度颅脑损伤合并顽固性颅内高压患者的巴比妥盐昏迷中的应用

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麻醉与镇痛 2010年第3期6卷 31-38页

作者： vincent Cottenceau, md Laurent Petit, md Francoise Masson, md Dominique Guehl, md, PhD Julien Asselineau, MS Jean-Frangois Cochard, md Catherine Pinaquy, md Main Leger, md Francois Sztark, md, PhD 沙欢欢(译) 李士通(校) Departments of Anesthesia and Intensive Care Unit Clinical Neurophysiology Clinical Epidemiology Unit Centre Hospitalo-Universitaire de Bordeaux Bordeaux France 不详

背景在重症创伤性颅脑损伤（TBI）患者运用巴比妥盐治疗中，通常将暴发．抑制模式的脑电图（EEG）作为监测指标。双频指数（BIS）是脑电图的衍生物，并且考虑到了皮层电静止。本研究测定一定范围内的BIS是否可以预测一个特殊的暴发．抑... 详细信息

背景在重症创伤性颅脑损伤（TBI）患者运用巴比妥盐治疗中，通常将暴发．抑制模式的脑电图（EEG）作为监测指标。双频指数（BIS）是脑电图的衍生物，并且考虑到了皮层电静止。本研究测定一定范围内的BIS是否可以预测一个特殊的暴发．抑制模式。方法前瞻性收入11例应用巴比妥盐治疗的TBI患者。每天记录1小时EEG，每5分钟从原始EEG上计算1分钟的暴发数量及抑制率[抑制率（SREBG）：从EEG上得到的前60秒皮层电静止所占的百分率]，并与BIS-XPTM监测仪上伴行的数据对比[BIS和抑制商（SRBIS）]。巴比妥盐昏迷的最佳水平定义为脑电图上每分钟有2—5个暴发发生。根据所得数据求出最佳水平的BIS预测值范围，对每一例数据都测定其精确度。结果SREEG和SRBIS一致性很高[组间相关系数0．94（95％可信区间：0．90—0.96）]。SREEG和BIS之间有显著相关性。在某些受试者中观察到显著不一致性。BIS值在6～15范围之间时预测精确度最高。结论应用巴比妥盐治疗的重症创伤性颅脑损伤患者，BIS和SREEG有很高相关性。当BIS值〈6时巴比妥盐输注速率需要降低，而当BIS值〉15时，则需要升高。BIS和抑制图形的关系应该周期性地通过EEG模拟信号（BIS-XPTM所示）来校正。

关键词：脑电双频指数颅脑损伤患者巴比妥盐监测指标重度颅脑损伤应用颅内高压昏迷

无阿片类药物应用时手术中输注艾司洛尔可以减少门诊腹腔镜胆囊切除术后芬太尼的用量

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麻醉与镇痛 2008年第6期4卷 52-59页

作者： vincent Collard,md Giovanni Mistraletti, md Ali Taqi, md Juan Francisco Asenjo,md Liane S. Feldman, md Gerald M. Fried, md Franco Carli, md, Mphil 颜学滔宋学敏(译) 王焱林(校) Department of Anesthesia and Surgery Steinberg-Bernstein Centre for Minimally Invasive Surgery McGill University Health Centre Montreal Quebec Canada 不详

背景门诊手术患者使用阿片类药物可以延迟出院时间或导致意外入院。对手术中持续输注艾司洛尔替代阿片类药物能否减少手术后阿片类药物用量效应的报道结论不一。本研究比较了手术中持续输注艾司洛尔、间断输注芬太尼或连续输注瑞芬太尼... 详细信息

背景门诊手术患者使用阿片类药物可以延迟出院时间或导致意外入院。对手术中持续输注艾司洛尔替代阿片类药物能否减少手术后阿片类药物用量效应的报道结论不一。本研究比较了手术中持续输注艾司洛尔、间断输注芬太尼或连续输注瑞芬太尼的手术后阿片类药物的用量、副作用及患者的出院时间。方法90例患者分3组，进行前瞻性、随机双盲研究。对照组（n=30），手术中间断输注芬太尼；艾司洛尔组（聍=30），手术中持续输注艾司洛尔（5～15μg·kg～min^-1），不补充阿片类药物；瑞芬太尼组（n=30），持续输注瑞芬太尼（0．1-0．5μg·kg^-1·min^-1）。标准化全身麻醉，辅助药物包括：对乙酰氨基酚、酮洛酸、切皮时使用局麻药、地塞米松和氟哌利多。手术后使用芬太尼镇痛。结果手术后在麻醉恢复室，艾司洛尔组与其他2组相比，芬太尼的用量明显减少，为91．5±42．7μg；瑞芬太尼组为237．8±54．7μg，对照组为168．1±96．8μg（P〈0．0001）。与艾司洛尔组（30％）相比，瑞芬太尼组（67．9％）和对照组（66．7％）手术后恶心的发生率更高（P〈0．01）。手术后White-Song评分，艾司洛尔组到达12～14的速度比瑞芬太尼组更快（P〈0．01），出院时间早45-60分钟（P〈0．004）。结论手术中持续输注艾司洛尔能显著减少手术后芬太尼和昂丹司琼的用量，有利于患者及早出院。

关键词：阿片类药物门诊手术患者瑞芬太尼艾司洛尔腹腔镜胆囊切除术后术中输注用量药物应用