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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay vincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Tourism Developments Increase Tsunami Disaster Risk in Pangandaran, West Java, Indonesia

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International Journal of Disaster Risk Science 2021年第5期12卷 764-769页

作者： vincent Nijman Department of Social Sciences Oxford Brookes UniversityOxford OX30BP.United Kingdom

On 17 July 2006,the tourist resort of Pangandaran on Java’s south coast was hit by a tsunami,resulting in 413 fatalities and severe damage to *** tsunami resulted in major rebuilds with a focus on mass *** of the impact of a future tsunami focussed on building development and suggest limited change since *** article presents a case study on the development of(largely domestic)tourism in Pangandaran and how this has increased the tsunami disaster *** numbers were stable at about 900,000 visitors a year prior to the tsunami,down to slightly over 250,000 visitors a year in its aftermath,and from 2007 onwards numbers are doubling every three years to about 4 million visitors in *** increase has been most pronounced during *** to 2006,Pangandaran was characterized by wooden structures and one-and two-story buildings of clay-brick masonry;by 2019,14 three to sixstory hotels have been erected along the *** many more visitors,most of whom are unfamiliar with tsunami risks,and shelter facilities for less than a quarter of visitors during peak times,future impacts and the potential cost to life are considerably higher now than in 2006,especially if a tsunami were to hit over a *** tourists upon arrival and throughout their stay should be better informed about the risks of tsunamis,and of the location of tsunami shelters and evacuation routes.

关键词： Disaster resilience Effective warning Indonesia Risk mitigation Tourism Tsunami

Strain and stress analysis on Zn multicrystal film by XRD method

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中国有色金属学会会刊：英文版 2006年第B02期16卷 735-738页

作者： vincent JI LIM UMR CNRS8006ENSAM 151Boulevard de I'Hopital75013 ParisFrance

A new method was denonstrated to determine stress in a single crystal for multicrystal material and this new method could be specially applied for any symmetric crystalline systems. The strain tensor e was determined by the change of the metric tensor G before the initial state and after the deformed state in the crystal reference system. Then stress tensor at grain scale was calculated by the HOOK's law. The stress evaluations were carried out in coarse grains of a thin galvanized coating on a steel substrate during tensile loading. This makes it possible to link the microstructure evolution to the elastic heterogeneity at grain scale or between the grains.

关键词：锌多晶膜单晶应力应变分析 XRD法锌镀层

GeSnOI mid-infrared laser technology

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Light(Science & Applications) 2021年第12期10卷 2408-2420页

作者： Binbin Wang Emilie Sakat Etienne Herth Maksym Gromovyi Andjelika Bjelajac Julien Chaste Gilles Patriarche Philippe Boucaud Frédéric Boeuf Nicolas Pauc vincent Calvo Jérémie Chrétien Marvin Frauenrath Alexei Chelnokov vincent Reboud Jean-Michel hartmann Moustafa El Kurdi UniversitéParis-Saclay CNRSC2N10 boulevard Thomas Gobert91120 PalaiseauFrance UniversitéCôte d’Azur CNRSCRHEARue Bernard Grégory06905 Sophia-AntipolisFrance STMicroelectronics Rue Jean Monnet38054 CrollesFrance UniversitéGrenoble Alpes CEAIRIG-DePhy17 rue des Martyrs38000 GrenobleFrance UniversitéGrenoble Alpes CEALeti17 rue des Martyrs38000 GrenobleFrance

GeSn alloys are promising materials for CMOS-compatible mid-infrared lasers ***,Sn alloying and tensile strain can transform them into direct bandgap *** growing laser technology however suffers from a number of limitations,such as poor optical confinement,lack of strain,thermal,and defects management,all of which are poorly discussed in the ***,a specific GeSn-on-insulator(GeSnOI)stack using stressor layers as dielectric optical claddings is demonstrated to be suitable for a monolithically integration of planar Group-IV semiconductor lasers on a versatile photonic platform for the near-and mid-infrared spectral ***-shape resonators on mesa structures were fabricated from GeSnOI,after bonding a Ge_(0.9)Sn_(0.1) alloy layer grown on a Ge strain-relaxed-buffer,itself on a Si(001)*** GeSnOI microdisk mesas exhibited significantly improved optical gain as compared to that of conventional suspended microdisk resonators formed from the as-grown *** further show enhanced vertical out-coupling of the disk whispering gallery mode in-plane radiation,with up to 30%vertical out-coupling *** a result,the GeSnOI approach can be a valuable asset in the development of silicon-based mid-infrared photonics that combine integrated sources in a photonic platform with complex lightwave engineering.

关键词： GeSn OI coupling

Multicomponent flow modeling

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Science China Mathematics 2012年第1期55卷 285-308页

作者： GIOVANGIGLI vincent CMAP-CNRS Ecole

We present multicomponent flow models derived from the kinetic theory of gases and investigate the symmetric hyperbolic-parabolic structure of the resulting system of partial differential *** address the Cauchy problem for smooth solutions as well as the existence of deflagration waves,also termed anchored *** further discuss related models which have a similar hyperbolic-parabolic structure,notably the SaintVenant system with a temperature equation as well as the equations governing chemical equilibrium *** next investigate multicomponent ionized and magnetized flow models with anisotropic transport fluxes which have a different mathematical *** finally discuss numerical algorithms specifically devoted to complex chemistry flows,in particular the evaluation of multicomponent transport properties,as well as the impact of multicomponent transport.

关键词： multicomponent reactive flow Cauchy problem deflagration wave multicomponent transport

Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques,levels of LDL,and cardiorespiratory fitness in the elderly

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Journal of Sport and Health Science 2024年第3期13卷 288-296,I0002页

作者： Tim Böttrich Pascal Bauer vincent Gröβer Magdalena Huber hartmann Raifer Torsten Frech Svenja Nolte Theresa Dombrowski Franz Cemic Natascha Sommer Robert Ringseis Klaus Eder Karsten Krüger Christopher Weyh Department of Exercise Physiology and Sports Therapy Institute of Sports ScienceJustus-Liebig-UniversityGiessen 35394Germany Department of Cardiology and Angiology Justus-Liebig-University GiessenGiessen 35392Germany Institute for Systems Immunology Center for Tumor und ImmunologyMarburg 35032Germany TH Mittelhessen Department of Computer ScienceUniversity of Applied Sciences GiessenGiessen 35390Germany Department of Internal Medicine Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Giessen 35394Germany Excellence Cluster Cardio-Pulmonary Institute(CPI) Justus-Liebig UniversityGiessen 35394Germany Institute of Animal Nutrition and Nutrition Physiology Justus-Liebig-University GiessenGiessen 35390Germany

Background:Atherosclerosis forms the pathological basis for the development of cardiovascular *** pathological processes initially develop without clinically relevant symptoms,the identification of early markers in the subclinical stage plays an important role for initiating early *** is evidence that regulatory T cells(Tregs)are involved in the development of ***,the present study aimed to identify and investigate associations with Tregs and their subsets in a cohort of healthy elderly individuals with and without subclinical atherosclerotic plaques(SAP).In addition,various lifestyle and risk factors,such as cardiorespiratory fitness,were investigated as associated ***:A cross-sectional study was performed in 79 participants(male:n=50;age=63.6±3.7 years;body mass index=24.9±3.1 kg/m2;mean±SD)who had no previous diagnosis of chronic disease and were not taking *** of the carotids to identify SAP,cardiovascular function measurement for vascular assessment and a cardiorespiratory fitness test to determine peak oxygen uptake were ***,tests were conducted to assess blood lipids and determine glucose *** of Tregs and their subtypes(resting(rTregs)and effector/memory(mTregs))was performed by 8-chanel flow *** were categorized according to atherosclerotic plaque *** and logistic regression models were used to analyze associations between ***:SAP was detected in a total of 29 *** participants with plaque were older(64.8±3.6 years vs.62.9±3.5 years)and had higher peripheral systolic blood pressure(133.8±14.7 mmHg vs.125.8±10.9 mmHg).The participants with SAP were characterized by a lower percentage of rTregs(28.8%±10.7%vs.34.6%±10.7%)and a higher percentage of mTregs(40.3%±14.7%vs.30.0%±11.9%).Multiple logistic regression identified age(odds ratio(OR)=1.20(95%confidence interval(95%CI):1.011.42))and

关键词： Cardiorespiratory fitness Elderly Regulatory T cells Subclinical atherosclerosis

Experimental study of path planning problem using EMCOA for a holonomic mobile robot

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Journal of Systems Engineering and Electronics 2021年第6期32卷 1450-1462页

作者： MOHSENI Alireza DUCHAINE vincent WONG Tony Department of System Engineering École de Technologie SupérieureMontreal QC H3C 1K3Canada

In this paper,a comparative study of the path planning problem using evolutionary algorithms,in comparison with classical methods such as the A*algorithm,is presented for a holonomic mobile *** configured navigation system,which consists of the integration of sensors sources,map formatting,global and local path planners,and the base controller,aims to enable the robot to follow the shortest smooth path ***-based mapping is used for scoring paths efficiently,allowing the determination of collision-free trajectories from the initial to the target *** work considers the evolutionary algorithms,the mutated cuckoo optimization algorithm(MCOA)and the genetic algorithm(GA),as a global planner to find the shortest safe path among others.A non-uniform motion coefficient is introduced for MCOA in order to increase the performance of this algorithm.A series of experiments are accomplished and analyzed to confirm the performance of the global planner implemented on a holonomic mobile *** results of the experiments show the capacity of the planner framework with respect to the path planning problem under various obstacle layouts.

关键词： holonomic robot path planning evolutionary algorithm(EA)

Scattering and diffraction of plane P-waves in a 2-D elastic half-space Ⅱ：shallow arbitrary shaped canyon

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Earthquake Engineering and Engineering Vibration 2017年第3期16卷 459-485页

作者： Heather P.Brandow vincent Lee Civil and Environmental Engineering University of Southern California Los Angeles 90089 United States

Scattering and Diffraction of elastic in-plane P-and SV-waves by a surface topography such as an elastic canyon at the surface of a half-space is a classical problem which has been studied by earthquake engineers and strong-motion seismologists for over forty years. The case of out-of-plane SH waves on the same elastic canyon that is semi-circular in shape on the half-space surface is the first such problem that was solved by analytic closed form solutions over forty years ago by Trifunac. The corresponding case of in-plane P-and SV-waves on the same circular canyon is a much more complicated problem because, the in-plane P-and SV-scattered waves have different wave speeds and together they must have zero normal and shear stresses at the half-space surface. It is not until recently in 2014 that analytic solution for such problem is found by the author in the work of Lee and Liu. This paper uses the technique of Lee and Liu of defining these stress-free scattered waves to solve the problem of the scattered and diffraction of these in-plane waves on an almost-circular surface canyon that is arbitrary in shape.

关键词： diffraction elastic P-waves SV-waves weighted-residual method arbitrary-shaped canyon

Cropping leads to loss of soil organic matter: How can we prevent it?

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Pedosphere 2023年第1期33卷 8-10页

作者： vincent CHAPLOT Pete SMITH Institut de Recherche pour le Développement(IRD) Laboratoire d’Océanographie et du ClimatExpérimentations et Approches NumériquesUMR 7159IRD-CNRS-UPMC-MNHNCedex 05Paris 75252France Institute of Biological and Environmental Sciences School of Biological SciencesUniversity of AberdeenAberdeen AB243UUUK

Soil organic matter(SOM),which associates carbon(C)to key plant nutrients,has been stored in soil for thousands of *** have long recognised its positive impact on key environmental functions such as food production and climate *** soon as a virgin land(forest or grassland)is cultivated,there is a tendency for the soil to lose its SOM,and we still largely misunderstand the underlying mechanisms,leading to inappropriate decisions being taken to fight soil,climate,and overall ecosystem degradation.

关键词： soil grassland forest