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Assessing foundation behaviour under complex loading near tunnels

Journal of Mountain science 2024年第10期21卷 3503-3520页

作者： Piyush KUMAR vinay Bhushan CHAUHAN Aayush KUMAR Civil Engineering Department Madan Mohan Malaviya University of TechnologyGorakhpur 273010India

The stability of strip footings subjected to eccentrically inclined loads is critical for reliable foundation *** study investigates the effect of a circular unlined tunnel in a rock mass on the ultimate bearing capacity(UBC)of a foundation with width B under inclined and eccentric *** finite element limit analysis was employed to evaluate the reduction in UBC of the footing resting above a *** examined critical parameters include normalized load eccentricity(e/B),load inclination(β),and horizontal and vertical distances of the tunnel from the foundation(P/B and Q/B,respectively),along with rock mass *** results reveal that for e/B≥0.25 and≤60°,the reduction coefficient,Rc≥0.90,suggesting that the presence of a tunnel has a minimal impact on the load-bearing capacity of the footing,with failure primarily governed by load eccentricity and ***,potential failure mechanisms are explored,showing that at lower e/B,higherβ,and lower Q/B,the tunnel significantly affects footing's failure ***,at higher e/B and lowerβ,failure is due to rotational effects of footing,regardless of the tunnel's *** predict the Rc more accurately,due to the time-consuming nature of direct calculations,both MLR and ANN models were *** MLR model provided a baseline for comparison,while the ANN model,with a coefficient of determination(R2)of 0.98,demonstrated superior accuracy compared to the R2=0.96 of *** both approaches ensured robust and efficient predictions of *** Rc does not directly provide the reduced UBC of footing due to presence of tunnel,the study introduced bearing capacity factor(Nc)to enable direct calculation of the reduced UBC of *** findings offer theoretical guidelines for preliminary design and provide practitioners with an effective tool for evaluating UBC reduction in complex loading scenarios involving tunnels.

关键词： Unlined tunnel shallow foundation FELA Rock Mass ANN MLR

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Prostaglandin E1 administration post liver transplantation and renal outcomes:A retrospective single center experience

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World Journal of Transplantation 2024年第4期14卷 101-109页

作者： vinay Jahagirdar Mohamed Ahmed Ifrah Fatima Hassam Ali Laura Alba John H Helzberg Lee s Cummings Matthew Wilkinson Jameson Forster Alisa Likhitsup Department of Internal Medicine Saint Luke’s Health System of Kansas City and the University of Missouri-Kansas CityKansas CityMO 64111United States Department of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Internal Medicine Department of Gastroenterology and HepatologySaint Luke’s Health System of Kansas City and University of Missouri-Kansas CityKansas CityMO 64111United States Department of surgery University of Missouri-Kansas City and Transplant SurgerySaint Luke’s Hospital of Kansas CityKansas CityMO 64111United States Department of Gastroenterology and Hepatology University of MichiganAnn ArborMI 48109United States

BACKGROUND Prostaglandin E1(PGE1),or alprostadil,is a potent vasodilator that improves hepatic blood flow and reduces ischemia-reperfusion injury post-liver transplantation(LT).However,the benefits of PGE1 on renal function after LT have not yet been well *** To assess the impact of PGE1 administration on renal function in patients who underwent liver or liver-kidney *** This retrospective study included all patients who underwent liver or liverkidney transplant at our institution from January,2011 to December,*** were classified based on whether they received ***1 was administered post-LT to those with transaminases>1000 U/L in the immediate postoperative ***,post-LT treatments and/or complications,renal function,and survival were *** logistic regression analysis was performed,and a two-tailed P values considered statistically *** A total of 145 patients underwent LT,with 44(30%)receiving *** patient characteristics were comparable,except the PGE1 group had significantly higher aspartate aminotransferase(AsT)(1961.9 U/L±1862.3 U/L vs 878 U/L±741.4 U/L,P=0.000),alanine aminotransferase(1070.6 U/L±895 U/L vs 547.7 U/L±410 U/L,P=0.000),international normalized ratio on post-LT day 1(2±0.74 vs 1.8±0.4,P=0.03),a longer intensive care unit stay(8.1 days±11.8 days vs 3.8 days±4.6 days,P=0.003),more vasopressor use(55.53 hours±111 hours vs 16.33 hours±26.3 hours,P=0.002),and higher immediate postoperative complications(18.6%vs 4.9%,P=0.04).The PGE1 group also had a significantly higher 90-day readmission rate(29.6%vs 13.1%,P=0.02)and lower 1-year liver graft survival(87.5%vs 98.9%,P=0.005).However,30-day readmission(31.6%vs 27.4%,P=0.64),LT complications(hepatic artery thrombosis,biliary complications,rejection of liver graft,cardiomyopathy),1-year patient survival(96.9%vs 97.8%,P=0.77),overall liver graft survival,and overall patient survival were similar between t

关键词： Liver transplantation Alprostadil Protective agents Transplant Prostaglandin E1

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4-1BB signaling beyond T cells

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Cellular & Molecular Immunology 2011年第4期8卷 281-284页

作者： Dass s vinay Byoung s Kwon section of Clinical Immunology Allergyand RheumatologyDepartment of MedicineTulane University Health Sciences CenterNew OrleansLAUSA Cell and Immunobiology and R&D Center for Cancer TherapeuticsNational Cancer CenterIlsanGyeonggi-DoKorea

Originally discovered as a T cell-activating molecule,4-1BB(CD137)is now also recognized as an activator of non-T cells,thus imparting a new dimension to its potential in vivo effects.4-1BB expression is seen on a variety of non-T cells including activated dendritic cells(DCs),monocytes,neutrophils,B cells and natural killer(NK)cells,and promotes their individual effector *** T cell-and non-T cell-activating ability of 4-1BB may be the basis of its powerful anti-cancer,anti-autoimmune and anti-viral *** we discuss the consequence and importance of 4-1BB signaling in non-T *** consider its effects on immune regulation,and the distinct and/or overlapping pathways involved in these responses,as well as possible therapeutic applications.

关键词： APC cytokines natural killer cells T cells 4-1BB

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Atypical causes of cholestasis

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World Journal of Gastroenterology 2014年第28期20卷 9418-9426页

作者： Ken D Nguyen vinay sundaram Walid s Ayoub Department of Internal Medicine Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of Gastroenterology and Hepatology Multi Organ Transplant CenterCedars Sinai Medical CenterLos AngelesCA 90048United States

Cholestatic liver disease consists of a variety of disorders. Primary sclerosing cholangitis and primary biliary cirrhosis are the most commonly recognized cholestatic liver disease in the adult population, while biliary atresia and Alagille syndrome are commonly recognized in the pediatric population. In infants, the causes are usually congenital or inherited. Even though jaundice is a hallmark of cholestasis, it is not always seen in adult patients with chronic liver disease. Patients can have “silent” progressive cholestatic liver disease for years prior to development of symptoms such as jaundice and pruritus. In this review, we will discuss some of the atypical causes of cholestatic liver disease such as benign recurrent intrahepatic cholestasis, progressive familial intrahepatic cholestasis, Alagille syndrome, biliary atresia, total parenteral nutrition induced cholestasis and cholestasis secondary to drug induced liver injury.

关键词： Cholestasis Benign recurrent intrahepatic cholestasis Progressive familial intrahepatic cholestasis Alagille syndrome Biliary atresia Total parenteral nutrition Drug induced liver injury

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Development of anti-phishing browser based on random forest and rule of extraction framework

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Cybersecurity 2018年第1期1卷 879-892页

作者： Mohith Gowda HR Adithya MV Gunesh Prasad s vinay s B.E in Computer science and Engineering PES College of Engineering4011Vasuda Krupa3rd CrossShankar NagarMandyaKarnataka 571401India B.E in Computer science and Engineering PES College of Engineering19321st Main RoadHalahalli ExtNear Vinayaka Auto StandMandyaKarnataka 571401India B.E in Computer science and Engineering PES College of Engineering20/195th crossShakthi NagarNear Shakthi Nagar ParkMysoreKarnataka 570019India Information science and Engineering PES College of EngineeringPES Engineering College RdPES College CampusMandyaKarnataka 571401India

Phishing is a technique under social Engineering attacks which is most widely used to get user sensitive information,such as login credentials and credit and debit card information,*** is carried out by a person masquerading as an authentic *** protect web users from these attacks,various anti-phishing techniques are developed,but they fail to protect the user from these attacks in various *** this paper,we propose a novel technique to identify phishing websites effortlessly on the client side by proposing a novel browser *** this system,we use the rule of extraction framework to extract the properties or features of a website using the URL *** list consists of 30 different properties of a URL,which will later be used by the Random Forest Classification machine learning model to detect the authenticity of the website.A dataset consisting of 11,055 tuples is used to train the *** processes are carried out on the client-side with the help of a redesigned browser *** Researches have come up with machine learning frameworks to detect phishing sites,but they are not in a state to be used by individuals having no technical *** make sure that these tools are accessible to every individual,we have improvised and introduced detection methods into the browser architecture named as‘Embedded Phishing Detection Browser’(EPDB),which is a novel method to preserve the existing user experience while improving the *** newly designed browser architecture introduces a special segment to perform phishing detection operations in *** have prototyped this technique to ensure maximum security,better accuracy of 99.36% in the identification of phishing websites in realtime.

关键词： Phishing attack Machine learning Intelligent browser engine Rule of extraction algorithm Browser architecture

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synergistic effect of hybrid Himalayan Nettle/Bauhinia-vahlii fibers on physico-mechanical and sliding wear properties of epoxy composites

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Defence Technology（防务技术） 2020年第4期16卷 762-776页

作者： sandeep Kumar KKsMer Brijesh Gangil vinay Kumar Patel Department of Mechanical Engineering S.O.E.T.H.N.B.Garhwal UniversitySrinagar-Garhwal246174UttarakhandIndia Department of Mechanical Engineering Govind Ballabh Pant Institute of Engineering and Technology GhurdauriPauri Garhwal246001UttarakhandIndia

The cellulosic bast fibers are recognized as a justifiable and biodegradable substitute for producing moderate strength polymer composite materials because of their characteristics of renewability,ecofriendliness,and higher specific *** the aim of this research work is to fabricate Himalayan bast fibers(Nettle fiber(NF)/bauhinia vahlii fiber(BF)) based mono/hybrid epoxy composites at varying weight percentage of 2-6 wt% and evaluate the physical(void fraction and water absorption),mechanical(tensile strength,flexural strength,hardness) and sliding wear properties of as-fabricated *** 6 wt% NBF reinforced composites exhibited higher mechanical properties as compared to NF and BF composites with tensile strength of 34.04 MPa,flexural strength of 42.45 MPa,and hardness of 37.01 Hv *** influence of various control factors(sliding velocity,NF/BF/NBF contents,normal load and sliding distance) on specific sliding wear rate of composites was evaluated by Taguchi(three factors at three levels) experimental design and the percentage contribution of these selected parameters on sliding wear performance was examined by Analysis of variance(ANOVA).The sliding wear property of as-developed composites was found to be greatly influenced by sliding velocity and the wear resistance was observed to be improved with the NF/BF/NBF *** wear mechanism of the as-fabricated composites has been elucidated by scanning electron microscopy *** research outcomes demonstrated that the hybridization of Bauhinia vahlii fiber with Nettle fiber led to improve the mechanical and wear properties of epoxy composites.

关键词： Natural fiber Physical properties Mechanical properties Wear properties Taguchi analysis

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Early versus delayed necrosectomy in pancreatic necrosis:A population-based cohort study on readmission,healthcare utilization,and in-hospital mortality

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World Journal of Methodology 2024年第3期14卷 55-67页

作者： Hassam Ali Faisal Inayat vinay Jahagirdar Fouad Jaber Arslan Afzal Pratik Patel Hamza Tahir Muhammad sajeel Anwar Attiq Ur Rehman Muhammad sarfraz Ahtshamullah Chaudhry Gul Nawaz Dushyant singh Dahiya Amir H sohail Muhammad Aziz Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64108United States Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Division of Gastroenterology and Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Division of Gastroenterology Hepatologyand MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Division of Gastroenterology and Hepatology The University of ToledoToledoOH 43606United States

BACKGROUND Acute necrotizing pancreatitis is a severe and life-threatening *** poses a considerable challenge for clinicians due to its complex nature and the high risk of *** minimally invasive and open necrosectomy procedures have been *** advancements in treatment modalities,the optimal timing to perform necrosectomy lacks *** To evaluate the impact of necrosectomy timing on patients with pancreatic necrosis in the United *** A national retrospective cohort study was conducted using the 2016-2019 Nationwide Readmissions *** with non-elective admissions for pancreatic necrosis were *** participants were divided into two groups based on the necrosectomy timing:The early group received intervention within 48 hours,whereas the delayed group underwent the procedure after 48 *** various intervention techniques included endoscopic,percutaneous,or surgical *** major outcomes of interest were 30-day readmission rates,healthcare utilization,and inpatient *** A total of 1309 patients with pancreatic necrosis were *** propensity score matching,349 cases treated with early necrosectomy were matched to 375 controls who received delayed *** early cohort had a 30-day readmission rate of 8.6% compared to 4.8%in the delayed cohort(P=0.040).Early necrosectomy had lower rates of mechanical ventilation(2.9%vs 10.9%,Pseptic shock(8%vs 19.5%,Pspital mortality(1.1%vs 4.3%,P=0.01).Patients in the early intervention group incurred lower healthcare costs,with median total charges of $52202 compared to$147418 in the delayed *** in the early cohort also had a relatively shorter median length of stay(6 vs 16 days,Psectomy did not significantly influence the risk of 30-day readmission,with a hazard ratio of 0.56(95%confidence interval:0.31-1.02,P=0.06).CONCLUsION Our findings show that

关键词： Acute necrotizing pancreatitis Pancreatic necrosis Early necrosectomy Delayed necrosectomy Readmission,Healthcare costs Mortality

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severe cholestatic hepatitis due to large vessel vasculitis:report of two cases

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Gastroenterology Report 2018年第1期6卷 68-71,I0003页

作者： Jason Xu Einar s.Bjo¨rnsson vinay sundaram Department of Medicine Cedars-Sinai Medical CenterLos AngelesCAUSA Department of Gastroenterology and Hepatology The National University Hospital of IcelandReykjavikIceland Faculty of Medicine University of IcelandReykjavikIceland Division of Gastroenterology and Hepatology and Comprehensive Transplant Center Cedars-Sinai Medical CenterLos AngelesCAUSA

Giant cell arteritis(GCA)is a vasculitis of medium and large sized vessels that occurs most often in people>50 years of age with associated symptoms of fever,weight loss,headache and jaw *** rheumatica(PMR),which is characterized by aching and stiffness in the shoulders,hip girdle,neck and torso,is intimately associated with GCA,and evidence suggests that GCA and PMR are two phases of the same *** occurrence of liver enzyme abnormalities in either of these conditions is ***,as these conditions occur most commonly in the elderly population who may be subject to polypharmacy,patients with elevated aminotransferases due to underlying GCA/PMR may mistakenly have their abnormal liver function tests attributed to drug-induced liver *** the potential complications of these diseases if left untreated,including ischemic stroke and blindness,early recognition and treatment are *** report two patients who developed severe cholestatic liver enzyme elevation,which had been initially attributed to drug toxicity,but was ultimately caused by large vessel vasculitis,specifically GCA and PMR.

关键词： acute liver injury polymyalgia rheumatica abnormal liver enzymes

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Untangling a complex web: Computational analyses of tumor molecular profiles to decode driver mechanisms

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Journal of Genetics and Genomics 2020年第10期47卷 595-609页

作者： sirvan Khalighi salendra singh vinay Varadan Division of General Medical sciences-Oncology Case Comprehensive Cancer CenterCase Western Reserve University School of MedicineClevelandOH 44106USA

Genome-scale studies focusing on molecular profiling of cancers across tissue types have revealed a plethora of aberrations across the genomic,transcriptomic,and epigenomic *** significant molecular heterogeneity across individual tumors even within the same tissue context complicates decoding the key etiologic mechanisms of this ***,it is increasingly likely that biologic mechanisms underlying the pathobiology of cancer involve multiple molecular entities interacting across functional *** has motivated the development of computational approaches that integrate molecular measurements with prior biological knowledge in increasingly intricate ways to enable the discovery of driver genomic aberrations across ***,we review diverse methodological approaches that have powered significant advances in our understanding of the genomic underpinnings of cancer at the cohort and at the individual tumor *** outline the key advances and challenges in the computational discovery of cancer mechanisms while motivating the development of systems biology approaches to comprehensively decode the biologic drivers of this complex disease.

关键词： Mutations systems biology Mutational significance Functional impact Pan-cancer analysis Multiomics integration

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A Characteristic Non-Reflecting Boundary Treatment in Lattice Boltzmann Method

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Chinese Physics Letters 2008年第6期25卷 1964-1967页

作者： KIM Dehee KIM Hyung Min JHON Myung s vinay Ⅲ stephen J. BUCHANAN John Department of Chemical Engineering Carnegie Mellon University 5000 Forbes Ave Pittsburgh PA 15213 USA Division of Mechanical system Design Engineering Kyonggi University Suwon Kyonggi-do Korea Bechtel Bettis Inc West Mifflin PA 15122 USA

In lattice Boltzmann methods, disturbances develop at the initial stages of the simulation, the decay characteristics depend mainly on boundary treatment methods; open boundary conditions such as equilibrium and bounce-back schemes potentially generate uncontrollable disturbances. Excessive disturbances originate from non-physical reflecting waves at boundaries. Characteristic boundary conditions utilizing the signs of waves at boundaries which suppress these reflecting waves, as well as their implementation in the lattice Boltzmann method, are introduced herein. The performance of our novel boundary treatment method to effectively suppress excessive disturbances is verified by three different numerical experiments.

关键词： HYPERBOLIC sYsTEMs EQUATION FLOWs

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