4-1BB signaling beyond T cells
作者机构：Section of Clinical ImmunologyAllergyand RheumatologyDepartment of MedicineTulane University Health Sciences CenterNew OrleansLAUSA Cell and Immunobiologyand R&D Center for Cancer TherapeuticsNational Cancer CenterIlsanGyeonggi-DoKorea
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2011年第8卷第4期
页 面：281-284页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：grants from the National Cancer Center,Korea(NCC-0890830-2 and NCC-0810720-2) the Korean Science and Engineering Foundation(Stem Cell-M10641000040 and Discovery of Global New Drug-M10870060009) the Korean Research Foundation(KRF-2005-084-E00001) and Korea Health 21 R&D(A050260)
主 题：APC cytokines natural killer cells T cells 4-1BB
摘 要：Originally discovered as a T cell-activating molecule,4-1BB(CD137)is now also recognized as an activator of non-T cells,thus imparting a new dimension to its potential in vivo effects.4-1BB expression is seen on a variety of non-T cells including activated dendritic cells(DCs),monocytes,neutrophils,B cells and natural killer(NK)cells,and promotes their individual effector *** T cell-and non-T cell-activating ability of 4-1BB may be the basis of its powerful anti-cancer,anti-autoimmune and anti-viral *** we discuss the consequence and importance of 4-1BB signaling in non-T *** consider its effects on immune regulation,and the distinct and/or overlapping pathways involved in these responses,as well as possible therapeutic applications.
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