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Role of platelets and breast cancer stem cells in metastasis

World Journal of Stem Cells 2020年第11期12卷 1237-1254页

作者： Gretel Mendoza-Almanza Luis Burciaga-Hernandez vilma maldonado Jorge Melendez-Zajgla Jorge Olmos CONACYT Universidad Autónoma de Zacatecas.Zacatecas 98060Mexico Maestría en Ciencias Biomédicas Universidad Autónoma de ZacatecasZacatecas 98160Mexico Laboratorio de Epigenética Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Génómica funcional del cáncer Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Biotecnología Marina Centro de Investigación Científica y de Estudios Superiores de EnsenadaEnsenada 22860Mexico

The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer cells,resistance to chemotherapy and radiotherapy,and tumor regression *** recent years,it has been shown that the presence of breast cancer stem cells is closely associated with the migration and metastatic ability of cancer cells,as well as with their resistance to chemotherapy and *** tumor microenvironment is one of the main molecular factors involved in cancer and metastatic processes development,in this sense it is interesting to study the role of platelets,one of the main communicator cells in the human body which are activated by the signals they receive from the microenvironment and can generate more than one *** can ingest and release RNA,proteins,cytokines and growth *** the platelets interact with the tumor microenvironment,they are called"tumor-educated platelets."Tumor-educated platelets transport material from the tumor microenvironment to sites adjacent to the tumor,thus helping to create microenvironments conducive for the development of primary and metastatic *** has been observed that the clone capable of carrying out the metastatic process is a cancer cell with stem cell *** stem cells go through a series of processes,including epithelial-mesenchymal transition,intravasation into blood vessels,movement through blood vessels,extravasation at the site of the establishment of a metastatic focus,and site ***-educated platelets support all these processes.

关键词： Breast cancer stem cells Platelets Metastasis Tumor microenvironment Epithelial-mesenchymal transition

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