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Journal of Biosciences and Medicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina Gallardo-Ortíz Juan Pablo de Jesús Benítez-Garrido Santiago C. Sigrist-Flores Juan Javier López-Guerrero Enrique Hong rafael villalobos-molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Carrera de Enfermerí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Departamento de Farmacobiologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Carrera de Mé dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. The aim of this work was to examine the impact of Ang II on the expression and function of α1-adrenergic receptors (α1-ARs) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated Wistar rat aorta was incubated for 24 h in DMEM at 37˚C, then subjected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10−5 M), and in some experiments, 5-Methylurapidil (α1A-AR antagonist), AH11110A (α1B-AR antagonist), or BMY-7378 (α1D-AR antagonist), were used to identify the α1-AR involved in the response. Desensitization of the contractile response to norepinephrine was observed due to incubation time, and by the Ang II action. α1D-AR was protected from desensitization by BMY-7378;while RS-100329 and prazosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and α1-ARs proteins were evaluated. α1D-AR increased at 30 and 60 min post Ang II exposure, the α1A-AR diminished from 1 to 4 h, while α1B-AR remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of α1D-AR at short times, and BMY-7378 protected α1D-AR from desensitization.

关键词： Angiotensin II α1D-AR α1-AR Expression Rat aorta Smooth Muscle Cells

Overweight/Obesity in University Students from Mexico: Comparison Using Different Indices

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Journal of Biosciences and Medicines 2024年第7期12卷 151-159页

作者： Gabriel Medrano-Donlucas Claudia Carolina Hernández-Peña Ricardo Juárez-Lozano Cecilia López-López Santiago C. Sigrist Flores rafael villalobos-molina Itzell A. Gallardo-Ortíz Instituto de Ciencias Biomdicas Universidad Autnoma de Ciudad Jurez Ciudad Jurez Mxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autnoma de Mxico Tlalnepantla de Baz Mxico

The goal was to compare body mass index (BMI), waist circumference (WC), waist to height ratio (WHtR), and relative fat mas (RFM), to identify the best predictor of overweight and obesity in university students from Mexico. This is a cross-sectional survey with 697 university students from northern and central Mexico (448 women, and 249 men aged 18 - 19 years). Data was collected during 2018. Overweight and obesity were calculated from those indices and for both, female and male students, the order of correlation between a pair of indices were WHtR vs. RFM > WHtR vs. WC > RFM vs. WC > WHtR vs. BMI > BMI vs. WC > RFM vs. BMI. It is concluded to use the WHtR and the RFM to better predict overweight and obesity in young Mexican university students.

关键词： Overweight and Obesity Anthropometry Anthropometry Indices

University Corporate Governance in the Literature From 2019 to 2024

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Journalism and Mass Communication 2024年第3期14卷 179-188页

作者： María del Rosario molina González María Teresa Gaxiola Sánchez María de Jesús Camargo Pacheco Marco Antonio Velderrain Rodríguez rafael Campoy Mendoza Cruz García Lirios Universidad de Sonora NavojoaMexico

Anti-pandemic policies impacted the governance of Higher Education Institutions(HEIs)through confinement and distancing *** an impact was observed in the identity,reputation,and image of the HEI in the face of the health *** objective of this work was to establish an empirical contrast between the theoretical structure consulted regarding the evaluations of summaries published from 2019 to 2024 by judges.A documentary,cross-sectional,and retrospective study was carried out with a sample of sources indexed in international *** results demonstrate that image and age regulate the impact of identity and income on *** relation to the state of the art,it is recommended to extend the study to sociocultural,demographic,economic,and educational variables in order to anticipate the transition from university governance to corporate governance.

关键词： COVID governance model nodes neural networks

Social Networks as a Didactic Support to Prevent Addictions in Nursing Students

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Open Journal of Nursing 2023年第4期13卷 217-225页

作者： Diana Cecilia Tapia-Pancardo rafael villalobos-molina Biomedicine Unit Graduate and Research Division Faculty of Higher Studies Iztacala National Autonomous University of Mexico Tlalnepantla Mexico

Health professionals and mainly nurses must be kept updated on context conditions where populations they have in charge, since this is the only way to maintain communication with those vulnerable groups avoiding barriers, there are topics of difficult approach such as the use and abuse of substances in adolescents, and currently adolescents communicate through social networks. We aimed to determine the influence of social networks as a pedagogic strategy in adolescents’ health education. Method: Qualitative and descriptive study with phenomenological design. Fifteen informants from nursing career participated, and selected by convenience. Data collection was through a semi-structured interview composed of 5 questions directed to informants, regarding their experience to make an informative video about use and abuse in adolescents;questions were about their experiences, found difficulties and any other element related with the making of the video, its spread, the login and acceptance that the audiovisual material had in social networks by students and the management of information with preventive goals. All final products were incorporated to a link where group members, as well as the student community, could revise the video and make comments, maintain a chat with others, and so on, a dynamic session of presentations on questions and comments was done. An informed consent was signed. Collected qualitative data were analyzed according to De Souza Minayo. Results: Three categories emerged with nine sub-categories, Category 1: Influence of social networks on students, sub-categories: 1.1) Perception about addictions, 1.2) Expectation on attention to addictions, 1.3) As educational strategy. Category 2: Experiences of students with social networks, sub-categories: 2.1) Motivates creativity, 2.2) Rescue learned skills and add others, 2.3) Motivates empathy. Category 3: Use of social networks by nurse students, sub-categories: 3.1) Constraint in videos production, 3.2) Ad

关键词： Social Networks Addiction Prevention Adolescents

Sport participation and vigilance in children:Influence of different sport expertise

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Journal of Sport and Health Science 2018年第4期7卷 497-504页

作者： rafael Ballester Florentino Huertas Enrique molina Daniel Sanabria Faculty of Physical Education ＆ Sport Sciences Catholic University of ValenciaValeneia 46900Spain Mind Brain and Behavior Research Center University of GranadaGranada 18071Spain ）Corresponding author.E-mail address：daniel@ugr.es

Purpose： The present study aimed to investigate the relationship between different types of sport expertise （externally-paced vs. self-paced sports） and vigilance performance in children by evaluating the cardiovascular fitness level of the participants. Methods： Three groups of children （11.0 ± 0.2 years） differentiated in terms of their regular sport participation （football players, n = 20; track and field athletes, n = 20; non-athletic controls, n = 20） took part in the study. In one session, participants performed the Leger Multi-stage fitness test to estimate their aerobic fitness level. In another session, participants completed the Psychomotor Vigilance Task （PVT） to evaluate their vigilance performance under 2 conditions of velocity demands （normal vs. speed）. Results： The results revealed that both groups of sport practitioners had higher cardiovascular fitness than non-athlete controls. In contrast, no significant differences in the performance PVT were found between track and field athletes and controls. Crucially, football players showed better performance in the PVT than track and field athletes and controls. These between-group differences were not modulated by the speed demands of the task. Conclusion： The major novel finding of this research points to a positive relationship between sport participation and vigilance performance during childhood. We discuss our results in terms of the different hypotheses put forward in the literature to explain the relationship between regular exercise and cognitive fimctioning： the ＂cardiovascular fitness＂ and the ＂cognitive component skills＂ hypotheses.2018 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. （http：//***/licenses/by-nc-nd/4.0/）.

关键词： Childhood Cognition Cognitive skills Physical activity Physical exercise Sustained attention

Perception of Losses Experienced by the Diabetic Patient

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Open Journal of Nursing 2022年第9期12卷 571-580页

作者： Diana Cecilia Tapia-Pancardo Lucia Velázquez-Hernández rafael villalobos-molina Graduate and Research Division Biomedicine Unit Faculty of Higher Studies Iztacala National Autonomous University of Mexico Tlalnepantla Mexico National Autonomous University of Mexico Tlalnepantla Mexico

A person living with diabetes mellitus is conscious that this pathology will not cause its death in the short term, but they face losses and experience grief on multiple occasions along with the chronicity of the disease. In most cases, the partner or close relative also experiences a great impact since they become a family caregiver. The goal of this study was: to analyze the perception of losses experienced by the diabetic patient along with the chronicity of the illness. Method: This was qualitative research, with a phenomenological method under the philosophical view of Husserl and the theoretical support of Kübler-Ross with a descriptive design. Four diabetic patients aged 18 to 75 years old of both genders participated;they asked for hospital attention due to complications of the disease. Selection of participants was by convenience up to reach saturation. Data were collected through semi-structured interviews, field notes and observation. The setting of the first contact was in a third-level hospital in Mexico City;the second one was through programmed home visits. These occurred by a chronogram agreed upon by the participants, and a room was selected with conditions of privacy to conduct the interviews;respect was always observed. Participants signed informed consent. Data analysis was according to Miles and Huberman, by means of three tasks: information acquisition, data transcription and codification, and conclusions. Results: After the qualitative analysis four categories emerged, as well as sub-categories, as follows: Category 1: Self-losses perceived by the patient, sub-categories 1.1 Beginning the mourn step: Negation;1.2 Silent illness that produces severe damage;1.3 Complicated/chronic mourn. Category 2: Emotions along the disease chronicity, sub-categories 2.1 Negation of emotions/distortion of natural emotions;2.2 Decisions taken based on feelings. Category 3: Changes in the diabetic patient’s nutrition, sub-categories 3.1 Culture: positive reinfor

关键词： Diabetes Patient Physical and Emotional Losses Thanatology

Altered Liver Gene Expression Due to Hypertension and Age in Rats

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Journal of Biosciences and Medicines 2023年第8期11卷 82-94页

作者： María Dolores Ronquillo-Sánchez Jorge Ramírez-Salcedo Itzell Alejandrina Gallardo-Ortíz rafael villalobos-molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Departamento de Biología Celular y del Desarrollo Instituto de Fisiología Celular Universidad Nacional Autónoma de México Ciudad de México México Carrera de Enfermería Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Hypertension and metabolic syndrome, both of which increase with age, are multifactorial disorders. Their etiology is complex, making it challenging to isolate involved genes. This study aimed to characterize the hepatic gene expression in spontaneously hypertensive rats (SHR) at different ages. Blood pressure in SHR was determined by tail-cuff method at one and three months of age. Hepatic RNA was isolated and gene expression was compared using microarrays. Comparison between SHR and normotensive rats revealed significant variation in gene expression: 98 genes were upregulated and 122 were downregulated in SHR;while 88 genes were upregulated and 139 genes were downregulated in age-matched normotensive rats. Furthermore, within the SHR group, 110 genes were found to be upregulated and 168 genes downregulated across different ages. Analyses via the Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes pathways revealed that several genes are potentially implicated in both, hypertension and metabolic syndrome. The results suggest that SHR display variations in gene expression due to aging, and when compared to normotensive rats. These variations could contribute to the development of hypertension and metabolic syndrome. Microarray studies involving older rats are necessary to further validate these findings.

关键词： Hypertension Metabolic Syndrome Gene Expression SHR Microarray

Emotions and Stressing Situations Adaptation of Nursing Students in the New Normality

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Health 2022年第7期14卷 766-774页

作者： Diana Cecilia Tapia-Pancardo Nancy Areli Martínez-Rangel Rocío Marisol Romero-Salgado José Luis Cadena-Anguiano rafael villalobos-molina División de Investigación y Posgrado Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de Enfermería Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de Odontología Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Background: New normality is uncertain in every sense, specifically in education and for many health disciplines. Being immersed in COVID-19 pandemics brought serious consequences for mental health, and is very important to handle emotions and stress coping strategies to obtain positive outcomes. Objective: To identify the most frequent emotions, as well as the adaptation strategies to the new normality faced by the students of nursing. Methods: Qualitative and phenomenological research, with the participation of 20 students from both genders in the middle term of nursing career at Faculty of Higher Studies Iztacala, National Autonomous University of Mexico, from August to November 2021. Information was collected from a focal group for ten sessions;analysis was according to De Souza Minayo, and there was a signed informed consent letter from participants. Results: Four categories emerged with sub-categories. Category I Maximized emotions. Sub-categories: 1) Frustration, anger, disappointment;2) Personal disappointment, hopelessness, uncertainty;3) Depression. Category II Support elements close to the new normality. Sub-categories: 1) Family communication;2) Education for mental and physical health. Category III Stressing situations that exceeded the student. Sub-category: Disease in lovely ones. Category IV Stress coping strategies. Sub-categories: 1) Friends and relatives that help to get better;2) Family values. Informers pointed out to have maximized emotion, and having no self-control on its negative outcomes occurred;in addition, the situation was not favorable at home with several losses of loved ones, as well as a poor economy that threatened students to give up studies. Conclusion: Emotions facing this new normality are very important and should be attended to, their proper handling will result in a new learning of socio-emotional abilities, stress coping strategies development, better adaptation and informed decisions taken.

关键词： Emotions Stressing Situations Adaptation Nursing Students New Normality

Problems-Based Learning during COVID-19 Pandemic: Experiences by Nursing Students

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Open Journal of Nursing 2021年第11期11卷 920-932页

作者： Isamar Carolina Castillo-Megchun Claudia Gabriela López-Rossell Maribel Araceli Padilla-Rivera rafael villalobos-molina Diana Cecilia Tapia-Pancardo Nursing Career Faculty of Higher Studies Iztacala National Autonomous University of Mexico Tlalnepantla Mexico Graduate and Research Division Biomedicine Unit Faculty of Higher Studies Iztacala National Autonomous University of Mexico Tlalnepantla Mexico

Introduction: Problems-based learning (PBL) methodology seeks challenges in the daily life context, where students protagonise their own learning using new technologies as the ideal means to find updated and adequate information, for its processing and dissemination towards a better active and participative role. The aim was to analyze the usefulness and importance of PBL, as a strategy of significant learning in daily experiences of nursing students during the COVID-19 pandemic. Method: The study was qualitative and phenomenological, with 15 informant students of the Module “Attention to addictions in the health area” aged 20 - 25 years, enrolled in the sixth semester of nursing from a public university. Data were collected through oral testimonies, texts, and semi-structured interviews of relevant aspects to them in their everyday life facing the COVID-19 pandemic, telling their experiences. Students signed an informed consent, and the qualitative analysis followed De Souza Minayo. Results: Four categories emerged: Category 1. Students’ experiences along pandemic;1.1, Positive experiences;1.2, Negative experiences. Category 2. Students’ knowledge and abilities for self-care along pandemic. Category 3. Abilities to promote problem solving. Category 4. Impact and usefulness of PBL in students’ experiences for health education;4.1, Positive impact of PBL;4.2 Negative impact of PBL. Conclusion: PBL is very useful for significant learning. It opens knowledge, developing skills to face, support, debate, evaluate and make decisions;it does incorporate critical thinking and problem solving. PBL does encourage collaborative work.

关键词： PBL Nurse Students Experiences COVID-19 Pandemic