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Increased paracellular permeability of tumor-adjacent areas in 1,2-dimethylhydrazine-induced colon carcinogenesis in rats

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Cancer Biology & Medicine 2018年第3期15卷 251-259页

作者： viktoria v.bekusova Evgeny L.Falchuk Larisa S.Okorokova Natalia M.Kruglova AlexANDer D.Nozdrachev AlexANDer G.Markov Department of Physiology St.Petersburg State University I.P.Pavlov Institute of Physiology Russian Academy of Sciences

Objective: The morphology and functions of the proximal and distal large intestine are not the same. The incidence of colorectal cancer in these regions is also different, as tumors more often appear in the descending colon than in the ascending *** bowel disease and colorectal cancer can increase transepithelial permeability, which is a sign of reduced intestinal barrier function. However, there is not enough evidence to establish a connection between the difference in colorectal cancer incidence in the proximal and distal colon and intestinal permeability or the effects of carcinogenesis on the barrier properties in various areas of the colon. The aim of the study was to assess the permeability of different segments of the large intestine according to a developed mapping methodology in healthy rats and rats with 1,2-dimethylhydrazine(DMH)-induced colon ***: The short circuit current, the transepithelial electrical resistance and the paracellular permeability to fluorescein of large intestine wall of male Wistar rats were examined in the Ussing chambers. The optical density of the solution from the serosa side to assess the concentration of the diffused fluorescein from mucosa to serosa was analyzed by spectrophotometry. The morphometric and histological studies were performed by optical ***: Rats with DMH-induced colon adenocarcinomas showed elevated transepithelial electrical resistance in the areas of neoplasm development. In contrast, there was no change in the electrophysiological properties of tumor adjacent areas, however,the paracellular permeability of these areas to fluorescein was increased compared to the control rats and was characterized by sharply reduced barrier ***: The barrier properties of the colon vary depending on tumor location. The tumors were less permeable than the intact intestinal wall and probably have a negative influence on tumor-adjacent tissues by disrupting their bar

关键词： Rat 1,2-dimethylhydrazine colorectal cancer Ussing chamber short circuit current transepithelial electrical resistance intestinal permeability

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Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats

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Cancer Biology & Medicine 2017年第1期14卷 100-107页

作者： viktoria v.bekusova vasily M.Patsanovskii Alexander D.Nozdrachev Alexandr P.Trashkov Margarita R.Artemenko vladimir N.Anisimov Department of Physiology St.Petersburg State UniversitySt.Petersburg 197183Russia I.P.Pavlov Institute of Physiology Russian Academy of Sciences St.Petersburg 199034Russia Deparment of Experimental Pharmacology I.M.Sechenov Institute of Evolutionary Physiology and BiochemistryThe Russian Academy of SciencesSt.Petersburg 194223Russia Department of Carcinogenesis and Oncogerontology N.N.Petrov Research Institute of OncologySt.Petersburg 197758 Russia

Effects of two doses of the anti-diabetic drug, metformin （MF）, on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine （DMH）-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin- like growth factor-l, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized maiority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.

关键词： Colon cancer prevention 1,2-dimethylhydrazine mefformin rat

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Postglacial incision-infill cycles at the Borisoglebsk Upland: Correlations between interfluve headwaters and fluvial network

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International Soil and Water Conservation Research 2019年第2期7卷 184-195页

作者： Yuliya v.Shishkina Ekaterina v.Garankina vladimir R.Belyaev Ilya G.Shorkunov Pavel v.Andreev Aleksey I.Bondar viktoria I.Potapova Tatiana A.verlova Faculty of Geography Department of Geomorphology and Palaeogeography and Laboratory for Soil Erosion and Fluvial ProcessesLomonosov Moscow State UniversityLeninskie Gory1Moscow 119991Russia Institute of Geography Department of Soil Geography and EvolutionRussian Academy of SciencesStaromonetnyj Lane29Moscow 119017Russia Institute of Earth Sciences of Saint-Petersburg State University St.PetersburgUniversitetskaya nab.7-9 199034Russia

The article discusses postglacial landscape transformation in the Northern Hemisphere Middle Pleistocene glaciation area located in the center of the Russian *** attempted to verify the regional paleogeographic model by reconstructing the Late Pleistocene incision-infill cycles at the Eastern Borisoglebsk Upland based on a comparison of inactive interfluves headwaters and actual fluvial network *** study was also aimed to determine the past extent of fluvial *** research of the actual and buried topography,Ethology and pedogenic properties of surface deposits was carrid out with remote sensing data interpretation,DGPS survey,and detailed description of geological cores *** study was followed by analysis of grain size,chemical and organic contents,microstructure,and numerical *** the available results,we propose a scenario of the fluvial network transformation at the Eastem Borisoglebsk Upland over the last 150 *** least four fluvial incision stages were determined while network extent has significantly changed through the Late *** can be generally associated with the regional base level decrease-Late Moscow,Late valdai and Late Holocene and accompanying isolation of the Nero Lake terraces of 130 m,100-105 m and 95-98 *** stages were separated by landscape stability or aggradation periods those were asynchronous at the middle and upper parts of the fluvial *** main agent of initial valley infill appears to be local lacustrine sedimentation altered by alluvial and colluvial deposition towards the second half of *** landscape conditions variability emphasize the importance of comprehensive local correlations for regional retrospective models.

关键词： Interfluve headwaters Fluvial Incision-Infill Cycle Pleistocene

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Highly efficient THz four-wave mixing in doped silicon

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Light(Science & Applications) 2021年第5期10卷 806-811页

作者： Nils Dessmann Nguyen H.Le viktoria Eless Steven Chick Kamyar Saeedi Alberto Perez-Delgado Sergey G.Pavlov Alexander F.G.van der Meer Konstantin L.Litvinenko Ian Galbraith Nikolay v.Abrosimov Helge Riemann Carl R.Pidgeon Gabriel Aeppli Britta Redlich Benedict N.Murdin Radboud University Institute for Molecules and MaterialsHFML-FELIXNijmegenThe Netherlands Advanced Technology Institute and Department of Physics University of SurreyGuildford GU27XHUK Institute of Optical Sensor Systems German Aerospace CenterBerinGermany Institute of Photonics and Quantum Sciences SUPAHeriot-Watt UniversityEdinburghUK Leibniz-Institut fur Kristallzuchtung(IKZ) BerlinGermany Laboratory for Solid State Physics ETH Zurich8093 ZurichSwitzerland Institut de Physique EPFL1015 LausanneSwitzerland Paul Scherrer Institute 5232 VlligenSwitzerland

Third-order non-linearities are important because they allow control over light pulses in ubiquitous high-quality centro-symmetric materials like silicon and *** four-wave mixing provides a direct measure of the third-order non-linear sheet susceptibility x^(3)(where L represents the material thickness)as well as technological possibilities such as optically gated detection and emission of *** picosecond pulses from a free electron laser,we show that silicon doped with P or Bi has a value of x^(3)Lin the THz domain that is higher than that reported for any other material in any wavelength *** immediate implication of our results is the efficient generation of intense coherent THz light via upconversion(also a x^(3)process),and they open the door to exploitation of nondegenerate mixing and optical nonlinearities beyond the perturbative regime.

关键词： mixing wave Highly

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Effects of cumulative COvID-19 cases on mental health:Evidence from multi-country survey

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World Journal of Psychiatry 2023年第7期13卷 461-477页

作者： Shanaya Rathod Saseendran Pallikadavath Elizabeth Graves Mohammad M Rahman Ashlea Brooks Pranay Rathod Rachna Bhargava Muhammad Irfan Reham Aly Haifa Mohammad Saleh Al Gahtani Zahwa Salam Steven Wai Ho Chau Theone S E Paterson Brianna Turner viktoria Gorbunova vitaly Klymchuk Peter Phiri Department of Research and Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Portsmouth-Brawijaya Centre for Global Health University of PortsmouthPortsmouth PO12UPUnited Kingdom Salford Business School University of SalfordSalford M54WTUnited Kingdom Patient and Public Involvement Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Department of Psychiatry All India Institute of Medical SciencesNew Delhi 110029India Department of Mental Health Psychiatry and Behavioral SciencesPeshawar Medical CollegeRiphah International UniversityIslamabad 46000Pakistan Department of Clinical Services Ministry of HealthCairo 4262114Egypt College of Medicine and Medical Sciences Arabian Gulf UniversityBahrain 329Bahrain Peshawar Dental College Ripah International UniversityIslamabad 46000Pakistan Department of Psychiatry The Chinese University of Hong KongHong KongChina Department of Psychology University of VictoriaVictoria BC V8P 5C2Canada Department of Social Psychology Zhytomyr State UniversityZhytomyr 10002Ukraine National Psychological Association Mental Health for Ukraine ProjectEuropean Federation of Psychologists'AssociationGFAKyiv 04071Ukraine School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom

BACKGROUND Depression and anxiety were both ranked among the top 25 leading causes of global burden of diseases in 2019 prior to the coronavirus disease 2019(COvID-19)*** pandemic affected,and in many cases threatened,the health and lives of millions of people across the globe and within the first year,global prevalence of anxiety and depression increased by 25%with the greatest influx in places highly affected by *** To explore the psychological impact of the pandemic and resultant restrictions in different countries using an opportunistic sample and online questionnaire in different phases of the *** A repeated,cross-sectional online international survey of adults,16 years and above,was carried out in 10 countries(United Kingdom,India,Canada,Bangladesh,Ukraine,Hong Kong,Pakistan,Egypt,Bahrain,Saudi Arabia).The online questionnaire was based on published approaches to understand the psychological impact of COvID-19 and the resultant *** standardised measures were included to explore levels of depression[patient health questionnaire(PHQ-9)],anxiety[generalized anxiety disorder(GAD)assessment],impact of trauma[the impact of events scale-revised(IES-R)],loneliness(a brief loneliness scale),and social support(The Multidimensional Scale of Perceived Social support).RESULTS There were two rounds of the online survey in 10 countries with 42866 participants in Round 1 and 92260 in Round *** largest number of participants recruited from the United Kingdom(112985 overall).The majority of participants reported receiving no support from mental health services throughout the *** study found that the daily cumulative COvID-19 cases had a statistically significant effect on PHQ-9,GAD-7,and IES-R *** scores significantly increased in the second round of surveys with the ordinary least squares regression results with regression discontinuity design specification(to control lockdown effects)confirming these ***

关键词： COvID-19 Mental health Global research International Pandemic Impact

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