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Polyhydroxybutyrate/Hydroxyapatite Highly Porous Scaffold for Small Bone Defects Replacement in the Nonload-bearing Parts

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Journal of Bionic Engineering 2017年第4期14卷 648-658页

作者： Fedor Senatov Natalia Anisimova Mikhail Kiselevskiy Aleksey Kopylov viktor Tcherdyntsev Aleksey Maksimkin National University of Science and Technology MISIS Leninskiy pr. 4 Moscow 119049 Russian Federation N.N. Blokhin Russian Cancer Research Center Kashirskoye sh. 23 Moscow 115478 Russian Federation

In the present work, Polyhydroxybutyrate （PHB）/Hydroxyapatite （HA） porous composites （10%, 20%, 30 %, 40%, 50% weight HA） were obtained by sintering. PHB/20% HA optimally combines satisfactory mechanical properties with a high content of the bioactive component （HA）. Porous PHB/20% HA scaffolds have shown high mechanical properties （compressive strength of 106 MPa and Young＇s modulus of 901 MPa）. A high volume fraction of interconnected pores （〉 50 vol.%） was achieved with pore size of 50 grn - 500 gm. Biocompatibility of porous pure PHB and PHB/20%HA, as its osseointegration were assessed in vitro and after implantation in laboratory animals. PHB/20% HA （-5% ＋ 0.9%） and pure PHB ~3% ~ 1.4%） samples after 24 hours of incubation with human leucocytes showed no significant level of cytotoxicity when p = 0.648 （p-value）. In vitro massive adhesion of mouse Multipotent Mesenchymal Stromal Cells （MMSC） to the surface of both porous samples was shown. PHB/20% HA induced more intensive MMSC proliferation compared to pure PHB, which are 31% ＋ 6.1% and 20% ＋ 5.7 % respectively when p = 0.039. We observed the resorption （implant surface area was reduced by 49 %） and integration of the porous PHB/20% HA samples into surrounding tissues after 30 days of implantation. The signs of osteoclasts accumulation, neo-angigenesis and new bone formation were observed, which make PHB/20% HA promising for bone tissue engineering.

关键词： polyhydroxybutyrate hydroxyapatite scaffold porous structure implant bone regeneration

Period variations of Algol-type eclipsing binaries AD And, TW Cas and IV Cas

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Research in Astronomy and Astrophysics 2018年第4期18卷 115-122页

作者： Stefan Parimucha Pavol Gajdos viktor Kudak Miroslav Fedurco Martin Vanko Institute of Physics Faculty of Science University of E J. Safarik 044 01 Kosice Slovakia Astronomical Institute Slovak Academy of Sciences 059 60 Tatranska Lomnica Slovakia

We present new analyses of variations in O-C diagrams of three Algol-type eclipsing binary stars：AD And,TW Cas and IV *** have used all published minima times（including visual and photographic）as well as newly determined ones from our and Super Wasp *** determined orbital parameters of 3^（rd） bodies in the systems with statistically significant errors,using our code based on genetic algorithms and Markov chain Monte Carlo *** confirmed the multiple nature of AD And and the triple-star model of TW Cas,and we proposed a quadruple-star model of IV Cas.

关键词： binaries close — binaries eclipsing — techniques photometric — stars individual(AD And TW Cas IV Cas)

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JIC总部设计

现代装饰 2024年第3期 78-85页

作者： Tomas Kozelsky(设计) viktor Odstrcilik(设计) Alexandra Georgescu(设计) Katerina Batkova(设计) Tana Kantor(设计) Marketa Fiserova(设计) Josef Rehak(设计) Natalie Hradilikova(设计) BoysPlayNice(摄影) 舒禹(编译) 不详

捷克建筑工作室KOGAA与南摩拉维亚创新中心(JIC)共同完成了其位于布尔诺的第二个改造项目,JIC作为支持该地区企业的重要开放创新生态系统,为学生、初创企业、规模化企业和老牌企业提供空间和支持服务。疫情期间和之后,工作模式发生变化... 详细信息

捷克建筑工作室KOGAA与南摩拉维亚创新中心(JIC)共同完成了其位于布尔诺的第二个改造项目,JIC作为支持该地区企业的重要开放创新生态系统,为学生、初创企业、规模化企业和老牌企业提供空间和支持服务。疫情期间和之后,工作模式发生变化,更趋向开放和协作。因此,原先的固定结构布局已过时,作为另类改造工作空间的专家,KOGAA被要求为办公室提出一个新的愿景,以促进协作,激活创造力,为新的公司结构寻找可持续的解决方案。

关键词：创新生态系统初创企业改造项目摩拉维亚布尔诺建筑工作室结构布局可持续的

Machine learning for exploring small polaron configurational space

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npj Computational Materials 2022年第1期8卷 1183-1191页

作者： viktor C.Birschitzky Florian Ellinger Ulrike Diebold Michele Reticcioli Cesare Franchini University of Vienna Faculty of Physics and Center for Computational Materials ScienceViennaAustria University of Vienna Vienna Doctoral School in PhysicsBoltzmanngasse 51090ViennaAustria Institute of Applied Physics Technische Universität Wien1040ViennaAustria Department of Physics and Astronomy’Augusto Righi’ Alma Mater Studiorum-Universitàdi BolognaBologna40127Italy

Polaron defects are ubiquitous in materials and play an important role in many processes involving carrier mobility,charge transfer and surface *** small polarons’spatial distributions is essential to understand materials properties and ***,the required exploration of the configurational space is computationally demanding when using first principles ***,we propose a machine-learning(ML)accelerated search that determines the ground state polaronic *** ML model is trained on databases of polaron configurations generated by density functional theory(DFT)via molecular dynamics or random *** establish a mapping between configurations and their stability,we designed descriptors modelling the interactions among polarons and charged point *** used the DFT+ML protocol to explore the polaron configurational space for two surface-systems,reduced rutile TiO_(2)(110)and Nb-doped SrTiO_(3)(001).The ML-aided search proposes additional polaronic configurations and can be utilized to determine optimal polaron distributions at any charge concentration.

关键词： configuration polaron charge

Harnessing the potential of gene editing technology using CRISPR in inflammatory bowel disease

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World Journal of Gastroenterology 2019年第18期25卷 2177-2187页

作者： viktor Limanskiy Arpita Vyas Lakshmi Shankar Chaturvedi Dinesh Vyas Department of Surgery San Joaquin General Hospital College of Medicine CNSU College of Medicine and College of Pharmacy California Northstate University

The molecular scalpel of clustered regularly interspersed short palindromic repeats/CRISPR associated protein 9(CRISPR/Cas9) technology may be sharp enough to begin cutting the genes implicated in inflammatory bowel disease(IBD) and consequently decrease the 6.3 billion dollar annual financial healthcare burden in the treatment of IBD. For the past few years CRISPR technology has drastically revolutionized DNA engineering and biomedical research field. We are beginning to see its application in gene manipulation of sickle cell disease,human immunodeficiency virus resistant embryologic twin gene modification and IBD genes such as Gatm(Glycine amidinotransferase, mitochondrial),nucleotide-binding oligomerization domain-containing protein 2, KRT12 and other genes implicated in adaptive immune convergence pathways have been subjected to gene editing, however there are very few publications. Furthermore,since Crohn's disease and ulcerative colitis have shared disease susceptibility and share genetic gene profile, it is paramount and is more advantageous to use CRISPR technology to maximize impact. Although, currently CRISPR does have its limitations due to limited number of specific Cas enzymes, off-target activity,protospacer adjacent motifs and crossfire between different target sites. However,these limitations have given researchers further insight on how to augment and manipulate enzymes to enable precise gene excision and limit crossfire between target sites.

关键词： Clustered regularly interspersed short palindromic repeats Inflammatory bowel disease Crohn’s disease Ulcerative colitis Gene excision Gene editing Gene therapy Financial impact of inflammatory bowel disease on healthcare Clustered regularly interspersed short palindromic repeats crossfire

Advances in soil erosion research:Mechanisms,modeling and applications-A special issue in honor of *** Nearing

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International Soil and Water Conservation Research 2023年第4期11卷 589-591页

作者： viktor Polyakov Claire Baffaut Vito Ferro Scott Van Pelt Southwest Watershed Research Center USDA-ARS2000 E Allen RdTucsonAZ85718USA Cropping Systems and Water Quality Research Unit USDA-ARS241 Ag Engineering BuildingUniversity of MissouriColumbiaMO65211USA Department of Agricultural Food and Forest SciencesUniversity of PalermoViale Delle ScienzeBuilding 490128PalermoItaly Cropping Systems Research Laboratory USDA-ARS38104th StLubbockTX79401USA

*** Long-term sustainability of soils is one of the critical challenges facing *** erosion is an intrinsic geomorphological pro-cess,which if accelerated can threaten natural ecosystems and agri-culture through loss of productivity,sedimentation,and associated *** efforts to mitigate these problems require changes in management practices and large *** puts special emphasis on understanding physical processes driving soil erosion,developing techniques for accurate estimation of erosion rates and its on-site and off-site impacts,as well as devel-oping new modeling,prediction,and management tools.

关键词： soil erosion driving

Evolutionary Process from Mockina bidentata to Parvigondolella andrusovi:Evidence from the Pizzo Mondello Section,Sicily,Italy

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Journal of Earth Science 2021年第3期32卷 667-676页

作者： Yixing Du Tetsuji Onoue viktor Karadi Ian S.Williams Manuel Rigo Department of Geosciences University of Padova35131 PadovaItaly Department of Earth and Planetary Sciences Kyushu UniversityFukuokaJapan Department of Palaeontology Eotvos Lorand UniversityBudapest 1117Hungary Research School of Earth Sciences The Australian National UniversityACT 2601 CanberraAustralia Institute of Geosciences and Earth Resources National Research Council of Italy35131 PadovaItaly

During their last phase of evolution,the pectiniform conodont elements manifested an evident trend of simplification and *** phase started from the late Norian(Sevatian)in the Late Triassic and the evolutionary process of genus Mockina to Parvigondolella,in particular between Mockina bidentata and Parvigondolella andrusovi,is one of the most significant *** has been reported worldwide since it was first described in the early ***,it has recently been suggested that genus Parvigondolella is an ecostratigraphic morphotype of genus Mockina,and thus a phenotype controlled by the environmental conditions,and not an independent *** the Pizzo Mondello Section(Sicily,Italy),transitional forms between *** and *** have been found at different evolutionary *** have investigated the oceanic conditions at the time by using redox-sensitive elements(Mn,Fe,V,Cr,and Ni)and seawater temperatures from biogenetic δ^(18)Ophos to understand the possible environmental influences on the phylogenetic evolution between Mockina and *** geochemical and isotope analyses indicate that the redox condition and temperature were stable during the evolution of genus Parvigondolella in Pizzo Mondello,confirming that genus Parvigondolella is a real taxon and not a phenotype.A new conodont species named Parvigondolella ciarapicae *** described here for the first time.

关键词： conodont Late Triassic evolution oxygen isotope geochemistry

Revision of the Conodont Mockina slovakensis and Its Paleogeographic Implications for the Upper Triassic Intraplatform Basins of the Alps

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Journal of Earth Science 2021年第3期32卷 657-666页

作者： Yixing Du viktor Karadi Guido Roghi Maurizio Ponton Andrea Cozzi Manuel Rigo Department of Geosciences University of Padova35131 PadovaItaly Department of Palaeontology Eotvos Lorand UniversityBudapest 1117Hungary Institute of Geosciences and Earth Resources National Research Council of Italy35131 PadovaItaly Department of Mathematics and Geosciences University of Trieste34128 TriesteItaly Eni Sharjah B.V 73500 SharjahUnited Arab Emirates

Mockina slovakensis,thought to have evolved from Epigondolella praeslovakensis,is an important species of the Norian(Upper Triassic),generally considered as the representative of the uppermost Alaunian to upper Sevatian in the *** previous description of *** was incomplete,thus has led to some *** thus update the description of *** and discuss its comparisons and occurrence based on the new conodont investigations in Dolomia di Forni and the data from previous *** conodont assemblage in the succession of Dolomia di Forni is dominated by ***,along with rare *** and *** described two morphotypes of ***(morphotypes A and B),on the basis of shape of the lateral *** two morphotypes can also be observed in the ***,*** is usually documented as almost monospecific conodont association in intraplatform basins,thus its paleogeographic implications are also discussed.

关键词： Mockina conodont morphotype intraplatform basin

Chronic hepatitis B in pregnant women: Current trends and approaches

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World Journal of Gastroenterology 2021年第23期27卷 3279-3289页

作者： Maria Belopolskaya viktor Avrutin Olga Kalinina Alexander Dmitriev Denis Gusev Polyclinical Department Botkin's Infectious Disease HospitalSt-Petersburg 195067Russia Chronic Viral Infectious Disease Lab Institute of Experimental MedicineSt-Petersburg 197376Russia Institute for Systems Theory University of StuttgartStuttgart 70569Baden-WurttembergGermany Faculty of Biomedical Sciences Almazov National Medical Research CentreSt-Petersburg 197341Russia Department of Molecular Microbiology Institute of Experimental MedicineSt-Petersburg 197376Russia Botkin's Infectious Disease Hospital St-Petersburg 195067Russia

Chronic hepatitis B(CHB)is a significant public health problem *** aim of the present review is to summarize the actual trends in the management of CHB in pregnant *** prevalence of hepatitis B virus(HBV)infection in pregnant women is usually comparable to that in the general population in the corresponding geographic *** women have to be screened for hepatitis B surface antigen(HBsAg)during *** examinations of pregnant women with CHB may include maternal hepatitis B e antigen,HBV viral load,alanine aminotransferase level,and HBsAg *** management of pregnancy depends on the phase of the HBV infection,which has to be determined before *** women of childbearing age with CHB,antiviral therapy can pursue two main goals:Treatment of active CHB,and vertical transmission *** pregnancy,tenofovir is the drug of choice in both cases.A combination of hepatitis B immunoglobulin and vaccine against hepatitis B should be administered within the first 12 h to all infants born to mothers with *** such cases,there are no contraindications to breastfeeding.

关键词： Chronic hepatitis B Hepatitis B viral load Pregnancy Antiviral treatment Newborns Mother-to-child transmission