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Hepatic Kaposi sarcoma: A case report and review of the literature

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World Journal of Hepatology 2017年第4期9卷 171-179页

作者： Brett Van Leer-Greenberg Abhisake Kole Saurabh chawla Department of Medicine Emory University School of Medicine Division of Digestive Diseases Department of Medicine Emory University School of Medicine

Kaposi sarcoma(KS) is an aggressive cancer caused by human herpesvirus-8, primarily seen in immunocompromised patients. As opposed to the well-described cutaneous manifestations and pulmonary complications of KS, hepatic KS is rarely reported before death as most patients with hepatic KS do not manifest symptoms or evidence of liver injury. In patients with acquired immune deficiency syndrome, hepatic involvement of KS is present in 12%-24% of the population on incidental imaging and in approximately 35% of patients with cutaneous KS if an autopsy was completed after their death. Patients with clinically significant hepatic injury due to hepatic KS usually have an aggressive course of disease with hepatic failure often progressing to multi-organ failure and death. Here we report an unusual presentation of acute liver injury due to hepatic KS and briefly review the published literature on hepatic KS.

关键词： Herpesvirus 8 Acquired immune deficiency syndrome-related Kaposi sarcoma Acquired immune deficiency syndrome hepatopathy Human Kaposi sarcoma

Scleral resection in chronic central serous chorioretinopathy complicated by exudative retinal detachment

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Eye and Vision 2016年第1期3卷 183-187页

作者： Pradeep Venkatesh Rohan chawla Koushik Tripathy Harsh Inder Singh Ravi Bypareddy Department of Ophthalmology Dr.Rajendra Prasad Centre for OphthalmologyAll India Institute of Medical SciencesNew Delhi 110029India

Background:Effective therapeutic options are limited for the management of chronic central serous chorioretinopathy(CSCR)complicated by exudative retinal detachments(RD).The authors describe the resolution of one such case following partial thickness scleral resection with mitomycin *** presentation:This 39-year-old male presented with a unilateral inferior exudative RD in the right *** was no history of steroid use either locally or *** fundus fluorescein angiogram showed window defects and leaks typical of chronic *** axial length was 21.06 mm in the right eye and 21 mm in the left *** of the ocular coats was evident on ocular *** an axial length in the borderline-low range inferotemporal and inferonasal partial thickness scleral resection with mitomycin C was *** exudative RD resolved at 4 ***:Partial thickness scleral resection may be considered as an option for treating chronic CSCR patients with borderline-low axial length complicated by exudative RD.

关键词： Nanophthalmos Uveal effusion syndrome Diffuse retinal pigment epitheliopathy Sclerectomy

Analysis of isoquinoline alkaloids from Mahonia leschenaultia and Mahonia napaulensis roots using UHPLC-Orbitrap-MSn and UHPLC-QqQ LIT-MS/MS

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Journal of Pharmaceutical Analysis 2017年第2期7卷 77-86页

作者： Awantika Singh vikas Bajpai Sunil Kumar Ajay Kumar Singh Rawat Brijesh Kumar Sophisticated Analytical Instrument Facility Division CSIR-Central Drug Research InstituteLucknow 226031India Academy of Scientific and Innovative Research New Delhi 110001India Pharmacognosy and Ethnopharmacology Division CSIR-National Botanical Research InstituteLucknow 226001India

Mahonia leschenaultia（ML） and Mahonia napaulensis（MN） are less known and unexplored medicinal plants of the family Berberidaceae. They are used by the Todas of Nilgiris in their religious and medical practices but chemically less identified. Hence, we decided to do extensive phytochemical analysis to explore the potential of these plant extracts. An ultrahigh performance electrospray tandem mass spectrometry（UHPLC-ESI-MS/MS）method was successfully developed for qualitative analysis of the bioactive components in Mahonia species using Orbitrap Velos Pro mass spectrometer. Sixteen compounds were identified by comparison of their retention times and mass spectra（MS） with authentic standards and reported literature. Multi-stage mass spectra（MS（2-8）） for the identification of protoberberine and aporphine alkaloids showed the sequential expulsion of all the substituents attached with their basic skeleton followed by CO loss. Eight of the identified compounds（berberine, jatrorrhizine, palmatine, magnoflorine, isocorydine, glaucine, tetrahydropalmatine and tetrahydroberberine） were simultaneously determined by another UHPLC-ESI-MS/MS method under the multiple reactions monitoring（MRM） mode quantitatively using triple quadrupole linear ion trap mass spectrometer. The analytical method was validated for 8 bioactive compounds with overall recovery in the range98.5%-103.6%（RSD≤2.2%）, precise（RSD≤2.07%） and linear（r≥0.9995） over the concentration range of 0.5-1000 ng/mL and successfully applied in ML and MN roots, which suggests the suitability of the proposed approach for the routine analysis of Mahonia species and their quality control.

关键词： Orbitrap-MS QqQLIT-MS Mahonia leschenaultia Mahonia napaulensis Isoquinoline alkaloids

Alkali feldspar syenites with shoshonitic affinities from Chhotaudepur area: Implication for mantle metasomatism in the Deccan large igneous province

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Geoscience Frontiers 2014年第2期5卷 261-276页

作者： K.R.Hari N.V.Chalapathi Rao vikas Swarnkar Guiting Hou School of Studies in Geology and Water Resource Management Pt.Ravishankar Shukla University Centre of Advance Study in Geology Banaras Hindu University Department of Civil Engineering Yugantar Institute of Technology and Management The Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space Sciences Peking University

Two petrologically distinct alkali feldspar syenite bodies （AFS-1 and AFS-2） from Chhotaudepur area, Deccan Large Igneous Province are reported in the present work. AFS-1 is characterized by hypidio-morphic texture and consists of feldspar （Or55Ab43 to Or25Ab71）, ferro-pargasite/ferro-pargasite horn-blende, hastingsite, pyroxene （Wo47, En5, Fs46）, magnetite and biotite. AFS-2 exhibits panidiomorphic texture with euhedral pyroxene （Wo47-50, En22-39, Fs12e31） set in a groundmass matrix of alkali feldspar （Or99Ab0.77 to Or1.33Ab98）, titanite and magnetite. In comparison to AFS-1, higher elemental concentra-tions of Ba, Sr and PREE are observed in AFS-2. The average peralkaline index of the alkali feldspar syenites is w1 indicating their alkaline nature. Variation discrimination diagrams involving major and trace elements and their ratios demonstrate that these alkali feldspar syenites have a shoshonite affinity but emplaced in a within-plate and rifting environment. No evidence of crustal contamination is perceptible in the multi-element primitive mantle normalized diagram as well as in terms of trace elemental ratios. The enrichment of incompatible elements in the alkali feldspar syenites suggests the involvement of mantle metasomatism in their genesis.

关键词： Alkali feldspar syenite Deccan large igneous province Mineralogy Geochemistry Shoshonite Mantle metasomatism

The role of genomic structural variation in the genetic improvement of polyploid crops

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The Crop Journal 2019年第2期7卷 127-140页

作者： Sarah-Veronica Schiessl Elvis Katche Elizabeth Ihien Harmeet Singh chawla Annaliese S.Mason Department of Plant Breeding Justus Liebig University

Many of our major crop species are polyploids, containing more than one genome or set of chromosomes. Polyploid crops present unique challenges, including difficulties in genome assembly, in discriminating between multiple gene and sequence copies, and in genetic mapping, hindering use of genomic data for genetics and breeding. Polyploid genomes may also be more prone to containing structural variation, such as loss of gene copies or sequences(presence–absence variation) and the presence of genes or sequences in multiple copies(copynumber variation). Although the two main types of genomic structural variation commonly identified are presence–absence variation and copy-number variation, we propose that homeologous exchanges constitute a third major form of genomic structural variation in polyploids. Homeologous exchanges involve the replacement of one genomic segment by a similar copy from another genome or ancestrally duplicated region, and are known to be extremely common in polyploids. Detecting all kinds of genomic structural variation is challenging, but recent advances such as optical mapping and long-read sequencing offer potential strategies to help identify structural variants even in complex polyploid genomes. All three major types of genomic structural variation(presence–absence, copy-number, and homeologous exchange) are now known to influence phenotypes in crop plants, with examples of flowering time, frost tolerance, and adaptive and agronomic traits. In this review,we summarize the challenges of genome analysis in polyploid crops, describe the various types of genomic structural variation and the genomics technologies and data that can be used to detect them, and collate information produced to date related to the impact of genomic structural variation on crop phenotypes. We highlight the importance of genomic structural variation for the future genetic improvement of polyploid crops.

关键词： Presence–absence variation Copy-number variation Homeologous exchanges Genome structure Pan-genome

Characteristics and distinct prognostic determinants of individuals with hepatosplenic T-cell lymphoma over the past two decades

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World Journal of Clinical Oncology 2024年第6期15卷 745-754页

作者： Ayrton Bangolo Pierre Fwelo Shraboni Dey Tanni Sethi Sowmya Sagireddy Jawaria Chatta Ashish Goel Sneha Nagpaul Eric Pin-Shiuan Chen Chiranjeeve Saravanan Sheeja Gangan Joel Thomas Sarah Potiguara Vignesh K Nagesh Daniel Elias Charlene Mansour Prajakta H Ratnaparkhi Priyanshu Jain Midhun Mathew Taylor Porter Shadiya Sultan Shailaja Abbisetty Linh Tran Megha chawla Abraham Lo Simcha Weissman Christina Cho Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Epidemiology Human Geneticsand Environmental SciencesUTHealth School of Public HealthHoustonTX 77030United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States Stem Cell Transplantation and Cellular Therapy John Theurer Cancer CenterHackensackNJ 07601United States

BACKGROUND Hepatosplenic T-cell lymphoma(HSTCL)is a rare and aggressive peripheral T-cell lymphoma with historically dismal outcomes,representing less than one percent of non-Hodgkin *** its rarity,the true incidence of HSTCL is unknown and most data have been extrapolated through case *** the best of our knowledge,the largest and most up to date study addressing the epidemiology and outcomes of patients with HSTCL in the United States covered a period from 1996 to 2014,with a sample size of 122 *** To paint the most updated epidemiological picture of *** A total of 186 patients diagnosed with HSTCL,between 2000 and 2017,were ultimately enrolled in our study by retrieving data from the Surveillance,Epidemiology,and End Results *** analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of *** with a P value<0.01 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors,with a hazard ratio of greater than 1 representing adverse prog-nostic *** Overall,the outlook for this rare malignancy is very *** this retrospective cohort study of the United States population,non-Hispanic blacks and the elderly had a higher *** data highlights the need for larger prospective studies to investigate factors associated with worse prognosis in one ethnic group,such as treatment delays,which have been shown to increase mortality in this racial/ethnic group for other cancers.

关键词： Extra nodal lymphoma Mortality Survival Racial disparity Age

Drag reduction by application of aerodynamic devices in a race car

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Advances in Aerodynamics 2021年第1期3卷 66-85页

作者： Devang S.Nath Prashant Chandra Pujari Amit Jain vikas Rastogi Department of Mechanical Engineering Delhi Technological UniversityDelhi 110042India

In this era of fast-depleting natural resources,the hike in fuel prices is *** stringent norms over environmental policies,the automotive manufacturers are on a voyage to produce efficient vehicles with lower ***-speed cars are at a stake to provide uncompromised performance but having strict rules over emissions drives the companies to approach through a different route to keep the demands of performance *** of the most sought-after ways is to improve the aerodynamics of the *** force is one of the major setbacks when it comes to achieving high speeds when the vehicle is in *** research aims to examine the effects of different add on devices on the vehicle to reduce drag and make the vehicle aerodynamically streamlined.A more streamlined vehicle will be able to achieve high speeds and consequently,the fuel economy is also *** three-dimensional car model is developed in SOLIDWORKS *** Fluid Dynamics(CFD)is performed to understand the effects of these add on *** is carried out in the ANSYS^(TM) 17.0 Fluent *** Coefficient(CD),Lift Coefficient(CL),Drag Force and Lift Force are calculated and compared in different *** result of the simulations was analyzed and it was observed that different devices posed several different functionalities,but maximum drag reduction was found in the case of GT with spoiler and diffuser with a maximum reduction of 16.53%.

关键词： Aerodynamics CFD Drag force Drag coefficient High speed car

Kikuchi-Fujimoto disease:A comprehensive review

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World Journal of Clinical Cases 2023年第16期11卷 3664-3679页

作者： Vikram K Mahajan vikas Sharma Neeraj Sharma Ritu Rani Department of Dermatology Venereology and LeprosyDr.Radhakrishnan Government Medical CollegeHamirpur 177001Himachal PradeshIndia

Kikuchi-Fujimoto disease,a rare form of necrotizing lymphadenitis,is an uncommon,benign,self-limiting disorder of obscure *** affects mostly young adults of both ***,it presents with fever and lymphadenopathy of a firm to rubbery consistency frequently involving cervical lymph nodes while weight loss,splenomegaly,leucopenia,and elevated erythrocyte sedimentation rate feature in severely affected *** involvement occurs in about 30%-40%of cases as facial erythema and nonspecific erythematous papules,plaques,acneiform or morbilliform lesions of great histologic *** Kikuchi-Fujimoto disease and systemic lupus erythematosus share an obscure and complex relationship as systemic lupus erythematosus may occasionally precede,develop subsequently,or sometimes be associated concurrently with Kikuchi-Fujimoto *** is often mistaken for non-Hodgkin lymphoma while lupus lymphadenitis,cat-scratch disease,Sweet’s syndrome,Still’s disease,drug eruptions,infectious mononucleosis,and viral or tubercular lymphadenitis are other common *** needle aspiration cytology mostly has features of nonspecific reactive lymphadenitis and immunohistochemistry studies usually show variable features of uncertain diagnostic *** its diagnosis is exclusively from histopathology,it needs to be evaluated more carefully;an early lymph node biopsy will obviate the need for unnecessary investigations and therapeutic *** treatment with systemic corticosteroids,hydroxychloroquine,or antimicrobial agents mostly remains *** article reviews clinicoepidemiological,diagnostic,and management aspects of KFD from the perspective of practicing clinicians.

关键词： Cervical lymphadenopathy Histiocytic necrotizing lymphadenitis Kikuchi’s disease Lymphadenopathy Lymphoma Systemic lupus erythematosus

Intraocular fine needle aspiration cytology as a diagnostic modality for retinoblastoma

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1233-1235页

作者： Bhavna chawla Anand Tomar Seema Sen Mandeep S.Bajaj Seema Kashyap Ocular Oncology & Paediatric Ophthalmology Service Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences Ocular Pathology Service Dr. Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences

INTRODUCTION The diagnosis of retinoblastoma(RB)is usually made by clinical examination and imaging modalities such as B-scan ultrasonography of the eye,CT scan and MRI of the *** role of fine needle aspiration cytology(FNAC)as a diagnostic modality for RB has been controversial,mainly due to concerns of tumor dissemination and extra-ocular spread[1-2].Although the majority of RB cases can be diagnosed without the need for any invasive procedure,in

关键词： FNAC RB