Kikuchi-Fujimoto disease:A comprehensive review

作     者：Vikram K Mahajan Vikas Sharma Neeraj Sharma Ritu Rani 

作者机构：Department of DermatologyVenereology and LeprosyDr.Radhakrishnan Government Medical CollegeHamirpur 177001Himachal PradeshIndia 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2023年第11卷第16期

页      面：3664-3679页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cervical lymphadenopathy Histiocytic necrotizing lymphadenitis Kikuchi’s disease Lymphadenopathy Lymphoma Systemic lupus erythematosus 

摘      要：Kikuchi-Fujimoto disease,a rare form of necrotizing lymphadenitis,is an uncommon,benign,self-limiting disorder of obscure *** affects mostly young adults of both ***,it presents with fever and lymphadenopathy of a firm to rubbery consistency frequently involving cervical lymph nodes while weight loss,splenomegaly,leucopenia,and elevated erythrocyte sedimentation rate feature in severely affected *** involvement occurs in about 30%-40%of cases as facial erythema and nonspecific erythematous papules,plaques,acneiform or morbilliform lesions of great histologic *** Kikuchi-Fujimoto disease and systemic lupus erythematosus share an obscure and complex relationship as systemic lupus erythematosus may occasionally precede,develop subsequently,or sometimes be associated concurrently with Kikuchi-Fujimoto *** is often mistaken for non-Hodgkin lymphoma while lupus lymphadenitis,cat-scratch disease,Sweet’s syndrome,Still’s disease,drug eruptions,infectious mononucleosis,and viral or tubercular lymphadenitis are other common *** needle aspiration cytology mostly has features of nonspecific reactive lymphadenitis and immunohistochemistry studies usually show variable features of uncertain diagnostic *** its diagnosis is exclusively from histopathology,it needs to be evaluated more carefully;an early lymph node biopsy will obviate the need for unnecessary investigations and therapeutic *** treatment with systemic corticosteroids,hydroxychloroquine,or antimicrobial agents mostly remains *** article reviews clinicoepidemiological,diagnostic,and management aspects of KFD from the perspective of practicing clinicians.