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Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika m.joshi Theresa Currier Thomas Nafisa m.Jadavji College of Osteopathic medicine Midwestern UniversityGlendaleCAUSA Department of Biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of B-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of B-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that B-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin B12 vitamin B2 vitamin B3

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Novel one-pot synthesis of 4H-chromene derivatives using amino functionalized silica gel catalyst

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Chinese Chemical Letters 2014年第3期25卷 455-458页

作者： vijaykumar m.joshi Rupali L.magar Prashant B.Throat Sunil U.Tekale Bhagavan R.Patil mangal P.Kale Rajendra P.Pawar Department of Chemistry Karmveer Ramraoji Aher ArtsScience and Commerce College Department of Chemistry Deogiri College Department of Chemistry Dnyanopasak College Department of Chemistry Sharda Mahavidyalaya

A simple, efficient, and environmentally benign method for the synthesis of 4H-chromene derivatives was developed using well ordered and recoverable amino functionalized silica gel as a base catalyst. The 4H-chromene derivatives were obtained in short time and excellent yield （87%-96%） by three component reaction of aldehydes, malononitrile and cyclic 1,3-diketones in water at 70 ℃.

关键词： Aldehydes4H-ChromenesAmino functionalized silica gel

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Overview of perspectives on cancer,newer therapies,and future directions

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Oncology and Translational medicine 2024年第3期10卷 105-109页

作者： Rajeev m.joshi Bhushan Telang Gagan Soni Asma Khalife Department of General Surgery T.N.Medical College&B.Y.L.Nair Charitable HospitalMumbaiIndia Department of Surgical Oncology Government Cancer Hospital AurangabadMaharashtraIndia Department of Surgical Disciplines All India Institute of Medical ScienceNew DelhiIndia

Theword“cancer”is associated with terrifying situations,and there is often an aggressive intent to *** about survival and fear of disfigurement cause major turmoil in the minds of patients and *** with multimodal care is the key to achieving satisfactory *** imaging modalities have aided in early detection and derivation of optimal treatment *** radical excision of tumors with neoadjuvant or concurrent chemotherapy/radiotherapy has long been the best management option,we have moved froma radical to a conservative *** advanced disease,the plan should be to provide supportive care and improve quality of *** and counseling play important *** support for correcting cancer cachexia is equally important during tumor *** therapies such as targeted therapy,stem cell therapy,and chemodynamic therapy are all focused on ensuring safe and efficient outcomes;however,the war against cancer continues to oscillate between hope and despair.

关键词： Cancer modern medicine Preventive oncology Psychology Nutrition

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印度杨树林地的农林复合种植：经济利益及其在碳储存中的作用（英文）

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Journal of Resources and Ecology 2024年第4期 880-888页

作者： Rajeev joshi Bharat SHARmA Hukum SINGH Nabin DHAKAL Santosh AYER Tek mARASENI 尼泊尔农林学院自然资源管理学院尼泊尔加德满都社区可持续发展倡议组织(SIFC) 印度森林研究所南昆士兰大学生命科学与环境研究所

农林复合种植被认为是一种既有生产效益又有环境保护效益的可持续土地利用策略。在印度旁遮普等地区，种植杨树在农民中越来越受欢迎，这些农民发展了成功的基于杨树的农林复合种植技术，有效利用土地资源，并协调作物的种植时机和布局... 详细信息

农林复合种植被认为是一种既有生产效益又有环境保护效益的可持续土地利用策略。在印度旁遮普等地区，种植杨树在农民中越来越受欢迎，这些农民发展了成功的基于杨树的农林复合种植技术，有效利用土地资源，并协调作物的种植时机和布局以提高经济收益。对于块状种植，有效的树间距为5 m×4 m，而排状种植将树木间隔安排在1–3 m之间。与其他树种相比，杨树被认为能够为农民带来更高的利润。本文在系统综述137篇英文期刊文章的基础上，通过比较短轮杨树（SRC）和非常短轮杨树（v SRC）种植，采用贴现现金流（DCF）分析，对比评估了不同种植方式的经济利益。杨树种植增加了遮蔽水平，从而导致作物产量下降，从早春到收获期，30%、60%和90%的遮蔽水平分别导致减产37%、70%和99%。扩大杨树的行间距可减轻资源竞争。在印度萨哈朗普普尔地区的成本效益分析表明，基于杨树的农林复合种植平均年净收益为346.36美元/年，而纯作物轮作仅为140.73美元/年。在亚穆那加尔和哈里杜瓦尔地区的经济分析显示，收益成本比介于2.35–3.70之间。杨树组成的块状和边界种植在长期生物量中贮存了大量碳，并作为化石燃料的替代品（块状和边界种植中，每公顷贮存碳量分别为5.45和1.84吨/年）。此外，它们通过提高土壤侵蚀等级、侵蚀比例和水稳团聚体，有助于控制土壤侵蚀。总之，农林复合种植系统通过有效贮存碳并为农民提供燃料、饲料、木材和木制品，在缓解对现有自然森林的压力方面发挥着关键作用。

关键词：农林复合种植杨树经济可行性碳封存印度

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尼泊尔桑可西河流域新格地子流域滑坡评价

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Journal of Resources and Ecology 2024年第2期15卷 431-438页

作者： BASNET Bhuwan joshi Rajeev SHARmA Ram Prasad SUBEDI Rajan 特里布万大学林业研究所(博卡拉校区) 尼泊尔博卡拉33700 尼泊尔农林大学自然资源管理学院林学系尼泊尔卡塔里56310

山体滑坡是尼泊尔山区的主要灾害,主要是由于其脆弱的地貌、强烈的降雨、不当的土地管理和在修建山区道路过程中没有采取必要的稳定措施所导致的。由于频繁的山体滑坡,下游地区人类的生命财产遭受了巨大损失,并导致生态系统生产力和功... 详细信息

山体滑坡是尼泊尔山区的主要灾害,主要是由于其脆弱的地貌、强烈的降雨、不当的土地管理和在修建山区道路过程中没有采取必要的稳定措施所导致的。由于频繁的山体滑坡,下游地区人类的生命财产遭受了巨大损失,并导致生态系统生产力和功能下降,河道泥沙淤积。土地利用与土地覆被、地形、道路、排水、地质环境和降雨等多种空间因素与滑坡的发生紧密相关,并决定了该地区滑坡的易感性。了解滑坡现象及其引发的相关因素,对于采取适当的预防、控制和恢复措施至关重要。本研究在尼泊尔桑科西河流域的新格地子流域进行,旨在了解滑坡危害、引发的相关因素以及为最大限度地减少可能的危害而采取的最佳预防策略。滑坡评估是通过使用时序谷歌影像和实地调查,对滑坡体进行识别和数字化来进行的。利用GIS软件对滑坡危险性进行评估,编制影响因子图,并对现场观测数据进行分析的基础上,计算了滑坡的规模。此外,在相关家庭的问卷调查(n=60)中,进行目的性抽样,探讨人们对山体滑坡、对生计资产的主要影响因素的看法。并采用Friedman非参数检验评估滑坡对当地人感知的最主要影响因素。根据现场调查,在研究区域的不同位置共调查了46处滑坡体,滑坡总面积为4.77km^(2)。通过使用Friedman检验的比较矩阵分析,本研究确定了滑坡发生的主要原因是农村道路、施工、边坡因素、降雨和土地利用与土地覆被。距离道路200-500 m造成最高比率的滑坡灾害,东南方向坡度30°-45°的山体对滑坡的易感性最高。与其他土地利用相比,因为在林内松软地区修建道路,茂密的森林更易受到山体滑坡的影响。比较道路建设前后滑坡的影响,约80%的受访者认为对滑坡有重要影响。

关键词：滑坡灾害滑坡评估滑坡因素分析

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Double-face urethroplasty in patients with obliterative bulbar strictures post-transurethral resection of the prostate mid-term outcomes in high-volume referral center

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Asian Journal of Urology 2023年第4期10卷 512-517页

作者： Pankaj m.joshi manuel Hevia Yatam Lakshmi Sreeranga marco Bandini Amey Patil Shreyas Bhadranavar Vipin Sharma Sandeep Bafna Sanjay B.Kulkarni Kulkarni Reconstructive Urology Center 3Rajpath SocietyPaud RoadPune 411038India Urology Department Ramón y Cajal University HospitalIRYCISUniversity of AlcaláMadridSpain Urological Research Institute(URI) Unit of UrologyIRCCS Ospedale San RaffaeleVita SaluteSan Raffaele UniversityMilanMIItaly

Objective Incidences of post-transurethral resection of the prostate(post-TURP)strictures are between 2.2%and 9.8%.Stricture commonly occurs within the first 6 *** objective was to assess the outcomes of patients with obliterative strictures post-TURP that underwent a double-face *** This is a single-center prospective study of 17 patients with obliterative proximal bulbar stricture post-TURP who underwent double-face graft urethroplasty by two surgeons between January 2014 and January *** defined post-TURP obliterative strictures as those patients who presented with complete or almost complete obstruction of the urethral lumen and who have had a history of acute urine *** have excluded patients with bladder neck *** outcome was treatment success,defined as the no need for further *** outcome was post-urethroplasty continent *** Seventeen patients were included in the study with median age of 66(interquartile range 40-77)years;median time of follow-up was 24(interquartile range 12-84)months;median stricture length was 4(interquartile range 2-6)*** the 17 patients,15(88.2%)were *** patients were continent after *** With mid-term follow-up,treatment of obliterative proximal bulbar strictures with double-face buccal mucosa graft is a safe and effective *** proximal bulbar strictures merit double-face urethroplasty with high-rate success and functional outcomes.

关键词： Double-face urethroplasty Obliterative urethral stricture Post-transurethral resection of prostate Urethral stricture Spongiofibrosis Iatrogenic stricture

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Flaps for bulbar urethral ischemic necrosis in pelvic fracture urethral injury

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Plastic and Aesthetic Research 2022年第1期9卷 678-687页

作者： Pankaj m.joshi marco Bandini Christian Yepes Sandeep Bafna Shreyas Bhadranavar Vipin Sharma Giuseppe Ottone Cirulli Sanjay B.Kulkarni Kulkarni Endo Surgery Institute and Reconstructive Urology Center PuneMaharashtra 411038India Urological Research Institute(URI) IRCCS Ospedale San RaffaeleVita-Salute San Raffaele UniversityMilan 20132Italy Centro Chirurgico Toscano Arezzo 52100Italy

Bulbar urethral ischemic necrosis(BUIN)is an iatrogenic entity resulting from repeated attempts at performing anastomotic urethroplasty for pelvic fracture urethral *** speaking,BUIN is related to a compromised blood supply of the bulbar urethra,which normally relies on anterograde supply from bulbar arteries and retrograde supply from recurrent branches of dorsal penile arteries,through the *** each transection of the bulbar urethra,both the anterograde and retrograde supplies are compromised,increasing the risk of *** though this term is widely used among reconstructive urologists,BUIN is orphan of an accepted scientific *** aim to report our personal perspective on BUIN,to identify factors associated with its occurrence,and to describe the management options in these patients.

关键词： Bulbar urethral ischemic necrosis inferior pubectomy pedicled preputial tube Q-flap

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Global wild rice germplasm resources conservation alliance:World Wild-Rice Wiring

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molecular Plant 2024年第4期17卷 516-518页

作者： Xiaoming Zheng Disna Ratnasekera Jiayu Fan Robert J.Henry Beng-Kah Song Kenneth m.Olsen Bal Krishna joshi maria Celeste N.Banaticla-Hilario Tonapha Pusadee Adane Getachew melaku Yeyinou Laura Estelle Loko Koukham Vilayheuang Gavers K.Oppong Samuel Aduse Poku Peterson W.Wambugu Song Ge Aldo merotto Junior Ohn mar Aung Ramaiah Venuprasad Ajay Kohli Wenbin Zhou Qian Qian National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Sanya National Research Institute of Breeding in Hainan Chinese Academy of Agricultural SciencesBeijing 100081China International Rice Research Institute DAPO Box 7777Metro Manila 4031Philippines Department of Agricultural Biology Faculty of AgricultureUniversity of RuhunaMatara 81000Sri Lanka Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China Hainan University Haikou 570228China ARC Centre of Excellence for Plant Success in Nature and Agriculture University of QueenslandBrisbaneQLD4072Australia School of Science Monash University Malaysia47500 Bandar SunwaySelangor 47500Malaysia Department of Biology Washington University in St.LouisSt.LouisMO 63130-4899USA National Agriculture Genetic Resources Center(Genebank) KhumaltarPO Box 3055KathmanduNepal Plant Biology Division Insttute of Biological SciencesUniversity of the Pilippines Los BanosLos BanosLaguna 4031Philippines Division of Agronomy Department of Plant and Soil SciencesFaculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Bio and Emerging Technology Institute Addis Ababa 1165Ethiopia National University of Sciences TechnologiesEngineering and Mathematics(UNSTIM)Dassa-ZouméBP 14Benin National Genebank Rice and Cash Crops Research CenterNAFRIVientiane 0605Lao PDR Plant Sciences and the Bioeconomy Rothamsted ResearchHarpenden AL52JQUK UK Future Food Beacon of Excellence and School of Biosciences and University of Nottingham Nottingham LE125RDUK Department of Plant and Environmental Biology University of GhanaAccraGhana Kenya Agricultural and Livestock Research Organization Genetic Resources Research InstituteNairobi 00200Kenya Institute of Botany Chinese Academy of SciencesBeijing 100093China Federal University of Rio Grande do Sul UFRGSPorto Alegre 91501-970RSBrazil Department of Agricultur

Wild relatives of crop are key genetic resources serving as diversity reservoirs for crop improvement under changing ***(Oryza sativa)is one of the most important crops in the world,providing staple food for half of the world's *** rice is thus a critical germplasm resource for sustained global food security,ensuring high production yields,improved quality,and stress resistance in the face of climate *** rice is closely related to domesticated rice and has a rich genetic diversity and exceptional adaptability to extreme *** has played a pivotal role in the history of rice hybridization and has become a key resource for rice breeding *** identification of wild-type cytoplasmic male sterility resources paved the way for the achievement of the“three lines”goal in hybrid rice,leading to a significant increase in rice *** addition,the use of resistance alleles found in wild rice is making rice production more resilient to losses caused by environmental ***,wild rice germplasm resources are threatened due to habitat destruction and other anthropogenic *** the same time,the lack of centralized distribution of wild rice has hampered the sharing of basic information on wild rice resources and the utilization and conservation of wild rice in each country,as well as collaboration among scientists.

关键词： germplasm breeding crops

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Crustal Deformation Revealed by GPS in Kumaun Himalaya,India

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Journal of mountain Science 2014年第1期11卷 41-50页

作者： Rakesh K.DUmKA Bahadur S.KOTLIA Kireet KUmAR Gokul S.SATYAL Lalit m.joshi Institute of Seismological Research Centre of Advanced Study in Geology Kumaun University G.B.Pant Institute of Himalayan Environment and Development

The foremost Global Positioning System(GPS) derived measurements in the Kumaun Himalaya indicate that most of the crustal motion of the Indian plate is accommodating towards the base as well as on the hanging wall of main Central Thrust(mCT).Deformation pattern within the Kumaun Himalaya varies from south to north and indicates maximum deformation rate near *** study,based on the campaign mode GPS survey during 2003- 2006,reveals that the area between north of North Almora Thrust(NAT) and at the base of Great Himalaya registers maximum strain rate,which is lowered towards the Trans Himadri Fault(THF).The GAmIT-GLOBK processed campaign data of the area show that currently,the Himalayan Frontal Fault(HFF) and main Boundary Thrust(mBT) are locked with the Indian plate,and a 6.7 ± 2.5 mm/yr of horizontal shortening is taking place between the Lesser Himalaya and Peninsular India.

关键词： Kumaun Himalaya Faults thrust systems Deformation Convergence Crustal strain

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Assessing anthropogenic pressure and threats on Paeonia emodi *** Royle habitats in Garhwal Himalaya

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Journal of mountain Science 2023年第3期20卷 810-820页

作者： Praveen joshi Prem PRAKASH Vijay Kant PUROHIT Department of Botany Govt.M.B.P.G.CollegeHaldwani 263641Indial High Altitude Plant Physiology Research Centre H.N.B.Garhwal Central UniversitySrinagar Garhwal 263671India

The Garhwal Himalaya is among the major repositories of immensely valuable wild edible plants and provides food security to the local *** the valuable plant species that grow in this region,Paeonia emodi(family Paeoniaceae)is an important wild edible species that found in temperate regions with an altitude range between 1800 and 2800 *** species is facing a severe threat to its sustainability due to overharvesting,habitat disturbances,and a lack of effort regarding *** the first time,this study investigated anthropogenic pressure,population decline perceptions in the natural habitat,and vulnerability assessment of *** under selected study sites(n=23 villages).A semi structured questionnaire was used to interview approximately 45%of the local inhabitants,including herbal practitioners(Vaidhyas or Dais)of each *** the basis of demographic characteristics,the perceptions and responses of 464 local people were documented regarding potential causes of deterioration and feasible options for sustainable *** the weight survey method,we estimated the actual amount of collection based on personal interaction and direct *** order to determine the threats status,a rapid vulnerability assessment(RVA)was performed and were used based on the current exploitation and *** present study revealed that leaf(100%)was the most frequently harvested part,followed by stem(95.65%),seed(26.09%),root(21.74%)and flower(13.04%).The village Triyuginarayan and Pothivasa recorded the highest collection scores while the purpose of the collection was mostly edible(100%),medicinal(100%),and least commercial(8.70%).According to the literature review and the present survey,the RVA(total=21)is categorized as category II(intermediate side of the RVA index),indicating a degree of *** study revealed that *** faces extinction in the Garhwal *** this species through agro-production techniques may alleviate th

关键词： Anthropogenic pressure Conservational strategies Garhwal Himalaya Paeonia emodi Rapid vulnerability assessment Wild edibles

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