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Defence Technology（防务技术） 2014年第3期10卷 251-260页

作者： G.MAGUDEESWARAn Sreehari R.nair L.SUnDAR n.HARIKAnnAn Department of Mechanical Engineering PSNA College of Engineering and Technology Ador Welding Limited Melakottaiyur

The activated TIG(ATIG) welding process mainly focuses on increasing the depth of penetration and the reduction in the width of weld bead has not been paid much *** shape of a weld in terms of its width-to-depth ratio known as aspect ratio has a marked influence on its solidification cracking *** major influencing ATIG welding parameters,such as electrode gap,travel speed,current and voltage,that aid in controlling the aspect ratio of DSS joints,must be optimized to obtain desirable aspect ratio for DSS *** in this study,the above parameters of ATIG welding for aspect ratio of ASTM/UnS S32205 DSS welds are optimized by using Taguchi orthogonal array(OA)experimental design and other statistical tools such as Analysis of Variance(AnOVA) and Pooled AnOVA *** optimum process parameters are found to be 1 mm electrode gap,130 mm/min travel speed,140 A current and 12 V *** aspect ratio and the ferrite content for the DSS joints fabricated using the optimized ATIG parameters are found to be well within the acceptable range and there is no macroscopically evident solidification cracking.

关键词： Duplex stainless steel ATIG welding Aspect ratio Taguchi design Ferrite number Solidification cracking

Extended criteria donors in liver transplantation—from marginality to mainstream

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Hepatobiliary Surgery and nutrition 2018年第5期7卷 386-388页

作者： Amit nair Koji Hashimoto Department of General Surgery Digestive Disease and Surgery Institute Cleveland Clinic Cleveland OH USA

Further to refinements in immunosuppression and the significant gains witnessed in outcomes over recent decades, liver transplantation has firmly established itself as the definitive treatment for end stage liver disease and selected instances of hepatic malignancy. However, there exists a constant divide between organ supply and demand, with the numbers of new entrants to liver transplant waiting lists consistently and significantly outstripping that of transplants performed annually, as exemplified by United network for Organ Sharing (UnOS) data from the United States (1).

关键词： annually stripping lists

Fuzzy inferencing-based path planning with a cyber-physical framework and adaptive second-order SMC for routing and mobility control in a robotic network

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IET Cyber-Systems and Robotics 2020年第3期2卷 149-160页

作者： Anuj nandanwar Ranjith Ravindranathan nair Laxmidhar Behera Department of Electrical Engineering Indian Institute of Technology KanpurKanpur 208016India Department of Electronics and Communication Engineering Indian Institute of Information Technology PunePune 411048India

In this study,the authors address the problem of optimal routing and relative motion control in a network of *** path planning scheme has been designed using a fuzzy-based potential function employing optimal routing *** optimal routing variables,such as routing probability and the transmission rate are obtained using a discrete optimisation *** deal with the disturbances and uncertainties in the physical system,an adaptive second-order sliding mode control(SMC)scheme has been proposed for the relative motion control of the networks of robots,where the disturbances are estimated using a novel disturbance observer and the controller parameters are updated online using an adaptive tuning algorithm derived based on Lyapunov *** robustness of the proposed path planner and the control scheme are validated through simulation as well as through real-time experimentation based on Pioneer P3-DX *** comparison results based on conventional SMC and adaptive SMC are also drawn.

关键词： network Pioneer tuning

Gastric electrical stimulation: An emerging therapy for children with intractable gastroparesis

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World Journal of Gastroenterology 2019年第48期25卷 6880-6889页

作者： Aniruddh Setya Priyanka nair Sam Xianjun Cheng Department of Pediatric Gastroenterology Hepatology and Nutrition University of Florida

Management of gastroparesis remains challenging,particularly in pediatric *** care and pharmacological therapies for symptoms remain the mainstay *** they are effective for mild and some moderately severe cases,often time they do not work for severe *** are a few prokinetics available,yet the use of these drugs is limited by a lack of persistent efficacy and/or safety ***,the only modality for adult patients with severe intractable gastroparesis is surgery,e.g.,pyloroplasty and partial gastrectomy,however,this option is generally considered too radical for a growing *** therapeutic approaches,particularly those which are less invasive,are *** article explores gastric electrical stimulation(GES),a new therapy for *** others,it neither needs medications nor gastrectomy;rather,it treats through the use of microelectrodes to deliver high-frequency low energy electric stimulation to the pacemaker area of the ***,it is tolerated and safe in *** in adult patients,GES appears to work in releasing symptoms,improving nutrition,and enhancing the quality of life;it also helps wean off medications and eliminate many needs for *** the transient nature of gastroparesis in children in many occasions,GES is considered a“bridging”therapy after failed medical interventions and before surgery.

关键词： Gastroparesis Gastric electrical stimulation nausea Vomiting Prokinetics

A Comparative Study of the Technological Characteristics of Cotton Fibers from Two Types of Gins in Côte d’Ivoire

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American Journal of Plant Sciences 2025年第1期16卷 11-21页

作者： Brou Julien Kouakou Tièba Victor Ouattara Koffi Christophe Kobenan Kouadio Emmanuel n’Goran nogbou Ferdinand Amangoua Malanno Kouakou n’Guessan Maxime Kouame Centre national de Recherche Agronomique Programme Coton Bouak Cte dIvoire UFR Agroforesterie Universit Jean Lorougnon Gud Daloa Cte dIvoire

Production of this crop is experiencing significant challenges, resulting in a decline in seed and fiber quality. To address this challenge, generations of high-performance cotton plants of the Gossypium hirsutum L. species have been developed and are currently being commercialized. This study evaluated the impact of gin types on the agro-industrial quality of cotton in Côte d’Ivoire. To this end, cotton from the G3, R1, and R2 generations was harvested, sampled, and ginned on machines with 10 and 170 saws in the localities of Ouangolodougou, Ferkessédougou, Korhogo, M’Bengué, Boundiali, Séguéla, and Mankono, as well as at the Centre national de Recherche Agronomique CnRA) in Bouaké. The results demonstrated that cotton fibers obtained from ginning on 10-saw machines exhibited superior quality compared to those from 170-saw machines. Fiber length, fiber length uniformity, and short fiber rate exhibited the highest deviations according to gin type. The use of 170-saw gins resulted in a notable decline in quality. Conversely, micronaire index, fiber tenacity and elongation, and reflectance remained consistent across machine types. These results will enable us to more effectively regulate and advise cotton-processing factories, which primarily utilize 170-saw gins to enhance agro-industrial quality in Côte d’Ivoire. Furthermore, these results will assist breeders in incorporating them into their processes to enhance the quality of the varieties they offer to farmers.

关键词： Agro-Industrial Quality Technological Characteristics Gossypium Hirsutum L. Saw Gin Côte d’Ivoire

Health anxiety and work loss in patients diagnosed with serrated polyposis syndrome:A cross sectional study

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World Journal of Clinical Oncology 2025年第2期16卷 52-62页

作者： Angus Thompson natalie R Dierick Louise Heiniger Stuart n Kostalas School of Clinical Medicine University of New South WalesPort Macquarie 2444New South WalesAustralia Department of Gastroenterology Port Macquarie GastroenterologyPort Macquarie 2444New South WalesAustralia

BACKGROUnD Serrated polyposis syndrome(SPS)is a polyposis condition with neoplastic potential,but its psychological impact is not well *** To assess health anxiety prevalence in a regional Australian cohort of SPS patients and explore factors influencing it,including workforce impacts of regular *** This cross-sectional study screened patients aged 18-65 undergoing colonoscopy in a regional gastroenterology practice between January 2015 and June *** SPS patients were invited to *** included the Short Health Anxiety Inventory,employment status,and previous demographic and medical *** Health anxiety was found in 21.57%of SPS patients,with anxious patients being significantly more concerned about surveillance(OR=7.70).Patients lost an average of 11.04 work hours per *** Health anxiety in SPS patients aligns with rates in other gastroenterology *** it may improve management,though further research is needed to better understand prevalence and care improvements.

关键词： Serrated polyposis syndrome Health anxiety Colorectal cancer Surveillance

On Regularization of a Source Identification Problem in a Parabolic PDE and its Finite Dimensional Analysis

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Journal of Partial Differential Equations 2021年第3期34卷 240-257页

作者： MOnDAL Subhankar nair M.Thamban Department of Mathematics IIT MadrasChennai 600036India

We consider the inverse problem of identifying a general source term,which is a function of both time variable and the spatial variable,in a parabolic PDE from the knowledge of boundary measurements of the solution on some portion of the lateral *** transform this inverse problem into a problem of solving a compact linear operator *** the regularization of the operator equation with noisy data,we employ the standard Tikhonov regularization,and its finite dimensional realization is done using a discretization procedure involving the space L^(2)(0,τ;L^(2)(Ω)).For illustrating the specification of an a priori source condition,we have explicitly obtained the range space of the adjoint of the operator involved in the operator equation.

关键词： Ill-posed source identification Tikhonov regularization weak solution

Pharmacometrics of nutraceutical sulforaphane and its implications in prostate cancer prevention

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Journal of Chinese Pharmaceutical Sciences 2016年第1期25卷 12-22页

作者： Sujit nair Ah-ng Tony Kong Amrita Cancer Discovery Biology Laboratory Amrita Vishwa Vidyapeetham University Center for Cancer Chemoprevention Research and Department of Pharmaceutics Rutgers The State University of New Jersey

Sulforaphane(SFn), found in broccoli and other cruciferous vegetables, has a beneficial effect in chemoprevention of prostate cancer, whose incidence and associated mortality have gradually increased worldwide. There is great enthusiasm for bench-to-bedside development of SFn as a potent chemopreventive agent, possibly alone or as an adjunct to existing chemotherapy regimens, in the oncology care setting to reduce toxicity of chemotherapeutics and potentially enhance their cancer cell-kill efficacy. In this review, we appreciate existing knowledge on SFn using a pharmacometrics approach, which is fast becoming a gold standard in discovery research and validation of new Chemical Entities and new Biological Entities in pharmaceutical industry. We discuss the epistemology of SFn target engagement and quantitative systems pharmacology with due emphasis on mechanistic pharmacology, pharmacodynamics, pharmacogenomics and metabolism of SFn. In addition, we explore the quantitative freeway to SFn translational medicine by assessing the preclinical and clinical PK/metabolism aspects of SFn that form the cornerstone of SFn pharmacometric evaluation, as well as the promise of SFn in prostate cancer. Taken together, we share perspectives on the exciting developments in translational cancer chemoprevention, with emphasis on the pharmacometric aspects, of the nutraceutical SFn which is currently in clinical trials, and suggest that the pharmacometric approach holds great promise in the SFn translational pharmacology paradigm for prostate cancer.

关键词： Pharmacometrics Pharmacokinetics Quantitative systems pharmacology Target engagement Metabolism Pharmacogenomics Chemoprevention Sulforaphane Isothiocyanate Prostate cancer

Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World Journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： Hasan M Isa Marwa J Abdulnabi nawra S naser Fatema n Lahmda noor M AlAnsari Zahra H Isa Afaf M Mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of Medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUnD Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CMPA).AIM To evaluate CMPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CMPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya Medical Complex,Bahrain,between 2014 and 2022,and assessed CMPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the Mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CMPA and 595(96.3%)were included;CMPA prevalence was 2%.Most patients were Bahraini(93.8%)and males(55.3%).non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CMPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Pnd presented with more cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Pnd positive physical findings(P=0.002)than non-IgE-mediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CMPA was associated with a longer follow-up duration than non-IgE-mediated CMPA(17.3 months±14.0 mo

关键词： Children Milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

The Quest toward limb regeneration:a regenerative engineering approach

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Regenerative Biomaterials 2016年第2期3卷 123-125页

作者： Cato T.Laurencin Lakshmi S.nair Department of Orthopaedic Surgery Institute for Regenerative EngineeringRaymond and Beverly Sackler Center for BiomedicalBiologicalPhysical and Engineering SciencesUniversity of Connecticut HealthFarmingtonCT 06030USA Department of Biomedical Engineering University of ConnecticutStorrsCT 06269USA Department of Materials Science and Engineering University of ConnecticutStorrsCT 06269USA Department of Chemical and Biomolecular Engineering University of ConnecticutStorrsCT 06269USA Department of Craniofacial Sciences School of Dental MedicineUniversity of Connecticut HealthFarmingtonCT 06030USA.

The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated *** remarkable advances in the scientific understanding of regeneration,stem cell science,material science and engineering,physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound *** we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration.

关键词： regenerative engineering limb regeneration stem cells advanced biomaterial science clinical translation