The Quest toward limb regeneration:a regenerative engineering approach

作     者：Cato T.Laurencin Lakshmi S.Nair 

作者机构：Department of Orthopaedic SurgeryInstitute for Regenerative EngineeringRaymond and Beverly Sackler Center for BiomedicalBiologicalPhysical and Engineering SciencesUniversity of Connecticut HealthFarmingtonCT 06030USA Department of Biomedical EngineeringUniversity of ConnecticutStorrsCT 06269USA Department of Materials Science and EngineeringUniversity of ConnecticutStorrsCT 06269USA Department of Chemical and Biomolecular EngineeringUniversity of ConnecticutStorrsCT 06269USA Department of Craniofacial SciencesSchool of Dental MedicineUniversity of Connecticut HealthFarmingtonCT 06030USA. 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2016年第3卷第2期

页      面：123-125页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the NIH Director’s Pioneer Award,1DP1AR068147,R21-AR062771,R01-AR063698 funding from Raymond and Beverly Sackler Center for Biomedical,Biological,Physical and Engineering Sciences.C.T.L.was the recipient of the Presidential Faculty Fellowship Award from President William Clinton and the Presidential Award for Excellence in Science,Mathematics,and Engineering Mentorship and the National Medial of Technology and Innovation from President Barack Obama. 

主　　题：regenerative engineering limb regeneration stem cells advanced biomaterial science clinical translation 

摘      要：The Holy Grail to address the clinical grand challenge of human limb loss is to develop innovative strategies to regrow the amputated limb.The remarkable advances in the scientific understanding of regeneration,stem cell science,material science and engineering,physics and novel surgical approaches in the past few decades have provided a regenerative tool box to face this grand challenge and address the limitations of human wound healing.Here we discuss the convergence approach put forward by the field of Regenerative Engineering to use the regenerative tool box to design and develop novel translational strategies to limb regeneration.