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In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 595-601页

作者： Mayank Gangwar vijay C Verma Tryambak D singh Sushil K singh RK Goel Gopal Nath Department of Microbiology Institute of Medical Sciences Banaras Hindu University Department of Pharmacology Institute of Medical Sciences Banaras Hindu University Department of Medicinal Chemistry Institute of Medical Sciences Banaras Hindu University Department of Pharmaceutical Engineering Institute of Technology Banaras Hindu University

Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.

关键词： Protoscolicidal Echinococcus Hydatidosis Mallotus sp. Anti-helminthic agents Trypan blue

Zinc partitioning in basmati rice varieties as influenced by Zn fertilization

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The Crop Journal 2018年第2期6卷 136-147页

作者： Prakash Chand Ghasal Yashbir singh Shivay vijay Pooniya Mukesh Choudhary Rakesh Kumar Verma ICAR-Indian Agricultural Research Institute New Delhi 110012India

Zinc(Zn) ferti-fortification using different sources and methods in Zn deficient soils is being advocated to increase Zn concentration in rice kernel as an alternative to pursuing greater Zn-use efficiency(ZnUE). A two-year field study was conducted to assess the effect of Zn application on Zn content and uptake at several growth stages and in several parts of the rice kernel: hull, bran, and the white rice kernel. Variety ‘PB 1509' with 1.25 kg Zn ha^(-1) as Zn-EDTA + 0.5% foliar spray(FS) at maximum tillering(MT) and panicle initiation(PI) stages registered the highest Zn content in hull, bran, and white rice kernel. Among parts of the rice kernel, Zn concentration decreased in the order hull > bran > white rice kernel,indicating that brown rice kernels are much denser in Zn content than polished *** the higher Zn accumulation in the bran, brown rice consumption, especially in Asia and Africa, could be recommended to overcome Zn malnutrition. The variety ‘PB 1401'showed the highest Zn uptake in rice straw, while ‘PB 1509' showed the highest Zn uptake in hull and white rice kernel. Application of 1.25 kg Zn ha^(-1)(Zn-EDTA) + 0.5% FS at MT and PI and 2.5 kg Zn ha^(-1) ZnSO_4·7H_2O(ZnSHH) + 0.5% FS at MT and PI resulted in higher Zn uptake than other treatments. On average, about one third of total Zn uptake remained in the white rice kernel, with the remaining two thirds accumulating in both hull and bran of brown rice. Zn-EDTA along with 0.5% FS, despite the application of a lower quantity of Zn leading to the highest Zn mobilization efficiency index(ZnMEI) and Zn-induced nitrogen recovery efficiency(ZniNRE), produced the highest kernel yield. However, of the two Zn sources, Zn-EDTA contributed more to the increase in ZnUE than did ZnSHH.

关键词： Aromatic rice Zn fertilization Zn-EDTA ZnSO4·7H2O Zn use efficiency Zn mobilization efficiency index

Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.:A review

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BIOCELL 2023年第5期47卷 1159-1176页

作者： vijay KUMAR PRAVEEN C.RAMAMURTHY SIMRANJEET singh DALJEET singh DHANJAL PARUL PARIHAR DEEPIKA BHATIA RAM PRASAD JOGINDER singh Central Ayurveda Research Institute JhansiUttar Pradesh284003India Interdisciplinary Centre for Water Research Indian Institute of SciencesBangalore560012India Department of Biotechnology Lovely Professional UniversityPhagwaraPunjab144411India Department of Botany Lovely Professional UniversityPhagwaraPunjab144411India Department of Biotechnology Baba Farid CollegeBathindaPunjab151001India Department of Botany Mahatma Gandhi Central UniversityMotihari845401India Department of Microbiology Lovely Professional UniversityPhagwaraPunjab144411India

Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese *** several decades,the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever,diabetes,constipation,jaundice,ulcers,biliousness,anemia,anorexia,and *** the traditional system,Indian gooseberry has various ethnomedicinal *** the Ayurvedic system,different methods of administration(anupan)have shown different ethnomedicinal properties of Indian *** well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation,among which the flavonoids and phenols are most *** the toxicity perspective,it is considered a safe herb in India,and is taken as a food supplement in European *** wide-spectrum pharmacological activities of the crude extracts and isolates of Indian gooseberry are attributed to the predominance of phenols and ***,it is important to study the exact mechanism of the activity of the phytochemicals in Indian gooseberry,especially in anti-cancer *** of Indian gooseberry enhances proliferation in several cancer cells in vitro,including stem cells like ovarian cancer(OC)cells,and also has been observed to possess anti-proliferative characteristics in *** review intends to explore the therapeutic potential of Indian gooseberry based on scientific reports and attempts to find the gaps for future research.

关键词： Phyllanthus emblica Amla Vitamin C Antioxidant Stem cells Phytochemistry Pharmacology

Role of MgF2 addition on high energy ball milled kalsilite:Implementation as dental porcelain with low temperature frit

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Journal of Advanced Ceramics 2014年第4期3卷 332-338页

作者： Pattem Hemanth KUMAR Abhinav SRIVASTAVA vijay KUMAR Nandini JAISWAL Pradeep KUMAR Vinay Kumar singh Department of Ceramic Engineering Indian Institute of Technology(BHU)VaranasiIndia Department of Chemical Engineering Indian Institute of Technology(BHU)VaranasiIndia

Porcelain fused to metal(PFM)has received great attention over the last few years due to its importance in the ***(K_(2)O·Al_(2)O_(3)·SiO_(2))is a high thermal expansion porcelain,suitable for bonding to ***,kalsilite is a metastable phase which gets converted into crystalline leucite upon *** the current work feasibility of developing stable kalsilite phase,dispersion of MgF2 in it as an additive and using mechanochemical synthesis are *** fine dental material has been formulated by mixing prepared kalsilite with low temperature frit(LTF)in different *** crystalline phases evolved in fired powders are characterized by powder X-ray diffraction(XRD)*** with different ratio of LTF has been cold pressed and heat treated to examine its coefficient of thermal expansion(CTE),flexural strength,apparent porosity(AP),bulk density(BD)and *** indicate that MgF_(2) addition and high milling duration help in kalsilite *** also plays an important role in this stabilization,and at 1100℃single phase kalsilite formation is *** outcomes demonstrate that it is easily possible to synthesize a stable single phase kalsilite with desirable properties.

关键词： kalsilite porcelain fused to metal(PFM) dental ceramic mechanochemical synthesis thermal expansion X-ray diffraction(XRD)

Conservation Strategy for African Medicinal Species: In Vitro Biotechnological Approach

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 779-794页

作者： Priyanka Jha Swati Chahal Devendra Kumar Pandey Joginder singh Ram Prasad vijay Kumar Amity Institute of Biotechnology Amity UniversityKolkataWest Bengal700156India Plant Biotechnology Laboratory Division of Research and DevelopmentLovely Professional UniversityPhagwara144411PunjabIndia Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara144411PunjabIndia Department of Microbiology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara144411PunjabIndia Department of Botany School of Life SciencesMahatma Gandhi Central UniversityMotihariBihar845401India

The use of medicinal plants for different therapeutic values is well documented in African *** diverse biodiversity hotspots provide a wide range of endemic species,which ensures a potential medicinal *** feasible conservation approach and sustainable harvesting for the medicinal species remains a huge ***,conservation approach through different biotechnological tools such as micropropagation,somatic embryogenesis,synthetic seed production,hairy root culture,molecular markers based study and cryopreservation of endemic African medicinal species is much *** this review,an attempt has been made to provide different in vitro biotechnological approaches for the conservation of African medicinal *** present review will be helpful in further technology development and deciding the priorities at decision-making levels for in vitro conservation and sustainable use of African medicinal species.

关键词： Biotechnological approach conservation medicinal plant African traditional medicine(ATM) start codon targeted polymorphism(SCoT) somatic embryogenesis

A comparison of visual outcomes in three different types of monofocal intraocular lenses

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1173-1178页

作者： vijay Shetty Suhas S Haldipurkar Rujuta Gore Rita Dhamankar Anirban Paik Maninder singh Setia Laxmi Eye Institute

AIMTo compare the visual outcomes (distance and near) in patients opting for three different types of monofocal intraocular lens (IOL) (Matrix Aurium, AcrySof single piece, and AcrySof IQ lens).METHODSThe present study is a cross-sectional analysis of secondary clinical data collected from 153 eyes (52 eyes in Matrix Aurium, 48 in AcrySof single piece, and 53 in AcrySof IQ group) undergoing cataract surgery (2011-2012). We compared near vision, distance vision, distance corrected near vision in these three types of lenses on day 15 (±3) *** 69% of the eyes in the Matrix Aurium group had good uncorrected distance vision post-surgery; the proportion was 48% and 57% in the AcrySof single piece and AcrySof IQ group (P=0.09). The proportion of eyes with good distance corrected near vision were 38%, 33%, and 15% in the Matrix Aurium, AcrySof single piece, and AcrySof IQ groups respectively (P=0.02). Similarly, The proportion with good “both near and distance vision” were 38%, 33%, and 15% in the Matrix Aurium, AcrySof single piece, and AcrySof IQ groups respectively (P=0.02). It was only the Matrix Aurium group which had significantly better both “distance and near vision” compared with the AcrySof IQ group (odds ratio: 5.87, 95% confidence intervals: 1.68 to 20.56).CONCLUSIONMatrix Aurium monofocal lenses may be a good option for those patients who desire to have a good near as well as distance vision post-surgery.

关键词： visual acuity monofocal lenses cataract surgery

Randomized controlled trial of topical EMLA and vapocoolant spray for reducing pain during wDPT vaccination

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World Journal of Pediatrics 2017年第3期13卷 236-241页

作者： Navratan Kumar Gupta Amit Upadhyay Ajeet Kumar Dwivedi Astha Agarwal vijay Jaiswal Abhishek singh Department of Pediatrics LLRMMedical CollegeMeerut(UP)India

Background:Intramuscular vaccination is among the most common source of iatrogenic pain in *** sprays are rapid-acting alternative to topical *** provide transient anesthesia via evaporation induced skin cooling,and reduce pain due to vaccine injection in children and *** objective was to compare the synergistic analgesic effect of eutectic mixture of local anesthetics (EMLA) with breastfeeding (EB group) and vapocoolant spay with breastfeeding (VB group) to that of only breastfeeding (BO group) during whole cell diptheria,pertussis and tetanus (wDPT) ***:A double blind randomized controlled trial was done to include infants up to 3 months of age who came for their first wDPT *** primary outcome variable was the duration of cry after *** outcome variables were Modified Facial Coding Score,Neonatal Infant Pain Scale and latency of onset of ***:Of the 201 eligible participants,111 babies were excluded and remaining 90 babies were randomized into three groups of thirty *** groups did not differ significantly in baseline *** (interquartile range,IQR) of duration of cry was lesser [35.86 (21.07-107.75) seconds] in babies receiving EMLA cream with breast feeding (EB group) and in babies receiving vapocoolant spray with breast feeding (VB group) [32.58 (21.25-106.21) seconds] as compared to babies receiving only breast feeding (BO group) [67.5 (27.6-180) seconds] (P=-0.147).Difference in median (IQR) of latency of cry was not statistically *** Facial Coding Score and Neonatal Infant Pain Scale at 1 minute and 3 minutes was significantly lower in the EB and VB group,as compared to the BO group (P<0.05).Conclusions:Addition of topical EMLA application or vapocoolant spray to breastfeeding during wDPT vaccination does not reduce duration of cry in infants up to 3 months of ***,they are able to show reduction in pain score and further studi

关键词： diptheria,pertussis and tetanus vaccine eutectic mixture of local anesthetics Modified Facial Coding Score Neonatal Infant Pain Scale

Chemotherapy and drug resistance status of malaria parasite in northeast India

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 583-588页

作者： Diganta Goswami Indra Baruah Sunil Dhiman Bipul Rabha vijay Veer Lokendra singh Dhirendra Kumar Sharma Division of Medical Entomology Defence Research LaboratoryTezpurAssam.India Directorate of Life Sciences DRDO HQNew DelhiIndia Department of Zoology Gauhati UniversityGuwahatiIndia

India reports the highest number of malaria cases in Southeast Asia,of which Plasmodium falciparum contribute more than half of the cases every *** eastern states of India contribute only 3.96%of country’s population but account for>10%of total reported malaria cases.11%of Plasmodium falciparum cases and 20%of malaria related deaths *** India,chloroquine resistance was reported for the first time from northeast region and since then chloroquine treatment failure is being reported from many parts of the *** chloroquine treatment failure has led to change of the drug policy to artemisinin combination therapy as first line of malaria treatment in the ***,replacing chloroquine to artemisinin combination therapy has not shown significant difference in the overall malaria incidence in the region,The present review addresses the current malaria situation of northeastern region of India in the light of antimalarials drug resistance.

关键词： Malaria Chemotherapy Antimalarials Drug resistance

Atropine eye-drop-induced acute delirium:a case report

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General Psychiatry 2020年第3期33卷 197-198页

作者： Prashant Maravi Dheerendra Kumar Mishra Amrendra singh vijay Niranjan Department of Psychiatry Shyam Shah Medical CollegeRewaIndia Department of Psychiatry M.G.M.Medical CollegeIndoreIndia

Atropine is an anticholinergic drug which is used in both parental and topical *** eye-drops of atropine sulfate are used as mydriatic and *** atropine-induced delirium is well known but topical atropine eye-drop-induced delirium cases are very limited in *** this case report,an elderly man underwent cataract surgery and developed delirium after the use of 1%atropine sulfate eye-drops as *** case supports the notion that even atropine eye-drops can cause delirium in patients at therapeutic doses in elderly.

关键词： doses Atropine cataract