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Is prophylactic placement of drains necessary after subtotal gastrectomy?

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World Journal of Gastroenterology 2007年第27期13卷 3738-3741页

作者： Manoj kumarl Seung Bong Yangl vijay kumar Jaiswall Jay N Shahl Manish Shreshthal Rajesh Gongal Department of Surgery Patan Hospital Kathmandu Nepal

AIM： To determine the evidence-based values of prophylactic drainage in gastric cancer surgery. METHODS： One hundred and eight patients, who underwent subtotal gastrectomy with D1 or D2 lymph node dissection for gastric cancer between January 2001 and December 2005, were divided into drain group or no-drain group. Surgical outcome and post-operative complications within four weeks were compared between the two groups. RESULTS： No significant differences were observed between the drain group and no-drain group in terms of operating time （171 ± 42 rain vs 156 ± 39 rain）, number of post-operative days until passage of flatus （3.7 ± 0.5 d vs 3.5 ± 1.0 d）, number of post-operative days until initiation of soft diet （4.9±0.7 d vs 4.8±0.8 d）, length of post-operative hospital stay （9.3±2.2 d vs 8.4±2.4 d）, mortality rate （5.4% vs 3.8%）, and overall postoperative complication rate （21.4% vs 19.2%）. CONCLUSION： Prophylactic drainage placement is not necessary afer subtotal gastrectomy for gastric cancer since it does not offer additional benefits for the patients.

关键词： Prophylactic drainage Subtotal gastrectomy Gastric cancer Post-operative complications Operative outcome

Severe cytomegalovirus infections in immunocompetent patients at admission as dengue mimic:Successful treatment with intravenous ganciclovir

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Asian Pacific Journal of Tropical Medicine 2012年第11期5卷 920-922页

作者： Suhasini Tirumala Bijayini Behera Shilpa Lingala B.vijay kumar Pradeep kumar Mishra Gurunath JM HariCharan Kartik Naresh Yashoda Hospital SecunderabadIndia

Cytomegalovirus(CMV) infection is associated with adverse clinical outcomes in immunosuppressed *** incidence and association of CMV reactivation with adverse clinical outcomes in critically ill persons lacking evidence of immunosuppression at ICU admission has received great attention in the practice of critical care *** ill patients in ICU who had associated risk factors such as mechanical ventilation,severe sepsis, or blood transfusion are more prone to CMV activation,which in turn led to increased mortality and morbidity in tenns of increased ICU stay,longer duration of mechanical ventilation,and higher rates of nosocomial ***,severe CMV as initial presentation mimicking dengue infection is *** recently came across seven cases with positive CMV serology at ICU admission,which we discuss in the light of current literature.

关键词： Cytomegalovirus Immunosuppression Dengue Mimicking Ganciclovir

Methyl-salicylate:A surveillance system fortriggering immunity in neighboring plants

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Journal of Integrative Plant Biology 2024年第2期66卷 163-165页

作者： Saumya Jaiswal Durgesh kumar Tripathi Ravi Gupta JingHe Zhong-Hua Chen vijay Pratap Singh Plant Physiology Laboratory Department of Botany C.M.P.Degree CollegeA Constituent Post Graduate College ofUniversity of AllahabadPrayagraj 211002India Crop Nanobiology and Molecular Stress Physiology LabAmity Institute of Organic Agriculture Amity University UttarPradeshNoida 201313India College of General Education Kookmin UniversitySeoul 02707South Korea School of Science Western Sydney UniversitySydney 2751New South WalesAustralia Hawkesbury Institute for the Environment Western SydneyUniversitySydney 2751New South WalesAustralia

Plant behavioral actions have been one of the major topicsof research in plant biology and *** actionsfrom plants are determined by their instant structural andphysical reactions to the circumstances(Bouwmeester et al.,2019).Upon sensing abiotic factors such as salinity,flooding,high temperature,drought,plants make suitable changes intheir physiology and behavior to survive such harsh conditions.

关键词： immunity neighboring salinity

Effect of Helicobacter pylori-eradication therapy on hepatic steatosis in patients with non-alcoholic fatty liver disease:a randomized–controlled pilot study

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Gastroenterology Report 2020年第2期8卷 104-110,I0001,I0002页

作者： Vikas Maharshi Pooja Gupta vijay L.kumar Ashish Datt Upadhyay Prasenjit Das Rajni Yadav Baibaswata Nayak Ramesh kumar Shalimar Department of Pharmacology All India Institute of Medical SciencesNew DelhiIndia Department of Biostatistics All India Institute of Medical SciencesNew DelhiIndia Department of Pathology All India Institute of Medical SciencesNew DelhiIndia Department of Gastroenterology All India Institute of Medical SciencesNew DelhiIndia

Background:Helicobacter pylori infection has been associated with insulin resistance and non-alcoholic fatty liver disease(NAFLD).This study was done to evaluate the effect of ***-eradication therapy(HPET)in patients with NAFLD compared to standard management therapy(SMT).Methods:Eighty NAFLD patients with *** co-infection were randomized into SMT(diet and exercise,n=36)and HPET(SMT plus amoxicillin,clarithromycin,and pantoprazole,n=44)*** controlled attenuation parameter(CAP),anthropometric parameters,liver enzymes,lipid profile,and glycemic parameters including homeostasis model assessment-insulin resistance(HOMA-IR)were measured and compared between two groups at the baseline and 24 ***:Sixty-four participants(SMT group[n=28]and HPET group[n=36])were included in amodified intention-to-treat *** the SMT group and the HPET group had a significant reduction in CAP scores at 24weeks(P=0.002 and P<0.001,respectively),but the change between the groups was insignificant(P=0.213).Successful eradication of *** occurred in 68%of the HPET group and led to greater improvement in HOMA-IR at 24weeks compared to SMT or non-responder patients(P=0.007).The liver enzymes reduced significantly at 24weeks in both groups,but the changes between the groups were *** lipid parameters remained unchanged within the groups and between the groups at 24weeks.A significant increase in the levels of reduced glutathione was noted in the HPET group,but the change between the two groups was not statistically ***:HPET was found to be comparable to SMT alone in reducing hepatic steatosis and liver enzymes at 24 weeks in NAFLD ***,successful eradication of *** led to greater improvement in HOMA-IR(Trial registration CTRI/2017/05/008608).

关键词： non-alcoholic fatty liver disease H.pylori infection H.pylori-eradication therapy controlled attenuation parameter insulin resistance

Analysis of docosanol using GC/MS:Method development,validation,and application to ex vivo human skin permeation studies

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Journal of Pharmaceutical Analysis 2022年第2期12卷 287-292页

作者： vijay kumar Shankar Mei Wang Srinivas Ajjarapu Praveen Kolimi Bharathi Avula Reena Murthy Ikhlas Khan Sathyanarayana Narasimha Murthy Department of Pharmaceutics and Drug Delivery University of MississippiOxfordMS38677USA Natural Products Utilization Research Unit Agricultural Research ServiceU.S.Department of AgricultureOxfordMS38677USA National Center for Natural Products Research Research Institute of Pharmaceutical SciencesSchool of PharmacyUniversity of MississippiOxfordMS38677USA Topical Products Testing LLC OxfordMS38677USA

Docosanol is the only US Food and Drug Administration(FDA)approved over-the-counter topical product for treating recurrent oral-facial herpes simplex *** analytical methods for docosanol are required to demonstrate the bioequivalence of docosanol topical products.A gas chromatography/selected ion monitoring mode mass spectrometry(GC/SIM-MS)method was developed and validated for docosanol determination in biological *** and isopropyl palmitate(internal standard)were separated on a high-polarity GC capillary column with(88%cyanopropy)aryl-polysiloxane employed as the stationary *** ions of m/z 83 and 256 were selected to monitor docosanol and isopropyl palmitate,respectively;the total run time was 20 *** GC/SIM-MS method was validated in accordance with US FDA guidelines,and the results met the US FDA acceptance *** docosanol calibration standards were linear in the 100-10000 ng/mL concentration range(R^(2)>0.994).The recoveries for docosanol from the receptor fluid and skin homogenates were>93.2%and>95.8%,*** validated method was successfully applied to analyze ex vivo human cadaver skin permeation *** applying Abreva®cream tube and Abreva®cream pump,the amount of docosanol that penetrated human cadaver skin at 48 h was 21.5±7.01 and 24.0±6.95 ng/mg,***,we concluded that the validated GC/SIM-MS was sensitive,specific,and suitable for quantifying docosanol as a quality control *** method can be used for routine analysis as a costeffective alternative to other techniques.

关键词： Docosanol Fatty alcohols Gas chromatography-mass spectrometry Topical formulation Skin permeation

Chemotherapy and drug resistance status of malaria parasite in northeast India

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 583-588页

作者： Diganta Goswami Indra Baruah Sunil Dhiman Bipul Rabha vijay Veer Lokendra Singh Dhirendra kumar Sharma Division of Medical Entomology Defence Research LaboratoryTezpurAssam.India Directorate of Life Sciences DRDO HQNew DelhiIndia Department of Zoology Gauhati UniversityGuwahatiIndia

India reports the highest number of malaria cases in Southeast Asia,of which Plasmodium falciparum contribute more than half of the cases every *** eastern states of India contribute only 3.96%of country’s population but account for>10%of total reported malaria cases.11%of Plasmodium falciparum cases and 20%of malaria related deaths *** India,chloroquine resistance was reported for the first time from northeast region and since then chloroquine treatment failure is being reported from many parts of the *** chloroquine treatment failure has led to change of the drug policy to artemisinin combination therapy as first line of malaria treatment in the ***,replacing chloroquine to artemisinin combination therapy has not shown significant difference in the overall malaria incidence in the region,The present review addresses the current malaria situation of northeastern region of India in the light of antimalarials drug resistance.

关键词： Malaria Chemotherapy Antimalarials Drug resistance

Strong, lightweight, and highly conductive CNT/Au/Cu wires from sputtering and electroplating methods

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Journal of Materials Science & Technology 2020年第5期40卷 99-106页

作者： Thang Q.Tran Jeremy Kong Yoong Lee Amutha Chinnappan W.A.D.M.Jayathilaka Dongxiao Ji Vishnu vijay kumar Seeram Ramakrishna Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1EA-07-05Singapore 117575Singapore

In this study, we present a 2-step deposition method via sputtering and electroplating that uses carbon nanotube(CNT) wires synthesized from a wet-spinning technique to produce high-performance CNT/Au/Cu composite wires. After the Au sputtering pre-treatment, the deposition of Cu on the CNT wires was found to be much more homogeneous due to improved wettability and reactivity of the wire surface. At different electrodeposition time, the mechanical strength of the CNT/Au/Cu composite wires could be as high as 0.74 GPa(~2 times stronger than metal wires) while their electrical conductivity could reach 4.65 × 10~5 S/cm(~80% of that for copper). More importantly, the CNT/Au/Cu composite wires with high CNT volume fraction are expected to be lightweight(up to 42% lower than Cu mass density), suggesting that our high-performance composite wires are a promising candidate to substitute conventional heavy metal wires in the future applications.

关键词： Carbon nanotube wires Sputtering Electrical conductivity Electrodeposition

A novel strategy of constructing 2D supramolecular organic framework sensor for the identification of toxic metal ions

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Nano Materials Science 2023年第3期5卷 335-342页

作者： Ying Wang Ning Han Chao-Qun Ma Hui Liu Shengsheng Yu Rongzhou Wang vijay kumar Thakur Ling-Bao Xing School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo255000PR China Department of Materials Engineering KU LeuvenLeuven3001Belgium Biorefining and Advanced Materials Research Center Scotland's Rural College(SRUC)Kings BuildingsWest Mains RoadEdinburghEH93JGUK

Two novel two-dimensional(2D)supramolecular organic frameworks were fabricated in water based on the encapsulation-enhanced donor-acceptor interaction between the methyl viologen(MV)units,methoxy naphthyl(MN)units,and CB[8].The tetraphenylethylene(TPE)derivatives 1 with four MV units were employed as rigid building blocks and the two MN units modified oligoethylene glycol derivatives 2 and 3 served as flexible edges,*** obtained two SOFs have obvious sheet-like structures and exhibit fluorescence emission at 350-500 *** addition,these two SOFs were employed for the luminescent detection of Cr(Ⅵ)and Mn(Ⅶ)in aqueous solutions,and the detection limits of CrO_(4)^(2-),Cr_(2)_(O)_(7)^(2-),and MnO_(4)were calculated in a very low concentration range,indicating that these two SOFs can serve as a potential sensor for Cr(Ⅵ)and Mn(Ⅶ)detection in *** work constructs two SOFs in an aqueous solution through a facile method and further enriches the applications of SOFs.

关键词： Two-dimensional supramolecular organic framework Encapsulation-enhanced donor-acceptor interaction Luminescent detection

Synthesis, characterization, antibacterial and anticancer evaluation of some novel flavone-3-ols

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 187-188页

作者： Aravinda Pai D.vijay kumar B.S.Jayashree Department of Pharmaceutical Chemistry Manipal College of Pharmaceutical Sciences

A series of novel flavonols were synthesized by cyclizing corresponding hydoxy chalcones using Algar flynn Oyamada reaction (1)The synthesized compounds were characterized by various spectrochemical methods including IR, MASS, NMR spectroscopy. Out of 13 compounds screened for antibacterial activity [2], compound VMF 12 (a bromo derivative) showed activity with an IC50value at 0.16μM against S. aureus.

关键词： Flavonols Antibacterial Anticancer HeLa V79