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A strategy for uncovering germline variants altering anti-tumor CD8 T cell response

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Journal of Genetics and Genomics 2023年第5期50卷 353-361页

作者： vijay kumar Ulaganathan Martina H.Vasileva Klinik fur Dermatologie&Allergology Universitatsmedizin GottingenGottingen 37075Germany Institut fuir Multiple Sklerose Forschung NeuroimmunologieUniversitatsmedizin GottingenGottingen 37075Germany University of Lorraine NGERE UnitFaculte de Medecine9 Avenue de La Foret de HayeVandoeuvre-les-Nancy 54505France

Among many factors known to alter the outcomes of T cell receptor(TCR)-induced proximal signaling,the role of human germline variants in dictating the individuality of the anti-tumor CD8 T cell response has remained challenging to ***,we describe a convenient strategy for molecular and functional characterization of phosphotyrosine-altering non-synonymous single nucleotide variations(pTyr-SNVs)that directly impact TCR-induced proximal phosphotyrosine motif-based signaling *** devise an experimental co-cultivation set-up comprising a C57BL/6 mouse-derived metastatic melanoma cell line engineered to constitutively present ovalbumin(OVA)antigens and retrovirally engineered syngeneic major histocompatibility complex(MHC)Class I restricted OVA TCR-transgenic CD8 T cells(OT-I).Using the synthetic version of pTyr-SNV rs1178800678-G/T-encoding integrin alpha 4(ITGA4)p.S1027I variant as a prototype,we show that under identical TCR stimulation conditions,genetically determined membrane-proximal immunoreceptor tyrosin activation motif(ITAM)results in increased tyrosine phosphorylation of 70 kDa zeta-chain-associated protein(ZAP70)and the levels of cytotoxic effector molecule granzyme B(GZMB),which in turn result in enhanced cytotoxic activity against metastatic melanoma cell *** strategy paves the way for rapid molecular and functional characterization of anti-tumor immune response-linked germline pTyr-SNVs so as to improve our understanding of the genetic basis of individual-to-individual differences in anti-tumor CD8 T cell response.

关键词： Non-synonymous single nucleotide variants(nsSNVs) Membrane-proximal phosphotyrosine signalling motifs Phosphotyrosine-altering non-synonymous single nucleotide variants(pTyr-SNVs) Immunoreceptor tyrosine activation motif(ITAM) CD8 T cells Melanoma B16-F10

Beneficial and detrimental effects of processed dietary fibers on intestinal and liver health:health benefits of refined dietary fibers need to be redefined!

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Gastroenterology Report 2020年第2期8卷 85-89,I0001页

作者： Vishal Singh Matam vijay-kumar Department of Nutritional Sciences The Pennsylvania State UniversityUniversity ParkPAUSA UT-Microbiome Consortium Department of Physiology and PharmacologyThe University of Toledo College of Medicine and Life SciencesOHUSA Department of Medical Microbiology&Immunology The University of ToledoOHUSA

Consumption of processed foods—which are generally composed of nutritionally starved refined ingredients—has increased exponentially worldwide.A rise in public health awareness that low fiber intake is strongly linked to new-age disorders has spurred food manufacturers to fortify processed foods with refined dietary fibers(RDFs).Consumption of whole foods rich in natural fibers undoubtedly confers an array of health ***,it is not clear whether RDFs extracted from the whole plant,kernel,and fruit peels exert similar physiological effects to their naturally occurring *** studies caution that RDFs are not universally beneficial and that inappropriate consumption of RDFs may risk both gastrointestinal and liver ***,we briefly summarize the beneficial and detrimental effects of RDFs on digestive health and discuss the contribution of metabolites derived from microbial fermentation of RDFs in driving such positive or negative health outcomes.

关键词： gut microbiota fermentation IBD metabolic syndrome liver cancer

Low-velocity pneumatic conveying in horizontal pipe for coarse particles and fine powders

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Particuology 2008年第5期6卷 316-321页

作者： Yuji Tomita vijay kumar Agarwal Hiroyuki Asou Katsuya Funatsu Kyushu Institute of Technology 1-1 SensuichoTobataKitakyushu 804-5500Japan Indian Institute of Technology Hauz KhasNew Delhi 110016India

First, the characteristics of low-velocity conveying of particles having different hardness are experimentally investigated in a horizontal pipeline in terms of flow pattern and pressure drop to show that the slug flow can be classified into two types depending on the settling of particles along the pipeline, and the period is small for slug flow without the settled layer, which is called solitary slug flow. The pressure drop for soft particles is shown to be larger than that for hard particles. Then, experimental results are presented on horizontal fluidized-bed conveying of fine powders to show that air release from the top surface of the conveying channel is an imnortant factor for high mass flow rate of particles.

关键词： Low-velocity conveying Slug flow Soft particle Horizontal fluidized-bed conveying Fine powder

Role of MgF2 addition on high energy ball milled kalsilite:Implementation as dental porcelain with low temperature frit

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Journal of Advanced Ceramics 2014年第4期3卷 332-338页

作者： Pattem Hemanth kumar Abhinav SRIVASTAVA vijay kumar Nandini JAISWAL Pradeep kumar Vinay kumar SINGH Department of Ceramic Engineering Indian Institute of Technology(BHU)VaranasiIndia Department of Chemical Engineering Indian Institute of Technology(BHU)VaranasiIndia

Porcelain fused to metal(PFM)has received great attention over the last few years due to its importance in the ***(K_(2)O·Al_(2)O_(3)·SiO_(2))is a high thermal expansion porcelain,suitable for bonding to ***,kalsilite is a metastable phase which gets converted into crystalline leucite upon *** the current work feasibility of developing stable kalsilite phase,dispersion of MgF2 in it as an additive and using mechanochemical synthesis are *** fine dental material has been formulated by mixing prepared kalsilite with low temperature frit(LTF)in different *** crystalline phases evolved in fired powders are characterized by powder X-ray diffraction(XRD)*** with different ratio of LTF has been cold pressed and heat treated to examine its coefficient of thermal expansion(CTE),flexural strength,apparent porosity(AP),bulk density(BD)and *** indicate that MgF_(2) addition and high milling duration help in kalsilite *** also plays an important role in this stabilization,and at 1100℃single phase kalsilite formation is *** outcomes demonstrate that it is easily possible to synthesize a stable single phase kalsilite with desirable properties.

关键词： kalsilite porcelain fused to metal(PFM) dental ceramic mechanochemical synthesis thermal expansion X-ray diffraction(XRD)

Optimal promotional policy of an innovation diffusion model incorporating the brand image in a segment-specific market

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Journal of Management Analytics 2022年第1期9卷 120-136页

作者： Kuldeep Chaudhary Pradeep kumar Sudipa Chauhan vijay kumar Department of Mathematics AIASAmity UniversityNoidaIndia

This paper addresses the problem of determining the optimal promotional policy for a diffusion model in a segment-specific market under the assumption that the additional demand of the new product also improves brand image in the form of goodwill of the *** model is framed with the assumption that the firm uses the mass and differentiated promotion effort for each *** differentiated promotional efforts target each market segment independently and the mass promotional effort reaches different segments with a fixed *** derive the optimal promotional effort policy for each segment using maximumprinciple and also analyze the stability of the dynamical system by constructing a Lyapunov function through the graph theoretic *** analysis gives a deep insight into how the promotional effort should be planned by the decision makers keeping in mind the financial constrains without hindering the promotional effort at the end of the planning period.

关键词： market-segmentation brand-image maximum-principle stability analysis graph theoretic approach

Improved thermoelectric property of cation-substituted CaMnO_3

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Chinese Physics B 2015年第9期24卷 542-547页

作者： Pradeep kumar Subhash C.Kashyap vijay kumar Sharma H.C.Gupta Department of Physics Shyam Lal CollegeUniversity of Delhi Department of Physics Indian Institute of Technology Delhi

Single-phase pristine and cation-substituted calcium manganite（Ca1-xBixMn1-yVyO3-δ） polycrystalline samples were synthesized by the solid state reaction technique. Their thermoelectric properties were measured by a set up that was designed and assembled in the laboratory. The Ca1-x BixMn1-yVyO3-δsample with x = y = 0.04 has shown a power factor（S^2σ） of 176 μW/m/K^2 at 423 K, which is nearly two orders of magnitude higher than that of the pristine sample（2.1 μW/m/K2）. The power factor of the substituted oxide remains almost temperature independent as the Seebeck coefficient increases monotonically with temperature, along with the simultaneous decrease in electrical resistivity which is attributed to enhanced electron density due to co-doping of bismuth and vanadium and grain boundary scattering. These cation-substituted calcium manganites can be used as a potential candidate for an n-type leg in a thermoelectric generator（module）.

关键词： thermoelectric materials solid state reaction Seebeck coefficient power factor

Antimicrobial Materials: New Strategies to Tackle Various Pandemics

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Journal of Renewable Materials 2020年第12期8卷 1543-1563页

作者： Samarjeet Singh Siwal Qibo Zhang Adesh kumar Saini vijay kumar Thakur Key Laboratory of Ionic Liquids Metallurgy Faculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming650093China Department of Chemistry M.M.Engineering CollegeMaharishi Markandeshwar(Deemed to be University)Mullana-Ambala133207India State Key Laboratory of Complex Nonferrous Metal Resources Cleaning Utilization in Yunnan Province Kunming650093China Department of Biotechnology Maharishi Markandeshwar(Deemed to be University)Mullana-Ambala133207India Biorefining and Advanced Materials Research Center Scotland’s Rural College(SRUC)Kings BuildingsEdinburghUK Department of Mechanical Engineering School of EngineeringShiv Nadar UniversityUttar Pradesh201314India

Coronaviruses are responsible for a developing budgetary,human and fatality trouble,as the causative factor of infections,for example,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).It has been well recognized that SARS-CoV-2 may survive under severe atmosphere ***,efficient containment approaches,for example,sanitizing,are ***,living compounds contribute a substance of chemical heterogeneity,with antiviral movement,and therefore can have efficacy as therapeutic tools toward coronavirus ***,in this review article,we have described the antimicrobialbased materials,which can be used to inhibit the spreading of the *** have categorized these materials in three sections;(i)antimicrobial wall paint,(ii)antimicrobial papers and(iii)antimicrobial materials surface coating to be utilized as the antimicrobial-based materials for controlling the *** the last section,we have given the concluding remarks with prospects in this area.

关键词： Antimicrobial SARS-CoV-2 wall paint surface coating

Magnesium matrix composites for biomedical applications:A review

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Journal of Magnesium and Alloys 2019年第1期7卷 72-79页

作者： vijay kumar Bommala Mallarapu Gopi Krishna ChTirumala Rao Department of Mechanical Engineering Acharya Nagarjuna UniversityGuntur-522510Andhra PradeshIndia

In recent years,a new wave of bioactive,biocompatibility and biodegradable metallic materials were developed for orthopedic *** Magnesium,Magnesium alloys,Magnesium alloy-based composites are extensive material to the biomedical applications,by virtue of its high biocompatibility and reasonable *** magnesium,Magnesium alloys can corrode too fast during the physiological conditions and loses their properties before bone *** new era for the development of magnesium-based composites can satisfy the orthopedic ***-based composites,as bio-materials,can produce adjustable mechanical properties like Ultimate tensile strength,ductility,elastic modulus,and corrosion resistance in the physiological *** the Mg based composites,the matrix materials are biomedical magnesium alloys base like Mg-Ca,Mg-Al,Mg-Zn,and Mg-REE alloy and The reinforcements are based on hydroxyapatite(HAP),calcium polyphosphate(CPP),andβ-tricalcium phosphate(β-TCP)*** comprehensive review is focused on different grades of biodegradable magnesium matrix composites including their mechanical properties and corrosion resistance.

关键词： Magnesium composites Biodegradable Biocompatible Mechanical properties Biological corrosion

Remote Sensing Image Retrieval Based on 3D-Local Ternary Pattern(LTP)Features and Non-subsampled Shearlet Transform(NSST)Domain Statistical Features

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Computer Modeling in Engineering & Sciences 2022年第4期131卷 137-164页

作者： Hilly Gohain Baruah vijay kumar Nath Deepika Hazarika Department of Electronics and Communication Engineering Tezpur UniversityAssam784028India

With the increasing popularity of high-resolution remote sensing images,the remote sensing image retrieval(RSIR)has always been a topic of major issue.A combined,global non-subsampled shearlet transform(NSST)-domain statistical features(NSSTds)and local three dimensional local ternary pattern(3D-LTP)features,is proposed for high-resolution remote sensing *** model the NSST image coefficients of detail subbands using 2-state laplacian mixture(LM)distribution and its three parameters are estimated using Expectation-Maximization(EM)*** also calculate the statistical parameters such as subband kurtosis and skewness from detail subbands along with mean and standard deviation calculated from approximation subband,and concatenate all of them with the 2-state LM parameters to describe the global features of the *** various properties of NSST such as multiscale,localization and flexible directional sensitivity make it a suitable choice to provide an effective approximation of an *** order to extract the dense local features,a new 3D-LTP is proposed where dimension reduction is performed via selection of‘uniform’*** 3D-LTP is calculated from spatial RGB planes of the input *** proposed inter-channel 3D-LTP not only exploits the local texture information but the color information is captured ***,a fused feature representation(NSSTds-3DLTP)is proposed using new global(NSSTds)and local(3D-LTP)features to enhance the discriminativeness of *** retrieval performance of proposed NSSTds-3DLTP features are tested on three challenging remote sensing image datasets such as WHU-RS19,Aerial Image Dataset(AID)and PatternNet in terms of mean average precision(MAP),average normalized modified retrieval rank(ANMRR)and precision-recall(P-R)*** experimental results are encouraging and the NSSTds-3DLTP features leads to superior retrieval performance compared to many well known existing descriptors such as Gabor RGB,Granulometry,loc

关键词： Remote sensing image retrieval laplacian mixture model local ternary pattern statistical modeling,KS test,texture,global features