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multidisciplinary approach for patients with esophageal cancer

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World Journal of Gastroenterology 2012年第46期18卷 6737-6746页

作者： victoria m villaflor marco E Allaix Bruce minsky Fernando A Herbella marco G Patti Department of medicine Section Hematology/Oncology University of Chicago Medicine Department of Surgery University of Chicago Medicine Radiation Oncology University of Chicago Medicine

Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations.

关键词： Esophageal Cancer multimodality therapy multidisciplinary therapy Chemoradiotherapy Esophageal resection Esophagectomy

molecular mechanisms underlying SARS-CoV-2 hepatotropism and liver damage

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World Journal of Hepatology 2024年第1期16卷 1-11页

作者： Jorge Quarleri m victoria Delpino Instituto de Investigaciones Biomédicas en Retrovirus y Sida(INBIRS) Universidad de Buenos Aires(UBA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos Aires 1121Argentina

In coronavirus disease 2019(COVID-19),severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)primarily targets the respiratory system,but evidence suggests extrapulmonary organ involvement,notably in the *** RNA has been detected in hepatic tissues,and in situ hybridization revealed virions in blood vessels and endothelial *** microscopy confirmed viral particles in hepatocytes,emphasizing the need for understanding hepatotropism and direct cytopathic effects in COVID-19-related liver *** factors contribute to liver injury,including direct cytotoxicity,vascular changes,inflammatory responses,immune reactions from COVID-19 and vaccinations,and druginduced liver *** a typical hepatitis presentation is not widely documented,elevated liver biochemical markers are common in hospitalized COVID-19 patients,primarily showing a hepatocellular pattern of ***-term studies suggest progressive cholestasis may affect 20%of patients with chronic liver disease post-SARS-CoV-2 *** molecular mechanisms underlying SARS-CoV-2 infection in the liver and the resulting liver damage are ***“Editorial”highlights the expression of the Angiotensin-converting enzyme-2 receptor in liver cells,the role of inflammatory responses,the impact of hypoxia,the involvement of the liver's vascular system,the infection of bile duct epithelial cells,the activation of hepatic stellate cells,and the contribution of monocyte-derived *** also mentions that pre-existing liver conditions can worsen the outcomes of *** the interaction of SARS-CoV-2 with the liver is still evolving,and further research is required.

关键词： SARS-CoV-2 COVID-19 Hepatotropism Angiotensin-converting enzyme-2

Systemic analysis of metabolome reconfiguration in Arabidopsis after abiotic stressors uncovers metabolites that modulate defense against pathogens

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Plant Communications 2024年第1期5卷 55-68页

作者： Antoni Garcia-molina victoria Pastor Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB C/Vall MorontaEdifici CRAG08193 Bellaterra(Cerdanyola del Valles)BarcelonaSpain Department of Biology Biochemistryand Natural SciencesSchool of Technology and Experimental SciencesUniversitat Jaume I12006 Castellode la PlanaSpain

Understanding plant immune responses is complex because of the high interdependence among biological processes in homeostatic ***,the integration of environmental cues causes network rewiring that interferes with defense ***,plants retain molecular signatures configured under abiotic stress periods to rapidly respond to recurrent stress,and these can alter *** changes imposed by abiotic stressors are persistent,although their impact on defense remains to be *** this study,we profiled metabolomes of Arabidopsis plants under several abiotic stress treatments applied individually or simultaneously to capture temporal trajectories in metabolite composition during adverse conditions and *** systemic analysis was performed to address the relevance of me-tabolome changes and extract central features to be tested in *** results demonstrate irreversibility in major fractions of metabolome changes as a general pattern in response to abiotic stress ***-tionalanalysisofmetabolomesandco-abundancenetworkspoints toconvergence inthereconfigurationof organic acid and secondary metabolite *** mutant lines for components related to these metabolic pathways showed altered defense capacities against different ***,our data suggest that sustained metabolome changes configured in adverse environments can act as mod-ulators of immune responses and provide evidence for a new layer of regulation in plant defense.

关键词： abiotic stress Arabidopsis biotic stress combinatorial stress metabolomics systems biology

Auxin signaling gets oxidative to promote root hair growth

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molecular Plant 2024年第5期17卷 696-698页

作者： victoria Berdion Gabarain miguel A.Ibeas Hernan Salinas-Grenet Jose m.Estevez Fundación Instituto Leloir&IIBBA-CONICET Av.Patricias Argentinas 435Buenos Aires C1405BWEArgentina Centro de Biotecnología Vegetal Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile ANID Millennium Science Initiative ProgramMillennium Nucleus for the Development of Super Adaptable Plants(MN-SAP)SantiagoChile ANID Millennium Science Initiative ProgramMillennium Institute for Integrative Biology(iBio)SantiagoChile

Root hairs(RHs)emerge as cylindrical cell protrusions from the root epidermis in a polar manner,and these outgrows increase the rhizosphere space to acquire water and nutrients,anchor the plant,and interact with various soil *** is one of the key hormones to promote RH growth,and high levels of auxin are directly promoted by low levels of macronutrients in the soil,such as phosphate(Bhosale et al.,2018)and nitrates(Jia et al.,2023).The nutritional signals for roots,which rapidly change in both time and place within the soil,are tightly linked to signaling pathways that execute swifts on cellular processes to adjust to a challenging *** rapid alkalinization factors(RALFs)are peptides that are released outside the cell and act as peptide-hormone *** attach to the extracellular domains of members of the Catharanthus roseus RECEPTOR-LIKE KINASE 1-LIKE family,specifically FERONIA(FER)in conjunction with its co-receptor LORELEI-LIKE-GPIANCHORED PROTEIN 1.

关键词： soil outside alkali

A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： m.victoria Luzón Nuria Rodríguez-Barroso Alberto Argente-Garrido Daniel Jiménez-López Jose m.moyano Javier Del Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(mL)models in a distributed and decentralized *** allows mL models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different mL approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

An electropenetrography waveform library for the probing and ingestion behaviors of Culex tarsalis on human hands

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Insect Science 2024年第4期31卷 1165-1186页

作者： Anastasia m.W.Cooper Samuel B.Jameson victoria Pickens Cameron Osborne Elaine A.Backus Kristopher Silver Dana N.mitzel Department of Entomology Kansas State UniversityManhattanKansasUSA Department of Tropical medicine Tulane University School of Public Health and Tropical MedicineNew OrleansLos AngelesUSA USDA Agricultural Research Service San Joaquin Valley Agricultural Sciences CenterParlierCaliforniaUSA National Bio and Agro-Defense Facility USDA Agricultural Research ServiceManhattanKansasUSA

Culex tarsalis Coquillett(Diptera:Culicidae)mosquitoes are capable of vectoring numerous pathogens affecting public and animal ***,the probing behaviors of mosquitoes are poorly understood because they occur in opaque ***(EPG)has the potential to elucidate these behaviors by recording the electrical signals generated during *** used an AC–DC EPG with variable input resistors(Ri levels)to construct a waveform library for *** feeding on human *** events associated with mosquito probing were used to characterize waveforms at four Ri levels and with two electrical current *** optimal settings for EPG recordings of *** probing on human hands was an Ri level of 10^(7)Ohms using an applied signal of 150 millivolts alternating *** for *** included those previously observed and associated with probing behaviors in Aedes aegypti L.(Diptera:Culicidae):waveform families J(surface salivation),K(stylet penetration through the skin),L(types 1 and 2,search for a blood vessel/ingestion site),m(types 1 and 2,ingestion),N(type 1,an unknown behavior which may be a resting and digestion phase),and W(withdrawal).However,we also observed variations in the waveforms not described in ***,which we named types L3,m3,m4,and *** investigation enhances our understanding of mosquito probing *** also provides a new tool for the automated calculation of peak *** work will facilitate future pathogen acquisition and transmission studies and help identify new pest and disease management targets.

关键词： AC-DC blood feeders electrical penetration graph EPG human hands mosquitoes waveform library

Perilipin 2 inhibits replication of hepatitis B virus deoxyribonucleic acid by regulating autophagy under high-fat conditions

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World Journal of Virology 2024年第1期13卷 1-4页

作者： m victoria Delpino Jorge Quarleri Instituto de Investigaciones Biomédicas en Retrovirus y Sida Universidad de Buenos AiresConsejo Nacional de Investigaciones Científicas y TécnicasBuenos Aires 1121Argentina

Hepatitis B virus(HBV)infection poses a global health concern without a definitive cure;however,antiviral medications can effectively suppress viral *** study delves into the intricate interplay between lipid metabo-lism and HBV replication,implicating molecular mechanisms such as the stearoyl coenzyme A desaturase 1 autophagy pathway,SAC1-like phosphatidylinositol phosphatase,and galectin-9 mediated selective autophagy of viral core proteins in regulating HBV *** lipid droplets,perilipin 2(PLIN2)emerges as a pivotal guardian,with its overexpression protecting against autophagy and downregulation stimulating triglyceride catabolism through the autophagy *** editorial discusses the correlation between hepatic steatosis and HBV replication,emphasizing the role of PLIN2 in this *** study underscores the multifaceted roles of lipid metabolism,autophagy,and perilipins in HBV replication,shedding light on potential therapeutic avenues.

关键词： Perilipin 2 Hepatitis B virus Non-alcoholic fatty liver disease Liver Autophagy

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov Jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Damage mechanism of CK2 and IKAROS in Philadelphia Like Acute Lymphoblastic Leukemia

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Journal of Biosciences and medicines 2024年第4期12卷 49-59页

作者： Ignacio Vélez-Rodríguez victoria Carranza-Aranda Facultad mexicana de medicina Universidad La Salle Tlalpan M&#233xico Hospital General de mé xico Cuauht&#233moc M&#233xico

Acute lymphoblastic leukemia (ALL) is characterized by immature and poorly differentiated B lymphocytes in large numbers in the blood. B cells are distinct from the cell types involved in their development (common lymphoid progenitor cells, pro-B cells, pre-B cells, and mature cells). The process of B cell maturation depends on precise communication within the cell: signals activate specific genes that are essential for proper development. Errors in this intricate signaling network can lead to issues with B cell function and contribute to disease. B-lineage acute lymphoid leukemias, malignancies of precursor-stage B lymphoid cells inhibit lymphoid differentiation, leading to abnormal cell proliferation and survival. The process of developing leukemia (leukemogenesis) can be triggered by an overproduction of both hematopoietic stem cells (the cells that form all blood cells) and the immature versions of white blood cells called lymphoblasts. Acute lymphoblastic leukemia (ALL) with the presence of the Philadelphia chromosome (ALL Ph) is classified as a high-risk manifestation of the disease, this chromosome is the product of the reciprocal translocation, whose product is a BCR-ABL fusion protein. It is a highly active tyrosine kinase that can transform hematopoietic cells into cytokine-independent. Hyperphosphorylation cascades inhibit the differentiating function of IKZF1 as a tumor suppressor gene which leads to an abnormal proliferation of B cells due to the presence of the Philadelphia chromosome;it inhibits the differentiating process, leukemogenesis involving immature B cells in the bloodstream can result from the uncontrolled growth and division of hematopoietic stem cells and immature lymphoblasts (the precursors to B cells).

关键词： Acute Lymphoblastic Leukemia IKAROS Dephosphorylation Philadelphia Chromosome CK2