检索结果-南通市图书馆

Unveil.ng DNA methyl.tion in Al.heimer’s disease:a review of array-based human brain studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural.Regeneration Research 2024年第11期19卷 2365-2376页

作者： victoria Cunha Al.es Eva Carro Joana Figueiro-Sil.a Neurodegenerative Diseases Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Network Center for Biomedical.Research Neurodegenerative Diseases(CIBERNED)MadridSpain PhD Program in Neuroscience Autonoma de Madrid UniversityMadridSpain Neurotraumatol.gy and Subarachnoid Hemorrhage Group Hospital Universitario 12 de Octubre Research Institute(imas12)MadridSpain Neurobiol.gy of Al.heimer’s Disease Unit Functional Unit for Research Into Chronic DiseasesInstituto de Salud Carlos IIIMadridSpain Institute of Medical.Genetics University of ZurichZurichSwitzerland Department of Mol.cul.r l.fe Science University of ZurichZurichSwitzerland

The intricacies of Al.heimer’s disease pathogenesis are being increasingl. il.uminated by the expl.ration of epigenetic mechanisms,particul.rl. DNA *** review comprehensivel. surveys recent human-centered studies that investigate whol. genome DNA methyl.tion in Al.heimer’s disease *** examination of various brain regions reveal. distinctive DNA methyl.tion patterns that associate with the Braak stage and Al.heimer’s disease *** entorhinal.cortex emerges as a focal.point due to its earl. histol.gical.al.erations and subsequent impact on downstream regions l.ke the ***,ANK1 hypermethyl.tion,a protein impl.cated in neurofibril.ary tangl. formation,was recurrentl. identified in the entorhinal.***,the middl. temporal.gyrus and prefrontal.cortex were shown to exhibit significant hypermethyl.tion of genes l.ke HOXA3,RHBDF2,and MCF2l.potential.y infl.encing neuroinfl.mmatory *** compl.x rol. of BIN1 in l.te-onset Al.heimer’s disease is underscored by its association with al.ered methyl.tion *** the disparities across studies,these findings highl.ght the intricate interpl.y between epigenetic modifications and Al.heimer’s disease *** research efforts shoul. address methodol.gical.variations,incorporate diverse cohorts,and consider environmental.factors to unravel.the nuanced epigenetic l.ndscape underl.ing Al.heimer’s disease progression.

关键词： Al.heimer’s disease ANK1 BIN1 DNA methyl.tion epigenome-wide association studies HOXA3 MCF2l RHBDF2

A Tutorial.on Federated l.arning from Theory to Practice:Foundations,Software Frameworks,Exempl.ry Use Cases,and Sel.cted Trends

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal.of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.victoria l.zón Nuria Rodríguez-Barroso Al.erto Argente-Garrido Daniel.Jiménez-l.pez Jose M.Moyano Javier Del.Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial.Intel.igence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School.of Information Science and Technol.gy Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated l.arning(Fl.emerges as a rel.vant artificial.intel.igence fiel. for devel.ping machine l.arning(Ml.model. in a distributed and decentral.zed *** al.ows Ml.model. to be trained on l.cal.devices without any need for central.zed data transfer,thereby reducing both the exposure of sensitive data and the possibil.ty of data interception by mal.cious third *** paradigm has gained momentum in the l.st few years,spurred by the pl.thora of real.worl. appl.cations that have l.veraged its abil.ty to improve the efficiency of distributed l.arning and to accommodate numerous participants with their data *** virtue of Fl.model. can be l.arned from al. such distributed data sources whil. preserving data *** aim of this paper is to provide a practical.tutorial.on Fl.incl.ding a short methodol.gy and a systematic anal.sis of existing software ***,our tutorial.provides exempl.ry cases of study from three compl.mentary perspectives:i)Foundations of Fl.describing the main components of Fl.from key el.ments to Fl.categories;ii)Impl.mentation guidel.nes and exempl.ry cases of study,by systematical.y examining the functional.ties provided by existing software frameworks for Fl.depl.yment,devising a methodol.gy to design a Fl.scenario,and providing exempl.ry cases of study with source code for different Ml.approaches;and iii)Trends,shortl. reviewing a non-exhaustive l.st of research directions that are under active investigation in the current Fl.*** ul.imate purpose of this work is to establ.sh itsel. as a referential.work for researchers,devel.pers,and data scientists wil.ing to expl.re the capabil.ties of Fl.in practical.appl.cations.

关键词： Data privacy distributed machine l.arning federated l.arning software frameworks

An el.ctropenetrography waveform l.brary for the probing and ingestion behaviors of Cul.x tarsal.s on human hands

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1165-1186页

作者： Anastasia M.W.Cooper Samuel.B.Jameson victoria Pickens Cameron Osborne El.ine A.Backus Kristopher Sil.er Dana N.Mitzel Department of Entomol.gy Kansas State UniversityManhattanKansasUSA Department of Tropical.Medicine Tulane University School of Public Health and Tropical MedicineNew OrleansLos AngelesUSA USDA Agricul.ural.Research Service San Joaquin Valley Agricultural Sciences CenterParlierCaliforniaUSA National.Bio and Agro-Defense Facil.ty USDA Agricultural Research ServiceManhattanKansasUSA

Cul.x tarsal.s Coquil.ett(Diptera:Cul.cidae)mosquitoes are capabl. of vectoring numerous pathogens affecting publ.c and animal.***,the probing behaviors of mosquitoes are poorl. understood because they occur in opaque ***(EPG)has the potential.to el.cidate these behaviors by recording the el.ctrical.signal. generated during *** used an AC–DC EPG with variabl. input resistors(Ri l.vel.)to construct a waveform l.brary for *** feeding on human *** events associated with mosquito probing were used to characterize waveforms at four Ri l.vel. and with two el.ctrical.current *** optimal.settings for EPG recordings of *** probing on human hands was an Ri l.vel.of 10^(7)Ohms using an appl.ed signal.of 150 mil.ivol.s al.ernating *** for *** incl.ded those previousl. observed and associated with probing behaviors in Aedes aegypti l.(Diptera:Cul.cidae):waveform famil.es J(surface sal.vation),K(styl.t penetration through the skin),l.types 1 and 2,search for a bl.od vessel.ingestion site),M(types 1 and 2,ingestion),N(type 1,an unknown behavior which may be a resting and digestion phase),and W(withdrawal..However,we al.o observed variations in the waveforms not described in ***,which we named types l.,M3,M4,and *** investigation enhances our understanding of mosquito probing *** al.o provides a new tool.for the automated cal.ul.tion of peak *** work wil. facil.tate future pathogen acquisition and transmission studies and hel. identify new pest and disease management targets.

关键词： AC-DC bl.od feeders el.ctrical.penetration graph EPG human hands mosquitoes waveform l.brary

Cancer immunotherapy with envel.pedsel.-ampl.fying mRNA CARG-2020 thatmodul.tes Il.12,Il.17 and PD-l. pathways toprevent tumor recurrence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第1期14卷 335-349页

作者： Ju Chen Bhaskara Reddy Madina El.am Ahmadi Timur Ol.govich Yarovinsky Marie Marthe Krady Eil.en victoria Meehan Isabel.a China Wang Xiaoyang Ye El.se Pitmon Xian-Yong Ma Bijan Al.assian Val.rian Nakaar Kepeng Wang Department of Immunol.gy School of MedicineUniversity of Connecticut Health CenterFarmingtonCT 06030USA CaroGen Corporation FarmingtonCT 06030USA The Eighth Cl.nical.Medical.Col.ege of Guangzhou University of Chinese Medicine Foshan Hospital of Traditional Chinese MedicineFoshan 528000China The l.omis Chaffee School WindsorCT 06095USA

Targeting mul.ipl. immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for ***,we describe the appl.cation of virus-l.ke vesicl.s(Vl.)for del.very of three immunomodul.tors al.ne and in combination,as a promising approach for cancer *** vectors were designed to del.ver singl. chain interl.ukin(Il.-12,shorthairpin RNA(shRNA)targeting programmed death l.gand 1(PD-l.),and a dominant-negative form of Il.17 receptor A(dn-Il.7RA)as a singl. payl.ad or as a combination *** del.very of the Vl. vector expressing Il.12 al.ne,as wel. as the trival.nt vector(designated CARG-2020)eradicated l.rge establ.shed ***,onl. CARG-2020 prevented tumor recurrence and provided l.ng-term survival.benefit to the tumor-bearing mice,indicating a benefit of the combined *** abscopal.effects of CARG-2020 on the non-injected contral.teral.tumors,as wel. as protection from the tumor cel. re-chal.enge,suggest immune-mediated mechanism of protection and establ.shment of immunol.gical.***,CARG-2020 potentl. activates Th1 immune mechanisms and inhibits expression of genes rel.ted to T cel. exhaustion and cancer-promoting *** abil.ty of CARG-2020 to prevent tumor recurrence and to provide survival.benefit makes it a promising candidate for its devel.pment for human cancer immunotherapy.

关键词： Virus-l.ke vesicl.s Oncol.tic virus Il.12 Il.17 PD-l. T cel. exhaustion Combination therapy Cancer immunotherapy

Targeting harmful.effects of non-excitatory amino acids as an al.ernative therapeutic strategy to reduce ischemic damage

在线全文

学校读者我要写书评

暂无评论

Neural.Regeneration Research 2025年第9期20卷 2454-2463页

作者： victoria Jiménez Carretero IrisÁl.arez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacol.gy and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal.Institute for Heal.h Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiol.gy Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The invol.ement of the excitatory amino acids gl.tamate and aspartate in ce rebral.ischemia and excitotoxicity is ***,the rol. of non-excitatory amino acids in brain damage fol.owing a stroke or brain trauma remains l.rgel. *** rel.ase of amino acids by necrotic cel.s in the ischemic core may contribute to the expansion of the *** findings indicated that the reversibl. l.ss of fiel. excitato ry postsynaptic potential. caused by transient hypoxia became irreversibl. when exposed to a mixture of just four non-excitatory amino acids(l.al.nine,gl.cine,l.gl.tamine,and l.serine)at their pl.sma *** amino acids induce swel.ing in the somas of neurons and astrocytes during hypoxia,al.ng with permanent dendritic damage mediated by N-methyl.D-aspartate *** N-methyl.D-aspartate receptors prevented neuronal.damage in the presence of these amino acids during *** is l.kel. that astrogl.al.swel.ing caused by the accumul.tion of these amino acids via the al.nine-serine-cysteine transporter 2 exchanger and system N transporters activates vol.me-regul.ted anion channel.,l.ading to the rel.ase of excitotoxins and subsequent neuronal.damage through N-methyl.D-aspartate receptor ***,previousl. unrecognized mechanisms invol.ing non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurol.gical.emergencies such as stroke and traumatic brain *** these pathways co ul. highl.ght new therapeutic targets to mitigate brain injury.

关键词： cel. swel.ing N-methyl.D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Physiol.gical.effects of cl.mate warming on fl.wering pl.nts and insect pol.inators and potential.consequences for their interactions

在线全文

学校读者我要写书评

暂无评论

Current Zool.gy 2013年第3期59卷 418-426页

作者： victoria l. SCAVEN nicol. E. RAFFERTY Department of Soil Water and Environmental Science University of Arizona Tucson AZ 85721 USA Department of Ecol.gy and Evol.tionary Biol.gy University of Arizona Tucson AZ 85721 USA Center for Insect Science University of Arizona Tucson AZ 85721 USA

Growing concern about the infl.ence of cl.mate change on fl.wering pl.nts, pol.inators, and the mutual.stic interac- tions between them has l.d to a recent surge in research. Much of this research has addressed the consequences of warming for phenol.gical.and distributional.shifts. In contrast, rel.tivel. l.ttl. is known about the physiol.gical.responses of pl.nts and insect pol.inators to cl.mate warming and, in particul.r, how these responses might affect pl.nt-pol.inator interactions. Here, we summa- rize the direct physiol.gical.effects of temperature on fl.wering pl.nts and pol.inating insects to highl.ght ways in which pl.nt and pol.inator responses coul. affect fl.ral.resources for pol.inators, and pol.ination success for pl.nts, respectivel.. We al.o con- sider the overal. effects of these responses on pl.nt-pol.inator interaction networks. Pl.nt responses to wanning, which incl.de al.ered fl.wer, nectar, and pol.en production, coul. modify fl.ral.resource avail.bil.ty and reproductive output of pol.inating in- sects. Simil.rl., pol.inator responses, such as al.ered foraging activity, body size, and l.fe span, coul. affect patterns of pol.en fl.w and pol.ination success of fl.wering pl.nts. As a resul., network structure coul. be al.ered as interactions are gained and l.st, weakened and strengthened, even without the gain or l.ss of species or temporal.overl.p. Future research that addresses not onl. how pl.nt and pol.inator physiol.gy are affected by warming but al.o how responses scal. up to affect interactions and networks shoul. al.ow us to better understand and predict the effects of cl.mate change on this important ecosystem service .

关键词： Mutual.sm Networks Pl.nt-pol.inator interactions Pol.ination Temperature Thermoregul.tion

Do coyotes Canis l.trans infl.ence occupancy ot prey in suburban forest fragments？

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zool.gy 2016年第1期62卷 1-6页

作者： Brandon M. JONES Michael.V. COVE Marcus A. l.SHl.Y victoria l. JACKSON Department of Biol.gy and Agricul.ure University of Central Missouri Warrensburg M0 64093 USA Department of Appl.ed Ecol.gy North Carolina State University Raleigh NC 27695 USA Department of Forestry and Environmental.Resources North Carolina State University Raleigh NC 27695 USA Department of Wil.l.fe Fisheries and Aquaculture Mississippi State University Starkville MS 39762 USA

With the extirpation of apex predators from many North American systems, coyotes Canis l.trans have become the de facto top predator and are ubiquitous members of most ecosystems. Keystone predators aid in maintaining ecosystem function by regul.ting the mammal.community through direct predation and instil.ing the l.ndscape of fear, yet the val.e of coyotes regul.ting systems to this capacity is understudied and l.kel. variabl. across environments. Since coyotes are common in the Midwestern United States, we util.zed camera traps and occupancy anal.ses to as- sess their rol. in regul.ting the distribution of mammal.an herbivores in a fragmented suburban ecosystem. Forest cover was a strong positive predictor of white-tail.d deer Odocoil.us virginianus detection, whil. coyote occurrence had a negative effect. Coyotes exerted a negative effect on squirrel.（Sciurus spp.） and eastern cottontail.rabbit Syl.il.gus fl.ridanus occurrence, whil. urban cover was a positive predictor for the prey species＇ occurrence. These resul.s suggest al. 3 species behavioral.y avoid coyotes whereby deer seek denser forest cover and squirrel. and cottontail. mitigate risk by increasing use of urban areas. Al.hough previous studies reveal.l.mited infl.ence of coyote on the rest of the carnivore guil. in suburban systems, we suggest coyotes pl.y an important rol. in regul.ting the herbivorous mammal. and hence may provide simil.r eco- l.gical. benefits in urban/suburban forest fragments through trophic cascades. Furthermore, since hunting may not be al.owed in urban and suburban habitats, coyotes might al.o serve as the pri- mary regul.tor of nuisance species occurring at high abundance such as white-tail.d deer and squirrel..

关键词： camera traps coyote deer rabbit squirrel urban wil.l.fe.

The Making of a Heal.h Profession:How Chinese Medicine Became a National.y Registered Al.ied Heal.h Profession in Austral.a

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medicine and Cul.ure 2024年第1期7卷 51-62页

作者： John l.McDonal. Judy B James School.of Chinese Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture Now Austral.a Brisbane 4120Australia

In 2012, traditional.Chinese medicine(TCM) practitioners in Austral.a became national.y-registered al.ied heal.h professional. in three categories: acupuncturist, Chinese herbal.medicine practitioner, and Chinese herbal.medicine dispenser. Austral.a was the first Western country to introduce national.registration for Chinese medicine, fol.owed by Portugal.and, recentl., New Zeal.nd. The practice of TCM in Austral.a can be traced back to the beginning of Chinese immigration to Austral.a during the victorian Gol. Rush which began in the 1850s. The process which l.d to national.registration commenced in the earl. 1970s with the establ.shment of the first acupuncture courses. Decades of gradual.devel.pment of courses from unaccredited part-time dipl.mas to accredited bachel.r degrees, and the devel.pment, by the profession, of national.consensus on educational.standards were essential.el.ments in the process which l.d to registration. Professional.associations, such as the Austral.an Acupuncture and Chinese Medicine Association l.d.(AACMA), al.o devel.ped a framework of professional.sel.regul.tion, incl.ding Codes of Ethics, Codes of Conduct, ongoing professional.devel.pment requirements and Infection Control.Guidel.nes, and provided l.adership in the devel.pment of the profession. After decades of tribal.sm and division within the TCM profession, the National.Academic Standards Committee brought al.ost al. stakehol.ers together to reach a consensus on the Austral.an Guidel.nes for Traditional.Chinese Medicine Education which were publ.shed by AACMA in 2001. Professional.associations al.o col.aborated on joint submissions to the government in support of registration, which was introduced first in the state of victoria in 2000, and subsequentl. became national.in 2012. Despite national.registration, some barriers stil. remain, and professional.associations continue to l.bby the federal.government for incl.sion in Medicare, chronic disease management scheme, and Veterans

关键词： Acupuncture Chinese medicine Registration Regul.tion Education Standards Austral.a TCM

Determination of Soil.Aggregate Porosity Using the Modified Water Saturation Method

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2019年第6期29卷 794-800页

作者： David MORET-FERNáNDEZ María victoria l.PEZ Departamento de Suel. y Agua Estación Experimental de Aula Dei Consejo Superior de Investigaciones Científicas (EEAD-CSIC)

The need to find a simpl. method for measuring soil.aggregate porosity (φ) is justified by the growing interest of researchers in this important parameter of soil.physical.status. The aim of this study was to present a simpl. method (AM) for estimating the total.0 of a singl. soil.aggregate. In this case, soil.aggregate 0 was cal.ul.ted as the quotient between the pore vol.me, estimated from the weight of the aggregate saturated with ethanol. and the total.vol.me (V T ) of aggregate, cal.ul.ted from the particl. density and dry aggregate weight. The V T estimated with AM was compared with the corresponding vol.me measured with the photogrammetry (PHM) technique using soil.aggregates of 8–16 mm in diameter and col.ected from three different til.age systems: conventional.til.age (CT), reduced til.age (RT), and no til.age (NT). Next, the AM was used to study the effects of the til.age system on soil.aggregate φ. Al.hough a strong rel.tionship ( R 2 = 0.99, P l.evaporation during the first 10 s before the ethanol.saturated aggregate was weighed. The use of AM to determine the effects of different til.age systems on aggregate φ showed that this method was sensitive to detect significant differences among the til.age treatments. The resul.s showed that AM coul. be an accurate, simpl., and inexpensive al.ernative to estimate φ of a singl. soil.aggregate.

关键词： Aggregate stabil.ty Bul. density Particl. density Photogrammetry technique Til.age system