检索结果-南通市图书馆

CD74 in antigen presentation,inflammation,and cancers of the gastrointestinal tract

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2009年第23期15卷 2855-2861页

作者： Ellen j Beswick victor E Reyes Department of Pediatrics University of Texas Medical Branch Galveston TX 77555 United States Department of Pediatrics and Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States

CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori （H pylon）. The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-κB and Erkl/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.

关键词： CD74 Invariant chain Cancer Inflammation Helicobacterpylori Gastrointestinal tract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

硒和维生素E缺乏和过量的比较病理学

中华地方病学杂志 1989年第5期 33+61-74+60页

作者： john F.Van Vleet,victor.j.ferrans Bethesda Maryland20205 Department of Pathology School of Veterinary Medicine Purdue University West Lafayette Indiana47907 Pathology Branch National Heart Lung and Blood Institute National Institutes of Health

本文报告了缺硒和维生素 E（简称 Se—VE）动物的病理学改变。Se—VE缺乏病多见于子鸭、猪、羔羊、牛犊、鹌鹑、鼠、猫和鸡雏等动物。以上各种 Se—VE缺乏动物的病理改变不尽相同,但多数动物的主要病理所见为骨骼肌的变性,坏死,肉眼病... 详细信息

本文报告了缺硒和维生素 E（简称 Se—VE）动物的病理学改变。Se—VE缺乏病多见于子鸭、猪、羔羊、牛犊、鹌鹑、鼠、猫和鸡雏等动物。以上各种 Se—VE缺乏动物的病理改变不尽相同,但多数动物的主要病理所见为骨骼肌的变性,坏死,肉眼病变呈白色条纹状,心肌也出现不同程度的坏死。小肠和砂囊的平滑肌也发生坏死,多见于火鸡和鹌鹑等。荷兰猪、鼠的肝脏

关键词：硒维生素 E 病理学

Immune response to H pylori

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2006年第35期12卷 5593-5598页

作者： Giovanni Suarez victor E Reyes Ellen j Beswick Department of Pediatrics University of Texas Medical Branch Galveston TX 77555 United States Department of Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555United StatesDepartment of Microbiology and Immunol-ogy University of Texas Medical Branch Galveston TX 77555 United States

The gastric mucosa separates the underlying tissue from the vast array of antigens that traffic through the stomach lumen. While the extreme pH of this environment is essential in aiding the activation of enzymes and food digestion, it also renders the gastric epithelium free from bacterial colonization, with the exception of one important human pathogen, Hpylori. This bacterium has developed mechanisms to survive the harsh environment of the stomach, actively move through the mucosal layer, attach to the epithelium, evade immune responses, and achieve persistent colonization. While a hallmark of this infection is a marked inflammatory response with the infiltration of various immune cells into the infected gastric mucosa, the host immune response is unable to clear the infection and may actually contribute to the associated pathogenesis. Here, we review the host responses involved during infection with Hpylori and how they are influenced by this bacterium.

关键词： H pylori Immune response T cell Dendritic cells

H pylori and host interactions that influence pathogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2006年第35期12卷 5599-5605页

作者： Ellen j Beswick Giovanni Suarez victor E Reyes Departments of Pediatrics Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States

H py/ori is probably the most prevalent human pathogen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I carcinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduodenal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory response that becomes chronic, along with a detectable adaptive immune response, these responses are ineffective in clearing the infection. Hpylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they interact with the host epithelium to influence pathogenesis.

关键词： H pylori Gastric cancer Immune response Vacuolating cytotoxin

Stereodynamics of O（^3P）＋H2 at Scattering Energies of 0.5, 0.75, and 1.0 eV

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese journal of Chemical Physics 2010年第2期23卷 149-154,I0001页

作者： victor Wei-keh Wu 国立高雄应用科技大学、化学材料工程系高雄80782 胜利者基础研究实验室、比勒费尔德D-33602 德国

Quasiclassical trajectory calculation of the title reaction O（^3P）＋H2→OH＋H at three different scattering energies of 0.5, 0.75, and 1.0 eV on the lowest electronic potential energy surface 1^3A＂ has been done. Distribution P（θr） of polar angles between the relative velocityk of the reactant and rotational angular momentum vector j＇ of the product, distribution P（φr） of the azimuthal as well as dihedral angles correlating k-k＇-j＇, 3-dimensional distri-bution, and polarization-dependent differential cross sections （PDDCSs）dependent upon the scattering angle of the product molecule OH between the relative velocity k of the reactant and k＇ of the product at different scattering energies of 0.5, 0.75, and 1.0 eV are presented and discussed.

关键词： Quasiclassical trajectory calculation Stereodynamics Alignment Rotational angular momentum Polarization-dependent differential cross section O+H2 reaction

Finite Element Analysis of Residual Stress and Distortion in an Eccentric Ring Induced by Quenching

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料热处理学报 2004年第05B期25卷 746-751页

作者： LI M. victor Portland State University PO Box 751-ME Portland OR 97207-075J USA

The residual stresses and distortion induced by quenching in an eccentric ring were investigated in this study with finite element method. The ring was made of AISI 52100 steel. A fully coupled 3D temperature-displacement analysis was performed to simulate heat transfer, phase transformations, and mechanical stresses and strains during the heating and subsequent quenching processes. Commercial FEA package ABAQUS/Standard 6.4 was used for the analyses along with user subroutines developed by the authors to model the thermal and mechanical constitutive behavior. The simulation results show that transformation plasticity plays an important role on the residual stress distribution.

关键词：残余应力有限元分析变形偏心环相变塑性

Increasing effect of metamorphism on rock properties

在线全文

学校读者我要写书评

暂无评论

International journal of Mining Science and Technology 2015年第2期25卷 205-211页

作者： Akinbinu victor Abioye Department of Mining Engineering Federal University of Technology

This work studied the effect of increasing degree of metamorphism on the properties of *** properties investigated are the physical,mechanical and dynamic *** are important inputs in the design of many mining and civil engineering techniques such as in tunnelling,slope stability and dynamic activities associated with seismicity and *** work compared the degree of metamorphism examined through petrographic studies of the Transvaal Sequence in South Africa with the properties of the *** study shows that as the effect metamorphism increases,the state of stress,compaction of grains,cementation and the brittleness of the rocks *** addition,increase in the metamorphic effect increases the value of the rock *** degree of metamorphism of an outcrop is the key factor influencing its property *** the metamorphism effect of an outcrop may act as a guide to its engineering properties.

关键词： Geology of rock Rock property Brittleness Fragmentation and metamorphism

Changes in insomnia severity with advanced PAP therapy in patients with posttraumatic stress symptoms and comorbid sleep apnea:A retrospective,nonrandomized controlled study

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2019年第4期6卷 308-319页

作者： Barry j.Krakow Natalia D.McIver jessica j.Obando victor A.Ulibarri Sleep&Human Health Institute 6739 Academy Rd NE Ste380AlbuquerqueNM 87109USA Maimonides Sleep Arts&Sciences 6739 Academy Rd NE Ste380AlbuquerqueNM 87109USA Los Alamos Medical Center 3917 W RdLos AlamosNM 87544USA Institution:Mozaik Solutions Solana BeachCA 92075USA

Background:Sleep disorders frequently occur in posttraumatic stress disorder(PTSD)*** insomnia is a common feature of and criteria for the diagnosis of *** sleep disorder,obstructive sleep apnea(OSA),also occurs frequently in PTSD,and emerging research indicates OSA fuels chronic *** research has investigated the impact of OSA treatment on insomnia outcomes(Insomnia Severity Index,ISI)in trauma ***:OSA patients with moderately severe posttraumatic stress symptoms were studied in a retrospective chart ***-six patients who failed CPAP therapy due to expiratory pressure intolerance or complex sleep apnea or both underwent manual titration with advanced PAP modes[autobilevel(ABPAP);adaptive servo-ventilation(ASV)],which were subsequently *** use measured by objective data downloads divided the sample into three groups:compliant regular users(C-RU):n=68;subthreshold users(SC-RU):n=12;and noncompliant users(NC-MU):n=*** average follow-up was 11.89±12.22 *** and posttreatment ISI scores were analyzed to assess residual insomnia symptoms as well as cure ***:The C-RU group showed significant improvements in insomnia with very large effects compared to those in the NC-MU reference group(P=0.019).Insomnia severity significantly decreased in all three groups with large effects(C-RU,P=0.001;SC-RU,P=0.027;NC-MU,P=0.007).Hours of weekly PAP use and insomnia severity were inversely correlated(P=0.001,r=–0.321).However,residual insomnia symptoms based on established ISI cut-offs were quite common,even among the C-RU *** hoc analysis showed that several categories of sedating medications reported at baseline(hypnotics,anti-epileptic,opiates)as well as actual use of any sedating medication(prescription or nonprescription)were associated with smaller insomnia improvements than those in patients not using any sedating ***:In a retrospective,nonrandomized analysis of a selec

关键词： Insomnia Obstructive sleep apnea Complex insomnia CBT-I Posttraumatic stress symptoms CPAP Auto bi-level Adaptive servo-ventilation

Self-referenced photonic chip soliton Kerr frequency comb

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2016年第1期5卷 282-287页

作者： victor Brasch Erwan Lucas john D jost Michael Geiselmann Tobias j Kippenberg École Polytechnique Fédérale de Lausanne(EPFL)–IPHYS Lausanne CH-1015Switzerland

Self-referencing turns pulsed laser systems into self-referenced frequency *** frequency combs allow counting of optical frequencies and have a wide range of *** required optical bandwidth to implement self-referencing is typically obtained via nonlinear broadening in optical *** advances in the field of Kerr frequency combs have provided a path toward the development of compact frequency comb sources that provide broadband frequency combs,exhibit microwave repetition rates and are compatible with on-chip photonic *** devices have the potential to significantly expand the use of frequency *** to date,self-referencing of such Kerr frequency combs has only been attained by applying conventional,fiber-based broadening *** we demonstrate external broadening-free self-referencing of a Kerr frequency *** optical spectrum spanning two-thirds of an octave is directly synthesized from a continuous wave laser-driven silicon nitride microresonator using temporal dissipative Kerr soliton formation and soliton Cherenkov *** this coherent bandwidth and two continuous wave transfer lasers in a 2f–3f self-referencing scheme,we are able to detect the offset frequency of the soliton Kerr frequency *** stabilizing the repetition rate to a radio frequency reference,the self-referenced frequency comb is used to count and track the continuous wave pump laser’s *** work demonstrates the principal ability of soliton Kerr frequency combs to provide microwave-to-optical clockworks on a chip.

关键词： frequency combs integrated optics Kerr frequency combs metrology microresonator frequency combs nonlinear optics