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Impact of Motor Speech Intervention on Neural Activity.in Children with Speech Sound Disorders: Use of Magnetoencephalography

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Journal of Behavioral and Brain Science 2018年第7期8卷 415-429页

作者： vickie y. yu Darren S. Kadis Debra Goshulak Aravind K. Namasivay.m Margit Pukonen Robert M. Kroll Luc F. De Nil Elizabeth W. Pang Department of Communication Disorders and Sciences California State University Northridge California USA Division of Neurology.and Pediatric Neuroimaging Research Consortium Cincinnati Children’s Hospital Medical Center Cincinnati USA The Speech & Stuttering Institute Toronto Canada Department of Speech-Language Pathology University of Toronto Toronto Canada Neurosciences and Mental Health Sick Kids Research Institute Toronto Canada Division of Neurology Hospital for Sick Children Toronto Canada

We present the novel use of a neuroimaging technique, magnetoenceph-alography.(MEG), for examining therapy.related changes in neural activity.during a speech and a non-speech motor task in children with speech sound disorders (SSD). Nine children (mean age = 4.2 y.ars) with SSD were scanned in the MEG before and after an eight-week course of intensive motor speech therapy. MEG tasks involved an oromotor and a sy.lable production task. MEG analy.es identified significant post-therapy.changes in brain regions related to oromotor control and speech production. Behavioral assessments showed significant improvements on measures of motor speech skills and articulation following intervention. This is the first demonstration of the ability.of MEG to: 1) capture brain activations resulting from oromotor movements and simple sy.lable production in y.ung children, and 2) capture brain changes related to speech therapy. As the findings from this study.are promising, we discuss directions for the design of future studies to further examine specific neural dy.functions in speech sound disorders.

关键词： Speech Sound Disorders Children Intervention Neuroimaging Speech Production

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A particle-resolved heat-particle-fluid coupling model by.DEM-IMB-LBM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2267-2281页

作者： Ming Xia Jinlong Fu y.T.Feng Fengqiang Gong Jin y. Hunan Key.Laboratory.of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China Zienkiewicz Institute for Modelling Data and AISwansea UniversitySwanseaSA18EPUK School of Civil Engineering Southeast UniversityNanjing211189China Fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

Multifield coupling is frequently.encountered and also an active area of research in geotechnical *** this work,a particle-resolved direct numerical simulation(PR-DNS)technique is extended to simulate particle-fluid interaction problems involving heat transfer at the grain *** this extended technique,an immersed moving boundary.IMB)scheme is used to couple the discrete element method(DEM)and lattice Boltzmann method(LBM),while a recently.proposed Dirichlet-ty.e thermal boundary.condition is also adapted to account for heat transfer between fluid phase and solid *** resulting DEM-IBM-LBM model is robust to simulate moving curved boundaries with constant temperature in thermal *** facilitate the understanding and implementation of this coupled model for non-isothermal problems,a complete list is given for the conversion of relevant phy.ical variables to lattice ***,benchmark tests,including a single-particle sedimentation and a two-particle drafting-kissing-tumbling(DKT)simulation with heat transfer,are carried out to validate the accuracy.of our coupled *** further investigate the role of heat transfer in particle-laden flows,two multiple-particle problems with heat transfer are *** examples demonstrate that the proposed coupling model is a promising high-resolution approach for simulating the heat-particle-fluid coupling at the grain level.

关键词： Particle-fluid interaction Heat transfer Discrete element method(DEM) Lattice Boltzmann method(LBM) Dirichlet-ty.e thermal boundary Direct numerical simulation

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An MPI parallel DEM-IMB-LBM framework for simulating fluid-solid interaction problems

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2219-2231页

作者： Ming Xia Liuhong Deng Fengqiang Gong Tongming Qu y.T.Feng Jin y. Hunan Key.Laboratory.of Geomechanics and Engineering Safety Xiangtan UniversityXiangtan411105China School of Civil Engineering Southeast UniversityNanjing211189China Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyHong KongChina Zienkiewicz Centre for Computational Engineering Swansea UniversitySwanseaSA18ENUK Fujian Research Center for Tunneling and Urban Underground Space Engineering Huaqiao UniversityXiamen361021China

The high-resolution DEM-IMB-LBM model can accurately.describe pore-scale fluid-solid interactions,but its potential for use in geotechnical engineering analy.is has not been fully.unleashed due to its prohibitive computational *** overcome this limitation,a message passing interface(MPI)parallel DEM-IMB-LBM framework is proposed aimed at enhancing computation *** framework utilises a static domain decomposition scheme,with the entire computation domain being decomposed into multiple subdomains according to predefined processors.A detailed parallel strategy.is employ.d for both contact detection and hy.rody.amic force *** particular,a particle ID re-numbering scheme is proposed to handle particle transitions across sub-domain *** benchmarks are conducted to validate the accuracy.and overall performance of the proposed ***,the framework is applied to simulate scenarios involving multi-particle sedimentation and submarine *** numerical examples effectively.demonstrate the robustness and applicability.of the MPI parallel DEM-IMB-LBM framework.

关键词： Discrete element method(DEM) Lattice Boltzmann method(LBM) Immersed moving boundary.IMB) Multi-cores parallelization Message passing interface(MPI) CPU Submarine landslides

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Repeatability.interocular correlation and agreement of optic nerve head vessel density.in healthy.ey.s:a sweptsource optical coherence tomographic angiography.study

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International Journal of Ophthalmology.English edition) 2024年第5期17卷 896-903页

作者： Dan-Qi Fang Da-Wei y.ng Xiao-Ting Mai Carol y.Cheung Hao-y. Chen Joint Shantou International Ey. Center Shantou University&the Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology.and Visual Sciences Chinese University of Hong KongHong Kong 999077China

AIM:To assess the repeatability.interocular correlation,and agreement of quantitative swept-source optical coherence tomography.angiography.OCTA)optic nerve head(ONH)parameters in healthy.***:Thir ty.three healthy.subjects were *** ONH of both ey.s were imaged four times by.a swept-source-OCTA using a 3 mm×3 mm scanning *** of the radial peripapillary.capillary.were analy.ed by.a customized Matlab program,and the vessel density.fractal dimension,and vessel diameter index were *** repeatability.of the four scans was determined by.the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analy.is using the Pearson correlation coefficient,ICC and Bland-Altman ***:All swept-source-OCTA ONH parameters exhibited certain repeatability.with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary.vessel density.ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary.vessel density.exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary.vessel ***:OCTA ONH parameters demonstrate good repeatability.in healthy.*** interocular correlations of papillary.vessel density.fractal dimension and vessel diameter index are high,but the correlation for circumpapillary.vessel density.is moderate.

关键词： interocular correlation repeatability optic nerve head optical coherence tomography.angiography vessel density

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Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish

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Journal of Genetics and Genomics 2024年第3期51卷 359-362页

作者： Ao Zhang Jingao Lu Shachuan Feng Huapeng y. Tao y. Shizheng Zhao Kemin Chen Zhibin Huang Jin Xu Jianan y.Qu Zilong Wen Division of Life Science Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Department of Immunology.and Microbiology School of Life ScienceSouthern University of Science and TechnologyShenzhenGuangdong 518055China Biomedical Research Institute Shenzhen Peking University-Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Greater Bay.Biomedical Innocenter Shenzhen Bay LaboratoryShenzhenGuangdong 518067China

Macrophages and neutrophils are key.components of my.loid cells and play.critical roles in innate immune responses,organ formation,and tissue *** integrity.of their functions heavily.relies on the generation of a proper number of mature macrophages and neutrophils through embry.nic and adult *** mammalian adult my.lopoiesis,oligopotent common my.loid progenitors(CMPs)are known to be the earliest my.loid progenitors,which give rise to granulocy.e-macrophage progenitors(GMPs),subsequently.differentiate into unipotent neutrophil and macrophage precursors,and finally.mature macrophages and neutrophils(Orkin and Zon,2008).In contrast,the ontogeny.of embry.nic my.lopoiesis and the mechanism underly.ng the formation of macrophages and neutrophils remainless understood.

关键词： fish macrophage homeostasis

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Quantum Spin Exchange Interactions to Accelerate the Redox Kinetics in Li–S Batteries

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Nano-Micro Letters 2024年第5期16卷 370-383页

作者： y. Du Weijie Chen y. Wang y.e y. Kai Guo Gan Qu Jianan Zhang Key.Laboratory.of Advanced Energy.Cataly.ic and Functional Materials Preparation of Zhengzhou City College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001People’s Republic of China

Spin-engineering with electrocataly.ts have been exploited to suppress the“shuttle effect”in Li–S *** selec-tion,spin-dependent electron mobility.and spin potentials in activation barriers can be optimized as quantum spin exchange interactions lead-ing to a significant reduction of the electronic repulsions in the orbitals of ***,we anchor the MgPc molecules on fluorinated carbon nanotubes(MgPc@FCNT),which exhibits the single active Mg sites with axial *** to the density.functional theory.calculations,the electronic spin polarization in MgPc@FCNT not only.increases the adsorption energy.toward LiPSs intermediates but also facilitates the tunneling process of electron in Li–S *** a result,the MgPc@FCNT provides an initial capacity.of 6.1 mAh cm^(-2) even when the high sulfur loading is 4.5 mg cm^(-2),and still maintains 5.1 mAh cm^(-2) after 100 *** work provides a new perspective to extend the main group single-atom cataly.ts enabling high-performance Li–S batteries.

关键词： Metal phthalocy.nines Spin polarization Electrocataly.is Li–S batteries

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Inflammatory.Factor IL1αInduces Aberrant Astrocy.e Proliferation in Spinal Cord Injury.Through the Grin2c/Ca^(2+)/CaMK2b Pathway

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Neuroscience Bulletin 2024年第4期40卷 421-438页

作者： y. Xia Lu Ding Changlin Zhang Qi Xu Ming Shi Tianshun Gao Feng-Quan Zhou David y.B.Deng Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Department of Gy.ecology The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Pelvic Floor Disorders Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Big Data Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou310016China Orthopaedic and Neurological Repair Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Spinal cord injury.SCI)is one of the most devastating traumas,and the aberrant proliferation of astrocy.es usually.causes neurological ***,the mechanism underly.ng astrocy.e over-proliferation after SCI is ***2c(glutamate ionotropic receptor ty.e 2c)play. an essential role in cell *** bioinformatic analy.is indicated that Grin2c and Ca^(2+)transport functions were inhibited in astrocy.es after *** of Grin2c stimulated astrocy.e proliferation by.inhibiting the Ca^(2+)/calmodulin-dependent protein kinase 2b(CaMK2b)pathway.in *** screening different inflammatory.factors,interleukin 1α(IL1α)was further found to inhibit Grin2c/Ca^(2+)/CaMK2b and enhance astrocy.e proliferation in an oxidative damage *** of IL1αusing neutralizing antibody.resulted in increased Grin2c expression and the inhibition of astrocy.e proliferation ***,this study.suggests that IL1αpromotes astrocy.e proliferation by.suppressing the Grin2c/Ca^(2+)/CaMK2b pathway.after SCI,revealing a novel pathological mechanism of astrocy.e proliferation,and may.provide potential targets for SCI repair.

关键词： IL1α Grin2c Astrocy.e Spinal cord injury

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Transcriptomic and cellular decoding of scaffolds-induced suture mesenchy.e regeneration

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International Journal of Oral Science 2024年第2期16卷 306-321页

作者： Jiay. Wu Feifei Li Peng y. Changhao y. Chuy. Han y.tian Wang Fany.an y. Ling y. State Key.Laboratory.of Oral Diseases&National Center for Stomatology.National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key.Laboratory.of Oral Diseases&National Center for Stomatology.National Clinical Research Center for Oral Diseases&Department of Cariology.and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key.Laboratory.of Oral Diseases&National Center for Stomatology.National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal *** extensive studies on mineralized parenchy.al tissue rebuilding,regenerating and maintaining undifferentiated mesenchy.e within calvarial bone remain very.challenging with limited advances *** knowledge has evidenced the indispensability.of rebuilding suture mesenchy.al stem cell niches to avoid severe brain or even sy.tematic *** to date,the absence of promising therapeutic biomaterials/scaffolds *** reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of *** address these issues,in this study.we sy.tematically.investigated the cellular fate determinations and transcriptomic mechanisms by.distinct ty.es of commonly.used calvarial *** data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.A feasible scaffold,poly.actic acid electrospinning membrane(PLA),was next identified to precisely.control mesenchy.al ingrowth and self-renewal to rebuild non-osteogenic suture-like tissue at the defect center,meanwhile supporting proper osteointegration with defect bony.***,transcriptome analy.is and cellular mechanisms underly.ng the well-orchestrated cell fate determination of PLA were *** study.for the first time cellularly.decoded the fate regulations of scaffolds in suture-bony.composite defect healing,offering clinicians potential choices for regenerating such complicated injuries.

关键词： injuries healing suture

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Relative Broken Family.Sensitivity

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2297-2306页

作者： Zhuo Wei LIU Tao y. Department of Mathematics Shantou UniversityShantou 515063P.R.China

Letπ:(X,T)→(y.S)be a factor map between two topological dy.amical sy.tems,and F_(a) Furstenberg family.of *** introduce the notion of relative broken *** Fs(***,Finf)be the families consisting of all sy.detic subsets(*** upper Banach density.subsets,infinite subsets).We show that for a factor mapπ:(X,T)→(y.S)between transitive sy.tems,πis relatively.broken F-sensitive for F=Fs or Fpubd if and only.if there exists a relative sensitive pair which is an F-recurrent point of(R_(π),T^((2)));is relatively.broken Finf-sensitive if and only.if there exists a relative sensitive pair which is not *** a factor mapπ:(X,T)→(y.S)between minimal sy.tems,we get the structure of relative broken F-sensitivity.by.the factor map to its maximal equicontinuous factor.

关键词： Relative sensitivity recurrent points Furstenberg family relative sensitive pairs maximal equicontinuous factor

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The effect of Ti and Zr content on the structure,mechanics and energy.release characteristics of Ti—Zr—Ta alloy.

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Defence Technology.防务技术） 2024年第1期31卷 343-350页

作者： Jia-y. Meng Jing-zhi He Bin Zhang Jin Chen Shun Li Dun Niu y. Tang Xi’an Modern Chemistry.Research Institute Xi'an710065China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China

Energetic structural materials(ESMs)are a new ty.e of structural materials with bearing and damage *** this work the microstructure,mechanical properties and energy.release characteristics of multi-element Ti-Zr-Ta alloy. with good casting performance were *** microstructure of the Ti_(x)ZrTa alloy. gradually.change from BCC+HCP to single BCC structure with the increase of *** the Ti_(2)Zr_(y.Ta alloy. was still uniform and single BCC structure with the increase of *** evolution of microstructure and composition then greatly.affect the mechanical properties and energy.release characteristics of Ti-Zr-Ta *** sy.ergistic effect of dual phase structure increases the fracture strain of Ti_(x)ZrTa(x=0.2,0.5)with the Ti content decreases,while the fracture strain of Ti_(x)ZrTa(x=2.0,3.0,4.0)gradually.increase with the Ti content increases caused by.the annihilation of the obstacles for dislocation *** as Zr content increases,the fracture strain of Ti_(2)Zr_(y.Ta alloy. decrease,then the oxidation reaction rate and fragmentation degree gradually.*** higher oxidation rate and the lager exposed oxidation area jointly.leads the higher releasing energy.efficiency.of Ti_(x)ZrTa alloy. with low Ti content and Ti_(2)Zr_(y.Ta alloy. with high Zr content.

关键词： Energetic structural materials Ti-Zr-Ta Multi-element alloy Energy.release characteristics

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