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muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres marmol-Perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness vicente m.rtinez-vizcaino Jonatan R.Ruiz Luis Gracia-marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain maimonides Biomedical Research Institute of Cordoba(ImIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBmD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBmD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBmD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBmD(g/cm2).Associations between muscle strength and aBmD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBmD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** more than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBmD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBmD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBmD Z-scores at total body,total hip,and femoral *** muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBmD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

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Efficient removal of the recalcitrant metamizole contaminant from drinking water by using a CaLaCoO_(9) perovskite supported on recycled polyethylene

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Journal of Environmental Sciences 2024年第2期136卷 56-67页

作者： Ernesto Valadez-Renteria Christian Perez-Carrasco Dulce Yolotzin medina-Velazquez vicente Rodriguez-Gonzalez Jorge Oliva CONACYT-División de materiales Avanzados Instituto Potosino de Investigación Científica y Tecnológica A.C.San Luis PotosíSLP 78216México División de Ciencias Básicas e Ingeniería Universidad Autónoma Metropolitana AzcapotzalcoCol.Reynosa-TamaulipasC.P.MéxicoDF 02200México

metamizole(mZ)is a widely used anti-inflammatory *** to its common use,this contaminant is found in sewage and *** order to reduce the contamination produced by the mZ,we fabricated in this work a photocatalytic composite using recycled polyethylene(RPE)and the CaLaCoO_(9)(LCCO)*** nanoparticles had a microplate-like morphology and sizes of 1.4–5.5μm according to the analysis of *** photocatalytic properties of the LCCO powders were evaluated under ultraviolet-visible(UV-Vis)irradiation and found a removal efficiency of 96%.When the RPE+LCCO composite was employed for the photocatalytic degradation of mZ,a maximum degradation of 92.5%was *** influence of the pH on the photocatalytic activity was also studied and found that an initial pH=3 produced a total degradation of mZ after 240 min of UV-Vis ***,three reuse cycles were carried out for the pure LCCO powders and for the RPE+LCCO composites and found that the maximum loss of degradation was 5%.Furthermore,scavenger experiments demonstrated that the super oxide and hydroxyl radicals are formed during the photocatalytic reaction and were responsible for the degradation of ***,the X-ray photoelectron-spectroscopy and Raman analysis demonstrated the formation of defects(oxygen vacancies),those ones delayed the electron-hole recombination,which in turn,enhanced the degradation of the ***,the studies performed in this work proved that composites made with recycled plastics and LCCO perovskites are a low-cost and feasible alternative for the cleaning of water sources polluted with pharmaceutical compounds.

关键词： Photocatalysis metamizole Pharmaceutical contaminant UV-Vis irradiation Perovskite

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Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi:a scoping review

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Animal Diseases 2024年第1期4卷 48-58页

作者： Ricardo Sanchez Pérez Josémanuel Aranda-Coello JoséAntonio De Fuentes vicente Oscar Rico Chavez Facultad de Estudios Superiores Cuautitlan Universidad Nacional Autonoma deMexicoCuautitlan lzcalliEstadodeMexicoMexico El Colegio de la Frontera Sur-Unidad Campeche CampecheCampecheMexico Instituto de Ciencias Biologicas-Universidad de Ciencias y Artes de Chiapas Tuxtla GutierrezChiapasMexico Facultad de medicina Veterinaria y Zootecnia-Universidad Nacional Autonoma demexico Ciudad deMexicoMexico

Trypanosoma cruzi is the etiologic agent of Chagas *** flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family(known as"kissing bugs").Despite the fact that hundreds of species of wild mammals are part of the reservoir system,the morphologi-cal changes and clinical manifestations resulting from the pathogenesis of the infection have been largely *** aim of this review is to systematically compile the available information regarding clinicopathological altera-tions in wild mammals due to natural infection by *** was obtained from six online bibliographic data search platforms,resulting in the identification of 29 publications that met the inclusion *** was the most common clinical manifestation,cardiac damage was the main finding at necropsy,and lymphoplas-macytic inflammation was the most frequent microscopic ***,regardless of its role as a reservoir,*** has the potential to affect the health status of wild mammals,a situation that highlights the need for further research to analyze,measure,and compare its effects at both the individual and population levels.

关键词： Trypanosoma cruzi Chagas disease American trypanosomiasis Clinicopathological alterations Natural infection Wild mammals

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Tri-axial accelerometry shows differences in energy expenditure and parental effort throughout the breeding season in long-lived raptors

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Current Zoology 2022年第1期68卷 57-67页

作者： Pascual LOPEZ-LOPEZ Arturo mPERONA Olga EGEA-CASAS Jon mORANT vicente URIOS movement Ecology Laboratory Cavanilles Institute of Biodiversity and Evolutionary BiologyUniversity of Valencia.C/Catedratico JoseBeltran 2E-46980 PaternaValenciaSpain Department of Ornithology Aranzadi Sciences SocietyDonostia-S.SebastianGuipuzcoa 03690Spain Vertebrates Zoology Research Group University of AlicanteApdo.99Alicante E-03080Spain

Cutting-edge technologies are extremely useful to develop new workflows in studying ecological data,particularly to understand animal behavior and movement trajectories at the individual *** parental care is a well-studied phenomenon,most studies have been focused on direct observational or video recording data,as well as experimental ***,what happens out of our sight still remains *** high-frequency GPS/GSm dataloggers and tri-axial accelerometers we monitored 25 Bonelli’s eagles Aquila fasciata during the breeding season to understand parental activities from a broader *** used recursive data,measured as number of visits and residence time,to reveal nest attendance patterns of biparental care with role specialization between *** data interpreted as the overall dynamic body acceleration,a proxy of energy expenditure,showed strong differences in parental effort throughout the breeding season and between ***,males increased substantially their energetic requirements,due to the increased workload,while females spent most of the time on the ***,during critical phases of the breeding season,a low percentage of suitable hunting spots in eagles’territories led them to increase their ranging behavior in order to find food,with important consequences in energy consumption and mortality *** results highlight the crucial role of males in raptor species exhibiting biparental ***,we exemplify how biologging technologies are an adequate and objective method to study parental care in raptors as well as to get deeper insight into breeding ecology of birds in general.

关键词： biologging GPS movement ecology ODBA space use telemetry

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Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing

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Neural Regeneration Research 2022年第8期17卷 1652-1658页

作者： Carmen m.Labandeira Arturo Fraga-Bau David Arias Ron Elena Alvarez-Rodriguez Pablo vicente-Alba Javier Lago-Garma Ana I.Rodriguez-Perez Department of Clinical Neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain Laboratory of Cellular and molecular Neurobiology of Parkinson’s Disease Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Department of Clinical Oncology University Hospital ComplexOurenseSpain Department of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain Networking Research Center on Neurodegenerative Diseases(CiberNed) MadridSpain

In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,plasticity,oxidative stress and *** mellitus and Parkinson’s disease are both aging-associated diseases that are turning into epidemics *** mellitus and insulin resistance not only increase the possibility of developing Parkinson’s disease but can also determine the prognosis and progression of Parkinsonian ***,there are no available curative or disease modifying treatments for Parkinson’s disease,but the role of insulin and antidiabetic medications in neurodegeneration opens a door to treatment repurposing to fight against Parkinson’s disease,both in diabetic and nondiabetic Parkinsonian ***,it is essential to comprehend how a frequent and treatable disease such as diabetes can influence the progression of neurodegeneration in a challenging disease such as Parkinson’s ***,we review the present evidence on the connection between Parkinson’s disease and diabetes and the consequential implications of the existing antidiabetic molecules in the severity and development of Parkinsonism,with a particular focus on glucagon-like peptide-1 receptor agonists.

关键词： antidiabetic diabetes mellitus dopamine exenatide glucagon-like peptide-1 insulin neurodegeneration neuroinflammation Parkinson’s disease repurposing

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A novel and stretchable carbon-nanotube/Ni@TiO_(2):W photocatalytic composite for the complete removal of diclofenac drug from the drinking water

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Journal of Environmental Sciences 2023年第4期126卷 575-589页

作者： Ernesto Valadez-Renteria Rafael Perez-Gonzalez Christian Gomez-Solis Luis Armando Diaz-Torres Armando Encinas Jorge Oliva vicente Rodriguez-Gonzalez Consejo Nacional de Ciencia y Tecnología-División de materiales Avanzados Instituto Potosino de Investigación Científica y TecnológicaSan Luis Potosí78216México División de Ciencias e Ingenierías Universidad de GuanajuatoLeón 37150México Grupo de Espectroscopia de materiales Avanzados y Nanoestructurados(GEmANA) Centro de Investigaciones enópticaA.C.Lomas Del CampestreLeón 37150México

We present the structural,morphological and photocatalytic properties of stretchable composites made with carbon nanotubes (CNTs),silicon rubber and Ni@TiO_(2):W nanoparticles(TiWNi NPs) with average size of 37±2 *** images showed that the TiWNi NPs decorated the surface of the CNT fibers,which are oriented in a preferential *** NPs presented a mixture of anatase/rutile phases with cubic *** performance of the TiWNi powders and stretchable composites was evaluated for the photocatalytic degradation of diclofenac (DCF) anti-inflammatory drug under ultraviolet-visible *** results revealed that the maximum DCF degradation percentages were 34.6%,91.9%,97.1%,98.5%and 100%for the CNT composite (stretched at 0%),TiWNi powders,CNT+TiWNi(stretched at 0%),CNT+TiWNi (stretched at 50%) and CNT+TiWNi (stretched at 100%),***,stretching the CNT+TiWNi composites was a good strategy to enhance the DCF degradation percentage from 97.1%to 100%,since stretching created additional defects (oxygen vacancies) that acted as electron sink,delaying the electron-hole recombination,and favors the DCF ***/absorbance measurements confirmed the presence of such ***,the reactive oxygen species (ROS) were determined by the scavenger’s experiments and found that the main ROS were the·OH and O_(2)-radicals,which attacked the DCF molecules,causing their *** results of this investigation confirmed that the stretchable CNT/TiWNi-based composites are a viable alternative to remove pharmaceutical contaminants from water and can be manually separated from the decontaminated water,which is unviable using photocatalytic powders.

关键词： Diclofenac Pharmaceutical contaminant TiO_(2) Carbon nanotubes Stretchable composite Photocatalysis

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Theplant cytosolic m^(6)A RNA methylome stabilizes photosynthesis in the cold

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Plant Communications 2023年第6期4卷 70-84页

作者： Alexandre magno vicente Nikolay manavski Paul Torben Rohn Lisa-marie Schmid Antoni Garcia-molina Dario Leister Charlotte Seydel Leo Bellin Torsten möhlmann Gregor Ammann Stefanie Kaiser Jörg meurer Plant molecular Biology Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Development Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Physiology Faculty of BiologyUniversity of KaiserslauternErwin-Schröodinger-Street767663 KaiserslauternGermany Pharmaceutical Chemistry Goethe University FrankfurtMax-von-Laue-Str.960438 Frankfurt am MainGermany Present address:Loewe Biochemica GmbH Möuhlweg 2a82054 SauerlachGermany Present address:Center for Research in Agricultural Genomics 08193

The sessile lifestyle of plants requires an immediate response to environmental stressors that affect photosynthesis,growth,and crop ***,we showed that three abiotic perturbations—heat,cold,and high light—triggered considerable changes in the expression signatures of 42 epitranscriptomic factors(writers,erasers,and readers)with putative chloroplast-associated functions that formed clusters of commonly expressed genes in *** expression changes under all conditions were reversible upon deacclimation,identifying epitranscriptomic players as modulators in acclimation *** dysfunctions,particularly those induced by the oxidative stress-inducing norflurazon in a largely GENOmE UNCOUPLED-independent manner,triggered retrograde signals to remodel chloroplastassociated epitranscriptomic expression patterns.N6-methyladenosine(m^(6)A)is known as the most prevalent RNA modification and impacts numerous developmental and physiological functions in living *** cold treatment,expression of components of the primary nuclear m^(6)A methyltransferase complex was upregulated,accompanied by a significant increase in cellular m^(6)A mRNA *** the cold,the presence of FIP37,a core component of the writer complex,played an important role in positive regulation of thylakoid structure,photosynthetic functions,and accumulation of photosystemⅠ,the Cytb6f complex,cyclic electron transport proteins,and Curvature Thylakoid1 but not that of photosystemⅡcomponents and the chloroplast ATP *** of FIP37 affected abundance,polysomal loading,and translation of cytosolic transcripts related to photosynthesis in the cold,suggesting m^(6)Adependent translational regulation of chloroplast *** summary,we identified multifaceted roles of the cellular m^(6)A RNA methylome in coping with cold;these were predominantly associated with chloroplasts and served to stabilize photosynthesis.

关键词： m^(6)A RNA methylation cold acclimation stress response Arabidopsis thaliana photosynthesis chloroplast

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Carbon and Water Footprint Evaluation of 120Wp Rural Household Photovoltaic System: Case Study

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Smart Grid and Renewable Energy 2023年第3期14卷 31-59页

作者： Alberto Tama Diego vicente Department of Industrial Organization Engineering Universitat Carlemany (UCMA) Andorra France International University Center of Barcelona (UNIBA) University of Barcelona (UB) Barcelona Spain

This study uses the Life Cycle Analysis (LCA) to evaluate the magnitude of the environmental impact, in terms of global warming potential, and water footprint throughout the 20 years of useful life of a rural electrical energy concession comprised of 120Wp Households photovoltaic systems (HPS) in the isolated communities of San martin, in the Peruvian Amazon region. On the other hand, due to the particular conditions of the system (installation, operation, maintenance, monthly tariff collection), it is necessary to know its real impact and sustainability;not only through the aforementioned environmental impact indicators, but also by energy intensity values required by the system throughout its life cycle. Therefore, this paper used the Cumulative energy demand (CED) method to determine the amount of energy taken from natural resources for each process involved in the LCA and calculated with this, i.e., the Energy Payback Time (EPBT) of the whole system. Likewise, the HPS has been environmentally compared to other case studies and the Peruvian Energy mix, revealing a lower impact in the latter case and results within the range for stand-alone systems. Besides, the HPS shows a strong relation between energy production and O&m condition. Additionally, this study allows a further promotion of the use of this type of system in isolated areas, as well as the diversification of electricity generation in Peru.

关键词： Life Cycle Analysis Carbon Footprint Water Footprint Solar Home System Life Cycle Inventory

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mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

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Cellular & molecular Immunology 2023年第8期20卷 955-968页

作者： manuel m.vicente Inês Alves Ângela Fernandes Ana m.Dias Beatriz Santos-Pereira Elena Pérez-Anton Sofia Santos Tao Yang Alexandra Correia Anja münster-Kühnel Afonso R.m.Almeida Sarina Ravens Gabriel A.Rabinovich manuel Vilanova Ana E.Sousa SaloméS.Pinho i3S–Institute for Research and Innovation in Health University of PortoPortoPortugal Institute of Biomedical Sciences Abel Salazar(ICBAS) University of PortoPortoPortugal Graduate Program in Areas of Basic and Applied Biology(GABBA) ICBASUniversity of PortoPortoPortugal Faculty of medicine University of PortoPortoPortugal Nephrology Department Centro Hospitalar e Universitário do PortoPortoPortugal Institute of Immunology Hannover Medical SchoolHannoverGermany Institute of Clinical Biochemistry Hannover Medical SchoolHannoverGermany Instituto de medicina molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal Laboratorio de Inmunopatología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Laboratorio de Inmuno-oncología Translacional Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Ciudad de Buenos AiresArgentina Facultad de Ciencias Exactas y Naturales(FCEyN) Universidad de Buenos AiresCiudad de Buenos AiresArgentina

T-cell development ensures the formation of diverse repertoires of T-cell receptors(TCRs)that recognize a variety of *** is a major posttranslational modification present in virtually all cells,including T-lymphocytes,that regulates activity/*** these structures are known to be involved in TCR-selection in DP thymocytes,it is unclear how glycans regulate other thymic development processes and how they influence susceptibility to ***,we discovered stage-specific glycome compositions during T-cell development in human and murine thymocytes,as well as dynamic *** restricting the N-glycosylation profile of thymocytes to high-mannose structures,using specific glycoengineered mice(Rag1Cremgat1fl/fl),we showed remarkable defects in key developmental checkpoints,includingß-selection,regulatory T-cell generation andγδT-cell development,associated with increased susceptibility to colon and kidney inflammation and *** further demonstrated that a single N-glycan antenna(modeled in Rag1Cremgat2fl/fl mice)is the sine-qua-non condition to ensure normal *** conclusion,we revealed that mannosylated thymocytes lead to a dysregulation in T-cell development that is associated with inflammation susceptibility.

关键词： N-glycosylation T-cell development Thymocytes Glycocalyx Inflammation

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Genomic prediction of the performance of hybrids and the combining abilities for line by tester trials in maize

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The Crop Journal 2022年第1期10卷 109-116页

作者： Ao Zhang Paulino Pérez-Rodríguez Felix San vicente Natalia Palacios-Rojas Thanda Dhliwayo Yubo Liu Zhenhai Cui Yuan Guan Hui Wang Hongjian Zheng michael Olsen Boddupalli m.Prasanna Yanye Ruan Jose Crossa Xuecai Zhang College of Biological Science and Technology Shenyang Agricultural UniversityShenyang 110866LiaoningChina b International maize and Wheat Improvement Center(CImmYT) El BatanTexcoco 56237Mexico CImmYT-China Specialty maize Research Center Shanghai Academy of Agricultural SciencesShanghai 200063China Colegio de Postgraduados Estado De MéxicoMexico Crop Breeding and Cultivation Research Institute Shanghai Academy of Agricultural SciencesShanghai 200063China International maize and Wheat Improvement Center(CImmYT) P.O.Box 1041Village MarketNairobi 00621Kenya

The two most important activities in maize breeding are the development of inbred lines with high values of general combining ability(GCA)and specific combining ability(SCA),and the identification of hybrids with high yield *** selection(GS)is a promising genomic tool to perform selection on the untested breeding material based on the genomic estimated breeding values estimated from the genomic prediction(GP).In this study,GP analyses were carried out to estimate the performance of hybrids,GCA,and SCA for grain yield(GY)in three maize line-by-tester trials,where all the material was phenotyped in 10 to 11 multiple-location trials and genotyped with a mid-density molecular marker *** showed that the prediction abilities for the performance of hybrids ranged from 0.59 to0.81 across all trials in the model including the additive effect of lines and *** the model including both additive and non-additive effects,the prediction abilities for the performance of hybrids were improved and ranged from 0.64 to 0.86 across all *** prediction abilities of the GCA for GY were low,ranging between-0.14 and 0.13 across all trials in the model including only inbred lines;the prediction abilities of the GCA for GY were improved and ranged from 0.49 to 0.55 across all trials in the model including both inbred lines and testers,while the prediction abilities of the SCA for GY were negative across all *** prediction abilities for GY between testers varied from-0.66 to 0.82;the performance of hybrids between testers is difficult to *** offers the opportunity to predict the performance of new hybrids and the GCA of new inbred lines based on the molecular marker information,the total breeding cost could be reduced dramatically by phenotyping fewer multiple-location trials.

关键词： maize Genomic selection Line-By-Tester General combining ability Specific combining ability

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