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Intestinal anti-inflammatory effect of a plant sterol food supplement in experimental murine colitis and cell co-culture models

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Food Science and Human Wellness 2024年

作者： Mussa Makran Antonio Cilla Rosa maría Giner maría Carmen Recio Luisa Tesoriere Alessandro Attanzio Guadalupe Garcia-Llatas Nutrition and Food Science Area， Faculty of Pharmacy and Food Sciences， University of Valencia.Av.vicente Andrés Estellés s/n Department of Pharmacology， Faculty of Pharmacy and Food Sciences， University of Valencia.Av.vicente Andrés Estellés s/n Department of Biological， Chemical and Pharmaceutical Sciences and Technologies， University of Palermo

The potential of a plant sterol food supplement （PS-FS） in addressing intestinal inflammation in vivo and in vitro was evaluated. As in vivo model， C57BL/6J mice were exposed to 1.5% dextran sulfate sodium in three 5-day periods， with 10-day rest intervals in between， daily reciving PS-FS （35 mg PS/kg）. The in vitro approach involved a bi-cameral system with 8-day-differentiated Caco-2 （apical） and RAW264.7 cells （basolateral）. The bioaccessible fraction of PS-FS， obtained after INFOGEST 2.0 simulated gastrointestinal digestion， was added to the apical part （90 min）， followed by stimulation with lipopolysaccharide （1 μg/mL， 24 h）. PS-FS alleviated rectal bleeding and rebalanced pro- (tumor necrosis factor α， interleukin （IL）-6， and IL-8) and anti-inflammatory cytokines （IL-10）. Additionally， PS-FS ameliorated histopathological damage and enhancing occludin expression. A reduction in oxidative stress was evidenced by decreased myeloperoxidase activity and reactive oxygen species production. The anti-inflammatory mechanism included suppressing cyclooxygenase 2 expression， reducing prostaglandin E2production， and inhibiting the phosphorylation and nuclear translocation of the nuclear factor κB p65 subunit. This study reveals the potential of PS-FS as a therapeutic intervention for colitis. The alignment between in vivo and in vitro outcomes substantiates the appropriateness of the co-culture model to evaluate the anti-inflammatory activity of foods.

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From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio maría del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera maría Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José Paz-Ibarra marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

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Architectural graphics and the experience of space. Freehand drawing and photograph to deepen on communicative qualities in linear perspective

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Frontiers of Architectural Research 2023年第5期12卷 855-866页

作者： vicente Lopez-Chao marıa Rodrıguez-Grela Architectural Graphics Department School of ArchitectureUniversidade da CorunaLa Coruna 15071Spain

Architecture communication on photo-sharing social networking services like Instagram focuses on ***,the conceptual intention or the experience of the architectural space has less impact in these *** architectural graphics techniques are closer to this purpose due to their *** main objective is to identify the visual qualities of the architectural space experience from a linear *** do this,the research proposes the design of a visual pattern recognition tool and applies it to pairs of images(photography and drawing)from the same *** results provide the strategy design based on five variables:the level of human presence,the distortion of perspective,the chromatic distortion,the overlay realism and the ***,the visual summaries lead to values that help to understand the communicative qualities of the experience of space due to their ability to compare main milestones of visual information.

关键词： Architecture Visual communication Storytelling Architectural design Conceptual representation Photography

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Biodegradable stents in gastrointestinal endoscopy

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World Journal of Gastroenterology 2014年第9期20卷 2212-2217页

作者： vicente Lorenzo-Zú?iga vicente Moreno-de-Vega Ingrid marín Jaume Boix Endoscopy Unit Department of Gastroenterology Hospital Universitari Germans Trias i Pujol 08916 Badalona Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) 08916 Badalona Spain

Biodegradable stents(BDSs)are an attractive option to avoid ongoing dilation or surgery in patients with benign stenoses of the small and large *** experience with the currently the only BDS for endoscopic placement,made of Poly-dioxanone,have shown promising *** some aspects should be improved as are the fact that BDSs lose their radial force over time due to the degradable material,and that can cause stent-induced mucosal or parenchymal *** complication rate and modest clinical efficacy has to be carefully considered in individual patients prior to placement of ***,the price of these stents therefore it is nowadays an important limitation.

关键词： Biodegradable stents Strictures Endoscopy Endoscopic placement Stenoses

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Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells

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World Journal of Gastroenterology 2006年第36期12卷 5834-5845页

作者： Raquel Taléns-Visconti Ana Bonora Ramiro Jover vicente Mirabet Francisco Carbonell José vicente Castell maría José Gómez-Lechón Unidad de Hepatología Experimental Centro de Investigación Hospital La Fe Valencia Spain Departamento de Bioquímica y Biología Molecular Universidad de Valencia Valencia Spain. Unidad de Hepatología Experimental Centro de Investigación Hospital La Fe Valencia Spain Centro de Transfusión de la Comunidad Valenciana Generalidad ValencianaValencia Spain Unidad de Hepatología Experimental Centro de Investigación Hospital La Fe Valencia.Spain. Departamento de Bioquímica y Biología Molecular Universidad de Valencia Valencia Spain Unidad de Hepatología Experi-mental Centro de Investigación Hospital La Fe Valencia Spain

AIM： To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells （ADSC） and bone marrow-derived mesenchymal stem cells （BMSC） in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC. METHODS： BMSCs were obtained from patients undergoing total hip arthroplasty and ADSC from human adipose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver development using a 2-step protocol with sequential addition of growth factors, cytokines and hormones. Hepatic differentiation was RT-PCR-assessed and liver-marker genes were immunohistochemically ***： BMSC and ADSC exhibited a fibroblastic morphology that changed to a polygonal shape when cells differentiated. Expression of stem cell marker Thyl decreased in differentiated ADSC and BMSC. However, the expression of the hepatic markers, albumin and CYPs increased to a similar extent in differentiated BMSC and ADSC. Hepatic gene activation could be attributed to increased liver-enriched transcription factors （C/EBPβ and HNF4α）, as demonstrated by adenoviral expression ***： Mesenchymal stem cells can be induced to hepatogenic transdifferentiation in vitro. ADSCs have a similar hepatogenic differentiation potential to BMSC, but a longer culture period and higher proliferation capacity. Therefore, adipose tissue may be an ideal source of large amounts of autologous stem cells, and may become an alternative for hepatocyte regeneration, liver cell transplantation or preclinical drug testing.

关键词： Mesenchymal stem cells Bone marrow Adipose tissue Transdifferentiation Hepatic lineage Liver cell transplantation.

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Is the Export-led Growth Hypothesis Enough to Account for China's Growth?

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China & World Economy 2010年第4期18卷 34-51页

作者： maría Jesús Herrerias vicente Orts Department of Economics and lnstitut of International Economics Universitat Jaume I Department of Economics Universitat Jaume I

One of the missing pieces preventing us from understanding recent Chinese economic development is the role played by openness and capital accumulation in this process. The question is whether the sharp economic＇ growth that the Chinese economy has experienced is another case of export-led growth due to the open-door policy or whether, on the contrary, this growth has been caused by high domestic savings and investment rates （and the consequent capital accumulation）. To answer this question, we employed an empirical framework of the cointegrated vector autoregressive model. The empirical results show that both investment （in physieal capital and R＆D） and exports, as well as the exchange rate policy, are relevant factors in explaining China＇s long-run economic growth over the past 4 decades.

关键词： investment labor productivity openness output

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Genomic patterns of homozygosity and inbreeding depression in MurcianoGranadina goats

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Journal of Animal Science and Biotechnology 2022年第3期13卷 721-734页

作者： maría Gracia Luigi-Sierra Almudena Fernández Amparo martínez Dailu Guan Juan vicente Delgado Javier FernándezÁlvarez Vincenzo Landi Francesc Xavier Such Jordi Jordana maría Saura marcel Amills Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Departamento de Mejora Genética Animal INIACarretera de la Coruña km 7528040 MadridSpain Departamento de Genética Universidad de Córdoba14071 CórdobaSpain Department of Veterinary Medicine University of Bari“Aldo Moro”62 per Casamassima km.370010 ValenzanoSPItaly Group of Research in Ruminants(G2R) Department of Animal and Food ScienceUniversitat Autònoma de Barcelona(UAB)BellaterraBarcelonaSpain Departament de Ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain

Background:Inbreeding depression can adversely affect traits related to fitness,reproduction and productive *** current research suggests that inbreeding levels are generally low in most goat breeds,the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical ***:We genotyped 1040 goats with the Goat SNP50 *** information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity *** detected38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1,2,4,6,14,16 and *** hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk *** regions on chromosomes 8 and 25were significantly associated with inbreeding depression for the natural logarithm of the somatic cell ***,these regions contain several genes related with immunity,such as SYK,IL27,CCL19 and ***,one region on chromosome 2 was significantly associated with inbreeding depression for milk ***:Although genomic inbreeding levels are low in Murciano-Granadina goats,significant evidence of inbreeding depression for the logarithm of the somatic cell count,a phenotype closely associated with udder health and milk yield,have been detected in this *** inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis,which is one of the main causes of dairy goat culling.

关键词： Goat Inbreeding Milk yield Murciano-Granadina Somatic cell score

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Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment

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World Journal of Gastroenterology 2014年第38期20卷 13999-14003页

作者： Cristina Sánchez-Montes vicente Ortiz Guillermo Bastida Ester Rodríguez maría Yago Belén Beltrán mariam Aguas marisa Iborra vicente Garrigues Julio Ponce Pilar Nos Gastroenterology Unit Hospital Universitari i Politécnic La Fe

AIM: To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth (SIBO) in patients with inactive Crohn’s disease (CD).

关键词： Crohn’ s disease Bacterial overgrowth Thiopurines Biologics Inflammatory bowel disease

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Pelvic exenterations for primary rectal cancer:Analysis from a 10-year national prospective database

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World Journal of Gastroenterology 2018年第45期24卷 5144-5153页

作者： Gianluca Pellino Sebastiano Biondo Antonio Codina Cazador Josémaría Enríquez-Navascues Eloy Espín-Basany Jose vicente Roig-Vila Eduardo García-Granero Colorectal Unit Hospital Universitario y Politecnico La FeUniversity of ValenciaValencia 46026Spain Department of General and Digestive Surgery Colorectal UnitBellvitge University HospitalUniversity of Barcelona and IDIBELLL’Hospitalet de LlobregatBarcelona 08907Spain Department of General and Digestive Surgery--Colorectal Unit Josep Trueta University HospitalGirona 17001Spain General and Digestive Surgery Department Donostia University HospitalDonostia 20014Spain Department of General Surgery Colorectal Surgery UnitHospital Valle de HebronAutonomous University of BarcelonaBarcelona 08035Spain Unit of Coloproctology Hospital Vithas-Nisa 9 de OctubreValencia 46015Spain

AIM To identify short-term and oncologic outcomes of pelvic exenterations(PE) for locally advanced primary rectal cancer(LAPRC) in patients included in a national prospective *** Few studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Espa?ola de Cirujanos(AEC)]. Primary endpoints included procedure-associated complications, 5-year local recurrence(LR), disease-free survival(DFS) and overall survival(OS). A propensitymatched comparison with patients who underwent non-exenterative surgery for low rectal cancers was performed as a secondary *** Eight-two patients were included. The mean age was 61.8 ± 11.5 years. More than half of the patients experienced at least one complication. Surgical site infections were the most common complication(abdominal wound 18.3%, perineal closure 19.4%). Thirty-three multivisceral resections were performed, including two hepatectomies and four metastasectomies. The long-term outcomes of the 64 patients operated on before 2013 were assessed. The five-year LR was 15.6%, the distant recurrence rate was 21.9%, and OS was 67.2%, with a mean survival of 43.8 mo. R+ve resection increased LR [hazard ratio(HR) = 5.58, 95%CI: 1.04-30.07, P = 0.04]. The quality of the mesorectum was associated with DFS. Perioperative complications were independent predictors of shorter survival(HR = 3.53, 95%CI: 1.12-10.94, P = 0.03). In the propensity-matched analysis, PE was associated with better quality of the specimen and tended to achieve lower LR with similar *** PE is an extensive procedure, justified if disease-free margins can be obtained. Further studies should define indications, accreditation policy, and quality of life in LAPRC.

关键词： Pelvic exenteration Advanced rectal cancer Colorectal surgery Complication Outcome

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Postnatal development of fetuses with a single umbilical artery:differences between malformed and non-malformed infants

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World Journal of Pediatrics 2015年第1期11卷 61-66页

作者： Jose vicente Arcos-Machancoses Purificación marín-Reina Eugenia Romaguera-Salort Yolanda García-Camuñas Antonio Pérez-Aytés Máximo Vento Department of Pediatrics University & Polytechnic Hospital La Fe Valencia Spain Division of Neonatology University & Polytechnic Hospital La Fe Valencia Spain Department of Obstetrics & Gynecology University & Polytechnic Hospital La Fe Valencia Spain Division of Dysmorphology & Reproductive Assessment University & Polytechnic Hospital La Fe Valencia Spain

Background:The presence of a single umbilical artery(SUA)is a fetal soft marker of congenital *** the most common related malformations,there are cardiological,nephrourological and digestive anomalies,most of which are considered to have a vascular *** is an association between increased incidence of intrauterine growth retardation and adverse perinatal indicators,but whether this association is due to related anomalies or isolated SUA(SUA)is ***:We reviewed 96 cases of iSUA and non-isolated SUA(niSUA),diagnosed in a period of two years in a referral hospital for high-risk *** on prenatal explorations,including fetal ultrasonography and karyotyping,were *** was diagnosed when no malformations were found prenatally or in postnatal ***:Sixty-six newborns(68.8%)had no other anomalies and 30(31.3%)presented with a variety of malformations including heart diseases,urophaties,digestive,nervous and musculoskeletal disorders,genetic abnormalities and complex *** and nephrourological abnormalities were found to be the most frequent association with a SUA(both in 23.8%of malformed SUA newborns).Intrauterine growth restriction was not higher in iSUA newborns than in a normal *** allowed optimal prenatal diagnosis in most ***:The prognosis of the fetus with a SUA is determined by the presence of other malformations observed by an expert *** no other findings are made,only a routine physical examination should be performed in newborns,but no other complementary examinations are required.

关键词： cardiovascular abnormalities congenital abnormalities fetal growth retardation prenatal ultrasonography single umbilical artery

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