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Ultrathin monolithic 3D printed optical coherence tomography endoscopy for preclinical and clinical use

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Light(Science & Applications) 2020年第1期9卷 753-762页

作者： Jiawen Li Simon Thiele Bryden c.Quirk Rodney W.Kirk Johan W.Verjans Emma Akers christina A.Bursill Stephen J.Nicholls Alois M.Herkommer Harald Giessen Robert A.McLaughlin Australian Research council centre of Excellence for Nanoscale BioPhotonics Adelaide Medical SchoolUniversity of AdelaideAdelaideSA 5005Australia Institute for Photonics and Advanced Sensing The University of AdelaideAdelaideSA 5005Australia Institute of Applied Optics(ITO)and Research center ScoPE University of Stuttgart70569 StuttgartGermany South Australian Health and Medical Research Institute(SAHMRI) AdelaideSA 5000Australia Royal Adelaide Hospital AdelaideSA 5000Australia Monash cardiovascular Research centre Monash UniversityMelbourneVIC 3168Australia th Physics Institute and Research center ScoPE University of Stuttgart70569 StuttgartGermany

Preclinical and clinical diagnostics increasingly rely on techniques to visualize internal organs at high resolution via *** endoscopic probes are necessary for imaging small luminal or delicate organs without causing trauma to ***,current fabrication methods limit the imaging performance of highly miniaturized probes,restricting their widespread *** overcome this limitation,we developed a novel ultrathin probe fabrication technique that utilizes 3D microprinting to reliably create side-facing freeform micro-optics(chnique,we built a fully functional ultrathin aberration-corrected optical coherence tomography *** is the smallest freeform 3D imaging probe yet reported,with a diameter of 0.457 mm,including the catheter *** demonstrated image quality and mechanical flexibility by imaging atherosclerotic human and mouse *** ability to provide microstructural information with the smallest optical coherence tomography catheter opens a gateway for novel minimally invasive applications in disease.

关键词： smallest utilize overcome

Integrative Multi-omics Analyses of Barley Rootzones under Salinity Stress Reveal Two Distinctive Salt Tolerance Mechanisms

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Plant communications 2020年第3期1卷 107-123页

作者： William Wing Ho Ho camilla B.Hill Monika S.Doblin Megan c.Shelden Allison van de Meene Thusitha Rupasinghe Antony Bacic Ute Roessner School of BioSciences The University of MelbourneParkvilleVIC 3010Australia School of Veterinary and Life Sciences Murdoch UniversityMurdochWA 6150Australia La Trobe Institute for Agriculture&Food Department of AnimalPlant and Soil ScienceLa Trobe UniversityBundooraVIC 3086Australia ARc centre of Excellence in Plant Energy Biology School of AgricultureFood and WineUniversity of AdelaideGlen OsmondSA 5064Australia Metabolomics Australia The University of MelbourneParkvilleVIC 3010Australia

The mechanisms underlying rootzone-localized responses to salinity during early stages of barley development remain *** this study,we performed the analyses of multi-root-omes(transcriptomes,metabolomes,and lipidomes)of a domesticated barley cultivar(clipper)and a landrace(Sahara)that maintain and restrict seedling root growth under salt stress,*** generalized linear models were designed to determine differentially expressed genes(DEGs)and abundant metabolites(DAMs)specific to salt treatments,genotypes,or rootzones(meristematic Z1,elongation Z2,and maturation Z3).Based on pathway over-representation of the DEGs and DAMs,phenylpropanoid biosynthesis is the most statistically enriched biological pathway among all salinity responses *** with histological evidence,an intense salt-induced lignin impregnation was found only at stelic cell wall of clipper Z2,compared with a unique elevation of suberin deposition across Sahara *** suggests two differential salt-induced modulations of apoplastic flow between the *** on the global correlation network of the DEGs and DAMs,callose deposition that potentially adjusted symplastic flow in roots was almost independent of salinity in rootzones of clipper,and was markedly decreased in *** together,we propose two distinctive salt tolerance mechanisms in clipper(growth-sustaining)and Sahara(salt-shielding),providing important clues for improving crop plasticity to cope with deteriorating global soil salinization.

关键词： barley root transcriptomics metabolomics lipidomics omics integration salinity stress

Histone H3.3G34-Mutant Interneuron Progenitors co-opt PDGFRA for Gliomagenesis

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四川生理科学杂志 2020年第4期42卷 480-480页

作者： carol c L chen Department of Human Genetics McGill University Montreal QC H3A 0C7 Canada canadian centre for computational Genomics McGill University Montreal QC H3A 0E9 Canada Dana-Farber/Boston children’s cancer and Blood Disorders center Boston MA 02215 USA Department of Pathology Montreal Children’s Hospital McGill University Health Centre Montreal QC H4A 3J1 Canada UcL Queen Square Institute of Neurology London WC1N 3BG UK Department of Pediatrics McGill University and The Research Institute of the McGill University Health Centre Montreal QC H4A 3J1 Canada Samantha Dickson Brain cancer Unit University College London Cancer Institute London United Kingdom Second Department of Paediatrics Semmelweis University Budapest 1094 Hungary Department of Neurosurgery University of Debrecen Debrecen 4032 Hungary Department of Paediatric Haematology and Oncology Second Faculty of Medicine Charles University and University Hospital Motol Prague 150 06 Czech Republic Department of Pathology and Molecular Medicine Second Faculty of Medicine Charles University and University Hospital Motol Prague 150 06 Czech Republic children’s cancer center The Royal Children’s Hospital Murdoch children’s Research Institute Department of Pediatrics University of Melbourne Parkville VIC 3052 Australia Kids cancer centre Sydney Children’s Hospital Randwick NSW 2031 Australia Department of Pathology Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Montréal QC H3T 1C5 Canada Department of Pediatric Oncology Dana-Farber Boston Children’s Cancer and Blood Disorders Center Boston MA 02215 USA School of computer Science McGill University Montreal QC H3A 2A7 Canada and Murdoch children’s Research Institute Parkville VIC 3052 Australia Department of Biochemistry McGill University Montreal QC H3A 1A3 Canada Department of Pediatric Neurosurgery Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Montréal QC H3T 1C5 Canada Department of Biochemistry and

Histone H3.3 glycine 34 to arginine/valine(G34R/V)mutations drive deadly gliomas and show exquisite regional and temporal specificity,suggesting a developmental context permissive to their *** we show that 50%of G34R/V tumors(n=95)bear activating PDGFRA mutations that display strong selection pressure at *** considered gliomas,G34R/V tumors actually arise in GSX2/DLX-expressing interneuron progenitors,where G34R/V mutations impair neuronal *** lineage of origin may facilitate PDGFRA co-option through a chromatin loop connecting PDGFRA to GSX2 regulatory elements,promoting PDGFRA overexpression and *** the single-cell level,G34R/V tumors harbor dual neuronal/astroglial identity and lack oligodendroglial programs,actively repressed by GSX2/DLX-mediated cell fate specification.G34R/V may become dispensable for tumor maintenance,whereas mutant-PDGFRA is potently ***,our results open novel research avenues in deadly tumors.G34R/V gliomas are neuronal malignancies where interneuron progenitors are stalled in differentiation by G34R/V mutations and malignant gliogenesis is promoted by co-option of a potentially targetable pathway,PDGFRA signaling.

关键词： PDGFRA specificity connecting

三峡水库不同区域对鱼类群落结构和鱼类组成动态的影响(英文)

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水生生物学报 2014年第3期38卷 438-445页

作者： H.A.c.c.Perera 李钟杰 S.S.De Silva 张堂林苑晶叶少文夏雨果刘家寿中国科学院水生生物研究所淡水生态与生物技术国家重点实验室武汉430072 中国科学院大学北京100049 School of Ecology and Life Sciences Deakin UniversityWarrnamboolVIC 3280Australia

研究选取三峡水库三个不同的区域来研究离坝距离对鱼类群落结构和鱼类组成动态的影响。2010年11月到2011年10月期间共采集了8680尾鱼类样本,隶属于11科58种,其中鲤科鱼类占据了三峡水库鱼类的主体。夏季时的鱼类丰度显著高于其他季节的(... 详细信息

研究选取三峡水库三个不同的区域来研究离坝距离对鱼类群落结构和鱼类组成动态的影响。2010年11月到2011年10月期间共采集了8680尾鱼类样本,隶属于11科58种,其中鲤科鱼类占据了三峡水库鱼类的主体。夏季时的鱼类丰度显著高于其他季节的(P<0.05)。鱼类物种多样性与丰度在靠近大坝的江段(秭归)最低,中游江段(万州)相对较高,远离大坝的江段(涪陵)居中。随着三峡大坝的建成,鱼类区系也由适应流水生存的种类转变为适应静水生存的种类。因此,三峡水库蓄水已经明显地改变了其原有的鱼类群落结构,鱼类组成的相对丰度也随着时间发生了改变。

关键词：鱼类区系转变蓄水物种多样性三峡水库长江

Transcriptomic Profiling of Human Pluripotent Stem cell-derived Retinal Pigment Epithelium over Time

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 223-242页

作者： Grace E.Lidgerwood Anne Senabouth casey J.A.Smith-Anttila Vikkitharan Gnanasambandapillai Dominik c.Kaczorowski Daniela Amann-Zalcenstein Erica L.Fletcher Shalin H.Naik Alex W.Hewitt Joseph E.Powell Alice Pebay Department of Anatomy and Neuroscience The University of MelbourneParkvilleVIC 3010Australia Department of Surgery The University of MelbourneParkvilleVIC 3010Australia centre for Eye Research Australia Royal Victorian Eye and Ear HospitalEast MelbourneVIC 3002Australia Garvan Weizmann centre for cellular Genomics Garvan Institute of Medical ResearchThe Kinghorn Cancer CentreDarlinghurstNSW 2010Australia Single cell Open Research Endeavour The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Immunology Division The Walter and Eliza Hall Institute of Medical ResearchParkvilleVIC 3052Australia Department of Medical Biology The University of MelbourneParkvilleVIC 3010Australia School of Medicine Menzies Institute for Medical ResearchUniversity of TasmaniaHobartTAS 7005Australia UNSW cellular Genomics Futures Institute School of Medical SciencesUniversity of New South WalesSydneyNSW 2052Australia

Human pluripotent stem cell(h PSc)-derived progenies are immature versions of cells,presenting a potential limitation to the accurate modelling of diseases associated with maturity or ***,it is important to characterise how closely cells used in culture resemble their native *** order to select appropriate time points of retinal pigment epithelium(RPE)cultures that reflect native counterparts,we characterised the transcriptomic profiles of the h PSc-derived RPE cells from 1-and 12-month *** differentiated the human embryonic stem cell line H9 into RPE cells,performed single-cell RNA-sequencing of a total of 16,576 cells to assess themolecular changes of the RPE cells across these two culture time *** results indicate the stability of the RPE transcriptomic signature,with no evidence of an epithelial–mesenchymal transition,and with the maturing populations of the RPE observed with time in *** of Gene Ontology pathways revealed that as the cultures age,RPE cells upregulate expression of genes involved in metal binding and antioxidant *** might reflect an increased ability to handle oxidative stress as cells *** with native human RPE data confirms a maturing transcriptional profile of RPE cells in *** results suggest that long-term in vitro culture of RPE cells allows the modelling of specific phenotypes observed in native mature *** work highlights the transcriptional landscape of h PSc-derived RPE cells as they age in culture,which provides a reference for native and patient samples to be benchmarked against.

关键词： Human embryonic stem cell Human pluripotent stem cell Retinal pigment epithelium Single-cell RNA sequencing Ageing

IMAGe综合征:一种影响生长、肾上腺和性腺功能及骨骼肌发育的复杂疾病

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世界核心医学期刊文摘（儿科学分册） 2005年第2期1卷 40-41页

作者： Pedreira c.c. Savarirayan R. Zacharin M.R. 贺莉 Dr.Dept.of Endocrinology and Diabetes Royal Children's HospitalFlemington RdParkvilleVic.3052Australia

IMAGe综合征(宫内发育受限、干骺端发育不良、先天性肾上腺发育不全、生殖器畸形)是一种有广泛表现型的复杂的多系统紊乱。如果不被发现,该病可以导致严重的甚至可能危及生命的并发症。

关键词： IMAGe 性腺功能生殖器畸形肾上腺功能发育不全发育不良干骺端表现型小阴茎骨骼畸形

What is going on in magnesium alloys？

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Journal of Materials Science & Technology 2018年第2期34卷 245-247页

作者： X.J. Wang D.K. Xu R.Z. Wu X.B. chen Q.M. Peng L. Jin Y.c. Xin Z.Q. Zhang Y. Liu X.H. chen G. chen K.K. Deng H.Y. Wang School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Key Laboratory of Superlight Materials & Surface Technology (Ministry of Education) Harbin Engineering University Harbin 150001 China School of Engineering RMIT University City Campus Carlton VIC 3053 Australia State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 China National Engineering Research center of Light Alloy Net Forming Shanghai Jiao Tong University Shanghai 200240 China college of Materials Science and Engineering Chongqing University Chongqing 400030 China Key Lab of Electromagnetic Processing of Materials Ministry of Education Northeastern UniversityShnenyang 110819China Key Laboratory of Lightweight and High Strength Structural Materials of Jiangxi Province Nanchang University Nanchang 330031 China School of chemical Engineering and Technology Tianjin University Tianjin 300350 China Shanxi Key Laboratory of Advanced Magnesium-Based Materials Taiyuan University of Technology Taiyuan 030024 China Key Laboratory of Automobile Materials of Ministry of Education & School of Materials Science and Engineering Jilin University Changchun 130025 China

china has been developed into one of the most active regions in terms of both fundamental and applied research on magnesium （Mg） and its alloys in the world from a solid base laid by its prominent metallurgist and materials scientists over the past decades. Nowadays, a large number of young-generation researchers have been inspired by their predecessors and become the key participants in the fields of Mg alloys, which consequently led to the establishment of china Youth Scholar Society for Magnesium Alloys Research in 2015. Since then, the first two china Youth Scholars Symposiums on Mg Alloys Research had been held at Harbin （2015） and chongqing （2016） china, respectively. A number of crucial research inter- ests related to fundamental and applied Mg research were discussed at the conferences and summarized in this short perspective, aiming to boost far-reaching initiatives for development of new Mg-based materials to satisfy the requirements for a broad range of industrial employments. Herein, four main aspects are included as follows： i） Plastic deformation mechanism and strengthening strategy, ii） Design and development of new Mg-based materials, iii） Key service properties, and iv） New processing technologies.

关键词： Mg alloys Plastic deformation Strengthening Alloying design High performance corrosion Fatigue behavior creep Processing technologies Purification

Overcoming cancer therapeutic bottleneck by drug repurposing

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1449-1473页

作者： Zhe Zhang Li Zhou Na Xie Edouard cNice Tao Zhang Yongping cui canhua Huang State Key Laboratory of Biotherapy and cancer center West China Hospitaland West China School of Basic Medical Sciences&Forensic MedicineSichuan Universityand Collaborative Innovation Center for Biotherapy610041 ChengduChina Department of Biochemistry and Molecular Biology Monash UniversityClaytonVICAustralia The School of Biological Science and Technology Chengdu Medical College610083 ChengduChina Department of Oncology The Second Affiliated Hospital of Chengdu Medical CollegeChina National Nuclear Corporation 416 HospitalChengdu610051 SichuanChina cancer Institute Peking University Shenzhen HospitalShenzhen Peking University—the Hong Kong University of Science and Technology(PKU-HKUST)Medical Centerand Cancer InstituteShenzhen Bay Laboratory Shenzhen518035 ShenzhenChina Department of Pathology&Shanxi Key Laboratory of carcinogenesis and Translational Research on Esophageal cancer Shanxi Medical UniversityTaiyuan030001 ShanxiChina School of Basic Medical Sciences Chengdu University of Traditional Chinese MedicineChengdu611137 SichuanChina

Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing,the development of old drugs for new therapeutic *** strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease,facilitating rapid clinical *** an increased understanding of the hallmarks of cancer and the development of various data-driven approaches,drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic ***“treasure trove”of non-oncology drugs should not be ignored since they could target not only known but also hitherto unknown vulnerabilities of ***,different from targeted drugs,these old generic drugs,usually used in a multi-target strategy may bring benefit to *** this review,aiming to demonstrate the full potential of drug repurposing,we present various promising repurposed non-oncology drugs for clinical cancer management and classify these candidates into their proposed administration for either mono-or drug combination *** also summarize approaches used for drug repurposing and discuss the main barriers to its uptake.

关键词： drugs therapeutic classify

Emerging role of tumor cell plasticity in modifying therapeutic response

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Signal Transduction and Targeted Therapy 2020年第1期5卷 549-584页

作者： Siyuan Qin Jingwen Jiang Yi Lu Edouard cNice canhua Huang Jian Zhang Weifeng He State Key Laboratory of Biotherapy and cancer center West China Hospitaland West China School of Basic Medical Sciences and Forensic MedicineSichuan Universityand Collaborative Innovation Center for Biotherapy610041 ChengduPeople’s Republic of China School of Medicine Southern University of Science and Technology ShenzhenShenzhenGuangdong 518055People’s Republic of China Guangdong Provincial Key Laboratory of cell Microenvironment and Disease Research ShenzhenGuangdongPeople’s Republic of China Department of Biochemistry and Molecular Biology Monash UniversityClaytonVICAustralia School of Basic Medical Sciences Chengdu University of Traditional Chinese Medicine1166 Liutai Road611137 ChengduPeople’s Republic of China State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingPeople’s Republic of China chongqing Key Laboratory for Disease Proteomics ChongqingPeople’s Republic of China

Resistance to cancer therapy is a major barrier to cancer *** views have proposed that acquisition of resistance may result from genetic ***,accumulating evidence implicates a key role of non-mutational resistance mechanisms underlying drug tolerance,the latter of which is the focus that will be discussed *** non-mutational processes are largely driven by tumor cell plasticity,which renders tumor cells insusceptible to the drug-targeted pathway,thereby facilitating the tumor cell survival and *** concept of tumor cell plasticity highlights the significance of re-activation of developmental programs that are closely correlated with epithelial–mesenchymal transition,acquisition properties of cancer stem cells,and transdifferentiation potential during drug *** observations in various cancers,this concept provides an opportunity for investigating the nature of anticancer drug *** the years,our understanding of the emerging role of phenotype switching in modifying therapeutic response has considerably *** expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs,which are likely to improve patient outcomes in clinical practice.

关键词： therapeutic plasticity thereby