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Journal of Magnesium and Alloys 2024年第1期12卷 394-404页

作者： Lokesh Choudhary Parama Chakraborty Banerjee R.k.Singh Raman Derrek e.Lobo Christopher D.easton Mainak Majumder Frank Witte Jörg F.Löffler Department of Mechanical and Aerospace engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Department of Chemical and Biological engineering Monash UniversityClayton CampusMelbourneVIC 3800Australia Nanoscale Science and engineering Laboratory(NSeL) Bldg 37Monash UniversityClayton CampusMelbourneVIC 3800Australia CSIRO Materials Science and engineering Bayview AvenueClaytonVIC 3168Australia Julius Wolff Institute and Berlin Brandenburg Center for Regenerative Therapies Charité–Universitätsmedizin BerlinAugustenburger Platz 113353 BerlinGermany Laboratory of Metal Physics and Technology Department of MaterialsETH Zurich8093 ZurichSwitzerland

Biodegradable implants are critical for regenerative orthopaedic procedures,but they may suffer from too fast corrosion in human-body *** necessitates the synthesis of a suitable coating that may improve the corrosion resistance of these implants without compromising their mechanical *** this study,an AZ91 magnesium alloy,as a representative for a biodegradable Mg implant material,was modified with a thin reduced graphene oxide(RGO)-calcium carbonate(CaCO_(3))composite *** analytical and in-vitro electrochemical characterization reveals that this coating significantly improves the corrosion resistance and mechanical integrity,and thus has the potential to greatly extend the related application field.

关键词： Graphene coating Biodegradable implant Hydroxyapatite Corrosion Magnesium alloy

Observation of a single protein by ultrafast X-ray diffraction

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Light(Science & Applications) 2024年第1期13卷 80-90页

作者： Tomas ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.eichacker Linda e.Franken Davide e.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath koliyadu Olena kulyk Ruslan kurta Markus kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel e.Rivas Max Rose Amit k.Samanta Philipp Schmidt egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen küpper Michael Meyer Filipe R.N.C.Maia Laboratory of Molecular Biophysics Department of Cell and Molecular BiologyUppsala UniversityHusargatan 3(Box 596)SE-75124 UppsalaSweden Deutsches electronen-Synchrotron DeSY Notkestrasse 8522607 HamburgGermany european XFeL Holzkoppel 422869 SchenefeldGermany Diamond Light Source Harwell Science&Innovation CampusDidcot OX110DEUK University of Stavanger Centre Organelle ResearchRichard-Johnsensgate 44021 StavangerNorway Leibniz Institute for experimental Virology(HPI) Centre for Structural Systems BiologyNotkestraße 8522607 HamburgGermany Dipartimento di Fisica“Aldo Pontremoli” Universitàdegli Studi di Milanovia Celoria 1620133 MilanoItaly Center for Free-electron Laser Science DESY22607 HamburgGermany Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853USA PNSensor GmbH Otto-Hahn-Ring 6D-81739 MünchenGermany Biomedical and X-Ray Physics Department of Applied PhysicsAlbaNova University CenterKTH Royal Institute of TechnologySE-10691 StockholmSweden eLI Beamlines/IoP Institute of Physics AS CR v.v.i.Na Slovance 218221 Prague 8Czech Republic Multi-User CryoeM Facility Centre for Structural Systems BiologyNotkestr.8522607 HamburgGermany University Medical Center Hamburg-eppendorf(Uke) Martinistrasse 5220246 HamburgGermany The Hamburg Center for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Physics Universität HamburgLuruper Chaussee 14922761 HamburgGermany Department of Chemistry and Physics La Trobe Institute for Molecular ScienceLa Trobe UniversityMelbourneVIC 3086Australia Division of Scientific Computing Science for Life LaboratoryDepartment of Information TechnologyUppsala UniversityBox 337SE-75105 UppsalaSweden european Molecular Biology Laboratory c/o DESYNotkestrasse 8522607 HamburgGermany Department of Physics and Astronomy Uppsala UniversityBox 516SE-75120 UppsalaSweden Max Planck Institute for the Structure and Dynamics of Matter Luruper Chaussee 14922761 HamburgGe

The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired *** was one of the arguments for building X-ray free-electron *** to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably *** was first demonstrated on biological samples a decade ago on the giant *** then,a large collaboration has been pushing the limit of the smallest sample that can be *** ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of *** we show the first observation of an X-ray diffraction pattern from a single protein,that of escherichia coli GroeL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single *** the pattern,it is possible to determine the approximate orientation of the *** experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale.

关键词： smallest intense ultrafast

Molecular phylogenetic analysis reveals six new species of Diaporthe from Australia

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Fungal Diversity 2013年第4期61卷 251-260页

作者： Y.P.Tan J.edwards k.R.e.Grice R.G.Shivas Department of Agriculture Fisheries and Forestry Plant Pathology HerbariumBiosecurity QueenslandDutton ParkQld 4102Australia Department of Primary Industries Biosciences Research DivisionGully Delivery CentrePrivate Bag 15FerntreeVic 3156Australia Department of Agriculture Fisheries and Forestry Agri-Science QueenslandMareebaQld 4880Australia

t Six new species of Diaporthe,*** on Indigofera australis,***-angustifoliae on Fraxinus angustifolia ***,*** on Litchi chinensis,*** on Nothofagus cunninghamii,*** on Persea americana and *** on Salix purpurea from Australia are described and illustrated based on morphological characteristics and molecular *** of the new species no longer produced sporulating structures in culture and two of these were morphologically described from voucher *** relationships of the new species with other Diaporthe species are revealed by DNA sequence analyses based on the internal transcribed spacer(ITS)region,and partial regions of theβtubulin(BT)and translation elongation factor 1-alpha(TeF).

关键词： Diaporthe beilharziae Diaporthe fraxiniangustifoliae Diaporthe litchicola Diaporthe nothofagi Diaporthe pascoei Diaporthe salicicola BT ITS Phylogeny Phomopsis TeF

Study of a ZnO/36° LiTaO_3 SAW Biosensor with Gold Sensitive Layer

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稀有金属材料与工程 2006年第A3期35卷 327-329页

作者： k.kalantar-zadeh W.Wlodarski V.Vojisavljevic e.Pirogova I.Cosic S.kandasamy School of electrical & Computer engineering RMIT UniversityMelbourne VIC 3001Australia

The mass sensitivity of a layered surface acoustic wave (SAW) device,ZnO/36°LiTaO_3,has been *** layers of different thicknesses were deposited to form the protein-sensitive layer,in order to compare the responses to biological materials and to find the optimum thickness of the gold thin *** of the device was investigated by immobilization of lactate dehydrogenase (LDH) onto the device active area.

关键词： ZnO LiTaO3 SAW biosensor gold lactate dehydrogenase

Graphene coatings for corrosion resistance of nickel and copper in acidic,alkaline and neutral environments

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Journal of Materials Science & Technology 2023年第11期142卷 124-133页

作者： R.k.Singh Raman Abhishek kumar Arya kevin Tomy Faisal A Dip evelyn Lai Saad Al-Saadi Department of Mechanical&Aerospace engineering Monash UniversityVic 3800Australia Department of Chemical&Biological engineering Monash UniversityVic 3800Australia

Graphene coatings have been reported to provide impressive corrosion resistance to nickel(Ni)and copper(Cu),because of remarkable characteristics of inertness and impermeablity of ***,as the earlier investigations have generally been carried out in chloride environment,and it is important to understand the performance of graphene coating also in more aggressive environments such as acids and *** study investigated the electrochemical corrosion behaviour of bare and graphene-coated(by chemical vapour deposition(CVD))Ni and Cu in 0.5 M H_(2)SO_(4),0.1 M NaCl and 0.5 M NaOH *** tests and post corrosion characterisation revealed the improvement in the corrosion resistance of Ni due to multilayer graphene coating to be similar in the three solutions,i.e.,the robustness of the barrier property of the multilayer graphene is largely unaffected by the aggressiveness of the corrosive ***,the improvement in corrosion resistance of bare Ni due to multilayer graphene is considerably greater(nearly 3 orders of magnitude)in the most aggressive of the test solutions(0.5 M H_(2)SO_(4)).The improvement is considerably less in 0.5 M NaOH because bare Ni develops a robust passive layer in highly alkaline *** improvement in corrosion resistance of bare Cu is limited(within an order of magnitude)in the three solutions because Cu develops only 1-2 layers of graphene.

关键词： CVD graphene coatings electrochemical impedance spectroscopy(eIS) Potentiodynamic polarization(PDP) Raman spectroscopy

Length-based separation of Bacillus subtilis bacterial populations by viscoelastic microfluidics

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Microsystems & Nanoengineering 2022年第1期8卷 149-159页

作者： Ping Liu Hangrui Liu Lucie Semenec Dan Yuan Sheng Yan Amy k.Cain Ming Li Suqian University Suqian 223800China School of engineering Macquarie UniversitySydneyNSW 2109Australia Department of Physics and Astronomy Macquarie UniversitySydneyNSW 2109Australia ARC Centre of excellence in Synthetic Biology Department of Molecular ScienceMacquarie UniversitySydneyNSW 2109Australia Centre for Regional and Rural Futures Deakin UniversityGeelongVIC 3216Australia Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Biomolecular Discovery Research Centre Macquarie UniversitySydneyNSW 2109Australia

In this study,we demonstrated the label-free continuous separation and enrichment of Bacillus subtilis populations based on length using viscoelastic ***,a gram-positive,rod-shaped bacterium,has been widely used as a model organism and an industrial *** can be arranged in different morphological forms,such as single rods,chains,and clumps,which reflect differences in cell types,phases of growth,genetic variation,and changing environmental *** ability to prepare *** populations with a uniform length is important for basic biological studies and efficient industrial ***,we systematically investigated how flow rate ratio,poly(ethylene oxide)(PeO)concentration,and channel length affected the length-based separation of *** *** lateral positions of *** cells with varying morphologies in a straight rectangular microchannel were found to be dependent on cell length under the co-flow of viscoelastic and Newtonian ***,we evaluated the ability of the viscoelastic microfluidic device to separate the two groups of *** cells by length(i.e.,1-5μm and>5μm)in terms of extraction purity(eP),extraction yield(eY),and enrichment factor(eF)and confirmed that the device could separate heterogeneous populations of bacteria using elasto-inertial effects.

关键词： viscoelastic separation straight

月经周期中子宫内膜上皮和基质细胞的潜在干细胞活性

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 20-21页

作者： Schwab k.e. Gargett C.e. 李奎 Dr.Department of Obstetrics and Gynaecology Centre for Women's Health Research Monash University 246 Clayton Rd Clayton Vic. 3168 Australia

Objective: To determine whether menstrual cycle stage or activity has an effect on the clonogenic activity of human endometrial epithelial and stromal cells. Design: Clonal analysis of human endometrial epithelial and stromal cells derived from full-thickness endometrium. Setting: University research laboratory. Patient(s): Twenty-six women of varying age and race undergoing hysterectomy for nonendometrial pathologies. Intervention(s): Full-thickness human endometrial tissue was dissociated into single cells. epithelial and stromal cells were separated using magnetic beads, and cloning assays were performed in serum-containing or growth factor-supplemented serum-free medium. Main Outcome Measure(s): Clonogenic activity of epithelial and stromal cells. Result(s): Clonogenicity of epithelial and stromal cells did not vary significantly between proliferative, secretory, and inactive endometrium. However, epithelial and stromal cells did show a trend for greater numbers of clonogenic cells in secretory and proliferative endometrium respectively. A large variation between samples was observed, which may have masked any significant differences. Conclusion(s): We found that clonogenicity does not vary from the proliferative to secretory stage of the menstrual cycle, or between active, cycling and inactive endometrium for both epithelial and stromal cells. We have demonstrated for the first time that inactive endometrium contains clonogenic epithelial and stromal cells.

关键词：子宫内膜基质细胞月经周期分泌期子宫切除术增殖期非活动期血清基克隆分析生长因子

Structure-activity relationship of pyrazol-4-ylpyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4

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Acta Pharmaceutica Sinica B 2023年第1期13卷 213-226页

作者： Ahmed Haider Xiaoyun Deng Olivia Mastromihalis Stefanie k.Pfister Troels e.Jeppesen Zhiwei Xiao Vi Pham Shaofa Sun Jian Rong Chunyu Zhao Jiahui Chen Yinlong Li Theresa R.Connors April T.Davenport James B.Daunais Vahid Hosseini Wenqing Ran Arthur Christopoulos Lu Wang Celine Valant Steven H.Liang Department of Radiology Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA Department of Nuclear Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Drug Discovery Biology Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleVIC 3052Australia Neuromedicines Discovery Centre Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleVIC 3052Australia Hubei Collaborative Innovation Centre for Non-power Nuclear Technology College of Nuclear Technology&Chemistry and BiologyHubei University of Science and TechnologyXianning 437100China Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Physiology and Pharmacology Wake Forest School of MedicineWinston SalemNC 27157USA Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCA 90024USA Center of Cyclotron and PeT Radiopharmaceuticals Department of Nuclear Medicine and PET/CT-MRI Centerthe First Affiliated Hospital of Jinan UniversityGuangzhou 510630China

There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor4(M4)in schizophrenia and dementia with Lewy bodies,however,a clinically validated M4positron emission tomography(PeT)radioligand is currently *** such,the aim of this study was to develop a suitable M4PeT ligand that allows the non-invasive visualization of M4in the ***-activity relationship studies of pyrazol-4-yl-pyridine derivates led to the discovery of target compound 12—a subtype-selective positive allosteric modulator(PAM).The radiofluorinated analogue,[18F]12,was synthesized in 28±10%radiochemical yield,>37 GBq/μmol and an excellent radiochemical purity>99%.Initial in vitro autoradiograms on rodent brain sections were performed in the absence of carbachol and showed moderate specificity as well as a low selectivity of[18F]12 for the M4-rich ***,in the presence of carbachol,a significant increase in tracer binding was observed in the rat striatum,which was reduced by>60%under blocking conditions,thus indicating that orthosteric ligand interaction is required for efficient binding o f[18F]12 to the allosteric ***,however,the presence of carbachol was not required for high specific binding in the non-human primate(NHP)and human striatum,and did not further improve the specificity and selectivity of[18F]12 in higher *** results pointed towards significant species-differences and paved the way for a preliminary PeT study in NHP,where peak brain uptake of[18F]12 was found in the putamen and temporal *** conclusion,we report on the identification and preclinical development of the first radiofluorinated M4PeT radioligand with promising *** availability of a clinically validated M4PeT radioligand harbors potential to facilitate drug development and provide a useful diagnostic tool for non-invasive imaging.

关键词： Muscarinicacetylcholine receptor Positronemission tomography Neuroimaging Neuropharmacology Neurological disorders

Hydrogen and Ozone SAW Based Gas Sensors with RF Magnetron Sputtered InO_x and electron Beam evaporated SiN_y

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稀有金属材料与工程 2006年第A3期35卷 206-209页

作者： A.C.Fechete A.Wisitsora-at W.Wlodarskil k.kalantar-zadeh S.kandasamy A.S.Holland Sensor Technology Laboratory School of Electrical & Computer EngineeringRMIT UniversityMelbourne V1C 3001Australia NeCTeC 112 Thailand Science ParkKIong LuangPathumathani 12120Thailand Sensor Technology Laboratory School of Electrical & Computer EngineeringRMIT UniversityMelbourne VIC 3001Australia

Layered Surface Acoustic Wave (SAW) devices with an InO_x/SiN_u/36°YX LiTaO_3 structure were investigated for sensing low concentrations of hydrogen (H_2) and ozone (O_3) at different operating *** sensor consists of a 1μm thick silicon nitride (SiN_y) intermediate layer deposited by electron beam evaporation on a 36°Y-cut X-propagating piezoelectric lithium tantalate (LiTaO_3) substrate and a 100 nm thin indium oxide (InO_x) sensing layer deposited by *** *** device fabrication is described and the performance of the sensor is analyzed in terms of response magnitude as a function of operating *** frequency shifts of 360 kHz for 600μg/g of H_2 and 92 kHz for 40 ng/g O_3 were *** addition,the surface morphology of the deposited films were investigated by Atomic Force Microscopy (AFM) and the chemical composition by X-Ray Photoelectron Spectroscopy (XPS) to correlate gas-sensing behavior to structural characteristics of the thin film.

关键词： SAW gas sensors e-beam evaporated SiN_y InO_x O3 H2

electrical Tracking,erosion and Fire Retardancy Performance of Silicone Rubber Insulation Containing Aluminum Trihydrate,Graphene and Glass Fiber Additives

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CSee Journal of Power and energy Systems 2023年第5期9卷 1918-1925页

作者： M.Tariq Nazir Arslan khalid B.Toan Phung Arup k.Das Peter Cheetham Ashish Paramane Shakeel Akram khoi Loon Wong School of engineering RMIT UniversityMelbourneVIC 3000Australia. the Center for Advanced Power Systems(CAPS) Florida State UniversityFL 32310USA the Flame Security International Pty Limited Australia the School of electrical engineering and Telecommunications University of New South Wales SydneyNSW 2052Australia Department of electrical engineering National Institute of TechnologySilcharAssam 788010India the College of electrical engineering and Control Science Nanjing Tech UniversityNanjingJiangsu 211816China

Silicone rubber composite is a priority electrical insulating material used in high-voltage outdoor insulation *** electrical tracking/erosion and poor flame resistance performance of silicone rubber once ignited,substantially reduce its working *** paper attempts to investigate tracking/erosion performance of room temperature vulcanized(RTV)silicone rubber along with flame retardant parameters using aluminum trihydrate(ATH),graphene nanosheets(GN)and milled glass fiber(GF)*** inclined plane test(IPT)was performed in line with criteria defined in IeC 60587 using step-up tracking voltage method while flame retardancy is evaluated according to ASTM e 1354.0 using a cone *** suggest 30% of ATH assists in improving physical tracking/erosion resistance of pristine silicone elastomer rubber by impeding development of leakage current and a great reduction in maximum average temperatures on the surface of *** improvement in performance of RTV2 is achieved through introduction of 1%of GN and 5% of GF as seen in ***,30% of ATH reduces heat release rate and smoke production rate,and this trend is improved with the introduction of GN/***4 has pop up as the most promising silicone rubber composite with excellent electrical tracking,erosion,and flame resistance performance relative to its counterparts in this study.

关键词： Dry band arcing electrical tracking heat release rate leakage current silicone rubber smoke production rate