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A Study to Compare the Safety and Efficacy of Solifenacin, Tamsulosin and Tadalafil in Relieving Double-J Stent Related Symptoms

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Open Journal of Urology 2020年第3期10卷 42-51页

作者： Appiya Ramamoorthy Balaji Pritam Pritish Patnaik Javangula Venkata Surya Prakash Sattanathan Vetrichandar Krishnan Vembu Arasi Arun Kumar Paranjothi vetrivel natarajan Department of Urology & Renal Transplantation Government Stanley Medical College & Hospital Chennai India

Objective: To evaluate and compare the safety and efficacy of Solifenacin, Tamsulosin, and Tadalafil in treating ureteral stent related symptoms (SRS) in patients with indwelling Double-J ureteral stents. Materials and Methods: A prospective randomized controlled study was conducted on 146 consecutive patients in the department of urology, Government Stanley Medical College & Hospital, Chennai, Tamilnadu, India between Sept 2017-March 2019, with SRS after taking informed consent and confirming DJ Stent position by X-ray KUB post-operatively. Patients were randomized into 4 groups: Group A (Placebo), Group B (Solifenacin 5 mg), and Group B (Tamsulosin 0.4 mg) and group D (Tadalafil 5 mg) at end of 1st week till the removal of DJ stent at end of 3 weeks. All patients were assessed for bothersome lower urinary tract symptoms (LUTS) using the validated Ureteral Stent Symptom Questionnaire (USSQ) at 1st week and 3 weeks after the starting of medications. Appropriate statistical analysis as carried out and the level of significance was set at P Results: LUTS, general health, and work performance improved with Solifenacin, Tamsulosin and Tadalafil and all the three were comparable in relieving urinary symptoms. Tadalafil was better at relieving body pain, additional problems and sexual problems better than Tamsulosin. Tadalafil showed comparable improvement in LUTS, better sexual health and decreased body pain compared to solifenacin, whereas the latter had better general health, additional problems & work performance scores. Conclusion: Solifenacin is more effective than Tamsulosin in alleviating LUTS associated with SRS and both show a distinctive advantage over placebo. PDE inhibitor Tadalafil can also be tried for SRS and is as effective as antimuscarinics and α-blockers in relieving urinary symptoms and is more efficacious in relieving sexual symptoms and body pain.

关键词： Double J Stent Lower Urinary Tract Symptoms (LUTS) Stent Related Symptoms (SRS) Solifenacin Tadalafil Tamsulosin Ureteral Stent Symptom Questionnaire (USSQ)

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Heterogeneous crystallization of Chlorzoxazone for modulating the physicochemical properties of crystals Author links open overlay panel

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Particuology 2024年第8期91卷 249-259页

作者： Dhayananth natarajan Kalaichelvi Ponnusamy Radhakrishnan Thota Karunakaran Department of Chemical Engineering National Institute of TechnologyTiruchirappalli620015TamilnaduIndia

The polymer on modulating the crystal's habit is an evolving research in pharmaceutical *** study demonstrates the crystal habit modification of chlorzoxazone(CHZ)by heterogeneous crystallization(HC)in the binary solvent acetonitrile-ethanol(A-E(1:1))in the presence of polyvinylpyrrolidine(PVP)at concentrations of 0.50,0.75,and 1.00 wt%.The A-E(1:1)and PVP in HC experiments influenced to change the shape of crystals from needle to plate shape and reduced the crystal size producing a lower aspect ratio(in the range of 1.5-2.3).In the presence of PVP,the CHZ size distribution is 65-78μm which tends to enhance the powder flow-ability of CHZ crystals and as the PVP concentration increases,the nucleation rate *** solubility of size-reduced CHZ crystals at different pH is found to be improved by 1.2-1.4 ***,HC is deemed effective in modifying the physicochemical attributes of CHZ.

关键词： Chlorzoxazone Polyvinylpyrrolidine Heterogeneous crystallization Crystal habit modification Aspect ratio

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Protist and Plant Growth-Promoting Bacterium Interaction Alters GH3-2 Expression and Enhances Nutrient Content in Rice

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Rice science 2024年第2期31卷 134-138,I0017-I0019页

作者： Komal A.CHANDARANA natarajan AMARESAN C.G.Bhakta Institute of Biotechnology UkaTarsadia UniversityMaliba CampusBardoliSurat 394350GujaratIndia

The present study aimed to assess the interactive effects of four plant growth-promoting bacterium(PGPB)species[Providencia sp.(Pr),Stenotrophomonas sp.(St),Morganella sp.(Mo),and Lysinibacillus sp.(Lb)]and six protist species[two amoebae Vermamoeba vermiformis(A9)and Acanthamoeba genotype T4(A34),and four ciliates Crytolophosis mucicola(C1),Tetrahymena sp.(C2),Colpoda elliotti(C12),and an unidentified genus of the family Kreyellidae(C5)]on the uptake of nutrients and the expression of auxin-responsive gene(GH3-2)in *** findings revealed that rice seedlings grew healthily,and a statistically significant difference was observed after 30 d of incubation in pots under greenhouse conditions treated with each PGPB and protist-PGPB consortia,compared with the untreated control ***,the protist-PGPB treatments were more significant than PGPB treatment *** greatest improvement in rice seedling growth was observed in *** with Stenotrophomonas sp.(C12St)treatment,showing increased root and shoot length(88.57%and 79.69%).

关键词： seedling Plant GH3

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Advancements and applications of position-sensitive detector(PSD): a review

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Optoelectronics Letters 2024年第6期20卷 330-338页

作者： Shaher Dwik G.Sasikala S.natarajan Department of Electronics&Communication Engineering School of Electrical&CommunicationVel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600062India Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidyapeethamChennai 601103India1

This paper presents a review of the position-sensitive detector(PSD) sensor, covering different types of PSD and recent works related to this field. Furthermore, it explains the theoretical concepts and provides information about its structure and principles of operation. Moreover, it includes the main information about the available commercial PSDs from different companies, along with a comparison between the common modules. The PSD features include high position resolution, fast response, and a wide dynamic range. These features make it suitable for various fields and applications, such as imaging, spectrometry, spectroscopy and others.

关键词： Advancements and applications of position-sensitive detector a review PSD

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An artificial neural network based deep collocation method for the solution of transient linear and nonlinear partial differential equations

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1296-1310页

作者： Abhishek MISHRA Cosmin ANITESCU Pattabhi Ramaiah BUDARAPU Sundararajan natarajan Pandu Rang VUNDAVILLI Timon RABCZUK School of Mechanical Sciences Indian Institute of TechnologyBhubaneswar 752050India Institute of Structural Mechanics Bauhaus University of WeimarWeimar 99423Germany Department of Mechanical Engineering Indian Institute of Technology MadrasChennai 600036India

A combined deep machine learning(DML)and collocation based approach to solve the partial differential equations using artificial neural networks is *** developed method is applied to solve problems governed by the Sine–Gordon equation(SGE),the scalar wave equation and *** methods are studied:one is a space-time formulation and the other is a semi-discrete method based on an implicit Runge–Kutta(RK)time *** methodology is implemented using the Tensorflow framework and it is tested on several numerical *** on the results,the relative normalized error was observed to be less than 5%in all cases.

关键词： collocation method artificial neural networks deep machine learning Sine-Gordon equation transient wave equation dynamic scalar and elasto-dynamic equation Runge-Kutta method

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Mesenchymal stem cell-based TRAIL delivery inhibits the metastatic state of clinical therapy-resistant progressive neuroblastoma

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World Journal of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew Maher Sheeja Aravindan Zhongxin Yu Brian MBesch natarajan Aravindan Department of Radiation Oncology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Stephenson Cancer Center Oklahoma CityOKUSA Department of Pathology University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biology Laboratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neuroblastomas(pNBs)that defy current intensive multimodal clinical therapy(IMCT)are a significant contributor to overall childhood cancer deaths[l].Neuroblastomas(NBs)that survive first-line IMCT actively evolve to acquire genetic and molecular rearrangements and display unparalleled plasticity and evolution,which causes frequent relapses in a rapidly accelerating timeline[2-4].

关键词： neuroblastoma clinical evolve

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基于自适应双相场模型的纤维增强复合材料单层板断裂性能

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复合材料学报 2024年第3期41卷 1505-1515页

作者：郭雯马玉娥 Sundar natarajan 陈鹏程彭帆西北工业大学航空学院西安710072 Indian Institute of Technology Madras School of Mechanical EngineeringChennai 600036 长安大学理学院西安710064

相场法可以自动捕捉裂纹的萌生和演化,因此在模拟复合材料的复杂失效行为时具有明显优势。为区分纤维增强复合材料(Fiber-reinforced composites,FRC)中存在的不同断裂模式,采用双相场断裂模型来分别表征基体和纤维的损伤演化。同时采... 详细信息

相场法可以自动捕捉裂纹的萌生和演化,因此在模拟复合材料的复杂失效行为时具有明显优势。为区分纤维增强复合材料(Fiber-reinforced composites,FRC)中存在的不同断裂模式,采用双相场断裂模型来分别表征基体和纤维的损伤演化。同时采用相场变量作为误差指标,在各向异性的双相场模型中引入了基于四叉树分解的网格自适应细化策略。设计并开发了相应的Matlab程序,研究了单向及变刚度纤维增强复合材料单层板在拉伸位移载荷下的断裂行为。计算结果表明:采用基于自适应算法的各向异性双相场模型所得到的数值计算结果与试验结果吻合良好;自适应双相场模型能在保证较高计算精度的同时,配合序参量的演化准确地在裂纹路径上进行网格自动加密,简化网格前处理过程,减少网格数量,降低计算成本,提高计算效率。

关键词：纤维增强复合材料双相场各向异性自适应有限元

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Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu Phuong Linh Nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao Nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

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华尔街“赌徒” 比尔·黄被判有罪

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商业周刊（中文版） 2024年第11期 22-23页

作者： Sridhar natarajan Ava Benny-Morrison Katherine Burton 王非(译) 不详

这位在一周内赔掉360亿美元的著名金融家现在或面临牢狱之灾。比尔·黄(Bill Hwang)说,那来自他的一个梦。在梦里,基督的鲜血冲刷着纽约,洗涤着这座大都市的罪恶。比尔·黄被这个意象深深打动,于是委托一位著名艺术家把他的梦境呈现出来。

关键词：牢狱之灾华尔街大都市金融家赌徒

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Microbial aspects of acid mine drainage and its bioremediation

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中国有色金属学会会刊：英文版 2008年第6期18卷 1352-1360页

作者： K.A.natarajan Department of Materials Engineering Indian Institute of Science

象从一些被孤立的 Acidithiobacillus ferrooxidans， Acidithiobacillus thiooxidans 和 Leptospirillum ferrooxidans 那样的 chemolithotrophs 的角色放弃了矿并且在酸矿排水和有毒的金属溶解的产生处理了废物跟踪被讨论。酸形成和从铜，铅锌和忍受毒砂的硫化物矿石和跟踪的铜，锌，铁和砷的溶解的机制面对细菌的 Acidithiobacillus 组被建立。从上述矿地点孤立的硫酸盐减少细菌(SRB ) 能被用来猛抛溶解金属象铜，锌，铁和砷那样。砷 bioremediation 通过本国的微生物的使用被表明如此的 Thiomonas spp。它能氧化亚砷酸盐到砷酸盐。通过 jarosite 的使用的砷的 Bioremoval 猛抛由 Acidithiobacillus ferrooxidans 产生了， Leptospirillum ferrooxidans 也被发现很有效。Biotechnological 过程在酸矿排水和象铜，锌和砷那样的有毒的金属离子的有效移动的补习保持大诺言。

关键词：酸矿排水生物治疗砷含量硫酸盐硫化物沉淀

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