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Carcinosarcoma of the stomach:A case report and review of the literature

World Journal of Gastroenterology 2007年第41期13卷 5533-5536页

作者： Tomislav Randjelovic Branka Filipovic Darko Babic vesna cemerikic Branislav Filipovic Department of Gastrointestinal Surgery Clinical and Hospital Center "Bezanijska Kosa" BelgradeSerbia Department of Gastroenterohepatology Clinical and Hospital Center "Bezanijska Kosa " Belgrade 11080Serbia Department of Pathology Clinical and Hospital Center "Bezanijska Kosa" Belgrade 11080Serbia Laboratory for Histopathological and Cytological Diagnostics "Histolab " Belgrade 11080Serbia Institute of Anatomy School of MedicineUniversity of BelgradeBelgrade 11080Serbia

Carcinosarcomas are rare,malignant,biphasic tumors. We report the case of a 62-year-old man with gastric carcinosarcoma,along with its clinical,macroscopic and histopathological features. Macroscopically,a specimen of deformed stomach was obtained that measured 200 mm×150 mm×100 mm. A 150 mm×100 mm× 50 mm exophytic tumoral mass (Borrmann typeⅠ) was found,which involved the posterior wall from the cardia to the antrum. Histopathologically,a mixed type of malignancy was revealed: an adenocarcinoma with intestinal metaplasia,with interposed fascicles of fusiform atypical cells and numerous large,rounded and oval cells. The tumor showed positive histochemistry for cytokeratin 18,epithelial membrane antigen,carcinoembryonic antigen,chromogranin A and vimentin. Liver metastases were diagnosed 8 mo postoperatively,and the patient died 4 mo later. A review of the available literature is also presented.

关键词： Carcinosarcoma Histochemistry Pathology Stomach

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An unusual presentation of “silent” disseminated pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2004年第19期10卷 2919-2921页

作者： Dragomir Marisavljevic Natasa Petrovic Nikola Milinic vesna cemerikic Miodrag Krstic Olivera Markovic Dragoljub Bilanovic Medical Center"Bezanijska kosa" BelgradeYugoslavia Clinical Center Serbia BelgradeYugoslavia

To present a patient diagnosed with pancreatic carcinoidthat was extremely rare and produced an atypical carcinoidsyndrome. We reported a 58-year old male patient whopresented with long standing, prominent cervicallymphadenopathy and occasional watery *** and immunohistochemical examinationof lymph node biopsy showed a metastatic neuroendocrinetumor, which was histological type A of carcinoid (EMA+,cytokeratin+, CEA-, NSE+, chromogranin A+, synaptophysin+,insulin-). Bone marrow biopsy showed identical *** site of the tumor was pancreas and diagnosis wasmade according to cytological and immunocytochemicalanalysis of the tumor cells obtained with aspiration biopsyof pancreatic mass (12 mm in diameter) under endoscopicultrasound guidance. However, serotonin levels in bloodand urine samples were normal. It is difficulty to establishthe precise diagnosis of a "functionally inactive" pancreaticcarcinoid and aspiration biopsy of pancreatic tumor underendoscopic ultrasound guidance can be used as a newpotent diagnostic tool.

关键词：基因表达播散性胰腺神经内分泌内分泌肿瘤腹泻

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