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Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis(Coss. & Dur.) Maire

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 537-543页

作者： Hanene Zater Joelle Huet veronique fontaine Samir Benayache Caroline Stevigny Pierre Duez Fadila Benayache Unite de recherche : Valorisation des Ressources Naturelles Molecules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL) Faculte des Sciences Exactes Universite Freres Mentouri Constantine 125000 ConstantineAlgerie Universite Ziane Achour Cite du 5 JuilletRoute Moudjbara BP:311717000 DjelfaAlgerie Laboratoire de Pharmacognosie de Bromatologie et de Nutrition Humaine Universite Libre de Bruxelles (ULB)1050 BruxellesBelgique Laboratoire de Biopolymere et nanomateriaux supramoleculaire Universite Libre de Bruxelles (ULB)1050 BruxellesBelgique Unite de Microbiologie Pharmaceutique et Hygiene Faculte de Pharmacie Universite Libre de Bruxelles (ULB)1050 BrxellesBelgique Service de Chimie Therapeutique et de Pharmacognosie Universite de Mons (UMONS)7000MonsBelgique

Objective:To investigate the chemical composition of a moderately polar extract(CHC1_3 soluble part of the MeOH-H_2O extract) obtained from the aerial parts(leaves and flowers) of Centaurea diluta ***(Coss.& Dur.) Maire,a species endemic to Algeria and Morocco on which no reports are available to *** evaluate in vitro the cytotoxic,antifungal and antimicrobial activities of this extract and the cytotoxic and antimicrobial activities of its isolated secondary ***:The cytotoxic effects of the extract were investigated on 3 human cancer cell lines *** A549 non-small-cell lung carcinoma(NSCLC),the MCF7 breast adenocarcinoma and the U373 glioblastoma using a MTT colorimetric *** data allowed to guide the fractionation of the extract by separation and purification on silica gel 60(CC and TLC).The isolated compounds which were characterized by spectral analysis,mainly HR-ESIMS,HR-EIMS,UV and NMR experiments(~1H,^(13)C,COSY,ROESY,HSQC and HMBC) and comparison of their spectroscopic data with those reported in the literature,were evaluated for cytotoxic activities on six cancer cell lines(A549,MCF7,U373,Hs683 human glioma,PC3 human prostate and B16-F10 murine melanoma).The direct and indirect antibacterial and antifungal activities were determined using microdilution methods for the raw extract and TLC-bioautography and microdilution methods against standard and clinical strains for the isolated ***:The raw extract reduced cell viability with IC_(50)s of 27,25 and 21 μg/mL on A549,MCF7 and U373,*** secondary metabolites:two phenolic compounds(vanillin 1,paridol 3),a lignan[(-)-arctigenin 2]and two flavonoid aglycones(eupatilin 4 and jaceosidin 5),were then isolated from this *** cytotoxic effects were observed for(-)-arctigenin 2(IC_(50)s:28 and 33μM on Hs683 and B16-F10,respectively),eupatilin 4(IC_(50)s:33 and 47 μM on B16-F10 and PC3,respectively) and jaceosidin 5(IC_(50)s:32 a

关键词： Flavonoids Lignans Centaurea diluta Asteraceae Cytotoxic activity Direct and indirect antimicrobial activity MRSA

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Free-standing microscale photonic lantern spatial mode(De-)multiplexer fabricated using 3D nanoprinting

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Light(Science & Applications) 2024年第6期13卷 1170-1185页

作者： Yoav Dana Yehudit Garcia Aleksei Kukin Lauren Dallachiesa Sterenn Guerrier Nicolas K.fontaine Dan M.Marom Institute of Applied Physics Hebrew University of JerusalemJerusalemIsrael Nokia Bell Labs 600 Mountain AveNew ProvidenceNJ07974USA

Photonic lantern(PL)spatial multiplexers show great promise for a range of applications,such as future high-capacity mode division multiplexing(MDM)optical communication networks and free-space optical *** enable efficient conversion between multiple single-mode(SM)sources and a multimode(MM)waveguide of the same *** multiplexers operate by facilitating adiabatic transitions between the SM arrayed space and the single MM ***,current fabrication methods are forcing the size of these devices to multi-millimeters,making integration with micro-scale photonic systems quite *** advent of 3D micro and nano printing techniques enables the fabrication of freestanding photonic structures with a high refractive index contrast(photopolymer-air).In this work we present the design,fabrication,and characterization of a 6-mode mixing,375µm long PL that enables the conversion between six single-mode inputs and a single six-mode *** PL was designed using a genetic algorithm based inverse design approach and fabricated directly on a 7-core fiber using a commercial two-photon polymerization-based 3D printer and a *** the waveguides exhibit high index contrast,low insertion loss(−2.6 dB),polarization dependent(−0.2 dB)and mode dependent loss(−4.4 dB)were measured.

关键词： mode enable printing

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Defense and senescence interplay in legume nodules

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Plant Communications 2024年第4期5卷 112-126页

作者： Fathi Berrabah Farouk Benaceur Chaoyan Yin Dawei Xin Ke´vin Magne Marie Garmier veronique Gruber Pascal Ratet Faculty of Sciences University Amar Telidji03000 LaghouatAlgeria Research Unit of Medicinal Plants(RUMP) National Center of Biotechnology ResearchCRBt25000 ConstantineAlgeria Universite´Paris-Saclay CNRSINRAEUniversity of EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Universite´Paris Cite´ Institute of Plant Sciences Paris-Saclay(IPS2)91190 Gif-sur-YvetteFrance Key Laboratory of Soybean Biology in the Chinese Ministry of Education College of AgricultureNortheast Agricultural UniversityHarbin 150030China These authors contributed equally to this article.

Immunity and senescence play a crucial role in the functioning of the legume symbiotic *** miss-regulation of one of these processes compromises the symbiosis leading to death of the endosymbiont and the arrest of the nodule *** relationship between immunity and senescence has been exten-sively studied in plant organs where a synergistic response can be ***,the interplay be-tween immunity and senescence in the symbiotic organ is poorly discussed in the literature and these phe-nomena are often mixed *** studies revealed that the cooperation between immunity and senescence is not always observed in the nodule,suggesting complex interactions between these two pro-cesses within the symbiotic ***,we discuss recent results on the interplay between immunity and senescence in the nodule and the specificities of this relationship during legume-rhizobium symbiosis.

关键词： immunity senescence symbiosis nodules legumes rhizobia

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Chitin-glucan improves important pathophysiological features of irritable bowel syndrome

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World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Michaël Genin veronique Maquet Salvatore Modica Pierre Desreumaux Christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITE-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France ULR 2694-METRICS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BACKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(CG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of CG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(CRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving CG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflammatory effect of CG was evaluated using clinical and histological scores in 30 C57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with CG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(CB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5AC,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PCR *** modelling of CG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the abili

关键词： Chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier Molecular modelling Microbial cell walls chelation

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Dissolved Organic Matter Features of Three Adjacent Eastern Mediterranean Urbanized Watersheds

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Open Journal of Modern Hydrology 2024年第3期14卷 153-173页

作者： Nour Abboud Elias Michel Maatouk Zeinab Matar veronique Kazpard Research and Analysis Platform for Environmental Sciences (PRASE) Doctoral School of Sciences and Technology (EDST) The Lebanese University Rafic Hariri Campus Hadat Lebanon Laboratory of Georessources Geosciences and Environment (L2GE) Faculty of Sciences The Lebanese University Fanar Lebanon Department of Earth and Life Sciences Faculty of Sciences The Lebanese University Hadat Lebanon

Landscape urbanization broadly affects ecosystems in coastal watersheds, but, until now, the influence of nonpoint source urban inputs on dissolved organic matter (DOM) amount, composition, and source is poorly understood. To understand how DOM composition varied with urbanization, fluorescence excitation-emission matrices (EEMs) were determined for urban and non-urban waters from upstream to downstream sites along three adjacent coastal watersheds that flow into the Mediterranean Sea. Two humic DOM fluorescent components (humic-like and fulvic-like peaks) and two proteinic components (tyrosine-like and tryptophane-like peaks) were identified by EEM fluorescence. The results indicated that urbanization had an important influence on DOM concentration and composition, with urban waters having a high degree of DOM variation due to different land uses surrounding each body of water. Urban waters show a higher DOM fluorescence index (FI), the highest fluorescence intensity of protein-like manifested also by BIX values, and a lower value of the humification index (HIX) than non-urban waters which were dominated by allochthonous inputs. In addition, the EEM was compared in dry and wet season where higher DOM amounts and FI appeared in summer due to autochthonous production coming from algae growth compared to allochthonous input from rainfall dominated in wet season. The concentration of DOC increased from upstream to downstream for the three rivers, especially Beirut River. The increase in DOC values was observed in both dry and wet seasons by 39 and 19 times respectively compared to upstream (0.93 - 0.91 mgC/L).

关键词： Dissolved Organic Matter DOM EEM Fluorescence Spectroscopy Autochthonous/Allochthonous DOM Urbanization Upstream/Downstream Wet/Dry Season

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Comparative Study of the Types of Photovoltaic Panels Used in Solar Pumping Systems in Dry Tropical Zones: Case of Adamawa Region in Cameroon

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Open Journal of Energy Efficiency 2024年第3期13卷 79-87页

作者： Boussaibo Andre Waoudowa Kande veronique Ndjiya Ngasop Stephane Gautier Kitmo Department of Electrical Engineering University Institute of Ngaoundr Ngaoundr Cameroon Department of Electrical Energy and Automation National School of Agro-Industrial Sciences Ngaoundr Cameroon Department of Physics University of Ngaoundr Ngaoundr Cameroon

In the dry tropical zone where access to water is increasingly difficult for populations, solar pumping units are increasingly installed to provide water to population. In the local market, there are essentially two types of solar panels, namely monocrystalline and polycrystalline. However, the part of the local market is more dominated by the polycrystalline panel. In this work, comparative studies are carried out in order to characterize the two types of solar panels with regard to local constraints. Tests were carried out over the course of the sun to establish the performance of each type. The panels used have the same electrical characteristics and are connected to loads with same characteristics. Under the set operating conditions, the monocrystalline panel presents more performance than the polycrystalline panel. Although the local market is dominated by the polycrystalline panel, dust deposition tests on the surface of the panels show that the performance of the polycrystalline panel is more affected compared to the performance of the monocrystalline panel.

关键词： Solar Pumping Monocrystalline Cell Polycrystalline Cell Dry tropical Zone Dustdeposit

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Python Server Page Performance Analysis and Modeling

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Communications and Network 2024年第1期16卷 1-30页

作者： Razafindraibe Marolahy Alix Randrianomenjanahary Lala Ferdinand Rafamantanantsoa fontaine Mahatody Thomas F. Angelo Raherinirina University of Fianarantsoa Fianarantsoa Madagascar

Today, in the field of computer networks, new services have been developed on the Internet or intranets, including the mail server, database management, sounds, videos and the web server itself Apache. The number of solutions for this server is therefore growing continuously, these services are becoming more and more complex and expensive, without being able to fulfill the needs of the users. The absence of benchmarks for websites with dynamic content is the major obstacle to research in this area. These users place high demands on the speed of access to information on the Internet. This is why the performance of the web server is critically important. Several factors influence performance, such as server execution speed, network saturation on the internet or intranet, increased response time, and throughputs. By measuring these factors, we propose a performance evaluation strategy for servers that allows us to determine the actual performance of different servers in terms of user satisfaction. Furthermore, we identified performance characteristics such as throughput, resource utilization, and response time of a system through measurement and modeling by simulation. Finally, we present a simple queue model of an Apache web server, which reasonably represents the behavior of a saturated web server using the Simulink model in Matlab (Matrix Laboratory) and also incorporates sporadic incoming traffic. We obtain server performance metrics such as average response time and throughput through simulations. Compared to other models, our model is conceptually straightforward. The model has been validated through measurements and simulations during the tests that we conducted.

关键词： Performance Analysis Queue Performance Model Web Server Internet World Wide Web Web Server Performance

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Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk veronique Minard-Colin Caroline Chopinet Michael Dussiot Denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance Department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

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Mars geodesy,rotation and gravity

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Research in Astronomy and Astrophysics 2010年第8期10卷 713-736页

作者： Pascal Rosenblatt veronique Dehant Royal Observatory of Belgium

This review provides explanations of how geodesy, rotation and gravity can be addressed using radioscience data of an orbiter around a planet or of the lander on its surface. The planet Mars is the center of the discussion. The information one can get from orbitography and radioscience in general concerns the global static gravitational field, the time variation of the gravitational field induced by mass exchange between the atmosphere and the ice caps, the time variation of the gravitational field induced by the tides, the secular changes in the spacecraft＇s orbit induced by the little moons of Mars named Phobos and Deimos, the gravity induced by particular targets, the Martian ephemerides, and Mars＇ rotation and orientation. The paper addresses as well the determination of the geophysical parameters of Mars and, in particular, the state of Mars＇ core and its size, which is important for understanding the planet＇s evolution. Indeed, the state and dimension of the core determined from the moment of inertia and nutation depend in turn on the percentage of light elements in the core as well as on the core temperature, which is related to heat transport in the mantle. For example, the radius of the core has implications for possible mantle convection scenarios and, in particular, for the presence of a perovskite phase transition at the bottom of the mantle. This is also important for our understanding of the large volcanic province Tharsis on the surface of Mars.

关键词： planets and satellites Mars -- variables rotation, gravity, and interior of Mars

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Developed correlations between sound wave velocity and porosity, permeability and mechanical properties of sandstone core samples

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Petroleum Research 2020年第4期5卷 326-338页

作者： Ghareb Hamada veronique Joseph Petroleum Engineering depuroment College of Engineering American University of KurdistanKurdistanlrag Petroleurm Enginering Department Faculty of Engineering University Teknologi PetronasMalaysia

In the evaluation of a petroleum reserve,it is necessary to accurately determine certain petrophysical properties such as porosity and permeability of the reservoir rocks and rock mechanical *** properties are key factors in the reservoir descniption and geomechanical properties are determining parameters in drilling operations and in stimulation and hydraulic fracturing jobs and also the development plans for given *** is more convenient to use homogenous rock samples with nearly constant initial permeability;however,obtaining such cores is very *** this paper a simulated natural and homogeneous compacted sandstone rock with known physical and petrophysical propertie were *** properties of reservoir rocks incude pore size distribution;grain size,cementing material concentration,and confining pressure affect rock porosity and *** wave velocity was measured using an ultra sound tool on different sandstone core *** cor-relations have been developed between sound wave velocity(Vp and Vs)the petrophysical properties mainly porosity and *** correlations have been found between seismic wave ve-locity(Vp,Vs and VpVs)and mechanical parameters namely Young's modulus,shear modulus,bulk modulus and Poison's atio for sandstone core *** study has been carried out on dry core samples and core samples with different water saturations and results showed that there are changes in the correlation between seismic wave velocity and mechanical and ptrophysical properties as function of water saturation change from dry rock to water wet rock.

关键词： Seismic wave Porosity Permeability Mechanical parameters Sand core Samples Water saturation

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