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Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João b.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell biology(IbMC) University of PortoPortoPortugal department of biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(Ad).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Participation of Cd45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity

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World Journal of Gastroenterology 2000年第4期6卷 546-552页

作者： david Vermiilen bülent ahishali Vasilis Triantis Karin Vanderkerken Peter J. K.Kuppen Eddie Wisse Laboratory for Cell biology and Histology. department of Hematology and immunology Free University of Brussels(VUB)Brussels-JetteBelgium K Vanderkerken is a postdoctoral researcher of the Fund for Scientific Research Flanders. department of Surgery and Pathology Leiden University Medical CenterLeidenThe Netherlands

AIM Several triggering receptors have beendescribed to be involved in natural killer（NK）cell-mediated target *** these studies,NKcells derived from blood or spleen were *** are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK *** aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and Cd45 in pit cell-mediated killing oftarget *** 51Cr-release and dNA fragmentationwere used to quantify target cell lysis andapoptosis,*** Flow cytometric analysis showed thatpit cells expressed Cd45,NKR-P1A,and *** of pit cells with monoclonalantibody（mAb）to Cd45（ANK74）not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit *** mAbs to NKR-P1A（3.2.3）and ANK61 antigen（ANK61）had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive（FcγR+）P815 cytolysis *** enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof *** These results indicate that Cd45participates in pit cell-mediated CC531s and YAC-1target cytolysis and ***-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway.

关键词： hepatic NK cells pit cells cytolysis apoptosis perforin/granzyme pathway

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram d.dongale Atul C.Khot Chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea Computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Rethinking the solar flare paradigm

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Plasma Science and Technology 2018年第7期20卷 15-21页

作者： d b melrose SIfA School of PhysicsThe University of SydneyNSW 2006Australi

It is widely accepted that solar flares involve release of magnetic energy stored in the solar corona above an active region, but existing models do not include the explicitly time-dependent electrodynamics needed to describe such energy release. A flare paradigm is discussed that includes the electromotive force （EMF） as the driver of the flare, and the flare-associated current that links different regions where magnetic reconnection, electron acceleration, the acceleration of mass motions and current closure occur. The EMF becomes localized across regions where energy conversion occurs, and is involved in energy propagation between these regions.

关键词： solar flares electrodynamics time-dependence

biodiversity and interactions of acidophiles:Key to understanding and optimizing microbial processing of ores and concentrates

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中国有色金属学会会刊：英文版 2008年第6期18卷 1367-1373页

作者： d.b.JOHNSON School of biological Sciences Bangor University

采矿公司为从低档矿石恢复贱、宝贵的金属，并且为重新调停变得逐渐地知道 microbiological 途径的潜力从操作和放弃的矿地点排干的酸的、充满金属的废水。生物系统出现很多环境并且(有时) 超越常规途径的节俭的优点尽管他们的申请是，... 详细信息

采矿公司为从低档矿石恢复贱、宝贵的金属，并且为重新调停变得逐渐地知道 microbiological 途径的潜力从操作和放弃的矿地点排干的酸的、充满金属的废水。生物系统出现很多环境并且(有时) 超越常规途径的节俭的优点尽管他们的申请是，例如热冶学，别处于每种状况拨出。矿物质用微生物处理为提取黄金，铜，铀和钴被利用了，并且当前的开发正在指向另外的贱金属。最近，我们 biomining 环境，并且微生物怎么与对方一起交往的微生物学的差异的知识和理解有大增加。从模仿了搅动的坦克和堆生物反应器系统的实验室实验的结果证明了微生物引起的协会比氧化矿物质的 acidophiles 的纯文化更柔韧，并且也趋于在 bioleaching 和氧化简历的矿石更有效并且专注。纸论述了性质的简明评论和涉及硫化物矿物质的氧化的微生物引起的协会的相互作用，并且这些怎么可能被改编在 biomining 操作遇见未来挑战。

关键词：嗜酸细胞生物采矿生物多样性微生物加工

Structural and mass transport properties of liquid ytterbium in the temperature range 1123 K–1473 K

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Chinese Physics b 2023年第6期32卷 481-488页

作者： d d Satikunvar N K bhatt b Y Thakore department of Physics Sardar Patel UniversityVallabh VidyanagarGujarat 388120India department of Physics Maharaja Krishnakumarsinhji Bhavnagar UniversityBhavnagarGujarat 364001India

We have studied the structural and atomic transport properties of liquid f-shell Yb in the temperature range 1123 K–1473 K. Pair interactions between atoms are derived using a local pseudopotential. The potential parameters are fitted to the phonon dispersion curve at room temperature. The local pseudopotential used in the present study is computationally more efficient with only three parameters, and it is found to be transferable to the liquid phase without changing the *** the various computed properties agree with reported theoretical and experimental findings, the adopted fitting scheme is justified. As a significant outcome of the study, we find that(i) the melting in Yb is governed by the Lindemann's law,(ii)the mass transport mechanism obeys the Arrhenius law,(iii) the role of the three-particle correlation function in deriving the velocity autocorrelation function is small,(iv) the mean-square atomic displacement is more sensitive to the choice of interaction potential than the other bulk properties, and(v) liquid Yb does not show liquid–liquid phase transition within the studied temperature range. Further, due to the good description of the structural and mass transport properties, we propose that Yb remains divalent at reduced density.

关键词： transport properties pseudopotential single-particle dynamics ytterbium

Advanced analytical determination of volatile organic compounds (VOC) and other major contaminants in water samples using GC-Ion Trap MS

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Journal of Environmental Sciences 2001年第1期13卷 25-36页

作者： b M Koroma K X Wang d d Jinya Laboratory of Socioeconomic Science of Food Production Nagoya University Japan.

The GC-Ion Trap MS is recently one of the most efficient instrumental analysis recommended for understanding the chemistry of volatile organic compounds, not only in water but even in the food chain and other environmental media (air and soil). Results of the experiment conducted on water samples from Kuguri and Yatsutani sampling stations showed considerably higher levels of organic enrichment (COd = 10 mg/L and 11 mg/L respectively). Total concentrations of Pb (0.072 mg/L and 0.093 mg/L) and Cd (0.004 mg/L and 0.011 mg/L) on the other hand, invariably exceeded the maximum allowable concentrations for human health and the living environment (Pb = 0.005 mg/L; Cd = 0.001 mg/L respectively). And the toxicity levels for these contaminants at LC50 showed critical impact on rainbow trout (hypersensitive species) at 0.14 mg/L for Pb and 0.007 mg/L for Cd in 96 hours respectively. Although these major contaminants including phenol and 3-, 4-cresol, showed relatively higher toxicity impact in the experimental media, it would remain contentious to justify any associated potential dangers without regular routine water monitoring, at least for a period of one year. Nevertheless, the data could serve as a benchmark through which other phenomena can easily be investigated.

关键词： www Advanced analytical determination of volatile organic compounds and other major contaminants in water samples using GC-Ion Trap MS VOC Eb GC

Theoretical and numerical investigation of HF elastic wave propagation in two-dimensional periodic beam lattices

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Acta Mechanica Sinica 2013年第6期29卷 783-798页

作者： b.Tie b.Y.Tian d.Aubry Laboratory MSSMat(UMR-CNRS 8579) Ecole Centrale ParisGrande Voie des Vignes92295 Chatenay-Malabry CedexFrance

The elastic wave propagation phenomena in two-dimensional periodic beam lattices are studied by using the bloch wave transform. The numerical modeling is applied to the hexagonal and the rectangular beam lattices, in which, both the in-plane （with respect to the lattice plane） and out-of-plane waves are considered. The dispersion relations are obtained by calculating the bloch eigenfrequencies and eigenmodes. The frequency bandgaps are observed and the influence of the elastic and geometric properties of the primitive cell on the bandgaps is studied. by analyzing the phase and the group velocities of the bloch wave modes, the anisotropic behaviors and the dispersive characteristics of the hexagonal beam lattice with respect to the wave prop- agation are highlighted in high frequency domains. One im- portant result presented herein is the comparison between the first bloch wave modes to the membrane and bend- ing/transverse shear wave modes of the classical equivalent homogenized orthotropic plate model of the hexagonal beam lattice. It is shown that, in low frequency ranges, the homog- enized plate model can correctly represent both the in-plane and out-of-plane dynamic behaviors of the beam lattice, its frequency validity domain can be precisely evaluated thanks to the bloch modal analysis. As another important and original result, we have highlighted the existence of the retro- propagating bloch wave modes with a negative group veloc- ity, and of the corresponding ＂retro-propagating＂ frequency bands.

关键词： Elastic wave propagation Periodic beam lattice bloch wave theory bandgaps Anisotropy disper- sion relation

ON A PAIR OF NON-ISOMETRIC ISOSPECTRAL dOMAINS WITH FRACTAL bOUNdARIES ANd THE WEYL-bERRY CONJECTURE

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Chinese Annals of Mathematics,Series b 1998年第1期19卷 9-20页

作者： SLEEMAN,b.d. CHENHUA SchoolofMathematics UniversityofLeedsLeedsLS29JTEngland departmentofMathematics WuhanUniversityWuhan430072China

This paper is divided into two parts. In the first part the authors extend Kac's classical problem to the fractal case, i.e., to ask: Must two isospectral planar domains with fractal boundaries be isometric?It is demonstrated that the answer to this question is no, by constructing a pair of disjoint isospectral planar domains whose boundaries have the same interior bouligand-Minkowski dimension but are not isometric. In the second part of this paper the authors give the exact two-term asymptotics for the dirichlet counting functions associated with the examples given here and obtain sharp two sided estimates for the second term of the counting functions. The first result in the second part of the paper shows that the coefficient of the second term is an oscillatory function of λ, which implies that the Weyl-berry conjecture, for the examples given here, is false. The second result implies that the weaker form of the Weyl-berry conjecture, for these examples, is true. This in turn means that the interior bouligand-Minkowski dimension of the examples is a spectral invariant.

关键词： Non isometric Isospectral domain Fractal boundary Weyl berry conjecture