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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

A review on MBE-grown HgCdSe infrared materials on GaSb(211)B substrates

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Chinese Physics B 2019年第1期28卷 116-125页

作者： Z K Zhang w w Pan J L Liu w Lei Department of Electrical Electronic and Computer EngineeringThe University of Western Australia35 Stirling HighwayCrawley 6009Australia

we review our recent efforts on developing HgCdSe infrared materials on Ga Sb substrates via molecular beam epitaxy(MBE) for fabricating next generation infrared detectors with features of lower production cost and larger focal plane array format size. In order to achieve high-quality HgCdSe epilayers, ZnTe buffer layers are grown before growing HgCdSe, and the study of misfit strain in ZnTe buffer layers shows that the thickness of ZnTe buffer layer needs to be below 300 nm in order to minimize the generation of misfit dislocations. The cut-off wavelength/alloy composition of HgCdSe materials can be varied in a wide range by varying the ratio of Se/Cd beam equivalent pressure during the HgCdSe *** temperature presents significant impact on the material quality of HgCdSe, and lower growth temperature leads to higher material quality for HgCdSe. Typically, long-wave infrared HgCdSe(x = 0.18, cut-off wavelength of 10.4 μm at 80 K) presents an electron mobility as high as 1.3×10~5cm^2·V^(-1)·s^(-1), a background electron concentration as low as 1.6×10^(16)cm^(-3), and a minority carrier lifetime as long as 2.2 μs. These values of electron mobility and minority carrier lifetime represent a significant improvement on previous studies of MBE-grown HgCdSe reported in the open literatures,and are comparable to those of counterpart HgCdTe materials grown on lattice-matched CdZnTe substrates. These results indicate that HgCdSe grown at the University of western Australia, especially long-wave infrared can meet the basic material quality requirements for making high performance infrared detectors although further effort is required to control the background electron concentration to below 10^(15)cm^(-3). More importantly, even higher quality HgCdSe materials on GaSb are expected by further optimizing the growth conditions, using higher purity Se source material, and implementing postgrowth thermal annealing and defect/impurity gettering/filtering. Our results demonst

关键词： infrared detector HgCdSe GaSb molecular beam epitaxy

The Strategy of Escalation and Negotiation: The Iran Nuclear Dispute

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Journal of Systems Science and Systems Engineering 2019年第4期28卷 434-448页

作者： Tobias w. Langenegger Keith w. Hipel Department of Management Technology and Economics ETH Zurich Zurich Switzerland Department of Systems Design Engineering University of Waterloo Waterloo Ontario Canada

The strategic decisions and resulting consequences surrounding the conflict between the United States of America (US) and Iran regarding the Iranian nuclear program are formally investigated using a flexible decision methodology called the Graph Model for Conflict Resolution (GMCR). This highly controversial dispute caught the world's attention as concerns were growing that Iran would reach a position where it would be able to build nuclear weapons, thereby posing a risk to world security. while Iran insisted on its rights for the peaceful use of nuclear technology;the international community;led by the US, tried to discourage the nuclear activities of Iran to ensure its obligations to the non-proliferation of nuclear weapons. This led to an escalation of tension on both sides, with an extension of the nuclear program by Iran and an increase in sanctions by the US, before it was possible to arrive at a negotiated agreement. As demonstrated in this paper, a systematic GMCR investigation provides valuable strategic insights into this important conflict. Further, it illustrates ways in which the conflict could have evolved, as well as mechanisms for stopping an escalation like this in the future.

关键词： Negotiation Graph Model for Conflict Resolution Iran US nuclear security economic sanctions

Analysis on the velocity relationship and deceleration of long-rod penetration

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Acta Mechanica Sinica 2019年第4期35卷 852-865页

作者： w.J.Jiao X.w. Chen Department of Modern Mechanics University of Science and Technology of China Hefei230027 China Institute of Systems Engineering China Academy of Engineering Physics Mianyang621999 China The State Key Lab of Explosion Science and Technology Beijing Institute of Technology Beijing100081 China Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing 100081 China

The relationship between the average penetration velocity,UˉUˉ,and the initial impact velocity, V0V0,in long-rod penetration has been studied recently. Experimental and simulation results all show the linear relationship between UˉUˉ and V0V0 over a wide range of V0V0 for different combinations of rod and target materials. However, the physical essence has not been fully *** this paper, the Uˉ?V0Uˉ?V0relationship is profoundly analyzed using hydrodynamic model and Alekseevskii-Tate model. Especially, the explicitUˉ?V0Uˉ?V0 relationships are derived fromapproximate solutions of Alekseevskii-Tate model. Besides, the decelerationin long-rod penetration is discussed. The decelerationdegree is quantified by adeceleration index,α=2μˉ/(KΦJp)≈Ypρ?1/2p(ρ?1/2p+ρ?1/2t)V?20α=2μˉ/(KΦJp)≈Ypρp?1/2(ρp?1/2+ρt?1/2)V0?2, which is mostly related to the impact velocity, rod strength and rod/target densities. Thus, the state of penetration process can be identified and designed in experiments.

关键词： Long-rod penetration Average penetration velocity Initial impact velocity Alekseevskii-Tate model Deceleration

Effect of Al addition and heat treatment on the microstructures and corrosion resistance of Mg-Cu alloys

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Journal of Materials Science & Technology 2022年第3期98卷 219-232页

作者： X.w.wang w.wang w.Chen D.M.Chen Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China College of Material Science and Engineering University of Science and Technology of ChinaShenyang 110016China

The effects of Al content and annealing condition on the microstructures and corrosion performances of Mg-3 wt.%Cu-xAl(x=0,4 wt.%,8 wt.%)alloys were *** Mg-3 wt.%Cu alloy contains Mg_(2)Cu phase,but Al-bearing alloys contain MgAlCu and Mg_(17)Al_(12) *** Mg_(2)Cu and MgAlCu phases exhibit much higher Volta potential compared to Mg_(17)Al_(12) and α-Mg,and their volume fractions are related to Al content of alloys and annealing *** weight loss measurement and electrochemical tests are conducted to explore the corrosion performances of *** close relationship between weight loss rate of alloys and volume fraction of Cu-bearing phases indicates that the corrosion performances of alloys can be controlled by adjusting Al content of alloys and annealing conditions.

关键词： Magnesium Intermetallics weight loss EIS(electrochemical impedance spectroscopy)

Approximate solutions of the Alekseevskii–Tate model of long-rod penetration

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Acta Mechanica Sinica 2018年第2期34卷 334-348页

作者： w.J.Jiao X.w.Chen Department of Modern Mechanics University of Science and Technology of China Institute of Systems Engineering China Academy of Engineering Physics Advanced Research Institute for Multidisciplinary Science Beijing Institute of Technology The State Key Lab of Explosion Science and Technology Beijing Institute of Technology

The Alekseevskii–Tate model is the most successful semi-hydrodynamic model applied to long-rod penetration into semi-infinite targets. However, due to the nonlinear nature of the equations, the rod(tail) velocity, penetration velocity, rod length, and penetration depth were obtained implicitly as a function of time and solved numerically By employing a linear approximation to the logarithmic relative rod length, we obtain two sets of explicit approximate algebraic solutions based on the implicit theoretica solution deduced from primitive equations. It is very convenient in the theoretical prediction of the Alekseevskii–Tate model to apply these simple algebraic solutions. In particular, approximate solution 1 shows good agreement with the theoretical(exact) solution, and the first-order perturbation solution obtained by walters et al.(Int. J. Impac Eng. 33:837–846, 2006) can be deemed as a special form of approximate solution 1 in high-speed penetration. Meanwhile, with constant tail velocity and penetration velocity approximate solution 2 has very simple expressions, which is applicable for the qualitative analysis of long-rod penetration. Differences among these two approximate solutions and the theoretical(exact) solution and their respective scopes of application have been discussed, and the inferences with clear physical basis have been drawn. In addition, these two solutions and the first-order perturbation solution are applied to two cases with different initial impact velocity and different penetrator/target combinations to compare with the theoretical(exact) solution. Approximate solution 1 is much closer to the theoretical solution of the Alekseevskii–Tate model than the first-order perturbation solution in both cases, whilst approximate solution 2 brings us a more intuitive understanding of quasi-steady-state penetration.

关键词： Long-rod penetration Alekseevskii–Tate model Theoretical solution Approximate solution Perturbation solution

Free vibration of a sagged cable with attached discrete elements

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Applied Mathematics and Mechanics(English Edition) 2019年第5期40卷 631-648页

作者： w.PAKOS Faculty of Civil Engineering Wroc law University of Science and Technology

An algorithm is presented to analyze the free vibration in a system composed of a cable with discrete elements, e.g., a concentrated mass, a translational spring, and a harmonic oscillator. The vibrations in the cable are modeled and analyzed with the Lagrange multiplier formalism. Some fragments of the investigated structure are modeled with continuously distributed parameters, while the other fragments of the structure are modeled with discrete elements. In this case, the linear model of a cable with a small sag serves as a continuous model, while the elements, e.g., a translational spring, a concentrated mass, and a harmonic oscillator, serve as the discrete elements. The method is based on the analytical solutions in relation to the constituent elements, which, when once derived, can be used to formulate the equations describing various complex systems compatible with an actual structure. The numerical analysis shows that, the method proposed in this paper can be successfully used to select the optimal parameters of a system composed of a cable with discrete elements, e.g., to detune the frequency resonance of some structures.

关键词： free vibration sagged cable with attachments continuous discrete model

Aromatic compound degradation by iron reducing bacteria isolated from irrigated tropical paddy soils

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Journal of Environmental Sciences 2008年第12期20卷 1487-1493页

作者： w.Reichardt University of the Philippines at Diliman(UPD) Marine Science InstituteBolinao Marine Laboratory(BML)-UP Guiguiwanen RdBolinaoThe Philippines

Forty-six candidate phenol/benzoate degrading-iron reducing bacteria were isolated from long term irrigated tropical paddy soils by enrichment *** cultures and some prepared mixed cultures were examined for ferric oxide reduction and phenol/benzoate *** the isolates were iron reducers,but only 56.5%could couple iron reduction to phenol and/or benzoate degradation,as evidenced by depletion of phenol and benzoate after one week *** of degradative capability using Biolog...

关键词： aromatic compounds degradation iron reducing bacteria paddy soil

Effects of site productivity on individual tree maximum basal area growth rates of Eucalyptus pilularis in subtropical Australia

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Journal of Forestry Research 2023年第6期34卷 1659-1668页

作者： P.w.west Forest Research Centre Southern Cross UniversityLismoreNSW 2480Australia

Inventory data were available from 96 plots of even-aged,monoculture,tall-open forests of Eucalyptus pilularis Smith,aged 2-63 years,growing in sub-tropical regions along the east coast of Australia.A model was developed relating the maximum possible stem basal area growth rate of individual trees to their stem basal *** any tree size,this maximum increased as site productivity ***,the size at which this maximum occurred decreased as productivity *** research has shown that,at any stand age,trees of a particular stem basal area are taller on more productive sites than on less productive *** trees incur greater respiratory costs to ensure maintenance of the photo synthetic capacity of their canopies;this reduces their growth *** was concluded that trees with larger basal areas will have the maximum possible growth rate on a less productive site,whilst trees with smaller basal areas will have the maximum possible on a more productive *** model developed may constitute the first stage of a complete individual tree growth model system to predict wood yields from these forests.

关键词： Growth model Individual tree Maximum growth rate Eucalyptus pilularis Physiological eff ects