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Tools for the diagnosis of hepatitis C virus infection and hepatic fibrosis staging

World Journal of Gastroenterology 2014年第13期20卷 3431-3442页

作者： verónica saludes Victoria González Ramon Planas Lurdes Matas Vicente Ausina Elisa Martró Institut d’ Investigació en Ciències de la Salut Germans Trias i Pujol Hospital Universitari Germans Trias i Pujol (Universitat Autònoma de Barcelona)08916 BadalonaSpain CIBER Epidemiología y Salud Pública (CIBERESP) 08003 BarcelonaSpain Centre for Epidemiological Studies on HIV/STI in Catalonia (CEEISCAT)-ICO 08916 BadalonaSpain Liver Unit Hospital Universitari Germans Trias i Pujol08916 BadalonaSpain Ramon Planas CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD)08036 BarcelonaSpain CIBER Enfermedades Respiratorias (CIBERES) 07110 BunyolaSpain

Hepatitis C virus(HCV)infection represents a major public health issue.Hepatitis C can be cured bytherapy,but many infected individuals are unaware of their status.Effective HCV screening,fast diagnosis and characterization,and hepatic fibrosis staging are highly relevant for controlling transmission,treating infected patients and,consequently,avoiding end-stage liver disease.Exposure to HCV can be determined with high sensitivity and specificity with currently available third generation serology assays.Additionally,the use of point-of-care tests can increase HCV screening opportunities.However,active HCV infection must be confirmed by direct diagnosis methods.Additionally,HCV genotyping is required prior to starting any treatment.Increasingly,high-volume clinical laboratories use different types of automated platforms,which have simplified sample processing,reduced hands-on-time,minimized contamination risks and human error and ensured full traceability of results.Significant advances have also been made in the field of fibrosis stage assessment with the development of non-invasive methods,such as imaging techniques and serum-based tests.However,no single test is currently available that is able to completely replace liver biopsy.This review focuses on approved commercial tools used to diagnose HCV infection and the recommended hepatic fibrosis staging tests.

关键词： Hepatitis C virus Diagnosis Real-time poly-merase

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The Well-Connected Older Adult:Exploring the Youth’s“Older Adult Self”(OAS)—Visualizations Post-Encounter With an Older Adult Community in Bagac,Bataan

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Journal of Sociology Study 2020年第6期10卷 253-266页

作者： Brian saludes Bantugan St.Paul University Manila ManilaPhilippines

This paper sought to surface visualizations of“older adult selves”(OAS)of junior college students studying development communication after an interaction with older adults in Bagac,Bataan in the Philippines.It was done to figure out the ways by which such visualizations could be achieved through institutional efforts within an academic setting.Twenty-three students,mostly females who volunteered to participate in a reflection paper writing activity a week after the youth-older adult interaction,wrote their visions or projections of their life as older adults informed by their social exchanges with older adults in a rural community in the Philippines(Bagac,Bataan).The results indicated that an image of the well-connected older adult was shared across all narratives and it is characterized by youthfulness,openness and flexibility,and sense of accomplishment.Necessary conditions were drawn out from the data to help facilitate the fulfillment of such visions through the possible initiatives of St.Paul University Manila.

关键词： well-connected older adult older adult selves visualizations older adult community

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