Tools for the diagnosis of hepatitis C virus infection and hepatic fibrosis staging

作     者：Verónica Saludes Victoria González Ramon Planas Lurdes Matas Vicente Ausina Elisa Martró 

作者机构：Institut d’ Investigació en Ciències de la Salut Germans Trias i PujolHospital Universitari Germans Trias i Pujol (Universitat Autònoma de Barcelona)08916 BadalonaSpain CIBER Epidemiología y Salud Pública (CIBERESP)08003 BarcelonaSpain Centre for Epidemiological Studies on HIV/STI in Catalonia (CEEISCAT)-ICO08916 BadalonaSpain Liver UnitHospital Universitari Germans Trias i Pujol08916 BadalonaSpain Ramon PlanasCIBER Enfermedades Hepáticas y Digestivas (CIBEREHD)08036 BarcelonaSpain CIBER Enfermedades Respiratorias (CIBERES)07110 BunyolaSpain 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第13期

页      面：3431-3442页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by A Miguel Servet contract No.MS09/00044 funded by FIS-ISCIII(Spanish Government)to MartróE grant PI10/01734 within the"Plan Nacional de I+D+I" co-financed by"ISCIII-Subdirección General de Evaluación y el Fondo Eu-ropeo de Desarrollo Regional"(FEDER)to González V,Saludes V,MartróE 

主　　题：Hepatitis C virus Diagnosis Real-time polymerase chain reaction Serology Hepatitis C virus-RNA quantification Hepatitis C virus genotyping Hepatic fibrosis staging 

摘      要：Hepatitis C virus(HCV)infection represents a major public health *** C can be cured bytherapy,but many infected individuals are unaware of their *** HCV screening,fast diagnosis and characterization,and hepatic fibrosis staging are highly relevant for controlling transmission,treating infected patients and,consequently,avoiding end-stage liver *** to HCV can be determined with high sensitivity and specificity with currently available third generation serology ***,the use of point-of-care tests can increase HCV screening ***,active HCV infection must be confirmed by direct diagnosis ***,HCV genotyping is required prior to starting any ***,high-volume clinical laboratories use different types of automated platforms,which have simplified sample processing,reduced hands-on-time,minimized contamination risks and human error and ensured full traceability of *** advances have also been made in the field of fibrosis stage assessment with the development of non-invasive methods,such as imaging techniques and serum-based ***,no single test is currently available that is able to completely replace liver *** review focuses on approved commercial tools used to diagnose HCV infection and the recommended hepatic fibrosis staging tests.