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Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 295-318页

作者： Ramón Cantero-Cid Karla Marina Montalbán-Hernández Jenny Guevara Alejandro Pascual-Iglesias Elisa Pulido JoséCarlos Casalvilla Cristóbal Marcano Cristina Barragán Serrano Jaime Valentín Gloria Cristina Bonel-Pérez JoséAvendaño-Ortiz verónica Terrón Roberto Lozano-Rodríguez Alejandro Martín-quirós Elvira Marín Eva Pena Laura Guerra-Pastrián Eduardo López-Collazo Luis Augusto Aguirre Tumor Immunology Laboratory The Innate Immune Response GroupHospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Digestive Surgery Service La Paz University HospitalMadrid 28046Spain Emergency Department and Emergent Pathology Research Group Hospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Pathologic Anatomy Service Hospital La PazMadrid 28046Spain

BACKGROUND Colorectal cancer(CRC)accounts for 9.4%of overall cancer deaths,ranking second after lung *** the large number of factors tested to predict their outcome,most patients with similar variables show big differences in ***,right-sided CRC(RCRC)and left-sided CRC(LCRC)patients exhibit large differences in outcome after surgical intervention as assessed by preoperative blood leukocyte *** hypothesised that stronger indexes than circulating(blood)leukocyte ratios to predict RCRC and LCRC patient outcomes will result from combining both circulating and infiltrated(tumour/peritumour fixed tissues)concentrations of *** To seek variables involving leukocyte balances in peripheral blood and tumour tissues and to predict the outcome of CRC *** Sixty-five patients diagnosed with colon adenocarcinoma by the Digestive Surgery Service of the La Paz University Hospital(Madrid,Spain)were enrolled in this study:43 with RCRC and 22 with *** were followed-up from January 2017 to March 2021 to record overall survival(OS)and recurrence-free survival(RFS)after surgical *** concentrations in peripheral blood were determined by routine laboratory ***-fixed samples of tumour and peritumoural tissues were assessed for leukocyte concentrations by immunohistochemical detection of CD4,CD8,and CD14 marker *** of leukocyte concentration in blood and tissues were calculated and evaluated for their predictor values for OS and RFS with Spearman correlations and Cox univariate and multivariate proportional hazards regression,followed by the calculation of the receiver-operating characteristic and area under the curve(AUC)and the determination of Youden’s optimal cutoff values for those variables that significantly correlated with either RCRC or LCRC patient *** patients from the cohort were randomly assigned to modelling and validation sets,and clinician-friendly nomogra

关键词： Left colorectal cancer Leukocyte ratios Prognostic variables Recurrence-free survival Right colorectal cancer Overall survival

Communication between bone marrow mesenchymal stem cells and multiple myeloma cells:Impact on disease progression

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World Journal of Stem Cells 2023年第5期15卷 421-437页

作者： Daniel García-Sánchez Alberto González-González Ana Alfonso-Fernández Mónica Del Dujo-Gutiérrez Flor M Pérez-Campo Department of Molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain Servicio de Traumatología y Cirugía Ortopédica Hospital Universitario Marqués de ValdecillaInstituto de Investigación Sanitaria Valdecilla(IDIVAL)Facultad de MedicinaUniversidad de CantabriaSantander 39008CantabriaSpain

Multiple myeloma(MM)is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow(BM).The interaction between MM cells and the BM microenvironment,and specifically BM mesenchymal stem cells(BM-MSCs),has a key role in the pathophysiology of this *** data support the idea that BM-MSCs not only enhance the proliferation and survival of MM cells but are also involved in the resistance of MM cells to certain drugs,aiding the progression of this hematological *** relation of MM cells with the resident BM-MSCs is a two-way *** modulate the behavior of BM-MSCs altering their expression profile,proliferation rate,osteogenic potential,and expression of senescence *** turn,modified BM-MSCs can produce a set of cytokines that would modulate the BM microenvironment to favor disease *** interaction between MM cells and BM-MSCs can be mediated by the secretion of a variety of soluble factors and extracellular vesicles carrying microRNAs,long non-coding RNAs or other ***,the communication between these two types of cells could also involve a direct physical interaction through adhesion molecules or tunneling ***,understanding the way this communication works and developing strategies to interfere in the process,would preclude the expansion of the MM cells and might offer alternative treatments for this incurable disease.

关键词： Multiple myeloma Mesenchymal stem cells Bone marrow microenvironment Soluble factors Extra-cellular vesicles Cells adhesion molecules Tunnellingnanotubes

Scholz’s First Conjecture: A Brief Demonstration

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Applied Mathematics 2016年第1期7卷 70-76页

作者： José M. Sautto Agustín Santiago Carlos N. Bouza veró nica Campos Campus Costa Chica Universidad Aut&oacute noma de Guerrero Guerrero M&eacute xico Facultad de Matemá ticas Universidad Aut&oacute noma de Guerrero Acapulco M&eacute xico Facultad de Matemá tica y Computació n Universidad de la Habana Ciudad de La Habana Cuba

This paper presents a brief demonstration of Schulz’s first conjecture, which sets the upper and lower limits on the length of the shortest chain of addition. Two methods of the upper limit are demonstrated;the second one is based on the algorithm of one of the most popular methods for obtaining addition chains of a number, known as the binary method.

关键词： Addition Chain Exponentiation Short Chain Scholz’s Conjecture Binary Method

Discriminatory capacity of serum interleukin-6 between complicated and uncomplicated acute appendicitis in children:a prospective validation study

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World Journal of Pediatrics 2022年第12期18卷 810-817页

作者： Javier Arredondo Montero Giuseppa Antona Adriana Rivero Marcotegui Carlos BardajíPascual Mónica Bronte Anaut Raquel Ros Briones Amaya Fernández-Celis Natalia López-Andrés Nerea Martín-Calvo Pediatric Surgery Department Hospital Universitario de NavarraIrunlarrea 331008PamplonaSpain Clinical Analysis Department Hospital Universitario de NavarraPamplonaSpain Pathology Department Hospital Universitario de NavarraPamplonaSpain Cardiovascular Translational Research NavarraBiomed(Miguel Servet Foundation)Hospital Universitario de NavarraUniversidad Pública de Navarra(UPNA)IdiSNAPamplonaSpain School of Medicine Department of Preventive Medicine and Public HealthUniversity of NavarraPamplonaSpain CIBER Fisiopatología de la Obesidad y Nutrición(CIBERobn) Health Institute Carlos IIIMadridSpain Instituto de Investigación Sanitaria de Navarra IdiSNAPamplonaNavarraSpain

Background Serum interleukin-6(IL-6)has a moderate diagnostic performance in pediatric acute appendicitis(PAA).The evidence regarding its capacity to discern between complicated and uncomplicated PAA is *** We designed a prospective observational study to validate serum IL-6 as a marker for diagnostic classification between complicated and uncomplicated *** study included 205 patients divided into three groups:(1)patients who underwent major outpatient surgery(n=57);(2)patients with non-surgical abdominal pain(NSAP)in whom the diagnosis of PAA was excluded(n=53),and(3)patients with a confirmed diagnosis of PAA(n=95).The PAA patients were further classified as uncomplicated or complicated ***-6 concentration was determined in all patients at *** statistical analysis was performed using the Mann-Whitney U test,the Fisher exact test and the Kruskall Wallis *** area under the receiver operating characteristic curves(AUC)were *** Median(interquartile range,IQR)serum IL-6 values were 2 pg/mL(2.0–3.4)in group 1,3.9 pg/mL(2.4–11.9)in group 2,and 23.9 pg/mL(11.1–61.0)in group 3(Pnical and radiological variables may increase the diagnostic performance of this molecule.

关键词： Acute Appendicitis Complicated Diagnostic Interleukin-6 Pediatric Uncomplicated

Cardboard Eco-Bundle as an Alternative for Collation Shrink Film

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Open Journal of Applied Sciences 2023年第1期13卷 94-108页

作者： Jannes Roman Gilles verschueren Ward nica Peter Slaets Marc Juwet Department of Mechanical Engineering KU Leuven Campus Gent Belgium Department of Mechanical Engineering KU Leuven Campus Leuven Belgium

Due to increasing pressure on brand owners and distributors to avoid single use plastics such as plastic bundle packaging, a new bundle packaging that consists of corrugated board only, has been designed. Obviously this new packaging should equally enable transportability. This study compares the transportability of bundles using corrugated board on the one hand and bundles using plastic collation shrink film on the other. In particular, the resistance to varying horizontal inertial forces is compared experimentally. All tested bundle packagings of corrugated board perform well above expectations and significantly better than shrink film packaging. All additional requirements regarding marketing, durability, consumer convenience, …are met.

关键词： Transportability Collation Shrink Film Corrugated Board Packaging Horizontal Inertial Forces Fast Moving Consumer Goods Transportability

Application of Natural Antioxidants from Strawberry Tree(Arbutus unedo L.) and Dog Rose(Rosa canina L.) to Frankfurters Subjected to Refrigerated Storage

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Journal of Integrative Agriculture 2013年第11期12卷 1972-1981页

作者： Mónica Armenteros David Morcuende Sonia Ventanas Mario Estévez Animal Production and Food Science University of ExtremaduraAv.de la Universidad s/n

The effect of the addition of natural antioxidants from strawberry tree （Arbutus unedo L.; AU） and dog rose （Rosa canina L.; RC）, in frankfurters elaborated with or without the addition of antioxidant additives （sodium ascorbate and nitrite） was studied. Six different types of experimental frankfurters were prepared depending on the addition of phenolic-rich extracts from RC and AU and the presence （P） or absence （C） of antioxidant additives. Thiobarbituric acid reactive substances （TBARS）-numbers signiifcantly increased during chilled storage of C-frankfurters while additives and fruit phenolics inhibited lipid oxidation in P-frankfurters. The amount of protein carbonyls signiifcantly increased in all treatments except in P-AU frankfurters. The discoloration process that occurred during the chilled storage was reduced by the addition of substances with proven antioxidant activity （P-frankfurters）. Texture characteristics as hardness, springiness, cohesiveness and gumminess also suffered a signiifcant deterioration in C-frankfurters. The use of phenolic fruit extracts in combination with traditional antioxidant additives is a successful strategy to enhance the oxidative stability of frankfurters without modifying their color and texture properties.

关键词： fruit phenolics protein oxidation lipid oxidation nitrite ascorbate

CALLISTO facilities in Peru:spectrometer commissioning and observations of typeⅢsolar radio bursts

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Research in Astronomy and Astrophysics 2021年第6期21卷 329-336页

作者： Javier Alonso Rengifo veronica Loaiza-Tacuri Jose Bazo Walter Robert Guevara Day Seccion FIsica Departamento de CienciasPontificia Universidad Catolica del PeruAv.Universitaria 1801Lima 32Peru Direction de Astroflsica Comision National de Investigacion y Desarrollo AeroespacialCONIDALuis Felipe Villaran 1069LimaPeru Observatorio National Rua General Jose Cristino7720921-400 Sao CristovaoRio de JaneiroRJBrazil Facultad de Ciencias Ffsicas Universidad Nacional Mayor de San MarcosP.O.Box 14-149Lima 14Peru

The Astrophysics Directorate of CONIDA has installed two radio spectrometer stations belonging to the e-CALLISTO network in Lima,*** their strategic location near the Equator,it is possible to observe the Sun evenly throughout the whole *** receiver located at Pucusana,nearby the capital city of Lima,took data from October 2014 until August 2016 in the metric and decimetric bands looking for radio *** this period,this e-CALLISTO detector was unique in its time-zone *** asses the suitability of the sites and the performance of the antennas,we analyzed the radio ambient background and measured their radiation pattern and *** demonstrate the capabilities of the facilities for studying solar dynamics in these radio frequencies,we have selected and analyzed typeⅢSolar Radio *** study of this kind of burst helps to understand the electron beams traversing the solar corona and the solar atmospheric *** have characterized the most common radio bursts with the following mean values:a negative drift rate of-25.8±3.7 MHz s^(-1),a duration of 2.6±0.3 s and 35 MHz bandwidth in the frequency range of 114 to 174 *** addition,for some events,it was possible to calculate a global frequency drift which on average was 0.4±0.1 MHz s^(-1).

关键词： instrumentation:spectrographs Sun:radio radiation

Sustainable Potato Production in the Mountain Area of Ecuador, an Approach to Increase Productivity with Small Scale Farmers

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Agricultural Sciences 2022年第10期13卷 1080-1090页

作者： Alicia Villavicencio Chang Hwan Park Kangjin Cho Rona Bae Diego Peñ aherrera Gabriela Narváez Victoria López José Camacho Jovanny Suquillo Fausto Yumisaca Cesar Asaquibay María Nieto David Ortega verónica quimbiamba Cristian Torres Edwin Naranjo Stalin Cuenca Ricardo Alvarez Korean Program on International Agriculture and Technology—KOPIA Quito Ecuador Instituto Nacional de Investigaciones Agropecuarias—INIAP Quito Ecuador Extension Services KOPIA-INIAP Quito Ecuador

Ecuador potato crop is family based production system. Potato production has two roles in their economy, the first is providing food for their families and the second is a source of income for the household. However small scale farmers have limited access to local markets and most of the sales are through intermediates’ who purchase directly in the field at the lowest price possible. Potato production challenges for the small-scale farmers are among others availability of quality potato seed, direct sales, purchase of agrochemical inputs to maintain their crops and lack of education. In 2021, only 4% of potato farmers used certified seed. Potato yield is still low around 16.1 t·ha-1, in the last 10 years the total potato cultivated area was reduced by at least 50%. The farmers produce “Bokashi” and other organic fertilizer and these are effective to improve soil fertility and plant health. Homemade bio-pesticides reduce agrochemical pesticides. The Decision Support System (DSS) is a handheld device to control late blight, minimizes fungicide applications and improve fungicide rotation. In 2018 Candidatus Liberibacter solanacearum (Lso), the causal agent of zebra chip, and its vector, the potato psyllid Bactericera cockerelli, together created havoc for farmers and researchers. Promotion of early potato varieties INIAP—Libertad is an alternative to lower the impact of this newest pest.

关键词： Potato Yield Small-Scale Farmers Agro-Ecological Production Quality Seed

Tools for the diagnosis of hepatitis C virus infection and hepatic fibrosis staging

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World Journal of Gastroenterology 2014年第13期20卷 3431-3442页

作者： verónica Saludes Victoria González Ramon Planas Lurdes Matas Vicente Ausina Elisa Martró Institut d’ Investigació en Ciències de la Salut Germans Trias i Pujol Hospital Universitari Germans Trias i Pujol (Universitat Autònoma de Barcelona)08916 BadalonaSpain CIBER Epidemiología y Salud Pública (CIBERESP) 08003 BarcelonaSpain Centre for Epidemiological Studies on HIV/STI in Catalonia (CEEISCAT)-ICO 08916 BadalonaSpain Liver Unit Hospital Universitari Germans Trias i Pujol08916 BadalonaSpain Ramon Planas CIBER Enfermedades Hepáticas y Digestivas (CIBEREHD)08036 BarcelonaSpain CIBER Enfermedades Respiratorias (CIBERES) 07110 BunyolaSpain

Hepatitis C virus(HCV)infection represents a major public health *** C can be cured bytherapy,but many infected individuals are unaware of their *** HCV screening,fast diagnosis and characterization,and hepatic fibrosis staging are highly relevant for controlling transmission,treating infected patients and,consequently,avoiding end-stage liver *** to HCV can be determined with high sensitivity and specificity with currently available third generation serology ***,the use of point-of-care tests can increase HCV screening ***,active HCV infection must be confirmed by direct diagnosis ***,HCV genotyping is required prior to starting any ***,high-volume clinical laboratories use different types of automated platforms,which have simplified sample processing,reduced hands-on-time,minimized contamination risks and human error and ensured full traceability of *** advances have also been made in the field of fibrosis stage assessment with the development of non-invasive methods,such as imaging techniques and serum-based ***,no single test is currently available that is able to completely replace liver *** review focuses on approved commercial tools used to diagnose HCV infection and the recommended hepatic fibrosis staging tests.

关键词： Hepatitis C virus Diagnosis Real-time poly-merase